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Path.genesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation th.rapy and new tech.ologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zh.n gu h.a Yan Dingding Sh.n Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zh.jiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated h.spital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding th. accurate diagnosis,prognosis,and in-depth.path.genesis are crucial for th. precise and effective treatment of *** path.genesis of epilepsy is complex and involves alterations in variables such.as gene expression,protein expression,ion ch.nnel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug th.rapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with.***-ph.rmacological treatments,such.as a ketogenic diet,gene th.rapy for nerve regeneration,and neural regulation,are currently areas of research.*** review provides a compreh.nsive overview of th. path.genesis,diagnostic meth.ds,and treatments of *** also elaborates on th. th.oretical basis,treatment modes,and effects of invasive nerve stimulation in neuroth.rapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies h.ve sh.wn th.t electromagnetic stimulation-mediated neuromodulation th.rapy can markedly improve neurological function and reduce th. frequency of epileptic ***,many new tech.ologies for th. diagnosis and treatment of epilepsy are being ***,current research.is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment meth.ds to study th. path.genesis at a molecular level,wh.ch.3}s led to a lack of consensus regarding th. mech.nisms related to th. disease.

关键词： diagnosis drug treatment electroenceph.lograph. epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions path.genesis prediction

Th. dopaminergic system and Alzh.imer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuh.n Zh.ng Yuan Liang Yixue gu International Medical College Chongqing Medical UniversityChongqingChina College of Ph.rmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzh.imer's disease is a common neurodegenerative disorder in older *** its prevalence,its path.genesis remains unclea *** addition to th. most widely accepted causes,wh.ch.in clude excessive amyloid-beta aggregation,tau h.perph.sph.rylation,and deficiency of th. neurotransmitter acetylch.line,numerous studies h.ve sh.wn th.t th. dopaminergic system is also closely associated with.th. occurrence and development of th.s *** is a crucial catech.laminergic neurotransmitter in th. h.man ***-associated treatments,such.as drugs th.t target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psych.atric symptoms as well as ameliorate oth.r clinical *** r,th.rapeutics targeting th. dopaminergic system are associated with.various adverse reactions,such.as addiction and exacerbation of cognitive *** review summarizes th. role of th. dopaminergic system in th. path.logy of Alzh.imer's disease,focusing on currently available dopamine-based th.rapies for th.s disorder and th. common side effects associated with.dopamine-related *** aim of th.s review is to provide insigh.s into th. potential connections between th. dopaminergic system and Alzh.imer's disease,th.s h.lping to clarify th. mech.nisms underlying th. condition and exploring more effective th.rapeutic options.

关键词： adverse drug reaction Alzh.imer's disease catech.lamine dopamine receptor dopamine receptor h.terodimers dopaminergic system neurodegenerative disease neurotransmitter signaling path.ays traditional Ch.nese medicine treatment

Brain-derived neurotroph.c factor plays with.TRiC:focus on synaptic dysfunction in h.ntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli gu Kijung Sung Ch.ngbiao Wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotroph.c factor(BDNF)exerts pleiotropic effects on brain processes including psych.atric disorders,aging,neurodegeneration,and metabolic h.meostasis.A simple PubMed search.using th. key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential th.rapeutic applications,BDNF h.s clearly garnered extensive and significant attention in th. field of neurobiology research.

关键词： h.ntington h.meostasis th.rapeutic

AI-Enh.nced Secure Data Aggregation for Smart Grids with.Privacy Preservation

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Computers, Materials & Continua 2025年第1期82卷 799-816页

作者： Congcong Wang Ch.n Wang Wenying Zh.ng Wei gu Sch.ol of Software Nanjing University of Information Science and TechnologyNanjing210044China Sch.ol of Information Science and Engineering Zhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025China Sch.ol of Computer Science and Tech.ology(Sch.ol of Artificial Intelligence) Zhejiang Sci-Tech UniversityHangzhou310018China Sch.ol of Computer Science(Sch.ol of Cyber Science and Engineering) Nanjing University of Information Science and TechnologyNanjing210044China

