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INTERACTION OF PRECIPITATION AND RECRYSTALLIZATION IN RAPIDLY SOLIDIFIED Cu-Cr-Zr-Mg ALLOY

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Acta Metallurgica Sinica(English Letters) 1999年第3期12卷 273-275,576-277页

作者： Liu, P. Kang, B.X. Cao, X.G. huang, J.L. Yin, B. gu, h.C. Xi'an Jiaotong Univ Xi'an China

The recrystallization process of a rapidly solidified Cu-Cr-Zr-Mg alloy during its aging was investigate experimentally. It was found that (1) upon aging, the precipitation process takes place prior to recrystallization for the cold-deformed Cu-Cr-Zr-Mg alloy produced by rapid solidification, and the precipitates have a restrained effect on the following recrystallization process; (2) the hindrance of the dispersed fine precipitates to the common recrystallization leads to the simultaneous in situ and discontinuous recrystallization; (3) the resolution of the precipitates in the front of migrating grain boundaries takes place during the nucleation and growth of recrystallization, which results in a supersaturation in the recrystallized zones, while the re-precipitation of the supersaturated solute atoms in vacancies further increases the dispersion hardening effect.

关键词： Crystal microstructure Precipitation (chemical) Rapid solidification Recrystallization (metallurgy) Supersaturation

Fluid/melt in continental deep subduction zones: Compositions and related geochemical fractionations

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Science China Earth Sciences 2015年第8期58卷 1457-1476页

作者： XIAO YiLin SUN he gu haiOu hUANG Jian LI WangYe LIU Lei CAS Key Laboratory of Crust-Mantle Materials and Environments School of Earth and Space Sciences University of Science and Technology of China

Plate subduction is the most magnificent process in the Earth. Subduction zones are important sites for proceeding matter- and energy- transports between the Earth's surface and the interior, continental crust growth, and crust-mantle interactions. Besides, a number of geological processes in subduction zones are closely related to human beings' daily life, such as volcanic eruptions and earthquakes, formation of mineral deposits. Subduction process thus has long been the centric topic of Earth sciences. The finding in 1980 s that continental crust could be subducted to mantle depths is a revolutionary progress in plate tectonic theory. Compared to oceanic crust, continental crust is colder, drier, lighter, and much more geochemically/isotopically heterogeneous. hence, continental subduction process would affect the structure, compositions and evolutions of the overlying mantle wedge even more. During continental subduction and subsequent exhumation, fluids and melts can be generated in the(de)hydration process and partial melting process, respectively. These melts/fluids play important roles in crust-mantle interactions, elemental migrations, isotopic fractionations, and mantle metasomatism. By summarizing recent research works on subduction zones in this paper, we present a review on the types, physicochemical conditions and compositions of fluids/melts, as well as the migration behaviors of fluid-related characteristic elements(Nb-Ta-V) and the fractionation behaviors of non-traditional stable isotopes(Li-Mg) in subduction zones. The aim of this paper is to provide the readers an update comprehensive overview of the melt/fluid activities in subduction zones and of Li-Mg isotope systematics in subduction-related rocks and minerals.

关键词： subduction process melt/fluid composition crust-mantle interaction elemental mobility isotopic fractionation

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Action potential code modulates dopamine release in mouse striatum in vivo

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Action potential code modulates dopamine release in mouse st...

Mapping Sea Level Rise Behavior in an Estuarine Delta System：A Case Study along the Shanghai Coast

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Claire Xi ZhANG howard h.gu Institute of Molecular Medicine Peking University Department of Pharmacology Ohio State University

＜正＞Dopamine is a neurotransmitter crucial for movement,mood,drug addiction and many neural degeneration diseases including Parkinson’s *** electrochemical carbon fiber microelectrode（CFE） can record dopamine release from brain in *** action potentials（Aβs） induced secretion of dopamine in mouse brain striatum in *** stimulus pattern is defined as Aβcode[N,m,f,d]（N = total stimulating number,m = burst-number,f = frequency, d = inter-burst interval）.In wide type mice（WT）,with fixed Aβnumber N,the evoked dopamine release was strongly modulated by code parameters m,f and *** knockin mice（KI） has a functional dopamine transporter（DAT） that is insensitive to cocaine（Chen et al.,PNAS,2006）.In KI *** mice,both amplitude and kinetics of dopamine release was drastically changed following given stimulationAβ*** effect of Aβburstnumber（[144,m,80hz,0.5s],m= 1 vs.16）,or "m-effect",on dopamine release is increased by ＞ 400%in KI *** *** addition,we examined effects of cocaine on "m-effect" in KI and WT mice.

