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Surface properties of encapsulating hydrophobic nanoparticles regulate the main phase transition temperature of lipid bilayers： A simulation study

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Nano Research 2014年第8期7卷 1195-1204页

作者： Xubo Lin ning gu State Key Laboratory of Bioelectronics and Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science & MedicalEngineering Southeast University Nanjing 210096 China

The main phase transition temperature of a lipid membrane, which is vital for its biomedical applications such as controllable drug release, can be regulated by encapsulating hydrophobic nanoparticles into the membrane. However, the exact relationship between surface properties of the encapsulating nanoparticles and the main phase transition temperature of a lipid membrane is far from clear. In the present work we performed coarse-grained molecular dynamics simulations to meet this end. The results show the surface roughness of nanoparticles and the density of surface-modifying molecules on the nanoparticles are responsible for the regulation. Increasing the surface roughness of the nanoparticles increases the main phase transition temperature of the lipid membrane, whereas it can be decreased in a nonlinear way via increasing the density of surface-modifying molecules on the nanoparticles. The results may provide insights for understanding recent experimental studies and promote the applications of nanoparticles in controllable drug release by regulating the main phase transition temperature of lipid vesicles.

关键词： lipid bilayer phase transition nanoparticle surface roughness density surface molecules

Fusogenic charge-reversal vector:a viropexis-mimicking system for gene delivery

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Science China Materials 2015年第12期58卷 913-914页

作者： ning gu State Key Laboratory of Bioelectronics School of Biological Science & Medical EngineeringSoutheast University

Gene therapy is known highly effective for treatment of many diseases;however,its wide use has been severely bottlenecked by lack of safe and effective delivery vectors[1].Cationic polymers are safe nonviral gene vectors with great potential for large-scale applications[2],and widely used to condense the large macromolecules into cationic polymer/DNA complexes(polyplexes)nanoparticles,protect-

关键词： gene DNA Fusogenic charge-reversal vector

Preface on “Biomaterial Foundations of Therapeutic Delivery”

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Science China Materials 2017年第6期60卷 469-470页

作者： Hasan Uludag ning gu Department of Chemical & Materials Engineering Faculty of EngineeringUniversity of Alberta School of Biological Science and Medical Engineering Southeast University

Driven by the enormous clinical need,drug delivery systems（DDS）have become a prime research focus in the field of *** offer opportunities for developing new therapeutic approaches to prevent and treat debilitating a... 详细信息

关键词： overcome enormous naturally threatening hydrophilic Preface on fabrication conjugated encapsulation coated

Magnetic labeling of natural lipid encapsulations wit ron-based nanoparticles

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Nano Research 2018年第6期11卷 2970-2991页

作者： Dewen Ye Yan Li ning gu State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Sciences & Medical Engineering Southeast University Nanjing 210096 China Collaborative Innovation Center of Suzhou Nano Science and Technology Suzhou 215123 China

With superior biocompatibility and unique magnetic properties, iron-based nanoparticles （IBNP） are commonly encapsulated in cells and extracellular vesicles （EV） to allow for magnetic force controlled drug delivery and non-invasive tracking. Based on their natural source and similar morphologs; we classify both cells and EVs as being natural lipid encapsulations （NLEs）, distinguishing them from synthetic liposomes. Both their imaging contrast and drug effects are dominated by the amount of iron encapsulated in each NLE, demonstrating the importance of magnetic labeling efficiency. It is known that the membranes function as barriers to ensure that substances pass in and out in an orderly manner. The most important issue in increasing the cellular uptake of IBNPs is the interaction between the NLE membrane and IBNPs, which has been found to be affected by properties of the IBNPs as well as NLE heterogeneity. Two aspects are important for effective magnetic labelling： First, how to effectively drive membrane wrapping of the nanoparticles into the NLEs, and second, how to balance biosafety and nanoparticle uptake. In this review, we will provide a systematic overview of the magnetic labeling of NLEs with IBNPs. This article provides a summary of the applications of magnetically labeled NLEs and the labeling methods used for IBNPs. The review also analyzes the role of IBNPs physicochemical properties, especially their magnetic properties, and the of NLEs in the internalization pathway. At the same time, the future of magnetically labeled NLEs is also discussed. development

关键词： magnetic labeling iron-based nanopartide (IBNP) natural lipid encapsulation(NLE) IBNP-membrane interactions

Magnetic responsive scaffolds and magnetic fields in bone repair and regeneration

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Frontiers of Materials Science 2014年第1期8卷 20-31页

作者： Hai-Yan XU ning gu Department of Biomedical Engineering Institute of Basic Medical Sciences Chinese Academy of Medical Science & Peking Union Medical College Beijing 100005 China State Key Laboratory of Bioelectronics and Jiangsu Key Laboratory for Biomaterials and Devices School of Biological Science & Medical Engineering Southeast University Nanjing 210096 China

Increasing evidence shows that magnetic fields and magnetic responsive scaffolds can play unique roles in promoting bone repair and regeneration. This article addresses the synergistic effects of magnetic scaffolds in response to external magnetic fields on the bone regeneration in situ. Additionally, the exploration of using magnetic scaffolds as tools in the bone implant fixation, local drug delivery and mimicking microenvironment of stem cell differentiation are introduced. We also discussed possible underlying mechanisms and perspectives of magnetic responsive scaffolds in the bone repair and regeneration.

