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In vitro biological effects of magnetic nanoparticles

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Chinese Science Bulletin 2012年第31期57卷 3972-3978页

作者： LI Yan CHEN ZhongWen gu ning State Key Laboratory of Bioelectronics Jiangsu Key Laboratory of Biomaterials and DevicesSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China

Magnetic nanoparticles (MNPs) have great potential for a wide use in various biomedical applications due to their unusual properties. It is critical for many applications that the biological effects of nanoparticles are studied in depth. To date, many disparate results can be found in the literature regarding nanoparticle-biological factors interactions. This review highlights recent developments in this field with particular focuses on in vitro MNPs-cell interactions. The effect of MNPs properties on cellular uptake and cytotoxicity evaluation of MNPs were discussed. Some employed methods are also included. Moreover, nanoparticle-cell interactions are mediated by the presence of proteins absorbed from biological fluids on the nanoparticle. Many questions remain on the effect of nanoparticle surface (in addition to nanoparticle size) on protein adsorption. We review papers related to this point too.

关键词：磁性纳米粒子生物效应体外生物医学应用蛋白质吸附相互作用细胞间 MNP

Size-dependent peroxidase-like catalytic activity of Fe_3O_4 nanoparticles

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Chinese Chemical Letters 2008年第6期19卷 730-733页

作者： Fang Fang Peng YU Zhang ning gu State Key Laboratory of Bioelectronics Southeast University Nanjing 210096 China Jiangsu Laboratory for Biomaterials and Devices Southeast University Nanjing 210096 China School of Chemistry and Chemical Engineering Southeast University Nanjing 210096 China

Peroxidase-like catalytic properties of Fe3O4 nanoparficles （NPs） with three different sizes, synthesized by chemical coprecipitation and sol-gel methods, were investigated by UV-vis spectrum analysis. By comparing Fe3O4 NPs with average diameters of 11, 20, and 150 nm, we found that the catalytic activity increases with the reduced nanoparticle size. The electrochemical method to characterize the catalytic activity of Fe3O4 NPs using the response currents of the reaction product and substrate was also developed.

关键词： Fe3O4 nanoparticles Peroxidase-like catalytic activity Electrochemistry

Current applications and future prospects of nanotechnology in cancer immunotherapy

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Cancer Biology & Medicine 2019年第3期16卷 486-497页

作者： Sen Yan Peng Zhao Tingting Yu ning gu State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Science&Medical EngineeringSoutheast UniversityNanjing210096China Collaborative Innovation Center of Suzhou Nano Scienceand Technology Suzhou215123China Department of Medical Genetics School of Basic Medical ScienceNanjing MedicalUniversityNanjing211166China Jiangsu Key Laboratory of Xenotransplantation Nanjing Medical UniversityNanjing211166China

Cancer immunotherapy is an artificial stimulation of the immune system to recognize cancer cells and activate specific immune cells to target and attack cancer *** clinical trials, immunotherapy has recently shown impressive results in the treatment of multiple ***, cancer immunotherapy has gained a lot of attention for its unique advantages and promising *** extensive research on cancer immunotherapy, its safety and effectiveness has gradually been ***, it is still a huge challenge to expand and drive this therapy while maintaining low toxicity, high specificity, and long-lasting *** a unique technology, nanotechnology has been applied in many fields, the advantages of which will promote the development of cancer *** have tried to apply nanomaterials to cancer immunotherapy due to their advantageous properties,such as large specific surface areas, effective drug delivery, and controlled surface chemistry, to improve treatment ***,we briefly introduce the current applications of nanomaterials in cancer immunotherapy, including adoptive cell therapy(ACT),therapeutic cancer vaccines, and monoclonal antibodies, and throw light on future directions of nanotechnology-based cancer immunotherapy.

关键词： Cancer immunotherapy nanotechnology therapeutic cancer vaccine monoclonal antibody

Characterization of Cysteine Coated Magnetite Nanoparticles as MRI Contrast Agent

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Nano-Micro Letters 2012年第3期4卷 180-183页

作者： Reza Ahmadi ning gu Hamid Reza Madaah Hosseini Department of Materials Science and Engineering Sharif University of Technology Research Center for Molecular and Cellular Imaging Tehran University of Medical Sciences Jiangsu Key Laboratory of Biomaterials and Devices

In this work,a kind of stabilized ferrofluid based on magnetite nanoparticles(mean core and its coating size about 21.9 and 1.6 nm,respectively)was synthesized via coprecipitation *** was used as surfactant due to its proper conjunction to the surface of magnetite *** density and synthesized ferrofluids were characterized by using transmission electron microscope,thermogravimetry analysis,dynamic light scattering and fourier transform infrared spectroscopy *** resonance imaging studies show that the synthesized ferrofluid can be used as a potential contrast enhancement agent especially for imaging lymphatic system.

