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世界核心医学期刊文摘（神经病学分册） 2005年第2期1卷 58-59页

作者： gu'enot Serv. Neurochirurg. Stereotax. F. enot M. M. gu'h.opital P. Wertheimer 张玉龙 59 Bd Pinel 69003 Lyon France

To be considered for resective (curative) surgery, most seizures have to been proved to arise exclusively from one area of the brain that is functionally sile nt. The drug resistance must be certain, and the patient must be strongly motiv ated to undergo surgery. Temporal lobectomy for drug resistant temporo me sia l epilepsy is now scientifically validated by a randomized controled trial. hemi spherotomy, which consists in complete disconnection of one hemisphere, is a cur ative technique, which may be considered where there is a pre existing hemipleg iaassociated with a structural abnormality of the contralateral hemisphere. Ther efore, it is rarely performed in adult patients. Stereotactic radiosurgery is al so a curative technique, which shares most of its indications with those of temp oro mesial re sections. Callosotomy is a palliative technique, which consists in disconnecting the hemispheres, one from the other. It may be considered in in dividuals having frequent atonic seizures (drop attacks). Multiple subpial trans ection involves transection of transverse fibers, leaving longitudinal fibers in tact. It may be performed if the epileptogenic focus is located in an eloquent b rain area. The complication rate of resective surgery is low. Controlateral moto r impairement is the main permanent complication related to cortical resection. It is a rare occurence (1 to 2 percent of cases) due to peroperative lesions of the sylvian vasculature, or of the anterior choroidal artery, or even of the mot or area. Postoperative hematomas, infections, or hydrocephalus may also occur in 2 to 6 percent of cases, depending on the authors. Some postoperative neuropsyc hological complications are reported in the literature, especially after surgery on the dominant side. hydrocephalus and infection are the most frequent complic ations occuring after hemispherotomy (10 percent of cases). Dysconnexion syndrom is a rare complication, which can be seen after total callosotomy. It i

关键词：半球切除术大脑半球胼胝体切开软膜术后神经功能癫痫病灶频发性优势半球随机对照试验脉络膜前动脉

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广西平果上二叠统合山组关键金属锂和铌的超常富集与成因

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中国科学：地球科学 2021年第6期51卷 853-873页

作者：凌坤跃温汉捷张起钻罗重光顾汉念杜胜江于文修中国科学院地球化学研究所矿床地球化学国家重点实验室贵阳550081 中国科学院大学地球与行星科学学院北京100049 长安大学地球科学与资源学院西安710054 广西壮族自治区地质矿产勘查开发局南宁530023 东华理工大学核资源与环境国家重点实验室南昌330013 昆明理工大学国土与资源学院昆明650093

广西平果上二叠统合山组关键金属锂和铌超常富集的现象被首次发现,底部铝土矿层Nb_(2)O_(5)=0.02~0.04wt.%(平均0.035wt.%),上覆黏土岩层Li2O=0.06~1.05wt.%(平均0.44wt.%),均超过独立锂矿和铌矿的边界品位,找矿潜力巨大.本文初步探讨... 详细信息

广西平果上二叠统合山组关键金属锂和铌超常富集的现象被首次发现,底部铝土矿层Nb_(2)O_(5)=0.02~0.04wt.%(平均0.035wt.%),上覆黏土岩层Li2O=0.06~1.05wt.%(平均0.44wt.%),均超过独立锂矿和铌矿的边界品位,找矿潜力巨大.本文初步探讨其成因,以期对其他地区黏土型和沉积型锂、铌资源的研究、评价与找矿预测提供参考.研究获得以下认识:(1)铝土矿中含大量锐钛矿且与全岩TiO2和Nb含量呈显著正相关关系,指示Nb主要赋存于锐钛矿中;(2)黏土岩中锂绿泥石的大量存在及与全岩Li含量呈显著正相关关系指示锂绿泥石是Li的主要载体矿物,且锂绿泥石可能为成岩过程中由叶腊石、伊利石等黏土矿物与富Li、Mg滨海浅层地下卤水或孔隙水/地下水反应形成;(3)不活动元素Al、Ti、Nb、Ta、Zr、hf及REE物源示踪研究显示富Nb铝土矿及上覆富Li黏土岩的物源发生了突变,铝土矿及Nb的物源主要来自ELIP相关碱性长英质岩类,而黏土岩则主要来自古特提斯二叠纪岩浆弧相关过铝质或中等分异酸性岩.

关键词：合山组关键金属锂铌超常富集

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Neuroinflammation as a therapeutic target in huntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Thulani h.Palpagama Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. huntington's disease(hD) is a genetic, neurodegenerative disease that manifests as the loss of motor control,cognitive impairment,and mood and psychiatric changes in paents.

