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Increased index of microcirculatory resistance in older patients with heart failure with preserved ejection fraction

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Journal of Geriatric Cardiology 2018年第11期15卷 687-694页

作者： Zhuo XU hui-Ping gu Yang gu Wei SUN Kun YU Xi-Wen ZHANG Xiang-Qing KONG Department of Cardiology the First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Cardiology the Affiliated Huai'an No.1 People's Hospital of Nanjing Medical UniversityHuai'an China

Objective To study the coronary microvascular function in older patients with heart failure with preserved ejection fraction (HFpEF) using an invasive pressure–temperature sensor guidewire. Methods Patients undergoing echocardiography and cardiac catheterization examinations for exertional dyspnea and a positive stress test were retrospectively enrolled from January 2014 to November 2017, and were allocated into the control group or HFpEF group. The HFpEF group was secondary divided into two groups according to the age of 65 years. Comparing the clinical features and values obtained in examinations between the three groups, multivariate regression analysis was used to analyze the predictors of left ventricle end diastolic pressure (LVEDP). Results There were 87 patients enrolled in this study. The older HFpEF patients (n = 32) were more likely to be female;and had the most comorbidities, such as diabetes mellitus, atrial fibrillation, and chronic kidney dysfunction (CKD) with a low estimated glomerular filtration rate (eGFR), and had a similar hypertensive prevalence as the adult HFpEF group (n = 24), whose mean LVEDP and index of microcirculatory resistance (IMR) were highest in comparison to the adult HFpEF patients and controls (n = 31). The coronary flow reserve (CFR) in the older HFpEF and adult HFpEF groups was similarly reduced. In the regression analysis, the IMR linearly correlated to LVEDP, and was the only independent predictor of LVEDP. Conclusions An increased IMR and reduced CFR were characteristics of microvascular dysfunction in older HFpEF patients. The IMR independently had a positive linear correlation with LVEDP. Microvascular rarefaction might be a subsequent pathological progression in the development of HFpEF.

关键词： Heart failure Ejection fractions Microcirculatory resistance Microvascular dysfunction

肺康复分级策略联合风险管理对社区获得性肺炎患者康复效果研究

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河北医药 2024年第10期46卷 1556-1559页

作者：许菁顾慧王红蕊董运辉朱洋首都医科大学附属北京友谊医院感染内科北京市100050

目的探究肺康复分级策略联合风险管理在社区获得性肺炎患者中应用的康复效果,观察联合方案对并发症的预防效果。方法前瞻性随机对照研究,选取2022年11月至2023年5月首都医科大学附属北京友谊医院收治的70例社区获得性肺炎患者为研究对象... 详细信息

目的探究肺康复分级策略联合风险管理在社区获得性肺炎患者中应用的康复效果,观察联合方案对并发症的预防效果。方法前瞻性随机对照研究,选取2022年11月至2023年5月首都医科大学附属北京友谊医院收治的70例社区获得性肺炎患者为研究对象,将其按照随机数字表法分为试验组和对照组,每组35例。对照组实施常规风险管理干预,试验组进行肺康复分级策略指导下的风险管理干预,干预至出院。检测并比较干预前后2组患者血气指标水平,以评价患者肺部功能,反映康复效果;统计2组患者风险管理期间并发症发生情况,比较并发症总发生率;记录2组主要症状改善时间及住院时间;干预前后,采用生活质量综合评定问卷(GQOLI-74)评分评估2组患者生活质量。结果干预前,2组患者动脉血气指标水平比较,差异无统计学意义(P>0.05),干预后,2组二氧化碳分压、血乳酸值降低,氧合指数升高,试验组二氧化碳分压、血乳酸值低于对照组,氧合指数高于对照组,差异有统计学意义(P0.05),干预后,2组GQOLI-74评分显著升高,且试验组GQOLI-74评分高于对照组,差异有统计学意义(P<0.05)。结论肺康复分级策略联合风险管理可改善社区获得性肺炎患者肺部功能,并有效预防并发症的发生,患者主要症状得到更好更快的缓解,促进患者康复,提高患者生活质量。

