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In vivo assessment of structural changes of the urethra in lower urinary tract disease using cross-polarization optical coherence tomography

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Journal of Innovative Optical Health Sciences 2020年第6期3卷 55-70页

作者： Elena B.Kiseleva Alexander A.Moiseev Anton S.Kuyarov Muhammat A.Molvi grigory v.gelikonov.anna v.maslennikov. Olga S.Streltsova Privolzhsky Research Medical University 10/1 Minin and Pozharsky Square 603005 Nizhny NovgorodRussia Institute of Applied Physics Russian Academy of Sciences Ulyanova Street 46603950Nizhny NovgorodRussia

The paper presents the results of a study of the female urethra in cases of urethral pain syndrome(UPS)and inflammatory diseases of the lower urinary tract using cross-polarization optical coherence tomography(CP OCT).Urethral wall structure was studied in 86 patients;233 CP OCT images were collected.A comparative qualitative analysis of three groups of CP OCT images—"norm","Inflammation"and"UPS"—identified that despite the absence of a clear inflammatory factor in the patient's examination,the urethral tissues in UPS were in an altered *** changes in the urethral wall with UPS and in cases of inflammation were *** a point scale,three experts independently performed visual scoring of the CP OCT *** parameters:epithelial contrast,cavities and the minimum signal depth in the co-channel were *** was found that,individually,the parameters correlate only weakly with the *** under the receiver operating characteristic(ROC)curve was from 0.51 to *** joint use of a number of visual signs has a greater diagnostic value than the use of the criteria *** under the ROC curve using the developed cumulative criterion reached up to *** study could form the basis of a scoring system for assessing the state of the urethral tract using CP OCT images in real *** CP OCT method provides information on the state of urethral tissues that cannot be obtained with traditional cystoscopy.

关键词： Cross-polarization optical coherence tomography urethral pain syndrome connective tissue visual analysis of images automatic classification of images

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Practical obstacles and their mitigation strategies in compressional optical coherence elastography of biological tissues

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 51-63页

作者： vladimir Y.Zaitsev Alexandr L.Matveyev Lev A.Matveev Ekaterina v.Gubarkova Alexandr A.Sovetsky Marina A.Sirotkina grigory v.gelikonov Elena v.Zagaynova Natalia D.Gladkova Alex vitkin Institute of Applied Physics Russian Academy of Sciences Ulyanova Street 46 Nizhny Novgorod 603950 Russia Nizhny Novgorod State Medical Academy 10/1 Minina Square Nizhny Novgorod 603005 Russia University of Toronto and University Health Network 610 University Avenue Toronto ON M5G 2M9Canada

In this paper,we point out some practical obstacles arising in realization of compressional optical coherence elastography(OCE)that have not attracted sufficient attention ***-cally,we discuss(i)complications in quantification of the Young modulus of tissues related to partial adhesion between the OCE probe and soft intervening reference layer sensor,(i)distorting influence of tisue suface curvature/corrugation on the subsurface strain distri-bution mapping,(ii)ways of signal-to-noise mtio(SNR)enhancement in OCE strain mapping when periodic averaging is not realized,and(iv)potentially significant infuence of tissue elastic nonlinearity on quantification of its *** pnactical approaches to mitigate the effects of these complications are also described.

关键词： Optical coherence elastography optical coherence tomography phase-resolved methods strain mapping stiffness characterization

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Numerical method for axial motion artifact correction in retinal spectral-domain optical coherence tomography

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Frontiers of Optoelectronics 2020年第4期13卷 393-401页

作者： Sergey Yu.KSENOFONTOv Pavel A.SHILYAGIN Dmitry A.TERPELOv valentin M.gelikonov grigory v.gelikonov BioMedTech Lie Nizhny Novgorod 603155Russia Institute of Applied Physics of the Russian Academy of Science Nizhny Novgorod 603950Russia

A numerical method that compensates image distortions caused by random fluctuations of the distance to an object in spectral-domain optical coherence tomography(SD OCT)has been proposed and verified *** proposed method is based on the analysis of the phase shifts between adjacent scans that are caused by micrometer-scale displacements and the subsequent compensation for the displacements through phase-frequency correction in the spectral *** efficiency of the method is demonstrated in model experiments with harmonic and random movements of a scattering object as well as during in vivo imaging of the retina of the human eye.

