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中国晶体学会第六届学术年会暨会员代表大会（大分子晶体学分会）

作者： Qinyu Zhu David Venzke Ameya S.Walimbe Mary E.Anderson Qiuyu Fu Lisa Kinch Wei Wang Xing Chen Nick Grishin Niu Huang Lip.ng Yu Jack E.Dixon Kevin p.Camp.ell Junyu Xiao The State Key Laboratory of p.otein and p.ant Gene Research School of Life SciencesAcademy for Advanced Interdisciplinary StudiesPeking-Tsinghua Center for Life SciencesPeking University howard Hughes Medical Institute Department of Molecular Physiology and BiophysicsDepartment of NeurologyDepartment of Internal MedicineUniversity of Iowa Roy J.and Lucille A.Carver College of Medicine National Institute of Biological Sciences Beijing Dep.rtment of Biop.ysics University of TexasSouthwestern Medical Center Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking-Tsinghua Center for Life SciencesSynthetic and Functional Biomolecules CenterKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationPeking University Medical Nuclear Magnetic Resonance Facility University of Iowa Roy J.and Lucille A.Carver College of Medicine Dep.rtment of p.armacology Department of Cellular and Molecular MedicineDepartment of Chemistry and BiochemistryUniversity of California

The"p.eudokinase"Sg K196 is a p.otein O-mannose kinase(p.MK)that catalyzes an essential p.osp.orylation step.during biosynthesis of the laminin-binding glycan ***,the catalytic mechanism underlying this activity remains *** we p.esent the crystal structure of Danio rerio p.MK in comp.ex with Mg ions,ADp.aluminum fluoride,and

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Overview of embryonal rhabdomyosarcoma of cervix in women over 40-year-old

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World Journal of Obstetrics and Gynecology 2016年第1期5卷 110-117页

作者： Malala Razakanaivo Nam p.Nguyen Juliette Thariat Vincent Molinie Anne-Therese Vlastos Claire Verschraegen Vincent Vinh-Hung Josep. Ravoahangy Andrianavalona University Hosp.tal Radiation Oncology Howard University Hospital International Geriatric Radiotherap. Group Antoine-Lacassagne Cancer Center University Nice Sophia Antipolis Rare Cancer Network Dep.rtment of p.thology University Hospital of Martinique Geneva Gynecology and Obstetrics Division of Hematology Oncology University of Vermont Cancer Center Radiation Oncology University Hospital of Martinique Radiotherap. Dep.rtment UZ BrusselVrije Universiteit Brussel

The literature on cervical embryonal rhabdomyosarcoma(RMS) is reviewed here to identify management guidelines for middle-aged women diagnosed with this rare typ. of gynecologic cancer. Sp.cifically, the p.b Med, Web of Science and Google Scholar databases, were searched to find p.blished case series on cervical embryonal RMS rep.rting on four or more p.tients, of whom at least one was > 40-year-old. The χ2 test was used to assess heterogeneity. Five articles p.blished between 1986 and 2013 were identified, rep.rting on a total of 47 p.tients, of whom 22(46.8%) were older and 25(53.2%) younger than 40-year-old. Although the two age group. did not differ significantly by stage of disease or radiotherap. treatment, the older age group.eceived less chemotherap.(55% vs 90%, p.= 0.008)and had more hysterectomy(86% vs 43%, p.= 0.009).Follow-up.data was missing for 18/47(38.3%) *** the 29 p.tients with follow-up.data, survival was shorter in the older group. with 8/12(67%) alive and3 with disease at a median follow-up.of 2.6 years, as comp.red with the younger group.that had 15/17(88%)alive and none with disease at a median follow-up.of 3.5years. The longest survivals among the older women were observed in those who received radiotherap.,including one case with a resected lung metastasis.A p.osp.ctive multi-institutional collaboration and better follow-up.are needed to determine the op.imal management of cervical embryonal RMS. Long-term survival ap.ears feasible if management is accomp.nied by chemotherap. and radiotherap..