关键词： huntington inflammation Medicine

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Glial response in the midcingulate cortex in huntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Thulani h.Palpagama Andrea Kwakowsky Center for Brain Research and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Pharmacology and Therapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

huntington’s disease(hD)is a genetic disease characterized by the progressive degeneration of the striatum and *** can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive *** causal mutation underlying hD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关键词： huntington degeneration cortex

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Gly（82）Ser polymorphism of the receptor for advanced glycation end products is associated with an increased risk of gastric cancer in a Chinese population

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南京医科大学学报（自然科学版） 2008年第9期28卷 1094-1094页

作者： gu, h.J. Yang, L. Sun, Q. M. Zhou, B. Tang, N. P. Cong, R. h. Zeng, Y. Wang, B. Nanjing Med Univ Dept Pharmacol Key Lab Reprod Med Nanjing 210029 Peoples R China. Nanjing Med Univ Dept Gen Surg Affiliated Hosp 1 Nanjing Jiangsu Peoples R China

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Trinuclear gold-catalyzed site-selective alkylation of peptides

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Science China Chemistry 2025年第1期 249-256页

作者： Qing-Yun Fang Chengyihan gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian Zhu Jie han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–h in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

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高压泡沫涨裂破岩特性试验研究

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岩土工程学报 2025年第1期47卷 125-134页

作者：刘送永崔松顾聪聪中国矿业大学机电工程学院江苏徐州221116 中国矿业大学智能采矿装备技术全国重点实验室江苏徐州221116 安徽理工大学机电工程学院安徽淮南232001

针对钻爆法和机械法在岩石破碎工程中的弊端,基于泡沫的高黏性和可压缩性,提出了高压泡沫涨裂破岩技术。首先设计高压泡沫涨裂破岩装置,理论分析高压泡沫瞬间释放冲击岩石涨裂孔过程,搭建高压泡沫涨裂力测试装置并开展涨裂力影响试验,... 详细信息

针对钻爆法和机械法在岩石破碎工程中的弊端,基于泡沫的高黏性和可压缩性,提出了高压泡沫涨裂破岩技术。首先设计高压泡沫涨裂破岩装置,理论分析高压泡沫瞬间释放冲击岩石涨裂孔过程,搭建高压泡沫涨裂力测试装置并开展涨裂力影响试验,建立高压泡沫涨裂破岩试验系统,探讨不同空气体积分数时的泡沫涨裂特性,揭示高压泡沫涨裂破岩机理。研究表明:高压泡沫释放时,能够在涨裂孔内产生比泡沫初始压力更高的涨裂力,但涨裂力随泡沫空气体积分数增加而先增大后减小,高压泡沫涨裂破岩经历了裂纹初生、裂纹扩展、涨裂抛掷、涨裂结束4个阶段,破岩重量随泡沫空气体积分数的增加而先增大后减小,当空气体积分数为60%时,由高压泡沫冲击涨裂孔产生的压应力波在岩石上表面反射形成的拉应力造成岩石破坏形式为涨裂坑,空气体积分数为70%~90%时,泡沫涨裂形式为大块岩石分离,这主要是由孔底直角处应力集中效应造成。

关键词：高压泡沫涨裂破岩裂纹扩展涨裂力

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基于度量学习理论的马田系统改进及其应用研究

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管理工程学报 2025年第2期39卷 221-233页

作者：常志朋顾玉萍陈闻鹤安徽工业大学商学院安徽工业大学复杂系统多学科管理与控制安徽普通高校重点实验室安徽财经大学管理科学与工程学院南京理工大学经济管理学院

为提升马田系统的识别性能,本文利用度量学习理论对其进行改进。一是将传统协方差马氏距离改进为以度量矩阵为参变量的马氏距离函数,然后利用简单直接的KISSME度量学习算法估计一个最能反映数据间内在关系的度量矩阵,该度量矩阵可以使... 详细信息

为提升马田系统的识别性能,本文利用度量学习理论对其进行改进。一是将传统协方差马氏距离改进为以度量矩阵为参变量的马氏距离函数,然后利用简单直接的KISSME度量学习算法估计一个最能反映数据间内在关系的度量矩阵,该度量矩阵可以使同类样本更紧凑、非同类样本更分离,这有助于提升马田系统的识别性能。二是基于拉近同类样本、推远非同类样本的思想,定义一个新的特征子集评估函数代替田口方法中的信噪比,这有助于筛选出可以提高马田系统识别性能的特征。改进后的马田系统仍然保持了原理简单、易于操作的优势。本文选取6个UCI数据集进行验证,得出改进后的马田系统在Accuracy、Specificity、G-means和降维率等方面均明显优于传统马田系统的结论。最后,本文通过返贫识别验证了改进后马田系统的可行性和有效性。