关键词： optical coherence tomography(OCT) motion artifact correction retinal imaging numerical method

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Medium chromatic dispersion spectral-domain optical calculation and correction in coherence tomography

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Frontiers of Optoelectronics 2017年第3期10卷 323-328页

作者： vasily A. MATKIvSKY Alexander A. MOISEEv Sergey Yu. KSENOFONTOv Irina v. KASATKINA grigory v. gelikonov Dmitry v. SHABANOv Pavel A. SHILYAGIN valentine M. gelikonov Institute of Applied Physics Russian Academy of Sciences Nizhny Novgorod 603950 Russia

A method for determining and correcting distortions in spectral-domain optical coherence tomography images caused by medium dispersion was developed. The method is based on analysis of the phase distribution of the interference signal recorded by an optical coherence tomography device using an iterative approach to find and compensate for the effect of a medium＇s chromatic dispersion on point-spread function broadening in optical coherence tomography. This enables compensation of the impact of medium dispersion to an accuracy of a fraction of a radian （units of percent） while avoiding additional measurements and solution of the optimization problem. The robustness of the method was demonstrated experimentally using model and biological objects.

关键词： optical coherence tomography (OCT) dispersion image resolution restoration

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Giant non-linear susceptibility of hydrogenic donors in silicon and germanium

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Light(Science & Applications) 2019年第1期8卷 624-630页

作者： Nguyen H.Le grigory v.Lanskii Gabriel Aeppli Benedict N.Murdin Advanced Technology Institute and SEPNet University of SurreyGuildford GU27XHUK Institute of Monitoring of Climatic and Ecological Systems SB RAS 10/3 Academical Ave.Tomsk 634055Russia Laboratory for Solid State Physics ETH ZurichZurich CH-8093Switzerland Institut de Physique EPF LausanneLausanne CH-1015Switzerland Paul Scherrer Institut VilligenPSI CH-5232Switzerland

Implicit summation is a technique for the conversion of sums over intermediate states in multiphoton absorption and the high-order susceptibility in hydrogen into simple ***,we derive the equivalent technique for hydrogenic impurities in multi-valley *** the absorption has useful applications,it is primarily a loss process;conversely,the non-linear susceptibility is a crucial parameter for active photonic *** Si:P,we predict the hyperpolarizability ranges from χ^((3))/n_(3D)=2.9 to 580×10^(−38 )m^(5)/v^(2) depending on the frequency,even while avoiding *** samples of a reasonable density,n3D,and thickness,L,to produce thirdharmonic generation at 9 THz,a frequency that is difficult to produce with existing solid-state sources,we predict that χ^((3)) should exceed that of bulk InSb and χ^((3))L should exceed that of graphene and resonantly enhanced quantum wells.

关键词： susceptibility hydrogenic absorption

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Gut dysbiosis and small intestinal bacterial overgrowth as independent forms of gut microbiota disorders in cirrhosis

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World Journal of Gastroenterology 2022年第10期28卷 1067-1077页

作者： Roman maslennikov vladimir Ivashkin Irina Efremova Elena Poluektova anna Kudryavtseva George Krasnov Department of Internal Medicine Gastroenterology and HepatologySechenov UniversityMoscow 119435Russia Scientific Community for Human Microbiome Research Moscow 119435Russia Department of Internal Medicine 1 Сonsultative and Diagnostic Center 2 of the Moscow City Health DepartmentMoscow 107564Russia Laboratory of Postgenomic Research Engelhardt Institute of Molecular BiologyRussian Academy of SciencesMoscow 119991Russia

