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世界核心医学期刊文摘（眼科学分册） 2005年第9期1卷 37-38页

作者： michelson G. groh m. groh m.j.m. 张少娟 Augenklinik mit Poliklinik Universit¨at Erlangen-N¨urnberg Schwabachanlage 6 91054 Erlangen Germany Dr.

Background: Cerebral and retinal vessels behave similarly under the influence of vascular risk factors. Several groups have shown that retinal microvascular abnormalities represent an independent risk factor with regard to strokes and heart attacks. Aim of the Study: The aim of this study was to perform a prospective screening examinationwith regard to retinalmicrovascular abnormalities as well as an extended vessel diagnosis in a subgroup of patients with lower arteriovenous risk values. methods: In the course of a prospective cross-sectional study (“Talking Eyes”) between 1.9.2001 and 1.8.2002 a telemedical-supported screening of the retina (study 1) was carried out in 7,163 subjects. The patients were selected without any inclusion or exclusion criteria. The mean age was 48.2±8 years (18-83 years) with a sex distribution of 39.2%females to 60.8%males. Digital fundus photos of the right and left eyes were taken for all patients. The pictures were taken without pupil dilation using a CANON-Nm camera. The pictures and case histories were stored in a central server using web-based software (medStage, Siemens). In a central reading centre, the arteriovenous ratio of both eyes was determined telemedically using the Parr-Hubbard formula and the retinas subjected to a standardised examination by an ophthalmologist. The retinal risk factor was calculated on the basis of the arteriovenous ration, the presence of microvascular abnormalities and the case history. The reproducibility of measurement of the arteriovenous ratio (Kronbach alpha coefficient) was evaluated by double measurements on 1,332 images. In a subgroup of study 1 with arteriovenous ratio values measurement of 24-h blood pressure and vessel-relevant blood values (homocysteine, cholesterol, LDL, HDL, CRP, TG, HbA1c) was carried out (study II). Results: Study 1: The Kronbach alpha coefficient as a measure of reproducibility amounted to 0.77. The mean arterioveno

关键词：视网膜血管筛查技术远程医疗动静脉比视网膜微血管视网膜出血舒张期血压动静脉交叉征视网膜检查血压测定

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Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： Chao Weng Adam m.R.groh moein Yaqubi Qiao-Ling Cui jo Anne Stratton G.R.Wayne moore jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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Effect of divalent cations(Co^(2+) and Ni^(2+)) on microstructure,physical properties and application of NdFeO_(3)

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journal of Rare Earths 2025年第1期43卷 89-97,I0004页

作者： m.m.Arman materials Science Lab(1) Physics DepartmentFaculty of ScienceCairo UniversityGiza12613Egypt

The nanocrystalline samples Nd_(1-x)m_(x)FeO_(3)(x=0.0 and 0.1;m:Co^(2+)and Ni^(2+))were prepared using the citrate combustion *** X-ray diffraction(XRD)pattern confirmed that the nanoparticles were synthesized in an orthorhombic *** particle size of Nd_(1-x)m_(x)FeO_(3) is in the range of 29-59 *** selected area electron diffraction(SAED)indicates the samples were prepared in a polycrystalline *** samples Nd_(1-x)m_(x)FeO_(3)(x=0.0 and 0.1;m:Co^(2+)and Ni^(2+))have anti ferromagnetic *** Fe^(3+)spins are aligned antiparallel,forming the antiferromagnetic(AFm)properties,which are affected by many factors such as the bond angle between the Fe^(3+)(Fe^(3+)-O_(2)--Fe^(3+))and the Dzyaloshinskii-moriya(D-m)*** doping of Co^(2+)and Ni^(2+)ions in NdFeO_(3) enhances the magnetic properties of the NdFeO_(3).The saturation magnetization(ms)of Nd_(0.90)Co_(0.10)FeO_(3) increases 1.8times more than that of NdFeO_(3).The exchange bias field(HEX)of the Co-doped sample is two times greater than that of NdFeO_(3).The magnetic anisotropy constant(K)of the 10%Co-doped sample increases by 11 factors compared to that of NdFeO_(3).The Tauc plot illustrates that the samples have a direct optical *** divalent cation substitution(Co^(2+)and Ni^(2+))decreases the optical band gap of NdFeO_(3),leading to the recommendation of using the samples Nd_(0.90)Co_(0.10)FeO_(3) and Nd_(0.90)Ni_(0.10)FeO_(3) in photocatalysis of dye degradation from *** removal efficiencies of Cr6+at pH=6 are 88.06%,85.54%,and 85.52%for the samples NdFeO_(3),Nd_(0.90)Co_(0.10)FeO_(3),and Nd_(0.90)Ni_(0.10)FeO_(3),*** Freundlich isotherm mode is the best-fit model for NdFeO_(3) to adsorb Cr6+ions from aqueous solutions.