关键词：社区获得性肺炎肺康复分级风险管理康复效果并发症

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面向政企行业的业务支撑系统建设分析

电信工程技术与标准化 2024年第5期37卷 87-92页

作者：齐磊顾慧琼殷佩仪赵金中国移动通信集团设计院有限公司北京100080

随着社会发展和信息技术的普及,运营商业务条线从个人、家庭逐渐向政企延展,如何实现业务能力的多元化支撑、多层次运营,如何构筑“云网+DICT”产品运营体系,推动企业影响力提升,是运营商重点考虑的问题。本文结合政企业务产品的特点及... 详细信息

随着社会发展和信息技术的普及,运营商业务条线从个人、家庭逐渐向政企延展,如何实现业务能力的多元化支撑、多层次运营,如何构筑“云网+DICT”产品运营体系,推动企业影响力提升,是运营商重点考虑的问题。本文结合政企业务产品的特点及与公众业务的差异性,探讨面向政企的业务支撑系统建设模式,并分析在互联网+、大数据等新技术背景下,政企行业业务支撑系统的发展方向。

关键词：政企业务支撑产品运营 ToB DICT

Development of multi-group Monte-Carlo transport and depletion coupling calculation method and verification with metal-fueled fast reactor

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Nuclear Science and Techniques 2023年第11期34卷 20-39页

作者： hui guo Yi‑Wei Wu Qu‑Fei Song Yu‑Yang Shen Han‑Yang gu School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China

The accurate modeling of depletion,intricately tied to the solution of the neutron transport equation,is crucial for the design,analysis,and licensing of nuclear reactors and their fuel *** paper introduces a novel multi-group Monte-Carlo depletion calculation ***-group cross-sections(MGXS)are derived from both 3D whole-core model and 2D fuel subassembly model using the continuous-energy Monte-Carlo *** calculations employ the multi-group Monte-Carlo method,accommodating both homogeneous and specific local heterogeneous *** proposed method has been validated against the MET-1000 metal-fueled fast reactors,using both the OECD/NEA benchmark and a new refueling benchmark introduced in this *** findings suggest that microscopic MGXS,produced via the Monte-Carlo method,are viable for fast reactor depletion ***,the locally heterogeneous model with angular-dependent MGXS offers robust predictions for core reactivity,control rod value,sodium void value,Doppler constants,power distribution,and concentration levels.

关键词： Monte-Carlo Multi-group cross-section generation Depletion Fast reactors Metallic fuel

行为改变理论构建中年急性胰腺炎患者阶梯式饮食干预策略及应用

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河北医药 2024年第14期46卷 2234-2237页

作者：董运辉顾慧王红蕊许菁杨妍首都医科大学附属北京友谊医院感染内科北京市101125

目的通过行为改变理论构建阶梯式饮食干预策略,并探讨其在中年急性胰腺炎患者中的应用效果。方法采用前瞻性随机对照研究,选择2020年5月至2022年5月北京友谊医院感染内科收治的80例中年急性胰腺炎患者作为研究对象,经随机数字表法分... 详细信息

