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Chinese Medical Journal 2010年第19期123卷 2739-2740页

作者： YU Yang QI Dan-ni gu cheng-xiong Department of Cardiac Surgery Beijing Anzhen Hospital Capital Medical University Beijing 100029 China School of Medicine Tsinghua University Beijing 100084 China

Currently coronary artery bypass grafting （CABG） is the most commonly used procedure for revascularization of coronary heart disease. However it may not be suitable for the patients with diffuse coronary artery diseases. Under this circumstance, retrograde perfusion via cardiac venous system, namely retrograde coronary venous bypass graft （CVBG）,

关键词： off-pump coronary artery bypass arterialization coronary venous system diffuse coronary artery diseases

Epicardial radiofrequency ablation for left ventricular aneurysm related ventricular arrhythmias during off-pump coronary artery bypass surgery

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Chinese Medical Journal 2012年第21期125卷 3836-3839页

作者： YU Yang GAO Ming-xin LI Hai-tao ZHANG Fan gu cheng-xiong Department of Cardiac Surgery Beijing An Zhen HospitalCapital Medical UniversityBeijing 100029China

Background Left ventricular aneurysm （LVA） is one of the serious complications after acute myocardial infarction. We attempted to evaluate the preliminary efficacy of LVA repair combined with epicardial radiofrequen... 详细信息

关键词： Left ventricular aneurysm " offpump coronary artery bypass grqfiing" epicardium " radioJkequency ablation ventricular arrhythmias

Off-pump surgery for coronary artery disease combined with mitral stenosis

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Chinese Medical Journal 2013年第24期126卷 4807-4808页

作者： LI Hai-tao YU Yang HUANG Xin-sheng gu cheng-xiong Department of Cardiac Surgery Beijing An Zhen Hospital Capital Medical University Beijing 100029 China

Rheumatic heart disease is still highly prevalent in .developing countries where the incidence of coronaryartery disease （CAD） is also arising. Consequently the occurrence of coexistent CAD and mitral stenosis （MS） dominantly caused by rheumatic fever is more frequent in these countries. Comorbidities such as pulmonary and renal dysfunction occur frequently in these aging populations. Off-pump surgery is widely applied in patients with concomitant CAD and severe comorbidities due to lower incidence of postoperative morbidity. Closed mitral commissurotomy （CMC） is a well established treatment for patients with mitral stenosis. We report here a case of moderate stenosis combined with seriously diffuse 3-vessel CAD and severe chronic obstructive pulmonary disease （COPD） in an elder male treated with off-pump coronary artery bypass （OPCAB） plus CMC.

关键词： coronary artery disease, valvular disease, off-pump mitral commissurotomy

Off-pump sequential bilateral internal mammary artery grafting combined with selective arterialization of the coronary venous system

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Chinese Medical Journal 2011年第19期124卷 3017-3021页

作者： YU Yang YAN Xiao-lei WEI Hua YANG Jun-feng gu cheng-xiong Department of Cardiac Surgery Beijing An Zhen Hospital Capital Medical University Beijing 100029 China

Background Off-pump coronary artery bypass surgery （OPCAB） has been widely applied in recent years as a less invasive method of myocardial revascularization. This study evaluated the sequential bilateral internal mammary artery grafting combined with selective arterialization of the coronary venous system during *** From April 2004 to August 2010, patients with diffuse right coronary lesions were studied retrospectively and divided into two groups. Group 1 included seventeen patients who underwent this surgery while group 2 included twenty-one patients without right coronary artery surgical therapy. All patients presented with symptoms of angina. Blood flow of bridged vessels was measured. The perioperative ventricular parameters including left ventricular ejection fraction and end diastolic diameter were compared. During follow-up, myocardial nuclide imaging and coronary angiography were carried *** Off-pump coronary artery bypass was performed with an average of 3.6 grafts per patient. Hospital mortality was zero. At the time of follow-up, the patients in group 1 recovered better than in group 2 （P〈0.05）. In both groups, the mean New York Heart Association （NYHA） class and ejection fraction increased significantly （P〈0.001） and the mean left ventricular end-diastolic diameter decreased significantly （P 〈0.05）. Myocardial blood supply of inferior wall in group 1 was obviously improved by myocardial nuclide imaging. Coronary angiography for eight patients in group 1 verified that there was blood flow to myocardium in the arterialized *** Sequential bilateral internal mammary artery grafting combined with selective arterialization of the coronary venous system can be performed during OPCAB. A postoperative improvement in the cardiac functions and the quality of life was documented, increasing our expectation for extensive application.