关键词： Optical properties Nanoparticles magnetic properties Perovskites Removal efficiency Rareearths

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Honeycomb-spiderweb-inspired self-similar hybrid cellular structures for impact applications

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Defence Technology(防务技术) 2025年第1期43卷 182-200页

作者： K.Tewari m.K.Pandit m.m.mahapatra P.R.Budarapu School of mechanical Sciences Indian Institute of Technology BhubaneswarBhubaneswar752050India

Inspired by nature's self-similar designs,novel honeycomb-spiderweb based self-similar hybrid cellular structures are proposed here for efficient energy absorption in impact *** energy absorption is enhanced by optimizing the geometry and topology for a given *** proposed hybrid cellular structure is arrived after a thorough analysis of topologically enhanced self-similar *** optimized cell designs are rigorously tested considering dynamic loads involving crush and high-velocity bullet ***,the influence of thickness,radial connectivity,and order of patterning at the unit cell level are also *** maximum crushing efficiency attained is found to be more than 95%,which is significantly higher than most existing traditional *** on,the first and second-order hierarchical self-similar unit cell designs developed during crush analysis are used to prepare the cores for sandwich *** tests are performed on the developed sandwich structures using the standard 9-mm *** influence of multistaging on impact resistance is also investigated by maintaining a constant total thickness and mass of the sandwich ***,in order to avoid layer-wise weak zones and hence,attain a uniform out-of-plane impact strength,off-setting the designs in each stage is *** sandwich structures with first and second-order self-similar hybrid cores are observed to withstand impact velocities as high as 170 m/s and 270 m/s,respectively.

关键词： Sandwich structures Honeycomb-spider web inspired Self-similar hierarchy Crush analysis High-velocity impact Strong and weak zones multistaging

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Discovering causal models for structural,construction and defense-related engineering phenomena

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Defence Technology(防务技术) 2025年第1期43卷 60-79页

作者： m.Z.Naser School of Civil&Environmental Engineering and Earth Sciences(SCEEES) Clemson UniversityClemsonSouth Carolina 29634USA The Artificial Intelligence Research Institute for Science and Engineering(AIRISE) Clemson UniversityClemsonSouth Carolina 29634USA

Causality,the science of cause and effect,has made it possible to create a new family of *** models are often referred to as causal *** those of mathematical,numerical,empirical,or machine learning(mL)nature,causal models hope to tie the cause(s)to the effect(s)pertaining to a phenomenon(i.e.,data generating process)through causal *** paper presents one of the first works at creating causal models in the area of structural and construction *** this end,this paper starts with a brief review of the principles of causality and then adopts four causal discovery algorithms,namely,PC(Peter-Clark),FCI(fast causal inference),GES(greedy equivalence search),and GRa SP(greedy relaxation of the sparsest permutation),have been used to examine four phenomena,including predicting the load-bearing capacity of axially loaded members,fire resistance of structural members,shear strength of beams,and resistance of walls against impulsive(blast)*** from this study reveal the possibility and merit of discovering complete and partial causal ***,this study also proposes two simple metrics that can help assess the performance of causal discovery algorithms.

关键词： Causality Causal discovery Directed acyclic graphs machine learning metrics

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The effect of adsorbent textural and functional properties on model naphthenic acid adsorption

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journal of Environmental Sciences 2025年第2期148卷 27-37页

作者： Tyler m.Roy Elmira Nazari Oliver K.L.Strong Paul R.Pede Andrew j.Vreugdenhil material Science Department of ChemistryTrent University1600 West BankPeterboroughOntario K9L 0G2Canada Carbonix 690 Mountain RdSuite 200Fort William First NationOntario P7J 1G8Canada

Naphthenic acids,NAs,are a major contaminant of concern and a focus of much research around remediation of oil sand process affected waters,*** activated carbon adsorbents are an attractive option given their low cost of fabrication and implementation.A deeper evaluation of the effect NA structural differences have on uptake affinity is *** we provide an in-depth exploration of NA adsorption including many more model NA species than have been assessed previously with evaluation of adsorption kinetics and isotherms at the relevant alkaline pH of OSPW using several different carbon adsorbents with pH buffering to simulate the behaviour of real *** for the NA varied considerably regardless of the activated carbon used,ranging from 350 mg/g to near zero highlighting recalcitrant *** equilibrium data was explored to identify structural features of these species and key physiochemical properties that influence *** found that certainNAwill be resistant to adsorptionwhen hydrophobic adsorbents are *** isotherm modelling helped explore interactions occurring at the interface between NA and adsorbent *** identified the importance of NA hydrophobicity for activated carbon *** is also presented that indicates favorable hydrogen bonding between certain NA and surface site hydroxyl groups,demonstrating the importance of adsorbent surface functionality for NA *** research highlights the challenges associated with removing NAs from OSPW through adsorption and also identifies howadsorbent surface chemistry modification can be used to increase the removal efficiency of recalcitrant NA species.

关键词： Adsorption Activated carbon model naphthenic acids Isotherm modelling

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Clinical,laboratory,and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

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World journal of Clinical Pediatrics 2025年第1期14卷 78-92页

作者： Hasan m Isa marwa j Abdulnabi Nawra S Naser Fatema N Lahmda Noor m AlAnsari Zahra H Isa Afaf m mohamed Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Faculty of medicine Mansoura UniversityMansoura 35516Egypt Public Health Directorate Ministry of HealthManama 26671Bahrain

BACKGROUND Although breast milk is ideal for newborns,in some cases,it is replaced with cow’s milk,which contains proteins that increase the risk of cow’s milk protein allergy(CmPA).AIm To evaluate CmPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E(IgE)-and non-IgE-mediated *** This retrospective cohort study examined children with CmPA diagnosed at the pediatric gastroenterology outpatient clinic of the Salmaniya medical Complex,Bahrain,between 2014 and 2022,and assessed CmPA *** presentations,laboratory findings,dietary modifications,and outcomes were compared between children with IgE-mediated and non-IgE-mediated *** variables were compared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were compared using Student’s t-test or the mann-Whitney U *** Of 8332 patients,6022(72.3%)adhered to their *** them,618(10.3%)were suggested of having CmPA and 595(96.3%)were included;CmPA prevalence was 2%.most patients were Bahraini(93.8%)and males(55.3%).Non-IgE-mediated type accounted for 77.3%cases and IgE-mediated type,22.7%.IgE-mediated CmPA presented more in boys(P=0.030),and later in life(5.1 months±4.5 months vs 4.2 months±4.2 months,P=0.016,95%CI:0.08-1.73),had more associated diseases(Pmore cutaneous(P=0.024)and respiratory(P=0.003)manifestations,severe symptoms[rash/dry skin(P=0.031),facial swelling/angioedema(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(Pmediated *** patients were exclusively fed cow milk formula(50.3%).The amino acid-based formula(AAF)was most prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recommended to 49.6%,only 8.2%were exclusively ***-mediated CmPA was associated with a longer follow-up duration than non-IgE-mediated CmPA(17.3 months±14.0 mo

关键词： Children milk allergy Immunoglobulin E Breastfeeding Infant formula Bahrain

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Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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Structural,dielectric and magnetic properties of terbium doped strontium spinel ferrite（SrFe2O4） synthesized by sol-gel method

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journal of Rare Earths 2025年第2期43卷 337-344页

作者： Rifat Shaheen Hafeez Ullah m.m.moharam Ahmad m.Saeedi Ebraheem Abdu musad Saleh muhammad Ijaz Adel A.El-Zahhar Gamil A.A.m.Al-Hazmi Sana Ullah Asif Hafiz muhammad Tahir Institute of Physics Gomal University Department of Chemistry College of Arts and SciencesPrince Sattam Bin Abdulaziz University Chemical and Electrochemical Processing Department Central Metallurgical Research and Development Institute (CMRDI) Department of Physics Faculty of Applied ScienceUmm AL-Qura University Department of Chemistry College of ScienceKing Khalid University School of materials and Energy Yunnan University Department of Physics Govt. Graduate College Taunsa

In this research work,sol-gel technique was employed to prepare the strontium based spinel ferrite nanoparticles（SrFe2O4） with different ratios of terbium（Tb）.Different characterization techniques were used to investigate the structural,morphological,dielectric and magnetic properties of the prepared samples.X-ray diffraction（XRD） result suggests that face-centered cube spinel nanocrystalline structure is *** size of the SrFe2O4decreases with rising of Tb *** morphology,shape and size of the SrFe2O4were examined by scanning electron microscopy（SEm） analysis and results reveal inhomogeneous distributions of the nanostructures with high *** electrical resistivity of the SrFe2O4increases with rising of Tb ratio,which is confirmed from the cyclic *** is observed that dielectric constant of all the samples decreases with the increasing frequency *** is determined that the dielectric constants of the spinel ferrites are frequency dependent and decrease with increasing the frequency of applied electric *** magnetic behavior of SrFe2O4with different ratios of Tb was studied and it is found that the saturation magnetization values of samples decrease with increase in the substitution of Tb3+at octahedral sites for Fe3+.This decrease in the values of msis also attributed to spin at surface of nanoparticles.

关键词： Dielectric properties magnetic properties Rare earths Sol-gel Spinel ferrites Structural properties

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