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Experimental and DFT Investigations of AlNbTiVZr High Entropy Alloys with Excellent Mechanical Properties

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1480-1490页

作者： hongwei Yan Yong'an Zhang Wei Xiao Boyu xue Rui Liu Xiwu Li Zhihui Li Baiqing Xiong State Key Laboratory of Nonferrous Metals and Processes China GRINM Group Co.Ltd.Beijing100088China GRIMAT Engineering Institute Co. Ltd.Beijing101407China General Research Institute for Nonferrous Metals Beijing100088China

This study investigated the microstructure and mechanical properties of AlNbTiVZr series high-entropy alloys(HEAs)through both experimental studies and density functional theory *** improvements in the microstructures and mechanical properties were achieved for the AlNbTiVZr series HEAs by meticulously adjusting the alloy composition and employing homogenization heat ***,the specimen designated as Al_(0.5)NbTiVZr_(0.5) demonstrated excellent mechanical properties including a compressive yield strength of 1162 MPa and a compressive strength of 1783 *** homogenization heat treatment at 1000℃ for 24 h,the Al_(0.5)NbTiVZr_(0.5) alloy exhibits brittle-to-ductile *** atomic-scale theoretical simulations reveal that the decrease of Al content intrinsically enhances the ductility of the alloys,thereby indicating that the mechanical properties of the AlNbTiVZr series HEAs were significantly influenced by the chemical ***,specific atomic pair formations were observed to adversely affect the microstructure of the AlNbTiVZr series HEAs,particularly in terms of *** findings provide valuable insights for the design and optimization of light weight HEAs,emphasizing the synergistic adjustment of alloy composition and heat treatment processes to achieve a balance between the strength and ductility.

关键词： High-entropy alloy Microstructure Mechanical properties Density functional theory

Downregulation of Serum PTEN Expression in Mercury-Exposed Population and PI3K/AKT Pathway-Induced Inflammation

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Biomedical and Environmental Sciences 2024年第4期37卷 354-366页

作者： MEI Peng DING En Min YIN Hao Yang DING xue xue WANG Huan WANG Jian Feng HAN Lei ZHANG Heng Dong ZHU Bao Li School of Public Health Nanjing Medical UniversityNanjing 210000JiangsuChina Institute of Occupational Disease Prevention Jiangsu Province Center for Disease Prevention and ControlNanjing 21000JiangsuChina Suzhou Center for Disease Prevention and Control Suzhou 215004JiangsuChina Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 210000JiangsuChina

Objective This study investigated the impact of occupational mercury(Hg) exposure on human gene transcription and expression, and its potential biological *** Differentially expressed genes related to Hg exposure were identified and validated using gene expression microarray analysis and extended validation. Hg-exposed cell models and PTEN lowexpression models were established in vitro using 293T cells. PTEN gene expression was assessed using qRT-PCR, and Western blotting was used to measure PTEN, AKT, and PI3K protein levels. IL-6 expression was determined by *** Combined findings from gene expression microarray analysis, bioinformatics, and population expansion validation indicated significant downregulation of the PTEN gene in the high-concentration Hg exposure group. In the Hg-exposed cell model(25 and 10 μmol/L), a significant decrease in PTEN expression was observed, accompanied by a significant increase in PI3K, AKT, and IL-6 ***, a low-expression cell model demonstrated that PTEN gene knockdown led to a significant decrease in PTEN protein expression and a substantial increase in PI3K, AKT, and IL-6 *** This is the first study to report that Hg exposure downregulates the PTEN gene, activates the PI3K/AKT regulatory pathway, and increases the expression of inflammatory factors, ultimately resulting in kidney inflammation.

关键词： PTEN Occupational mercury exposure Occupational health PI3K/AKT pathway 293T cell IL-6

Heparin-binding protein as a predictor of mortality in patients with diabetes mellitus and community-acquired pneumonia in intensive care unit:a propensity score matched study

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World Journal of Emergency Medicine 2024年第4期15卷 263-272页

作者： Yuhan Sun Baoqing Sun Zhigang Ren Mingshan xue Changju Zhu Qi Liu Translational Medicine Center Department of Emergency Medicinethe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Infectious Disease the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Medical Key Laboratory of Emergency and Trauma Research Department of Emergency Medicinethe First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China