关键词： off-pump coronary artery bypass internal mammary artery," arterialization of the coronary venous system

Anteroapical aneurysm plication improves mechanical intraventricular dyssynchrony in patients with anterior myocardial infarction

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Chinese Medical Journal 2012年第7期125卷 1242-1248页

作者： HUANG Xin-sheng gu cheng-xiong YANG Jun-feng WEI Hua YU Yang ZHOU Qi-wen Department of Cardiac Surgery Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Background Left ventricular （LV） dyssynchrony has been described to occur in patients with myocardial infarction. Dyssynchrony of left ventricular mechanical contraction produces adverse hemodynamic consequences. This study aimed to test the capacity of geometric rebuilding by aneurysm plication to restore a more synchronous contractile pattern after a mechanical, rather than electrical, intervention. Methods A total of sixty patients with anterior myocardial infarction, QRS duration 〈120 ms, electively undergoing operation between January 2008 and January 2010 were included for analysis. Real-time 3-dimensional echocardiography was performed to assess LV function, LV systolic and diastolic dyssynchrony by measuring ejection fraction （EF）, peak ejection rate （PER）, peak filling rate （PFR） and LV dyssynchrony. LV dyssynchrony was defined as the systolic dyssynchrony of the time to reach the minimum systolic volume for 16 LV segments, expressed in percent cardiac cycle, systolic dyssynchrony index （SDI）. We compared changes of LV dyssynchrony at different interval times. Results LV contraction was significantly asynchronous because preoperative SDI was higher, EF, PER and PFR were lowered. Compared with function after operation, LV mechanical intraventricular resynchronization was improved with decreased SDI （（8.7_＋0.5） % vs. （14.3_＋1.6） %, P=0.01）; LV function was improved with EF increasing （（43_＋9）% vs. （37_＋7）%, P=0.001）, and LV systolic and diastolic dyssynchrony was improved with more rapid PFR （199.4_＋15.6 vs. 148.4_＋21.2, P=0.002） and PER （212.4_＋14.5 vs. 156.3_＋_26.2, P=0.001）. Conclusions Systolic and diastolic dyssynchrony was highly prevalent in patients with aneurysm, irrespective of QRS duration. Aneurvsm olication oroduces a mechanical *** rP.~***.

关键词： echocardiography myocardial contraction aneurysm cardiac surgical procedure

Three-dimensional fracture of UO2 ceramic pellets by phase field modeling

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 169-180页

作者： Wei xiong Xuan Ye Hongzhang cheng Xiaoming Liu Institute of Nuclear and New Energy Technology Collaborative Innovation Center of Advanced Nuclear Energy Technology Key Laboratory of Advanced Reactor Engineering and Safety of Ministry of Education Tsinghua University State Key Laboratory of Nonlinear Mechanics Institute of Mechanics Chinese Academy of Sciences School of Engineering Science University of Chinese Academy of Sciences

Fracture is the primary failure type for the UO2ceramic pellets,which are operated under irradiation and thermal processes,and physically confined by the *** this work,by combining closely coupled physical processes of heat conduction,heat transfer,and mechanical deformation with the cohesive phase field framework,we proposed a high-precision modeling of quasistatic cracking of three-dimensional （3D） UO2ceramic fuel pellets under high temperature and *** simulation results agree well with the experimental results,indicating that the proposed method has the potential to capture 3D crack modes in the interested time ***,we studied the relation of the 3D fracture patterns of fuel pellets with the peak power *** was found that the power level plays a critical role in determining the competition between radial and circumferential cracks,as well as transverse penetrating cracks.

关键词： phase field method nuclear fuel pellet coupled thermo-mechanical model thermal fracture

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弥漫性冠状动脉病变心肌血运重建的外科治疗

中华医学杂志 2010年第26期90卷 1830-1832页

作者：方颖顾承雄韦华陈长城首都医科大学附属北京安贞医院心脏外科 100029

目的回顾性分析弥漫性冠状动脉病变患者在非体外循环下行冠状动脉内膜剥脱加搭桥术重建心肌血运的治疗方法和经验,探讨其安全性与有效性.方法 2003年10月至2008年12月,在非体外循环下,对177例弥漫性冠状动脉病变患者、共229支病变血管... 详细信息

目的回顾性分析弥漫性冠状动脉病变患者在非体外循环下行冠状动脉内膜剥脱加搭桥术重建心肌血运的治疗方法和经验,探讨其安全性与有效性.方法 2003年10月至2008年12月,在非体外循环下,对177例弥漫性冠状动脉病变患者、共229支病变血管于冠状动脉最硬处远端且距离剥脱远端≥2 cm处行切口,进行内膜剥脱,再用乳内动脉或大隐静脉行旁路血管移植术.结果术中桥血流测定显示215支血管血流满意（93.9%）,桥血流量（27±12）ml/min;14支欠满意,桥血流量（7±4）ml/min.术后6例发生围手术期心肌梗死（3.4%）,其中3例无明显心脏血流动力学改变,3例发生低心排血量综合征,经主动脉内球囊反搏辅助治疗后好转出院.98例在术后3～40个月复查冠状动脉造影,显示桥血管均通畅.结论非体外循环下冠状动脉内膜剥脱后再行搭桥术,对于弥漫性冠状动脉病变心肌血运重建是一种安全、有效的治疗方法.

关键词：斑块切除术,冠状动脉冠状动脉旁路移植术,非体外循环冠状动脉硬化心肌血管重建术

Off-pump anteroapical aneurysm plication for left ventricular post-infarction aneurysm： long-term results

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Chinese Medical Journal 2012年第18期125卷 3228-3235页

作者： HUANG Xin-sheng gu cheng-xiong YANG Jun-feng WEI Hua LI Jing-xing YU Yang FANG Ying LIU Rui LI Hai-tao ZHOU Qi-wen Department of Cardtiac Surgery Beijing An Zhen Hospital CapitalMedical University China Beijing 100029

Background The temporal response to off-pump anteroapical aneurysm plication has not been well defined. We have evaluated the long-term clinical and functional results of this technique and compared the efficacy with the patch modeling repair. Methods From March 2005 to May 2010, 163 （115 men and 48 women） consecutive patients were operated on for post-infarction left ventricular aneurysm （LVA）, 54 patients underwent patch remodeling （group A） and 109 patients underwent off-pump anteroapical aneurysm plication repair （group B）. All patients had simultaneous coronary revascularization, other operative procedures included septoplasty in eight and ablation of ventricular tachycardia in six. Follow-up ranged from 1 to 5 years, short-term and mid-term outcomes, including complications, cardiac function, and mortality, were assessed. Results Early mortality was 1.8% for all patients （group A 1 death vs. group B 2 deaths, not significant （NS））. Peri-operative support included intraaortic balloon pumping in 16 （9.8%）, （group A 6 patients vs. group B 10 patients, NS） and inotropic drugs in 84 （51.5%）, （group A 34 vs. group B 50, NS）. During a mean follow-up of （3.7±0.8） years, eight patients died, with four due to cardiac-related causes. No patient required transplantation, and two required use of an implantable cardioverter-defibrillator for ventricular tachycardia. Survival at 1 and 5 years was 95% and 86%, respectively. It did not differ significantly between group A and group B. Functional class improved from 2.90±0.59 to 1.65±0.54 among the mid-term survivors （P 〈0.001）, with no significant difference between the two groups. Pre-operative risk factors for mortality or poor function were ejection fraction （EF）〈0.35 （OR=7.9, 95% CI 1.6-40.0）; congestive heart failure （CHF）（OR=4.4, 95% CI 1.0-19.0）; end-systolic volume index （ESVI）〉80 ml/m2 （OR=3.7, 95% CI 1.0-14.0）; and advanced age 〉70 years （OR=2.4, 95% CI 1.0-12.0）.