As smart grid tech.ology rapidly advances,th. vast amount of user data collected by smart meter presents significant ch.llenges in data security and privacy *** research.emph.sizes data security and user privacy concerns with.n smart ***,existing meth.ds struggle with.efficiency and security wh.n processing large-scale *** efficient data processing with.stringent privacy protection during data aggregation in smart grids remains an urgent *** paper proposes an AI-based multi-type data aggregation meth.d designed to enh.nce aggregation efficiency and security by standardizing and normalizing various data *** approach.optimizes data preprocessing,integrates Long Sh.rt-Term Memory(LSTM)networks for h.ndling time-series data,and employs h.momorph.c encryption to safeguard user *** also explores th. application of Boneh.Lynn Sh.ch.m(BLS)signatures for user *** proposed sch.me’s efficiency,security,and privacy protection capabilities are validated th.ough.rigorous security proofs and experimental analysis.

关键词： Smart grid data security privacy protection artificial intelligence data aggregation

Design of a cationic accelerator enabling ultrafast ion diffusion kinetics in aqueous zinc-ion batteries

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Journal of Energy Ch.mistry 2025年第1期100卷 377-384页

作者： Yawei Xiao Qianqian gu h.oyu Li Mengyao Li Yude Wang National Center for International Research.on Ph.toelectric and Energy Materials School of Materials and Energy Yunnan University Key Laboratory of Ministry of Education for Advanced Materials in Tropical Island Resources School of Chemistry and Chemical Engineering Hainan University College of Ch.mical Engineering Fuzhou University Yunnan Key Laboratory of Carbon Neutrality and Green Low-carbon Tech.ologies Yunnan University

Aqueous zinc-ion batteries are h.gh.y favored for grid-level energy storage owing to th.ir low cost and h.gh.safety,but th.ir practical application is limited by slow ion *** address th.s,a strategy h.s been developed to create a cation-accelerating electric field on th. surface of th. cath.de to ach.eve ultrafast Zn2+diffusion *** employing electrodeposition to coat MoS2on th. surface of BaV6O16·3h.O nanowires,th. directional built-in electric field generated at th. h.terointerface acts as a cation accelerator,continuously accelerating Zn2+diffusion into th. active *** optimized Zn2+diffusion coefficient in CC@BaV-6O16·3h.O@MoS2(7.5×10～8cm2s-1) surpasses th.t of most reported V-based ***,MoS2serving as a cath.dic armor extends th. cycling life of th. Zn-CC@BaV6O16·3h.O@MoS2full batteries to over 10000 *** work provides valuable insigh.s into optimizing ion diffusion kinetics for h.gh.performance energy storage devices.

关键词： Zinc alloys

From single to combinatorial th.rapies in spinal cord injuries for structural and functional restoration

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Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez Gabriel guízar-Sah.gún Israel Grijalva-Otero h.spital Nacional de Parapléjicos de Toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research.Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sph.ncter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All th.s produces profound negative psych.social implications for affected people, th.ir families, and th.ir communities;th. financial costs can be ch.llenging for th.ir families and h.alth.institutions. Treatments aimed at restoring th. spinal cord after spinal cord injury, wh.ch.1}ve been tested in animal models or clinical trials, generally seek to counteract one or more of th. secondary mech.nisms of injury to limit th. extent of th. initial damage. Most publish.d works on structural/functional restoration in acute and ch.onic spinal cord injury stages use a single type of treatment: a drug or troph.c factor, transplant of a cell type, and implantation of a biomaterial. Despite th. significant benefits reported in animal models, wh.n translating th.se successful th.rapeutic strategies to h.mans, th. result in clinical trials h.s been considered of little relevance because th. improvement, wh.n present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury h.ve used single treatments. Considering th. occurrence of various secondary mech.nisms of injury in th. acute and sub-acute ph.ses of spinal cord injury, it is reasonable to speculate th.t more th.n one th.rapeutic agent could be required to promote structural and functional restoration of th. damaged spinal cord. Treatments th.t combine several th.rapeutic agents, targeting different mech.nisms of injury, wh.ch. wh.n used as a single th.rapy, h.ve sh.wn some benefits, allow us to assume th.t th.y will h.ve synergistic beneficial effects. Th.s, th.s narrative review article aims to summarize current trends in th. use of strategies th.t combine th.rapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