目的通过行为改变理论构建阶梯式饮食干预策略,并探讨其在中年急性胰腺炎患者中的应用效果。方法采用前瞻性随机对照研究,选择2020年5月至2022年5月北京友谊医院感染内科收治的80例中年急性胰腺炎患者作为研究对象,经随机数字表法分为对照组与观察组,每组40例。对照组采用阶梯式饮食干预策略,观察组采用行为改变理论构建的阶梯式饮食干预策略。比较2组护理前后的营养指标[血清总蛋白(TP)、白蛋白(ALB)、血红蛋白(Hb)]、健康行为[健康促进生活方式量表-Ⅱ(HPLP-Ⅱ评分)]、生活质量[生活质量评价量表(SF-36评分)]以及护理满意度。结果观察组患者护理后TP、ALB、Hb均显著高于同期对照组(P<0.05);与对照组比较,观察组患者遵医嘱、自我监测、定期复查、控制饮食的占比更高(P<0.05)。观察组患者护理后HPLP-Ⅱ评分显著高于同期对照组(P<0.05);观察组患者护理后SF-36评分、ADL评分显著高于同期对照组(P<0.05);与对照组比较,观察组患者不良事件发生率更低,护理满意度更高(P<0.05)。结论中年急性胰腺炎患者采用行为改变理论构建的阶梯式饮食干预策略可以改善机体营养状态,提高自我管理、健康行为及生活质量水平,不良事件发生率更低,患者满意度更高。

关键词：中年人急性胰腺炎行为改变理论阶梯式饮食干预健康行为生活质量

Facile Synthesis of Polycarbonate Diol via Copolymerization of CO_(2) and Cyclohexene Oxide Catalysed by a Combination of One-Component Phosphonium Borane Lewis Pair and Water

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Chinese Journal of Polymer Science 2023年第5期41卷 735-744,I0009页

作者： Xiao-Wu Wang Ji-Wen hui Yu-Tao Li Yan-Ru gu Zhi-Bo Li State Key Laboratory Base of Eco-Chemical Engineering/College of Chemical Engineering Qingdao University of Science and TechnologyQingdao 266042China Key Laboratory of Biobased Polymer Materials Shandong Provincial Education Department/School of Polymer Science and EngineeringQingdao University of Science and TechnologyQingdao 266042China

Well-defined polycarbonate diol was successfully synthesized through a strategy using a combination of organocatalyst and *** strategy was less developed in organocatalyzed polymerization and frequently regarded as side ***,one-component phosphonium borane Lewis pairs PB1-PB8 were successfully applied in the copolymerization of CO_(2) and cyclohexene oxide(CHO)to generate poly(CHO-alt-CO_(2))carbonate(PCHC).Parameters of linker length and counter anion effects on the catalyst activity were *** was found that Lewis pair PB3 served as a dual initiator and catalyst in the copolymerization of CHO and CO_(2) with or without the presence of *** contrast,Lewis pair PB8 can serve as a true catalyst for the preparation of well-definedα,ω-hydroxyl PCHC *** was achieved by introducing a labile CF3COO group as counter anion through anion exchange reaction while water molecules acted as chain transfer *** function of trifluoroacetate group in the polymerization process was investigated in detail and possible mechanism was *** changing the amount of water and catalyst loading,PCHC diols with varied molecular weight(1.5 kg/mol to 7.5 kg/mol),low dispersities(D99%)could be easily *** low molecular weight PCHC diol was used as a bifunctional macroinitiator for the ring-opening polymerization of L-lactide(LLA)to afford ABA triblock copolymer in one-pot synthesis.

关键词： Polycarbonate Phosphonium borane Lewis pair CO_(2)utilization Organocatalysis Ring-opening polymerization

叶酸代谢基因检测在降低胎儿神经管畸形发生率中的应用

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中国妇幼保健 2024年第7期39卷 1325-1328页

作者：李华沈学萍卢绚丽顾惠凤湖州市妇幼保健院浙江湖州313000

目的探讨叶酸代谢基因检测指导孕妇科学服用叶酸在降低胎儿神经管畸形发生率中的作用。方法根据湖州市妇幼保健院产前门诊不同时期推荐叶酸服用方案,选取2016年1月—2017年12月7975例孕妇作为对照组,2020年1月—2021年12月11475例孕妇... 详细信息