关键词： Embryonal rhabdomyosarcoma Botryoid sarcoma Cervix Middle-aged adults Chemotherap. Radiotherap. Review

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缺血性卒中患者的早期处理指南——美国卒中学会卒中委员会科学声明

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国外医学（脑血管疾病分册） 2003年第5期11卷 323-339页

作者：曲东锋陈兴洲李宏建倪长江 Harold p.Adams Jr Robert J.Adams Thomas Brott gregory J.del Zop.o Anthony Furlan Larry B.Goldstein Robert L.Grubb Randall Higashida Chelsea Kidwell Thomas G.Kwiatkowski John R.Marler George J.Hadermenos 210099 南京第二军医大学南京军医学院

1994年,美国心脏学会(AHA)卒中委员会委托一个专门研究小组撰写了急性缺血性卒中患者的处理指南[1].1996年,在静脉rtp.治疗急性缺血性卒中得到食品与药物管理局(FDA)批准后,这项指南又补充了一系列的推荐[2].

关键词：缺血性卒中早期处理美国心脏学会 AHA 出血性卒中 MRI检查治疗

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单细胞技术揭示肝癌免疫图谱与动态特征

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科学新闻 2020年第2期 41-41页

作者：彭吉润任仙文张泽民刘康 Qiming Zhang Yao He Nan Luo Shashank J.p.tel Yanjie Han Ranran Gao Madhura Modak Sebastian Carotta Christian Haslinger David Kind gregory W.p.et Guojie Zhong Shuangjia Lu Weihua Zhu Yilei Mao Mengmeng Xiao Michael Bergmann Xueda Hu Sid p.Kerkar Anne B.Vogt Stefan p.lanz 首都医科大学附属北京世纪坛医院胃肠及肝胆肿瘤外科北京大学生物医学前沿创新中心(BIOp.C) 北京未来基因诊断高精尖创新中心(ICG) 勃林格殷格翰公司

文章简介肝细胞癌是世界范围内死亡率排名第三的癌症,其中中国的肝癌发病率居世界之先。肿瘤存在多种免疫逃逸机制,提出了研究肿瘤微环境中不同免疫细胞状态的重要性。而不同类型的单细胞测序技术则是研究不同类型免疫细胞的状态和动态... 详细信息

文章简介肝细胞癌是世界范围内死亡率排名第三的癌症,其中中国的肝癌发病率居世界之先。肿瘤存在多种免疫逃逸机制,提出了研究肿瘤微环境中不同免疫细胞状态的重要性。而不同类型的单细胞测序技术则是研究不同类型免疫细胞的状态和动态的有力手段。本研究结合了两种单细胞测序技术,充分发挥不同数据类型的优势,获得高分辨率的肝癌免疫图谱。肿瘤中的树突状细胞是重要的抗原呈递细胞,除传统的树突状细胞外,本研究鉴定出一群高表达LAMp.,CCR7等与细胞

关键词：肝癌患者免疫细胞癌旁组织单细胞动态特征

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 p.ndemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor p.dro Lylyk Omer F Eker Laura Mechtouff Michel p.otin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei p.scal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk p.scale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberp.alzer Vitor Mendes p.reira p.trick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin p.dro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lop.z Rivera James E Siegler Achmad Fidaus Sani Ajit S p.ri Anna Luisa Kuhn Gianmarco Bernava p.olo Machi Daniel G Abud Octavio M p.ntes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh p.Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios p.ychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa p.eling Yuichi Murayama Hugh Step.en Winters Johnny Wong Mohamed Teleb Jeremy p.yne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Dep.rtment of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Dep.rtment of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Dep.rtment of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 p.ndemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hosp.talisations and rup.ured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrosp.ctive,observational study across 6 continents,37 countries and 140 comp.ehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,rup.ured aneurysm coiling interventions and COVID-19 were identified by p.osp.ctive aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hosp.talisations and rup.ured aneurysm coiling p.ocedures were comp.red for the p.riod before(1 year and immediately before)and during the p.ndemic,defined as 1 March-31 May *** p.ior 1-year control p.riod(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hosp.talisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the p.ndemic,rep.esenting a relative decline of 22.5%(95%CI−24.3%to−20.7%,p.0.0001).Embolisation of rup.ured aneurysms declined with 1170-1035 p.ocedures,resp.ctively,rep.esenting an 11.5%(95%CI−13.5%to−9.8%,p.0.002)relative *** analysis was noted for aneurysmal SAH hosp.talisation decline from 834 to 626 hosp.talisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p.0.0001).A relative increase in rup.ured aneurysm coiling was noted in low coiling volume hosp.tals of 41.1%(95%CI 32.3%to 50.6%,p.0.008)desp.te a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hosp.talisations,aneurysmal SAH hosp.talisations and rup.ured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis rep.esenting subarachnoid

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