BACKGROUND:Patients with diabetes mellitus(DM)are vulnerable to community-acquired pneumonia(CAP),which have a high mortality *** aimed to investigate the value of heparin-binding protein(HBP)as a prognostic marker of mortality in patients with DM and ***:This retrospective study included CAP patients who were tested for HBP at intensive care unit(ICU)admission from January 2019 to April *** were allocated to the DM or non-DM group and paired with propensity score *** characteristics and clinical outcomes up to 90 days were *** primary outcome was the 10-day *** operating characteristic(ROC)curves,Kaplan-Meier analysis,and Cox regression were used for statistical ***:Among 152 enrolled patients,60 pairs were successfully *** was no significant difference in 10-day mortality,while more patients in the DM group died within 28 d(P=0.024)and 90 d(P=0.008).In the DM group,HBP levels at ICU admission were higher in 10-day non-survivors than in 10-day survivors(median 182.21[IQR:55.43-300]ng/ml *** 66.40[IQR:34.13-107.85]ng/mL,P=0.019),and HBP levels could predict the 10-day mortality with an area under the ROC curve of *** cut-off value,sensitivity,and specificity were 160.6 ng/mL,66.7%,and 90.2%,*** Cox regression analysis indicated that HBP was an independent prognostic factor for 10-day(HR 7.196,95%CI:1.596-32.455,P=0.01),28-day(HR 4.381,95%CI:1.449-13.245,P=0.009),and 90-day mortality(HR 4.581,95%CI:1.637-12.819,P=0.004)in patients with ***:Plasma HBP at ICU admission was associated with the 10-day,28-day,and 90-day mortality,and might be a prognostic factor in patients with DM and CAP.

关键词： Community-acquired pneumonia Diabetes mellitus Heparin-binding protein Propensity score match

Gas Molecule Assisted All-Inorganic Dual-Interface Passivation Strategy for High-Performance Perovskite Solar Cells

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Gas Molecule Assisted All-Inorganic Dual-Interface Passivati...

第十一届新型太阳能材料科学与技术学术研讨会

作者： Fancong Zeng Lin Xu Jiahe Xing Yanjie Wu Yuhong Zhang Huan Zhang Chencheng Hu Biao Dong xue Bai hongwei Song State Key Laboratory on Integrated Optoelectronics College of Electronic Science and EngineeringJilin University

The trap states at both the upper and bottom interfaces of perovskite layers significantly impact non-radiative carrier recombination [1,2].The widely used solvent-based passivation methods result in disordered distribution of surface components,posing challenges for the commercial application of large-area perovskite solar cells(PSCs).To address this issue,a novel NH3 gas-assisted all-inorganic dual-interfaces passivation strategy was *** the gas treatment of perovskite surface,NH3 molecules significantly enhanced the iodine vacancy formation energy(1.54 eV) and bonded with uncoordinated Pb2+ to achieve non-destructive ***,the reduction of the film defect states was accompanied by a decrease in the work function,which promoted carrier transport between the ***,a stable passivation layer was constructed to manage the bottom interfacial defects using inorganic potassium tripolyphosphate(PT),whose-P=O group effectively mitigated the charged defects and lowered the carrier transport barriers and nucleation barriers of PVK,while the gradient distribution of K+ improved the crystalline quality of PVK *** on the dual-interface synergistic effect,the optimal MAcontained PSC with an effective area of 0.1 cm2 achieved an efficiency of 24.51% and could maintain 90% of the initial value after aging(10-20% RH and 20°C) for 2000 h.

关键词： perovskite solar cells gas-assisted passivation all-inorganic treatment dual-interface passivation

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基于微震时空信息的近直立煤层致冲因素研究

煤矿安全 2024年第6期55卷 117-125页

作者：朱红伟薛雅荣李振雷杨菲何生全国家能源集团新疆能源公司乌东煤矿新疆乌鲁木齐830027 北京科技大学土木与资源工程学院北京100083

为掌握近直立煤层冲击地压致灾因素,基于矿井开采布局及现场微震监测数据,从时间和空间多维度对矿井微震事件的分布及历次冲击地压事件进行了深入分析,研究了不同开采深度下的致灾因素的演变规律。结果表明:近直立煤层的冲击地压主要由... 详细信息