关键词： dopamine electrochemical recording Parkinson’s disease

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Engineering 2018年第1期4卷 156-163页

作者： h.Q. Cheng J.Y. Chen Z.J. Chen R.L. Ruan G.Q. Xu G. Zeng J.R. Zhu Z.J. Dai X.Y. Chen S.h. gu X.L. Zhang h.M. Wang State Key Laboratory of Estuarine and Coastal Research East China Normal University Shanghai 200062 China Shanghai Water Planning Design and Research Institute Shanghai 200232 China Shanghai Water Authority Shanghai 200050 China School of Urban and Regional Science East China Normal University Shanghai 200062 China School of Ecological and Environmental Sciences East China Normal University Shanghai 200062 China Shanghai hydrological Station Shanghai 200232 China Shanghai Municipal Bureau of Urban Planning and Land Resources Shanghai 200003 China Shanghai Institute of Geological Survey Shanghai 200072 China

Sea level rise （SLR） is a major projected threat of climate change that is expected to affect developing coastal cities located in estuarine delta regions, Shanghai is one such city, being located in the Yangtze River Delta （YRD）, It is difficult, however, for decision-makers to implement adaptation due to the uncer- tain causes, magnitudes, and timings of SLR behaviors, This paper attempts to map the causes and mag- nitudes of SLR behaviors on a decadal scale, We analyze the tidal level records from 11 tidal gauge stations and the corresponding bathymetry measurements around these stations since 1921, We identify three new SLR behaviors along the Shanghai coast due to anthropogenic geomorphologic changes （AGCs）, besides the well-known eustatic sea level rise （ESLR）, tectonic subsidence （TS）, and urban land subsidence （ULS）, The first new behavior is regional sea level rise （RSLR）, which occurs as a result of land reclamation and deep waterway regulation, The second is regional sea level fall （RSLF）, which occurs because the channel bed is eroded due to sediment supply decline in the river catchment, The last SLR behavior is local tidal datum rise （LTDR）. Thus, we project that the magnitude of SLR for the Shanghai coast ranges from 10 cm to 16 cm from 2011 to 2030, Clarifying SLR behaviors is important to aid local decision- makers in planning structural and non-structural measures to combat escalating flood damage costs in an estuarine delta system; this field is full of future challenges,

关键词： Sea level rise behavior Anthropogenic geomorphologic change Local tidal datum Flood management Adaptation

Pathogenesis, diagnosis, and treatment of epilepsy: electromagnetic stimulation-mediated neuromodulation therapy and new technologies

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Neural Regeneration Research 2025年第4期20卷 917-935页

作者： Dian Jiao Lai Xu Zhen gu hua Yan Dingding Shen Xiaosong gu Academy of Medical Engineering and Translational Medicine Tianjin UniversityTianjinChina Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical SciencesZhejiang UniversityHangzhouZhejiang ProvinceChina Affiliated hospital of Nantong University NantongJiangsu ProvinceChina

Epilepsy is a severe,relapsing,and multifactorial neurological *** regarding the accurate diagnosis,prognosis,and in-depth pathogenesis are crucial for the precise and effective treatment of *** pathogenesis of epilepsy is complex and involves alterations in variables such as gene expression,protein expression,ion channel activity,energy metabolites,and gut microbiota *** results are lacking for conventional treatments for *** resection of lesions,drug therapy,and non-drug interventions are mainly used in clinical practice to treat pain associated with ***-pharmacological treatments,such as a ketogenic diet,gene therapy for nerve regeneration,and neural regulation,are currently areas of research *** review provides a comprehensive overview of the pathogenesis,diagnostic methods,and treatments of *** also elaborates on the theoretical basis,treatment modes,and effects of invasive nerve stimulation in neurotherapy,including percutaneous vagus nerve stimulation,deep brain electrical stimulation,repetitive nerve electrical stimulation,in addition to non-invasive transcranial magnetic stimulation and transcranial direct current *** studies have shown that electromagnetic stimulation-mediated neuromodulation therapy can markedly improve neurological function and reduce the frequency of epileptic ***,many new technologies for the diagnosis and treatment of epilepsy are being ***,current research is mainly focused on analyzing patients’clinical manifestations and exploring relevant diagnostic and treatment methods to study the pathogenesis at a molecular level,which has led to a lack of consensus regarding the mechanisms related to the disease.

关键词： diagnosis drug treatment electroencephalography epilepsy monitoring epilepsy nerve regeneration neurostimulation non-drug interventions pathogenesis prediction

The dopaminergic system and Alzheimer's disease

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Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang Yuan Liang Yixue gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in huntington’s disease

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Neural Regeneration Research 2025年第10期20卷 2919-2920页

作者： Yingli gu Kijung Sung Chengbiao Wu Department of Neurosciences University of California San DiegoLa JollaCAUSA

Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”to date,yields over 33,000 *** fundamental biology to potential therapeutic applications,BDNF has clearly garnered extensive and significant attention in the field of neurobiology research.

关键词： huntington homeostasis therapeutic

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基于卫气营血辨证谈温病六维辨证观

中国科学：生命科学 2016年第8期46卷 1038-1041页

作者：谷晓红北京中医药大学基础医学院北京100029

六维辨证观是指在临床辨证中把握整体,抓住机要,从病期、病位、病势、病因、病性、病理6个维度分辨证态,此辨证观基于现有辨证体系,但又区别于现有的各种辨证体系,旨在强调中医临床思维.现通过对卫气营血辨证内涵的梳理与思考,对六维辨... 详细信息

六维辨证观是指在临床辨证中把握整体,抓住机要,从病期、病位、病势、病因、病性、病理6个维度分辨证态,此辨证观基于现有辨证体系,但又区别于现有的各种辨证体系,旨在强调中医临床思维.现通过对卫气营血辨证内涵的梳理与思考,对六维辨证观加以探讨.望此文有助于临床识证的简要清晰,个人观点请同道指正.

关键词：辨证观卫气营血辨证温病学辨证体系气分证临床思维气血津液辨证六经辨证气郁营分

AI-Enhanced Secure Data Aggregation for Smart Grids with Privacy Preservation

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Computers, Materials & Continua 2025年第1期82卷 799-816页

作者： Congcong Wang Chen Wang Wenying Zheng Wei gu School of Software Nanjing University of Information Science and TechnologyNanjing210044China School of Information Science and Engineering Zhejiang Sci-Tech UniversityHangzhou310018China State Key Laboratory of Public Big Data Guizhou UniversityGuiyang550025China School of Computer Science and Technology(School of Artificial Intelligence) Zhejiang Sci-Tech UniversityHangzhou310018China School of Computer Science(School of Cyber Science and Engineering) Nanjing University of Information Science and TechnologyNanjing210044China

As smart grid technology rapidly advances,the vast amount of user data collected by smart meter presents significant challenges in data security and privacy *** research emphasizes data security and user privacy concerns within smart ***,existing methods struggle with efficiency and security when processing large-scale *** efficient data processing with stringent privacy protection during data aggregation in smart grids remains an urgent *** paper proposes an AI-based multi-type data aggregation method designed to enhance aggregation efficiency and security by standardizing and normalizing various data *** approach optimizes data preprocessing,integrates Long Short-Term Memory(LSTM)networks for handling time-series data,and employs homomorphic encryption to safeguard user *** also explores the application of Boneh Lynn Shacham(BLS)signatures for user *** proposed scheme’s efficiency,security,and privacy protection capabilities are validated through rigorous security proofs and experimental analysis.

关键词： Smart grid data security privacy protection artificial intelligence data aggregation