BACKGROUND Gut dysbiosis and small intestinal bacterial overgrowth(SIBO)are commonly observed in patients with *** the substantial number of articles describing the relations between disorders of gut microbiota and various manifestations of cirrhosis,dysbiosis and SIBO were always studied *** To study the relationship of gut dysbiosis and SIBO in *** This observational study included 47 in-patients with *** microbiome was assessed using 16 S r RNA gene *** was assessed using the lactulose hydrogen breath *** SIBO was found in 24/47(51.1%)*** with SIBO had a higher abundance of Firmicutes(P=0.017)and Fusobacteria(P=0.011),and a lower abundance of Bacteroidetes(P=0.013)than patients without *** increase in the abundance of Firmicutes occurred mainly due to an increase in the abundance of bacteria from the genus Blautia(P=0.020)of the Lachnospiraceae family(P=0.047),while the abundance of other major families of this phylum[Ruminococcaceae(P=0.856),Peptostreptococcaceae(P=0.066),Clostridiaceae(P=0.463),Eubacteriaceae(P=0.463),Lactobacillaceae(P=0.413),and veillonellaceae(P=0.632)]did not differ significantly between the patients with and without *** level of Bacteroidetes in samples from patients with SIBO was a result of the decrease in bacterial numbers from all the major families of this phylum[Bacteroidaceae(P=0.014),Porphyromonadaceae(P=0.002),and Rikenellaceae(P=0.047)],with the exception of Prevotellaceae(P=0.941).There were no significant differences in the abundance of taxa that were the main biomarkers of cirrhosis-associated gut dysbiosis[Proteobacteria(P=0.790),Bacilli(P=0.573),Enterobacteriaceae(P=0.632),Streptococcaceae(P=0.170),Staphylococcaceae(P=0.450),and Enterococcaceae(P=0.873)]between patients with and without *** Despite the differences observed in the gut microbiome between patients with and without SIBO,gut dysbiosis and SIBO are most

关键词： Dysbiosis Gut-liver axis Microbiome Small intestinal bacterial overgrowth Cirrhosis Microbiota

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Clostridioides difficile infection in patients with nonalcoholic fatty liver disease-current status

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World Journal of Hepatology 2023年第2期15卷 208-215页

作者： Yana v Kiseleva Roman v.maslennikov.Aida N Gadzhiakhmedova Tatyana S Zharikova Dmitry v Kalinin Yury O Zharikov International School“Medicine of the Future” I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119991Russia Department of Internal Medicine Gastroenterology and HepatologyI.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 119435Russia Department of Internal Medicine Сonsultative and Diagnostic Center No.2Moscow City Health DepartmentMoscow 107564Russia Department of Human Anatomy and Histology I.M.Sechenov First Moscow State Medical University(Sechenov University)Moscow 125009Russia Department of Pathology A.V.Vishnevsky National Medical Research Center of SurgeryMoscow 115093Russia

Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease,leading to fibrosis,cirrhosis and hepatocellular carcinoma and also associated with increased cardiovascular disease *** pathogenesis of NAFLD is not fully understood,although NAFLD is thought to be a hepatic form of metabolic *** is an increasing understanding of the role of microbiota disturbances in NAFLD pathogenesis,and as with many other conditions affecting the microbiota,NAFLD may be a novel risk factor for Clostridioides difficile(***)colonization(CDC)and *** infection(CDI).CDI is an emerging nosocomial disease,and community-acquired cases of infection are growing,probably due to an increase in CDC *** association of NAFLD with CDI has been shown in only 4 studies to date,three of which included less than 1000 patients,although the frequency of NAFLD in these studies was observed in almost 20%of the total patient *** data revealed that NAFLD is a risk factor for CDI development and,moreover,is a risk factor for intestinal complications of *** studies are needed to investigate this association and move forward CDC and CDI screening efforts for this group of patients.