关键词：马田系统度量学习 KISSME 返贫识别

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Observation of the Crab Nebula with LhAASO-KM2A−a performance study

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Chinese Physics C 2021年第2期45卷 518-530页

作者： F.Aharonian Q.An Axikegu L.X.Bai Y.X.Bai Y.W.Bao D.Bastieri X.J.Bi Y.J.Bi h.Cai J.T.Cai Z.Cao J.Chang J.F.Chang X.C.Chang B.M.Chen J.Chen L.Chen M.J.Chen M.L.Chen Q.h.Chen S.h.Chen S.Z.Chen T.L.Chen X.L.Chen Y.Chen N.Cheng Y.D.Cheng S.W.Cui X.h.Cui Y.D.Cui B.Z.Dai h.L.Dai Z.G.Dai D.della Volpe B.D'Ettorre Piazzoli X.J.Dong J.h.Fan Y.Z.Fan Z.X.Fan J.Fang K.Fang C.F.Feng L.Feng S.h.Feng Y.L.Feng B.Gao C.D.Gao Q.Gao W.Gao M.M.Ge L.S.Geng G.h.Gong Q.B.Gou M.h.gu J.G.guo X.L.guo Y.Q.guo Y.Y.guo Y.A.han h.h.he h.N.he J.C.he S.L.he X.B.he Y.he M.heller Y.K.hor C.hou X.hou h.B.hu S.hu S.C.hu X.J.hu D.h.huang Q.L.huang W.h.huang X.T.huang Z.C.huang F.Ji X.L.Ji h.Y.Jia K.Jiang Z.J.Jiang C.Jin D.Kuleshov K.Levochkin B.B.Li C.Li F.Li h.B.Li h.C.Li h.Y.Li J.Li K.Li W.L.Li X.Li X.R.Li Y.Li Y.Z.Li Z.Li E.W.Liang Y.F.Liang S.J.Lin B.Liu C.Liu D.Liu h.Liu h.D.Liu J.Liu J.L.Liu J.S.Liu J.Y.Liu M.Y.Liu R.Y.Liu S.M.Liu W.Liu Y.N.Liu Z.X.Liu W.J.Long R.Lu h.K.Lv B.Q.Ma L.L.Ma X.h.Ma J.R.Mao A.Masood W.Mitthumsiri T.Montaruli Y.C.Nan B.Y.Pang P.Pattarakijwanich Z.Y.Pei M.Y.Qi D.Ruffolo V.Rulev A.Sáiz L.Shao O.Shchegolev X.D.Sheng J.R.Shi h.C.Song Yu.V.Stenkin V.Stepanov Q.N.Sun X.N.Sun Z.B.Sun P.h.T.Tam Z.B.Tang W.W.Tian B.D.Wang C.Wang h.Wang h.G.Wang J.C.Wang J.S.Wang L.P.Wang L.Y.Wang R.N.Wang W.Wang X.G.Wang X.J.Wang X.Y.Wang Y.D.Wang Y.J.Wang Y.P.Wang Z.Wang Z.h.Wang Z.X.Wang D.M.Wei J.J.Wei Y.J.Wei T.Wen C.Y.Wu h.R.Wu S.Wu W.X.Wu X.F.Wu S.Q.Xi J.Xia J.J.Xia G.M.Xiang G.Xiao h.B.Xiao G.G.Xin Y.L.Xin Y.Xing D.L.Xu R.X.Xu L.Xue D.h.Yan C.W.Yang F.F.Yang J.Y.Yang L.L.Yang M.J.Yang R.Z.Yang S.B.Yang Y.h.Yao Z.G.Yao Y.M.Ye L.Q.Yin N.Yin X.h.You Z.Y.You Y.h.Yu Q.Yuan h.D.Zeng T.X.Zeng W.Zeng Z.K.Zeng M.Zha X.X.Zhai B.B.Zhang h.M.Zhang h.Y.Zhang J.L.Zhang J.W.Zhang L.Zhang L.X.Zhang P.F.Zhang P.P.Zhang R.Zhang S.R.Zhang S.S.Zhang X.Zhang X.P.Zhang Y.Zhang Y.F.Zhang Y.L.Zhang B.Zhao J.Zhao L.Zhao L.Z.Zhao S.P.Zhao F.Zheng Y.Zheng B.Zhou h.Zhou J.N.Zhou P.Zhou R.Zhou X.X.Zhou C.G.Zhu F.R.Zhu h.Zhu K.J.Zhu X.Zuo Key Laboratory of Particle Astrophyics&Experimental Physics Division&Computing Center Institute of High Energy PhysicsChinese Academy of Sciences100049 BeijingChina University of Chinese Academy of Sciences 100049 BeijingChina TIANFU Cosmic Ray Research Center ChengduSichuanChina State Key Laboratory of Particle Detection and Electronics China University of Science and Technology of China 230026 HefeiAnhuiChina Department of Engineering Physics Tsinghua University100084 BeijingChina National Astronomical Observatories Chinese Academy of Sciences100101 BeijingChina National Space Science Center Chinese Academy of Sciences100190 BeijingChina School of Physics Peking University100871 BeijingChina Center for Astrophysics Guangzhou University510006 GuangzhouGuangdongChina School of Physics and Astronomy&School of Physics(guangzhou) Sun Yat-sen University519000 ZhuhaiGuangdongChina School of Physical Science and Technology Guangxi University530004 NanningGuangxiChina hebei Normal University 050024 ShijiazhuangHebeiChina School of Physics and Microelectronics Zhengzhou University450001 ZhengzhouHenanChina School of Astronomy and Space Science Nanjing University210023 NanjingJiangsuChina Key Laboratory of Dark Matter and Space Astronomy Purple Mountain ObservatoryChinese Academy of Sciences210023 NanjingJiangsuChina Institute of Frontier and Interdisciplinary Science Shandong University266237 QingdaoShandongChina Key Laboratory for Research in Galaxies and Cosmology Shanghai Astronomical ObservatoryChinese Academy of Sciences200030 ShanghaiChina Tsung-Dao Lee Institute&School of Physics and Astronomy Shanghai Jiao Tong University200240 ShanghaiChina School of Physical Science and Technology&School of Information Science and Technology Southwest Jiaotong University610031 ChengduSichuanChina College of Physics Sichuan University610065 ChengduSichuanChina Key Laboratory of Cosmic Rays(Tibet University) Ministry of Education850000 LhasaTibetChina School of Physics and Tec