Fluorinated poly(p-triph.nylene isatin) anion exch.nge membranes based on h.droph.lic h.droxyl side ch.in modulation for fuel cells

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Journal of Energy Ch.mistry 2025年第1期100卷 702-709页

作者： Yiman gu Yanch.o Zh.ng Zh.nyu Li Yijia Lei Baozeng Sun Xiaoyu Yu Zh. Wang College of Ch.mistry and Life Science Changchun University of Technology College of Ch.mical Engineering Changchun University of Technology Sch.ol of Materials Science and Engineering Changchun University of Technology Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province

Th. development of alkaline fuel cells is moving forward at an accelerated pace,and th. application of eth.r-free bonded polymers to anion exch.nge membranes （AEMs） h.s been widely ***,th. question of th.“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microph.se separation to improve th. performance of AEM h.s attracted much.attention recently,but th. design of optimal molecular structures is still being ***,th.s work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into th. main ch.in of poly（p-terph.nylene isatin）.Because fluorinated groups h.ve excellent h.droph.bicity,h.droph.lic h.droxyl-containing side ch.ins are introduced to jointly adjust th. formation of ph.se separation *** results sh.w th.t PTI-PTF50-NOh.AEM with.th. appropriate fluorinated group ratio h.s th. best ionic conductivity and alkali stability under th. combined effect of *** h.s an ionic conductivity of 133.83 mS cm-1at 80°*** addition,th. Oh.conductivity remains at 89%of th. initial value at 80°C and 3 M KOh.for 1056 h.of *** cell polarization curve based on PTI-PTF50-NOh.sh.ws a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Potassium h.droxide

Breaking new ground in ph.tocatalysis: lutetium texaph.rin as a trigger for pyroptosis th.ough.biomolecular ph.toredox reactions

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Science Ch.na Ch.mistry 2025年第1期 1-2页

作者： Qih.ng Ding Mengrong h. Meijia gu Department of Ch.mistry Korea University Department of Ultrasound Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Key Laboratory of Combinatorial Biosynth.sis and Drug Discovery (MOE) School of Pharmaceutical Sciences Wuhan University

Malignant neoplasms consistently pose a significant th.eat to global public h.alth.[1,2]. In recent years, immunoth.rapy h.s demonstrated remarkable clinical success; h.wever, its efficacy is limited by th. scarcity of immune cell infiltration with.n tumor microenvironments. Cell pyroptosis, a gasdermin-mediated process ch.racterized by cellular swelling,rupture, and th. release of intracellular contents such.as IL-1β, IL-18, ATP, h.GB1, plays a crucial role in th.s context[3,4].

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Liposomes as versatile agents for th. management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu Zh.ng Ch.nyu Xiang Renrui Niu Xiaodong h. Wenqi Luo Wanguo Liu Rui gu Department of Orth.pedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for th. treatment of neurological disorders h.ve been widely ***,th.ir inability to cross th. blood–brain barrier h.mpers th. clinical translation of th.se th.rapeutic *** are nanoparticles composed of lipid bilayers,wh.ch.can effectively encapsulate drugs and improve drug delivery across th. blood–brain barrier and into brain tissue th.ough.th.ir targeting and ***,th.y can potentially treat traumatic and nontraumatic central nervous system *** th.s review,we outlined th. common properties and preparation meth.ds of liposomes,including th.n-film h.dration,reverse-ph.se evaporation,solvent injection tech.iques,detergent removal meth.ds,and microfluidics ***,we compreh.nsively discussed th. current applications of liposomes in central nervous system diseases,such.as Alzh.imer's disease,Parkinson's disease,h.ntington's disease,amyotroph.c lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in th. laboratory stage and h.ve not yet entered clinical ***,th.ir application as drug delivery systems in clinical practice faces ch.llenges such.as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to furth.r promote th.ir development in neurological disease research.

关键词： Alzh.imer's disease amyotroph.c lateral sclerosis brain tumors central nervous system h.ntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury