检索结果-南通市图书馆

作为研究的设计教学及其对中国建筑教育发展的意义

在线全文

学校读者我要写书评

暂无评论

时代建筑 2007年第3期50卷 14-19页

作者：顾大庆香港中文大学建筑学系

设计教师的日常工作——设计教学——是不是可以被看作为一种学术研究的特殊方式?这个问题的解答取决于设计教学是不是具有发展设计观念和方法的潜能。我国建筑设计教学的发展在“布扎”之后正面临着一个教什么和怎么教的学术真空,其解... 详细信息

设计教师的日常工作——设计教学——是不是可以被看作为一种学术研究的特殊方式?这个问题的解答取决于设计教学是不是具有发展设计观念和方法的潜能。我国建筑设计教学的发展在“布扎”之后正面临着一个教什么和怎么教的学术真空,其解决之道就在于从学术研究的角度来重新界定设计教学,把设计教学当作为设计研究的重要工具。

关键词：研究学术研究建筑学研究设计研究设计教学中国建筑教育

Trinuclear gold-catalyzed site-selective alkylation of peptides

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期 249-256页

作者： qing-Yun Fang Chengyihan gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词：

同方期刊数据库

在线全文

学校读者我要写书评

暂无评论

热轧窄带钢轧机窜辊原因分析与预防

轧钢 2000年第4期17卷 62-63页

作者：张桂南张长宏刘洪成顾大庆莱芜钢铁股份有限公司轧钢厂山东莱芜271126 莱芜钢铁股份有限公司技术中心山东莱芜271104

对莱钢 5 0 0mm热带轧机的窜辊问题进行了分析 ,得出窜辊现象与设备制造、轧制工艺、轧辊装配等因素有关 ;进而探讨了相应的改进措施。

关键词：窜辊热轧窄带钢轧机原因分析预防措施

Polyethylenimine-cyclodextrin-tegafur conjugate shows anti-cancer activity and a potential for gene delivery

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第9期12卷 720-729页

作者： Qi-da HU Hui FAN Wei-jian LOU qing-qing WANG gu-ping TANG Institute of Chemical Biology and Pharmaceutical Chemistry Zhejiang UniversityHangzhou 310028China Department of Pharmacy Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhou 310016China Institute of Immunology Zhejiang UniversityHangzhou 310058China The First Affiliated Hospital School of MedicineZhejiang UniversityHangzhou 310003China

Polyethylenimine-cyclodextrin-tegafur(PEI-CyD-tegafur) conjugate was synthesized as a novel multifunctional prodrug of tegafur for co-delivery of chemotherapeutic agent tegafur and enhanced green fluorescent protein(EGFP) reporter plasmid *** of tegafur to PEI-CyD via chemical linkage was characterized by 1 H NMR spectrometry and ultraviolet(UV) ***-CyD-tegafur was able to condense plasmid DNA into complexes of around 150 nm with positive charge at the N/P ratio of 25,in accordance with electron microscopy observation of compact and monodisperse *** results of in vitro experiments showed enhanced cytotoxicity and considerable transfection efficiency in B16F10 cell ***,PEI-CyD-tegafur may have great potential as a co-delivery system with anti-cancer activity and potential for gene delivery.

关键词： Polyethylenimine β-Cyclodextrin Tegafur Co-delivery Gene therapy

BIVARIATE LAGRANGE-TYPE VECTOR VALUED RATIONAL INTERPOLANTS

在线全文

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2002年第2期20卷 207-216页

作者： Chuan-qing gu Gong-qing Zhu Department of Mathematics Shanghai UniversityShanghai 200436China Department of Mathematics Hefei Polytechnic UniversityHefei 230009China

Focuses on a study that presented an axiomatic definition to bivariate vector valued rational interpolation on distinct plane interpolation points. Definition; Existence and uniqueness; Connection.

关键词： bivariate vector value rational interpolation determinantal formula

Transition-layer of coreerim structures andβ→a transformation in SiC ceramics

在线全文

学校读者我要写书评

暂无评论

Journal of Materiomics 2023年第2期9卷 299-309页

作者： qing-qing Shao Hui gu Materials Genome Institute School of Materials Science and EngineeringShanghai UniversityShanghai200444China

Similar to Si_(3)N_(4)ceramics,β→a phase transformation in SiC ceramics plays a key role in tailoring the microstructures thus optimizing related *** microstructures are dominated with the core erim structures by AlN-solution,and by EBSD analysis,a-lamellae were revealed as stacking-faults(SF)and twin-boundaries(TB)in b-grains,co-existing with the coreerim structures asα/β→α’/β’transformation by *** structural transformation can proceed much further by gas-pressuresintering than hot-pressing with only RE2O3 agents,while the latter retain a high-density of SF/TB in the metastable b-SiC *** high-angle secondary-electron imaging,nanoscale transition-layer(TL)was observed as an inter-phase to fully separate the core and rim,which is created by a transitory equilibrium in the solutionereprecipitation *** enrichment of AlN or RE in TL demonstrates their segregation to core surface until reaching the super-saturation and before the growth of *** higher AlN or RE solution and after sintering,a shear stress can develop from TL contour to drive the expansion of SF/TB in Martensitic transition,especially under an external isotropic *** combinations ofβ→a transformation,coreerim structures and viscous liquid-phase enable the comprehensive assessment of sintering-microstructure-property-performance relationship of SiC ceramics,as demonstrated for their creep behaviors and fracture toughness.

关键词： SiC ceramics Coreerim structures Transition-layer Martensitic transition Creep behaviors

Immunotoxicity of bisphenol A to Carassius auratus lymphocytes and macrophages following in vitro exposure

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2007年第2期19卷 232-237页

作者： YIN da-qiang HU Shuang-qing gu Ying WEI Li LIU Shu-shen ZHANG Ai-qian State Key Laboratory of Pollution Control and Resource Reuse School of the Environment Nanfing University Nanjing 210093 China Key laboratory of Yangtze River Water Environment Ministry of Education Tongji University Shanghai 200092 China

Bisphenol A （BPA） is the monomer component of polycarbonate plastics and classified as an endocrine disrupting chemical （EDC）. The reproductive toxicity of BPA has been extensively studied in mammals; however, relatively little information is available on the immunotoxic responses of fish to BPA. In this study, we investigated the effects of BPA on the immune functions of lymphocytes and macrophages in Carassius auratus. The effects of BPA were compared with those of two natural steroid hormones, estradiol and hydrocortisone. Proliferation of the two types of cells in response to PHA was measured using colorimetric MTT assay. Macrophage respiratory burst stimulated by Con A was measured using chemiluminescence assay. Results showed that BPA （0.054-5.4 mg/L）, estradiol （0.0002-2.0 mg/L） and hydrocortisone （5-50 mg/L） significantly induced Carassius auratus lymphocyte proliferation while higher doses of hydrocortisone （500-5000 mg/L） appeared to be inhibitory. BPA （0.005-50 mg/L）, estradiol （0.005-800 mg/L） and hydrocortisone （0.005-500 mg/L） markedly enhanced macrophage proliferation, whereas higher doses of BPA （500-1000 mg/L） appeared to inhibit cell proliferation. Furthermore, higher dosage of BPA （50 mg/L） and hydrocortisone （50 and 500 mg/L） suppressed the macrophages respiratory burst while estradiol is stimulative all the doses tested （0.05-500 mg/L）. In conclusion, BPA could have immunotoxicity to Carassius auratus and functional changes of lymphocyte and macrophage in Carassius auratus may be different between low and high dosages.

关键词： bisphenol A immunotoxicology lymphocyte macrophage Carassius auratus

Review of Some Advances and Applications in Real-time High-speed Vision: Our Views and Experiences

在线全文

学校读者我要写书评

暂无评论

International Journal of Automation and computing 2016年第4期13卷 305-318页

作者： qing-Yi gu Idaku Ishii Robotics Laboratory Graduate School of Engineering Hiroshima University Higashi-Hiroshima Hiroshima 738-8527 Japan

The frame rate of conventional vision systems is restricted to the video signal formats （e.g., NTSC 30 fps and PAL 25 fps） that are designed on the basis of the characteristics of the human eye, which implies that the processing speed of these systems is limited to the recognition speed of the human eye. However, there is a strong demand for real-time high-speed vision sensors in many application fields, such as factory automation, biomedicine, and robotics, where high-speed operations are carried out. These high-speed operations can be tracked and inspected by using high-speed vision systems with intelligent sensors that work at hundreds of Hertz or more, especially when the operation is difficult to observe with the human eye. This paper reviews advances in developing real-time high Speed vision systems and their applications in various fields, such as intelligent logging systems, vibration dynamics sensing, vision-based mechanical control, three-dimensional measurement/automated visual inspection, vision-based human interface, and biomedical applications.

关键词： Real-time high-speed vision target tracking abnormal behavior detection behavior mining vibration analysis 3D shapemeasurement cell sorting.

Intercalation-pseudocapacitance hybrid anode for high rate and energy lithium-ion capacitors

在线全文

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2021年第4期30卷 459-467页

作者： Chang Liu Ali Khosrozadeh qing-qing Ren Ling-Hui Yan Kokswee Goh Shi-Han Li Jian Liu Lei Zhao da-Ming gu Zhen-Bo Wang MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Lab of Urban Water Resource and EnvironmentSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina School of Engineering Faculty of Applied ScienceUniversity of British ColumbiaKelowna V1V 1V7BCCanada

Existing rechargeable batteries not only fail to meet the demand for high power applications but also cause heavy metal ***-ion capacitors(LICs),which can achieve higher charging speeds and energy densities than supercapacitors,have attracted extensive ***,sluggish Li-ion diffusion of the battery-type anode results in limited rate performance of ***,highperformance LICs using both battery and capacitor type Mn_(2)V_(2)O_(7)-graphene(MVO-G)anodes and hempstem-derivated activated carbon(HSAC)cathodes with a large surface area are first *** addition to high pseudocapacitance,the MVO-G possesses the advantage of fast Li^(+)storage performance making it a suitable choice for advanced LIC *** is employed to enhance overall conductivity and cycling stability leading to enhanced energy *** MVO-G//HSAC LICs exhibit a high energy density of 148.1 Wh kg^(-1) at a power density of 150 W kg^(-1) and 25 Wh kg^(-1) even at15 k W kg^(-1).More importantly,the MVO-G//HSAC LICs also show excellent cycling stability of 90%after15,000 cycles,which is expected for high performance energy storage systems.

关键词： Manganese vanadate Graphene Pseudocapacity Hempstem-based activated carbons Lithium ion capacitor