关键词： Nonalcoholic fatty liver disease Clostridioides difficile Clostridioides difficile colonization Clostridioides difficile infection Minireview

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Dynamic failure of dry and fully saturated limestone samples based on incubation time concept

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第1期9卷 125-134页

作者： Yuri v. Petrov Ivan v. Smirnov grigory A. volkov Andrei K. Abramian Anatoliy M. Bragov Stanislav N. verichev Saint Petersburg University Universitetskaya nab. 7-9 Saint Petersburg 199034 Russia Institute of Problems of Mechanical Engineering Russian Academy of Sciences Bolshoj pr. 61 V.O. Saint Petersburg 199178 Russia Lobachevsky State University of Nizhni Novgorod Prospekt Gagarina 23 Nizhny Novgorod 603950 Russia Allseas Engineering B.v. Poortweg 12 Delft 2612 PA The Netherlands

This paper outlines the results of experimental study of the dynamic rock failure based on the comparison of dry and saturated limestone samples obtained during the dynamic compression and split tests. The tests were performed using the Kolsky method and its modifications for dynamic splitting. The mechanical data(e.g. strength, time and energy characteristics) of this material at high strain rates are obtained. It is shown that these characteristics are sensitive to the strain rate. A unified interpretation of these rate effects, based on the structuraletemporal approach, is hereby presented. It is demonstrated that the temporal dependence of the dynamic compressive and split tensile strengths of dry and saturated limestone samples can be predicted by the incubation time criterion. Previously discovered possibilities to optimize(minimize) the energy input for the failure process is discussed in connection with industrial rock failure processes. It is shown that the optimal energy input value associated with critical load, which is required to initialize failure in the rock media, strongly depends on the incubation time and the impact duration. The optimal load shapes, which minimize the momentum for a single failure impact, are demonstrated. Through this investigation, a possible approach to reduce the specific energy required for rock cutting by means of high-frequency vibrations is also discussed.

关键词： Dynamic strength Incubation time criterion Split Hopkinson pressure bar(SHPB) test Tensile strength Compressive strength Water-saturated limestone vibration-assisted rock cutting

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An efficient synthetic approach towards new 5,5'-diaryl-2,2'-bipyridine-based fluorophores

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Chinese Chemical Letters 2017年第5期28卷 1099-1103页

作者： Alexey P.Krinochkin Dmitry S.Kopchuk Nikolay v.Chepchugov grigory A.Kim Igor S.Kovalev Matiur Rahman grigory v.Zyryanov Adinath Majee vladimir L.Rusinov Oleg N.Chupakhin Ural Federal University Yekaterinburg 620002Russian Federation Postovsky Institute of Organic Synthesis of RAS(Ural Division) Yekaterinhurg 620990Russian Federation Department of Chemistry Visva-Bharati(A Central University)Santiniketan 731235India

An efficient approach has been developed for the synthesis of 5,5＇-diaryl-2,2＇-bipyridines via their 1,2,4-triazine *** notable advantages of the present method are：The possibility of varying the aromatic substituents in the positions 5 and 5＇ of bipyridine core and the possibility for obtaining 2,2＇-bipyridines bearing a fused cyclopentene core to increase the solubility in organic *** 5,5＇-diaryl-2,2＇-bipyridines exhibited an intense emission in a range of ca.422-521 nm in acetonitrile solution;depending on the nature of the aromatic substituents and the presence of annulated cyclopentene *** from that,the significant bathochromic shifts of the both absorption and emission maxima were observed in comparison with a number of previously described similar *** some cases the significant increasing of the fluorescence quantum yields took place.

关键词： 2 2'-Bipyridines 1 2 4-Triazines Aza-Diels-Alder reaction Fluorescence

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Pendulum-type laser strainmeter

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Earthquake Science 2015年第4期28卷 311-317页

作者： grigory Ivanovich Dolgikh v.I.Il'ichev Pacific Oceanological Institute of the Far Eastern Branch Russian Academy of Sciences

Constructive disposition principles of the basic optical units of Michelson interferometers are used in making one-coordinate laser strainmeters of unequal-arm type. The fundamental advantages of pendulurn-type laser ... 详细信息

关键词： Amplitude-frequency characteristic Classical-type laser strainmeter Elastic wave Infrasound Pendulum-type laser strainmeter

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