A sub-array of the Large high Altitude Air Shower Observatory(LhAASO),KM2A is mainly designed to observe a large fraction of the northern sky to hunt for γ-ray sources at energies above 10 *** though the detector construction is still underway,half of the KM2A array has been operating stably since the end of *** this paper,we present the KM2A data analysis pipeline and the first observation of the Crab Nebula,a standard candle in very high energy γ-ray *** detect γ-ray signals from the Crab Nebula in both energy ranges of 10-100 TeV and>100 TeV with high significance,by analyzing the KM2A data of 136 live days between December 2019 and May *** the observations,we test the detector performance,including angular resolution,pointing accuracy and cosmic-ray background rejection *** energy spectrum of the Crab Nebula in the energy range 10-250 TeV fits well with a single power-law function dN/dE=(1.13±0.05stat±0.08sys)×10^(-14).(E/20 TeV)-309±0.06stat±0.02syscm^(-2) s^(-1) TeV^(-1).It is consistent with previous measurements by other *** opens a new window of γ-ray astronomy above 0.1 PeV through which new ultrahigh-energy γ-ray phenomena,such as cosmic PeVatrons,might be discovered.

关键词： γ-ray Crab Nebula extensive air showers cosmic rays

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Comparative chemical sensor for detection of chromium(Ⅵ) in aqueous solution

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Optoelectronics Letters 2025年第1期21卷 21-27页

作者： Sura h.AL-REKABI A.A.ALWAhIB Electrical Technique Department Al Suwayrah Technical Institute Middle Technical University Laser and Optoelectronics Department University of Technology-Iraq

A process for purifying aqueous solutions containing heavy and toxic metals such as chromium（Cr） has been investigated. One of the extremely harmful pollutants in rivers and seawater is the heavy metal ions due to their direct impacts on human, animals and plants are hexavalent Cr（Ⅵ）. Consequently, highly sensitive sensor to detect Cr is essential. Surface plasmon resonance（SPR） technique has attracted huge research interest in detecting heavy metals specifically. In this study, three types of prism-based SPR sensor, gold（Au）/silver（Ag）, Au/polyaniline（PANI） and Au/titanium dioxide（TiO2） nanostructured films, are investigated as potential sensing material to detect the presence of Cr（Ⅵ） ions in water. The base Au layer with thickness of 48.3 nm is deposited on a glass slide for all sensors. For Au/Ag, Au/PANI nanofibers and Au/TiO2sensor films, the Cr（Ⅵ） concentration is varied from 1 ppm to 15 ppm with sensitivity of 0.270 °ppm-1, 0.082 °ppm-1and 0.039 °ppm-1, respectively. Based on these results, the Au/PANI nanofibers are the most sensitive to Cr（Ⅵ） among the tested sensing materials.

关键词： Titanium dioxide

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