关键词： Magnetite Co-precipitation Cysteine MRI

Photophysical Behavior of Heteroduplexes Formed from Naphthalene Incorporated Foldamers,and Linear Donors and Pyromellitic Diimide Incorporated Foldamers

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Chemical Research in Chinese Universities 2009年第3期25卷 317-327页

作者： ZHAO Shu-min gu Hai-ning ZHOU Qi-zhong Key Laboratory for Molecular Design and Nutrition Engineering of ningbo Ningbo Institute of Technology of Zhejiang University Ningbo 315100 P. R. China Department of Chemistry Zhejiang University Hangzhou 310027 P. R. China

The authors synthesized the electron-rich 1,5-dioxonaphthyl group incorporated foldamers, and linear donors and electron-deficient pyromellitic diimide incorporated foldamers, which were investigated in organic solvents. There is an evident charge transfer process from the donors to the electron-deficient foldamers, due to the donor-acceptor interaction of the heteroduplexes formed from the donors and the electron-deficient foldamers in chloroform, observed by using the ultraviolet（UV） visible method. The charge transfer process of the heteroduplexes depends on the molecular structure（not only the number of 1,5-dioxonaphthyl groups and pyromellitic diimide groups in the heteroduplex, but also the intermolecular double hydrogen bond in the heteroduplex）, the intercalative π-π stacking motif, the initial concentration of heteroduplexes, and the polarity of the solvent. Fortunately, the authors found a critical bumping concentration（CBC） of the donors in acetonitrile or chloroform, which is useful in quantitative research, by using the fluorescence method. The value of CBC depends not only on intramolecular folding and the intramolecular hydrogen bond, but also on intramolecular π-π stacking and the solvent. The electron-deficient foldamers quenched the fluorescence of the donors. Fluorescence quenching depends not only on the number of pyromellitic diimide groups and 1,5-dioxonaphthyl groups in the heteroduplex, but also on the intercalative π-π stacking motif between the donor and the acceptor.

关键词： Heteroduplex Foldarner Linear donor Charge transfer Quench

Iron oxide nanoparticles:A promising approach for diagnosis and treatment of cardiovascular diseases

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Nano Research 2023年第11期16卷 12453-12470页

作者： Xue Bao Yu Mao guangxiang Si Lina Kang Biao Xu ning gu Cardiovascular Disease Research Center Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolMedical SchoolNanjing UniversityNanjing 210093China State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Sciences and Medical EngineeringSoutheast UniversityNanjing 210096China

Despite advances in diagnostic and therapeutic technologies for cardiovascular diseases(CVDs),it remains a leading cause of mortality and morbidity *** underscores the urgency for innovative approaches aiming at early and precise detection and treatment of CVDs to reduce the disease *** oxide nanoparticles(IONPs),with their unique magnetism and bioproperties,have shown great potential in this *** this review,we will begin with a brief overview of the synthesis and properties of *** will then focus on the latest applications of IONPs in CVDs,including diagnosis and *** use of IONPs in the integration of diagnosis and treatment for CVDs is a promising field,and will be addressed in a separate *** translational potential and challenges of IONPs will also be *** conclusion,ongoing research and development of IONP-based strategies are highly likely to address current challenges effectively,and offer more personalized and efficient options for the diagnosis and treatment of CVDs.

关键词： atherosclerosis cardiovascular disease diagnosis iron oxide nanoparticles theranostic treatment

Spy chemistry enables stable protein immobilization on iron oxide nanoparticles with enhanced magnetic properties

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Journal of Materials Science & Technology 2023年第30期161卷 161-169页

作者： Chu Shi Jingyi Sheng guangxiang Si Yan Li Yan Shen ning gu Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210009China School of Biomedical Engineering and Informatics Nanjing Medical UniversityNanjing 211166China Medical School Nanjing UniversityNanjing 210093China