目的探讨叶酸代谢基因检测指导孕妇科学服用叶酸在降低胎儿神经管畸形发生率中的作用。方法根据湖州市妇幼保健院产前门诊不同时期推荐叶酸服用方案,选取2016年1月—2017年12月7975例孕妇作为对照组,2020年1月—2021年12月11475例孕妇作为观察组。观察组进行叶酸代谢基因检测,根据检测结果给予个性化叶酸补充指导,对照组未经基因检测,按照常规剂量进行叶酸补充。分析观察组叶酸代谢基因检测结果,并评估其叶酸利用能力风险等级,比较两组胎儿神经管畸形发生情况。结果观察组孕妇亚甲基四氢叶酸还原酶(MTHFR)677CC、MTHFR 677CT、MTHFR 677TT基因型分布比例分别为36.45%、46.90%、16.64%。观察组孕妇叶酸利用能力低度风险、中度风险、重度风险比例分别为42.00%、28.00%、30.00%。观察组胎儿神经管畸形总发生率为0.64%,低于对照组的1.83%,差异有统计学意义(χ^(2)=60.307,P<0.05)。结论孕妇进行叶酸代谢基因检测十分必要,根据检测结果指导孕妇进行叶酸补充具有科学性,能够有效降低胎儿神经管畸形发生率。

关键词：叶酸基因检测胎儿神经管畸形

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高铁车站客运设备维修施工规范化标准化研究

中国铁路 2024年第4期 119-124页

作者：宗辉于克望顾伟庞学华秦岭陈国庆牟红婷中国铁路济南局集团有限公司客运部山东济南250000 济南铁路信息技术有限公司山东济南250000 中国铁路济南局集团有限公司临沂车务段山东临沂276000

客运设备的正常运行对于保障高铁列车的安全和乘客良好的出行体验至关重要,然而目前客运设备的维修施工受多种条件影响,现场维修效率低,安全卡控难度大。通过规范客运设备维修施工管理,厘清客运设备维修施工等级划分、计划提报审批、现... 详细信息

客运设备的正常运行对于保障高铁列车的安全和乘客良好的出行体验至关重要,然而目前客运设备的维修施工受多种条件影响,现场维修效率低,安全卡控难度大。通过规范客运设备维修施工管理,厘清客运设备维修施工等级划分、计划提报审批、现场标准落实以及风险防控4大管理措施;通过信息化、智能化手段卡控现场安全风险,对维修施工计划下达后的全流程、关键作业管控,加强维修施工作业标准化的落实,确保高铁车站维修施工安全管控到位,实现高铁车站客运设备维修施工标准化规范化。

关键词：高铁车站客运设备维修施工规范化标准化

Mutual mate choice in the Asiatic toad, Bufo gargarizans,exerts stabilizing selection on body size

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Chinese Science Bulletin 2014年第1期59卷 38-45页

作者： Zhenhua Luo Chenliang Li hui Wang Mian Zhao Qi gu Zhirong gu Chunlin Liao Hua Wu Molecular and Behavioural Ecology Research group College of Life Sciences Central China Normal University Badagongshan National Nature Reserve

Sexual selection is critical to both reproduction and *** effects of male–male competition and female choice regarding body size have been examined in a large number of taxa,including toad *** and females have different optimal reproductive strategies,achieving breeding advantages in discrepant ***,the relative contributions of intra-and inter-sexual size selection vary among ***,to understand the mechanisms affecting mating success,it is important to consider both male–male and male–female interactions simultaneously and elucidate their *** this study,we measured body sizes of all mated and unmated individuals in a population of Asiatic toad(Bufo gargarizans)and counted fertilized eggs of several *** on correlation and regression techniques,we tested for female choice and intra-sexual competition among males relative to body size gradients,and we compared the relative importance of these two processes for mating *** results reveal that male–male competition and female choice simultaneously contribute to sexual selection in ***,both interactions are most intense among smaller *** synergistic trends of male–male competition and female choice support the mutual mate choice hypothesis and works to stabilize body size in *** distributions of breeding success relative to body size were detected for both sexes,suggesting that medium-sized individuals enjoy a reproductive advantage in the population studied.

关键词：车身尺寸蟾蜍亚洲择偶稳定繁殖成功率繁殖策略竞争性