为掌握近直立煤层冲击地压致灾因素,基于矿井开采布局及现场微震监测数据,从时间和空间多维度对矿井微震事件的分布及历次冲击地压事件进行了深入分析,研究了不同开采深度下的致灾因素的演变规律。结果表明:近直立煤层的冲击地压主要由悬空顶板和中间岩柱对工作面产生的应力集中以及煤岩体破裂产生的动载扰动诱发,日推进度、开采深度及遗留煤柱与冲击地压事件的发生也具有强相关关系,是矿井冲击主要致灾因素;矿井浅部开采时中间岩柱受水平构造应力和自重应力对煤岩体产生的“撬动”作用是导致煤岩体失稳破坏的主控因素,进入深部开采后叠加了悬空顶板的“挤压”作用,冲击致灾因素转变为顶板和岩柱的“压+撬”共同作用,而遗留煤柱等因素影响程度减弱。

关键词：冲击地压微震监测主控因素时空信息近直立煤层煤岩失稳

胫骨平台伴髁间棘骨折外科修复后关节功能康复的影响因素分析

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中国骨与关节损伤杂志 2024年第8期39卷 820-824页

作者：薛宏伟郑如庚崔阳保定市第二中心医院骨科河北072750

目的探究胫骨平台伴髁间棘骨折患者外科修复后关节功能康复的影响因素。方法纳入自2018-05—2023-05于笔者所在医院接受外科修复治疗的100例胫骨平台伴髁间棘骨折。比较患者术前与术后3个月膝关节功能Lysholm评分、疼痛VAS评分、膝关节... 详细信息

目的探究胫骨平台伴髁间棘骨折患者外科修复后关节功能康复的影响因素。方法纳入自2018-05—2023-05于笔者所在医院接受外科修复治疗的100例胫骨平台伴髁间棘骨折。比较患者术前与术后3个月膝关节功能Lysholm评分、疼痛VAS评分、膝关节活动度及胫骨平台后倾角。根据患者术后3个月膝关节功能Lysholm评分进行分组,≥70分的纳入良好组(78例),<70分的纳入不良组(22例),收集两组的一般资料,并进行单因素及多因素分析,探究患者外科修复后关节功能康复的影响因素。结果所有患者均顺利完成手术并获得至少3个月的随访。术后3个月膝关节功能Lysholm评分各维度均较术前明显提高,差异有统计学意义(P<0.05)。术后3个月胫骨平台后倾角及膝关节活动度均较术前明显增大,疼痛VAS评分较术前降低,差异均有统计学意义(P<0.05)。单因素及多因素分析结果显示,年龄、体质量指数、术前ASA分级、骨质疏松、手术时间、术前膝关节活动度均会对患者术后关节功能的恢复情况产生影响(P<0.05)。结论胫骨平台伴髁间棘骨折患者外科修复后,膝关节功能得到改善,疼痛程度减轻,活动度增加,同时术后恢复情况受年龄、体质量指数、术前ASA分级、骨质疏松、手术时间、术前膝关节活动度等因素的影响,应予以密切关注。

关键词：胫骨平台伴髁间棘骨折外科修复关节功能影响因素

ABO血型抗体缺失致ABO血型正反定型不符的检测分析

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临床血液学杂志 2024年第8期37卷 545-549页

作者：秦洪伟许梦迪薛杰青岛市胶州中心医院输血科山东青岛266300

目的:分析ABO血型反定型抗体缺失样本的血型血清学及基因检测结果,探讨ABO血型抗体缺失的原因和输血策略。方法:采用Ortho AutoVue全自动血型系统对该院2019年11月至2023年10月33296例患者进行常规ABO血型检测,选择ABO血型正反定型不符... 详细信息

目的:分析ABO血型反定型抗体缺失样本的血型血清学及基因检测结果,探讨ABO血型抗体缺失的原因和输血策略。方法:采用Ortho AutoVue全自动血型系统对该院2019年11月至2023年10月33296例患者进行常规ABO血型检测,选择ABO血型正反定型不符疑为抗体缺失者,采用盐水试管法复核并增加ABO亚型检测、吸收放散试验检测红细胞上的A或B抗原,对ABO基因第6和第7外显子进行测序分析。结果:95例ABO血型正反定型不符样本中,7例疑为血型抗体缺失,其中4例确认为ABO血型抗原减弱,3例确认为ABO血型抗体缺失,本地区ABO血型抗体缺失检出率0.09‰,经过基因测序分析,确定血型抗体缺失者基因型分别为B.01/O.01.02、O.01.13/O.01.13、B.01/O.01.01。结论:疑似ABO血型抗体缺失者需要从正定型和反定型分别进行检测分析,ABO基因检测可明确具体ABO基因型,提高ABO血型鉴定的准确性并可明确ABO血型抗体缺失现象。对于疑似或确定为ABO血型抗体缺失者的输血,可采用相容性输血的方式。

