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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez Gabriel guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

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大坝安全综合评价多指标权重确定方法研究

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水电能源科学 2008年第4期26卷 88-90,94页

作者：顾艳玲顾冲时李波河海大学水利水电工程学院江苏南京210098

针对大坝安全综合评价中多指标权重的确定问题,将熵理论引入大坝安全综合评价中,应用广义最大熵原理,将不同赋权方法有机集成在一起确定大坝安全评价中多指标权重。该方法同时最大化体系内所有随机变量的香农熵,得到较稳健的估计结果。... 详细信息

针对大坝安全综合评价中多指标权重的确定问题,将熵理论引入大坝安全综合评价中,应用广义最大熵原理,将不同赋权方法有机集成在一起确定大坝安全评价中多指标权重。该方法同时最大化体系内所有随机变量的香农熵,得到较稳健的估计结果。通过工程实例验证了此方法有效可行,为相似工程问题的多指标权重确定提供新的思路。

关键词：大坝安全综合评价熵理论广义最大熵原理权重

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凤滩空腹重力拱坝坝顶切向位移变化规律分析

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水电能源科学 2005年第3期23卷 65-68,i006页

作者：张燕顾冲时河海大学水利水电工程学院江苏南京210098

针对凤滩空腹重力拱坝坝顶切向位移变化规律与拱坝常规变形规律的不同,从物理、力学角度出发分析其可能的原因,构建了空间挠度模型,据此分析该坝的变形规律,评价大坝的工作性态。

关键词：空腹重力拱坝切向位移空间挠度物理成因

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Fluorinated poly(p-triphenylene isatin) anion exchange membranes based on hydrophilic hydroxyl side chain modulation for fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 702-709页

作者： Yiman gu Yanchao Zhang Zhanyu Li Yijia Lei Baozeng Sun Xiaoyu Yu Zhe Wang College of Chemistry and Life Science Changchun University of Technology College of Chemical Engineering Changchun University of Technology School of Materials Science and Engineering Changchun University of Technology Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province

The development of alkaline fuel cells is moving forward at an accelerated pace,and the application of ether-free bonded polymers to anion exchange membranes （AEMs） has been widely ***,the question of the“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microphase separation to improve the performance of AEM has attracted much attention recently,but the design of optimal molecular structures is still being ***,this work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into the main chain of poly（p-terphenylene isatin）.Because fluorinated groups have excellent hydrophobicity,hydrophilic hydroxyl-containing side chains are introduced to jointly adjust the formation of phase separation *** results show that PTI-PTF50-NOH AEM with the appropriate fluorinated group ratio has the best ionic conductivity and alkali stability under the combined effect of *** has an ionic conductivity of 133.83 mS cm-1at 80°*** addition,the OH-conductivity remains at 89%of the initial value at 80°C and 3 M KOH for 1056 h of *** cell polarization curve based on PTI-PTF50-NOH shows a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Potassium hydroxide

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有限元强度折减法在土石坝边坡稳定分析中的应用

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水电能源科学 2006年第4期24卷 54-56,63页

作者：吴海真顾冲时河海大学水利水电工程学院

在指出传统边坡稳定分析方法的缺点和不足的同时,重点研究了有限元强度折减法的理论背景、突出优势、计算结果的影响因素、边坡失稳判据方法,探讨了该方法应用于土石坝边坡稳定分析中的可行性。采用摩尔-库仑屈服准则、非关联流动法则,... 详细信息

在指出传统边坡稳定分析方法的缺点和不足的同时,重点研究了有限元强度折减法的理论背景、突出优势、计算结果的影响因素、边坡失稳判据方法,探讨了该方法应用于土石坝边坡稳定分析中的可行性。采用摩尔-库仑屈服准则、非关联流动法则,在已知渗流场的前提下,基于有效应力原理逐步进行强度折减,直至满足力和位移不收敛的失稳判据,从而得到相应强度折减法的土石坝坝坡稳定安全系数。结果表明,无论是关键滑裂面位置还是最小安全系数,有限元强度折减法的计算结果与刚体极限平衡法的计算结果都相当接近,从而表明此法在土石坝边坡稳定分析中的可行性,拓宽了该法的应用范围。

关键词：土石坝边坡稳定有限元强度折减法

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Breaking new ground in photocatalysis: lutetium texaphyrin as a trigger for pyroptosis through biomolecular photoredox reactions

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Science China Chemistry 2025年第1期 1-2页

作者： Qihang Ding Mengrong He Meijia gu Department of Chemistry Korea University Department of Ultrasound Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) School of Pharmaceutical Sciences Wuhan University

Malignant neoplasms consistently pose a significant threat to global public health [1,2]. In recent years, immunotherapy has demonstrated remarkable clinical success; however, its efficacy is limited by the scarcity of immune cell infiltration within tumor microenvironments. Cell pyroptosis, a gasdermin-mediated process characterized by cellular swelling,rupture, and the release of intracellular contents such as IL-1β, IL-18, ATP, HMGB1, plays a crucial role in this context[3,4].

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Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zhang Chunyu Xiang Renrui Niu Xiaodong He Wenqi Luo Wanguo Liu Rui gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

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基于多变量灰色系统的乏信息堤防变形短期预测模型

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江苏水利 2024年第6期 1-5页

作者：顾冲时崔欣然顾昊吴艳朱明远林旭郭瑞河海大学水利水电学院江苏南京210098 新疆水利水电科学研究院新疆乌鲁木齐830049 淮安市水利勘测设计研究院有限公司江苏淮安223001

依据信息模糊和不确定状态下乏信息数据处理理论,提出了一种改进多变量灰色系统的乏信息堤防短期预测模型;引入多变量灰色模型对多测点的沉降变形序列进行拟合,结合混沌粒子群优化算法和分数阶微积分理论,实现了在乏信息条件下对堤防多... 详细信息

依据信息模糊和不确定状态下乏信息数据处理理论,提出了一种改进多变量灰色系统的乏信息堤防短期预测模型;引入多变量灰色模型对多测点的沉降变形序列进行拟合,结合混沌粒子群优化算法和分数阶微积分理论,实现了在乏信息条件下对堤防多测点变形的短期预测;由对比结果可知,研究提出的模型可行且有效,填补了堤防乏信息处理模型的空白。

关键词：乏信息堤防多变量灰色模型分数阶微积分混沌粒子群算法

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模糊控制的预测模型及其应用

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大坝观测与土工测试 2001年第2期25卷 17-20页

作者：马福恒王仁钟吴中如顾冲时水利部大坝安全管理中心南京210029 河海大学水利水电学院南京210098

本文以青铜峡大坝变形观测资料为例 ,依据模糊控制理论 ,研究了用模糊聚类分析法建立复杂结构混凝土坝变形的预测模型。

关键词：模糊控制预测模型聚类分析混凝土坝变形观测

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Boosting hydrocarbon conversion via Cu-doping induced oxygen vacancies on CeO2 in CO2 electroreduction

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Journal of Energy Chemistry 2025年第1期100卷 66-76页

作者： Lei Xue Tong Shi Chenhui Han Heng Zhang Fenrong Liu Haorun Li Yan Wang Xiaojun gu Shanghong Zeng Inner Mongolia Key Laboratory of Chemistry and Physics of Rare Earth Materials School of Chemistry and Chemical Engineering Inner Mongolia University State Key Laboratory of Coal Conversion Institute of Coal Chemistry Chinese Academy of Sciences Institute of Catalysis Department of Chemistry Zhejiang University National Key Laboratory of Baiyunobo Rare Earth Resource Research and Comprehensive Utilization Baotou Research Institute of Rare Earths

Conversion of CO2back to hydrocarbons is the most direct way of closing the“carbon cycle”,and its significance is further enlarged if this process is driven by renewable energies such as ***,precisely controlling the product selectivity towards hydrocarbons against the competitive hydrogen evolution remains challenging,especially for Cu-based ***,we report a novel defect engineering strategy,by which Cu-doping-induced oxygen vacancies on CeO2nanorods were effectively created,with adjustable vacancy/Cu *** resulting optimum catalyst shows up to 79% catalytic current density to hydrocarbons （excluding CO）,with 49% faradaic efficiency to *** and density functional theory unveil that the ratio between oxygen vacancy and Cu affects significantly the formation of*CHO and activation of H2O,which leads to the following deep hydrogenation to *** findings may spur new insights for designing and developing more controllable chemical process relevant to CO2utilization.

关键词： Nanorods

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