关键词： bone repair magnetic scaffold magnetic field physical stimulation

Superparamagnetic iron oxide nanoparticles assembled magnetic nanobubbles and their application for neural stem cells labeling

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Journal of Materials Science & Technology 2021年第4期63卷 124-132页

作者： Jing Li Zhenqiang Feng ning gu Fang Yang State Key Laboratory of Bioelectronics Jiangsu Key Laboratory for Biomaterials and DevicesSchool of Biological Sciences and Medical EngineeringSoutheast UniversityNanjing 210096China

Micro/nanobubbles for use as ultrasound contrast agents have been fabricated with different shell *** various biomedical nanoparticles have been embedded in the shells of bubbles,the composite structures have shown promising applications in multi-modal imaging,drug/gene delivery,and biomedical *** this study,we developed a new gas-liquid interface self-assembly method to prepare magnetic nanobubbles embedded with superparamagnetic iron oxide nanoparticles(SPIONs).The diameter of the generated assembled nanobubbles was 227.40±87.21 nm with a good polydispersity index(PDI)of *** the condition of 150 compression cycles,the nanobubble concentration could reach about 6.12×10^(9)/*** electron microscopy(TEM)and scanning electronic microscopy(SEM)demonstrated that the assembled nanobubbles had a hollow gas core with SPIONs adsorbed on the ***(US)imaging and magnetic resonance imaging(MRI)experiments indicated that the assembled magnetic nanobubbles exhibited good US and MR contrast ***,the assembled magnetic nanobubbles were used to label neural stem cells under ultrasound *** 40 s US exposure,the magnetic nanobubbles could be delivered into cells with 2.80 pg Fe per cell,which could be observed in the intracellular endosome by *** with common incubation methods,the ultrasound exposure method did not introduce the potential cytotoxicity of transfection reagents and the efficiency was about twice as high as the efficiency of ***,the assembled magnetic nanobubbles prepared through the pressure-driven gas-liquid interface assembly approach could be a potential US/MRI dual model imaging nanocarrier for regenerative applications.

关键词： magnetic shells bubble

guanxinⅤRelieves Ventricular Remodeling by Inhibiting Inflammation:Implication from Virtual Screening,Systematic Pharmacology,Molecular Docking,and Experimental Validation

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Chinese Journal of Integrative Medicine 2023年第12期29卷 1077-1086页

作者： LIANG Bo ZHANG Xiao-xiao gu ning Department of Cardiology Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing(210022)China Department of Nephrology the Key Laboratory for the Prevention and Treatment of Chronic Kidney Disease of ChongqingChongqing Clinical Research Center of Kidney and Urology DiseasesXinqiao HospitalArmy Medical University(Third Military Medical University)Chongqing(400037)China School of Chinese Medicine School of Integrated Chinese and Western MedicineNanjing University of Chinese MedicineNanjing(210046)China

Objective:To reveal the anti-inflammatory mechanism of guanxinⅤ,which is prescribed for ventricular remodeling in clinical ***:guanxinⅤ-,ventricular remodeling-,and inflammationrelated targets were obtained through an integrated strategy of virtual screening and systematic pharmacology,and then the shared targets were visualised with a Venn ***Ⅴnetwork and the protein-protein interaction network were drawn,and enrichment analysis was ***,the main results obtained from the integrated strategy were validated by molecular docking and in vivo ***:A total of 251,11,425,and 15,246 guanxinⅤ-,ventricular remodeling-,and inflammation-related targets were acquired,***,211 shared targets were considered to contribute to the mechanism of ventricular remodeling treated by guanxinⅤ.guanxin network and the protein-protein interaction network were drawn,and enrichment analysis showed some cardiovascular-related biological processes and signaling *** docking revealed that the guanxinⅤ-derived compounds could align with key *** in vivo experiments proved that guanxinⅤreverses ventricular remodeling by inhibiting ***:guanxinⅤrelieves ventricular remodeling by regulating inflammation,which provides new ideas for the anti-ventricular remodeling mechanism of guanxinⅤ.

关键词： guanxinⅤ Chinese medicine ventricular remodeling inflammation

On the cultural legacy of the Cold War:Sino-US educational exchange(1949−1990)

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Frontiers of Education in China 2006年第4期1卷 487-504页

作者： gu ning Institute of World History Chinese Academy of Social SciencesBeijing 100006China

The Cold War affected the Sino-US educational exchange between 1949 and *** those years,preparation for educational exchanges,personal contact and cross-government relations characterized the three periods of the ***,even though the relationship had developed very fast,it was by no means smooth *** exchanges served as a political barometer and also acted as a conduit between the two when diplomatic relations were *** eased the tension when the relationship between the two countries had *** 40 years of exchanges were a win-win situation for both sides and one of the valuable cultural legacies that came out of the Cold War era.

关键词： Cold War cultural legacy Sino-US relations educational exchange

A blockchain-enabled wiki framework based on participatory design

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Digital Communications and Networks 2022年第6期8卷 995-1004页

作者： Zheng Xu Chaofan Liu Peng Zhang Tun Lu ning gu School of Computer Science Fudan UniversityShanghaiChina Shanghai Key Laboratory of Data Science Fudan UniversityShanghaiChina

The 5G mobile Internet facilitates contents generation for online communities and platforms through human-to-human ***,a well-known online community,uses wiki technology to build an encyclopedia through collective intelligence and *** wiki systems adopt a centralized implementation,and while existing studies have optimized the efficiency of the wiki systems'centralized implementation,these systems still suffer from a lot of problems,for example,opacity and *** the years,blockchain has brought a flurry of fervour and decentralization to the system architecture,meanwhile giving users a sense of trust and ***,an innovative blockchain-enabled wiki framework called DecWiki is proposed to build one transparent,truthful,collaborative and autonomous *** several participatory design iterations,we present DecWiki's detailed architecture and its implementation in the form of a smart contract and use the interplanetary file system to complement the big data ***,we use the trusted execution environment to secure sensitive information in the wireless ***,the system overhead and the acceptance of the prototype are *** experiments present its significant performance.

关键词： Blockchain Wiki Participatory design Trusted execution envir onment Smart contract