关键词： coronary artery bypass, off-pump cardiac surgical procedures, aneurysm myocardial infarction

Comparison of drug eluting stent implantation with coronary artery bypass surgery in the treatment of patients with chronic total occlusion and multiple vessel disease

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Chinese Medical Journal 2011年第8期124卷 1169-1174页

作者： LIU Wei MA Chang-sheng KANG Jun-ping DU Xin CHEN Fang ZHOU Yu-jie Lu Shu-zheng HUANG Fang-jiong gu cheng-xiong ZHU Xiao-Ling Department of Carcliology Beiiing Anzllen Hospital Capital Medical University Beijing 100029 China Department of Cardiac Surgery Beijing Anzllen Hospital Capital MedicalUniversity Beijing 100029 China

Background In patients with chronic total occlusion （CTO） and multivessel coronary artery disease, the comparison of surgical and the percutaneous revascularization strategies has rarely been conducted. The aim of this study was to compare long term clinical outcomes of drug eluting stent （DES） implantation with coronary artery bypass surgery （CABG）in the patients with CTO and multivessel *** From a prospective registry of 6000 patients in our institution, we included patients with CTO and multivessel coronary artery disease who underwent either CABG （n=679） or DES （n=267） treatment. Their propensity risk score was used for adjusting baseline *** At a median follow-up of three years, propensity score adjusted Cox regression analysis showed that the rate of major adverse cardiac cerebrovascular events （MACCE） was lower in CABG group （12.7% vs. 24.3%, hazard ratio （HR） 1.969, 95% Cl 1.219-3.179, P=0.006） mainly due to lower rate of target vessel revascularization in CABG group than in DES group （3.1% vs. 17.2%, HR 16.14, 95% CI 5.739-45.391, P ＜0.001）. The incidence of cardiac death or myocardial infarction （composite end point） was not significantly different between these two groups. On multivariate analysis, the significant predictors of MACCE were only the type of revascularization. Age, left ventricular ejection fraction （LVEF）, and complete revascularization were identified as significant predictors of composite end *** Our study shows that in patients with CTO and multivessel coronary disease, DES can offer comparable long term outcomes in cardiac death and myocardial infraction free survival in comparison with CABG. However, there is an increased rate of MACCE which results from more repeat revascularizations. Obtaining a complete revascularization is crucial for decreasing adverse cardiac events.

关键词： chronic total occlusion drug eluting stent cardiopulmonary bypass complete revascularization

Surgical strategy for mild ischemic mitral insufficiency

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Chinese Medical Journal 2010年第1期123卷 5-5页

作者： gu cheng-xiong Wei Hua Yu Yang Capital Med Univ Dept Cardiac Surg Beijing Anzhen Hosp Beijing 100029 Peoples R China

To the Editor： We read with the interest the article by FAN Hong-guang and colleaguesl having obtained outstanding early and long-term clinical outcomes of left ventricular restoration for the patients with postinfarction ventricular aneurysm and low left ventricular ejection fraction （LVEF） of mean 37.7%. We would like to comment on surgical strategy for mild iscbemic mitral insufficiency.

关键词： left ventricular ventricular aneurysm the article strategy interest comment would LVEF