关键词： ABO血型 ABO反定型血型抗体缺失血型血清学基因测序

Numerical simulation of gas flow process in mining-induced crack network

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International Journal of Mining Science and Technology 2012年第6期22卷 793-799页

作者： Zhou hongwei Liu Jinfeng xue Dongjie Yi Haiyang xue Junhua State Key Laboratory of Coal Resources and Safe Mining China University of Mining & Technology State Key Laboratory of Deep Coal Mining and Environmental Protection Huainan Mining Group Corporation

The exploitation of coal bed methane or coal gas is one of the most effective solutions of the problem of coal gas hazard.A better understanding of gas flow in mining-induced cracks plays an important role in comprehensive development and utilization of coal gas as well as prevention of coal gas *** paper presents a case study of gas flow in mining-induced crack network regarding the situation of low permeability of coal seam.A two-dimensional physical model is constructed on the basis of geological background of mining face No.1122(1) in coal seam No.11-2,Zhangji Coal Mine,Huainan Mining group *** mining-induced stress and cracks in overburden rocks are obtained by simulating an extraction in physical *** evolution of mining-induced cracks in the process of advancing of coal mining face is characterized and three typical crack networks are taken from digital photos by means of image ***,the numerical software named COMSOL Multiphysics is employed to simulate the process of gas flow in three representative crack *** of gas pressure at various times in mining-induced crack networks are plotted,suggesting a shape and dimension of gas accumulation area.

关键词： Gas flow Gas pressure Physical modeling Mining-induced cracks COMSOL

Comparative transcriptomic analysis reveals the molecular changes of acute pancreatitis in experimental models

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World Journal of Gastroenterology 2024年第14期30卷 2038-2058页

作者： Pan Zheng xue-Yang Li Xiao-Yu Yang Huan Wang Ling Ding Cong He Jian-Hua Wan Hua-Jing Ke Nong-Hua Lu Nian-Shuang Li Yin Zhu Department of Gastroenterology Digestive Disease HospitalThe First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Acute pancreatitis(AP)encompasses a spectrum of pancreatic inflammatory conditions,ranging from mild inflammation to severe pancreatic necrosis and multisystem organ *** the challenges associated with obtaining human pancreatic samples,research on AP predominantly relies on animal *** this study,we aimed to elucidate the fundamental molecular mechanisms underlying AP using various AP *** To investigate the shared molecular changes underlying the development of AP across varying severity *** AP was induced in animal models through treatment with caerulein alone or in combination with lipopolysaccharide(LPS).Additionally,using Ptf1αto drive the specific expression of the hM3 promoter in pancreatic acinar cells transgenic C57BL/6J-hM3/Ptf1α(cre)mice were administered Clozapine N-oxide to induce ***,we conducted RNA sequencing of pancreatic tissues and validated the expression of significantly different genes using the Gene Expression Omnibus(GEO)*** Caerulein-induced AP showed severe inflammation and edema,which were exacerbated when combined with LPS and accompanied by partial pancreatic tissue *** with the control group,RNA sequencing analysis revealed 880 significantly differentially expressed genes in the caerulein model and 885 in the caerulein combined with the LPS *** Encyclopedia of Genes and Genomes enrichment analysis and Gene Set Enrichment Analysis indicated substantial enrichment of the TLR and NOD-like receptor signaling pathway,TLR signaling pathway,and NF-κB signaling pathway,alongside elevated levels of apoptosis-related pathways,such as apoptosis,P53 pathway,and phagosome *** significantly elevated genes in the TLR and NOD-like receptor signaling pathways,as well as in the apoptosis pathway,were validated through quantitative real-time PCR experiments in animal *** from the GEO database revealed that only MYD88 concurred in both mouse panc

关键词： Acute pancreatitis RNA-sequencing Experimental acute pancreatitis models Inflammatory Apoptosis TLR and NOD-like signaling pathways