Iron oxide nanoparticles(IONPs)modified with functional proteins hold great promise in the biomedical ***,conventional protein modification strategies,such as adsorption and covalent coupling,are either unstable or nonspecific,or may result in the changes of protein structure and ultimately the loss of protein *** of active proteins on small-sized IONPs with a particle size of less than 30 nm is especially difficult due to their high surface ***,we developed a universal modifica-tion method based on Spy chemistry for rapid and stable protein immobilization on small-sized IONPs,which only requires the presence of active groups on the surface of nanoparticles that can couple with *** short,the SpyCatcher peptides were first coated on the surface of IONPs by cross-linking with activated groups,and then the SpyTag peptide fused with a model protein(enhanced green fluo-rescent protein,EGFP)was engineered(SpyTag-EGFP)and directly coupled to SpyCatcher-modified IONPs by self-assembly,which is spontaneous and robust while avoiding the effect of chemical reactions on functional protein *** obtained EGFP-functionalized IONPs exhibited enhanced and stable green fluorescence and improved magnetic *** addition,the cell internalization efficiency of EGFP-functionalized IONPs was significantly increased as compared to unmodified IONPs,providing an ideal solution for efficient cell labeling and *** conclusion,here we report a rapid and easy strategy for EGFP immobilization on IONPs based on Spy chemistry,which could be further adapted to other functional proteins in the ***-modified IONPs and SpyTag-X(arbitrary functional fusion proteins)hold great potential to be applied as a versatile platform for protein immobilization on IONPs and enable its multifunctional application in the future.

关键词： Iron oxide nanoparticles Spy chemistry Protein immobilization Magnetic resonance imaging Cell labeling

The preparation and application of microbubble contrast agent combining ultrasound imaging and magnetic resonance imaging

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Chinese Science Bulletin 2009年第17期54卷 2934-2939页

作者： YANG Fang LI YiXin CHEN ZhongPing gu ning State Key Laboratory of Bioelectronics Jiangsu Laboratory for Biomaterials and Devices School of Biological Science and MedicalEngineering Southeast University Nanjing 210096 China

Encapsulated gas microbubbles are well known as ultrasound contrast agents (UCAs) for medical ultrasound (US) imaging. With the development of shell materials and preparation technologies, the application of microbubbles has been enormously popular in molecular imaging, drug delivery and targeted therapy, etc. The objective of this study is to develop Fe3O4 nanoparticle-inclusion microbubble construct. The in vitro US imaging experiment indicates that the Fe3O4 nanoparticle-inclusion microbubbles have higher US enhancement than those without Fe3O4 nanoparticle-inclusion. According to the microbubble dynamic theory, the acoustic scattering properties can be quantified by scattering cross-section of the shell. The scattering study on Fe3O4 nanoparticle-inclusion microbubbles of different concentration shows that within a certain range of concentration, the scattering cross-section of microbubble increases with the addition of Fe3O4 nanoparticles. When exceeding the concentration range, the ultrasonic characteristic of microbubbles is damped. On the other hand, since Fe3O4 nanoparticles can also serve as the Magnetic Resonance Imaging (MRI) contrast agent, they can be potentially used as contrast agents for the double-modality (MRI and US) clinical studies. However, it is important to control the concentration of Fe3O4 nanoparticles in the shell in order to realize the combined functions of US and MRI.

关键词： Fe3O4纳米粒子超声造影剂浓度范围外壳材料分子成像散射截面动力学理论声散射特性

Transmission electron microscopy and atomic force microscopy characterization of nickel deposition on bacterial cells

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Chinese Science Bulletin 2007年第21期52卷 2919-2924页

作者： WANG Jing HE ShiYing XU LiNa gu ning Jiangsu Laboratory for Biomaterials and Devices National Laboratory of Molecular and Biomolecular Electronics Department ofBiological Science and Medical Engineering Southeast University Nanjing 210096 China

Recently bacterial cells have become attractive biological templates for the fabrication of metal nano- structures or nanomaterials due to their inherent small size, various standard geometrical shapes and abundant source. In this paper, nickel-coated bacterial cells (gram-negative bacteria of Escherichia coli) were fabricated via electroless chemical plating. Atomic force microscopy (AFM) and transmission electron microscopy (TEM) characterization results reveal evident morphological difference between bacterial cells before and after deposition with nickel. The bare cells with smooth surface presented transverse outspreading effect at mica surface. Great changes took place in surface roughness for those bacterial cells after metallization. A large number of nickel nanoparticles were observed to be equably distributed at bacterial surface after activation and subsequent metallization. Furthermore, ultra thin section analytic results validated the presence and uniformity of thin nickel coating at bacte- rial surface after metallization.

关键词：原子粒显微镜电子显微镜金属化细菌细胞