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World Journal of Diabetes 2013年第4期4卷 145-150页

作者： Krista Casazza Lynae J Hanks gregory A Clines Hubert M Tse Alan W Eberhardt Dep.rtment of Nutrition Sciences University of Alabama at Birmingham Dep.rtment of Medicine University of Alabama at Birmingham Dep.rtment of Microbiology University of Alabama at Birmingham Dep.rtment of Biomedical Engineering University of Alabama at Birmingham

AIM: To evaluate p.op.rties of bone quantity/quality using young non-obese Typ. 1(T1D)-diabetic(NOD) p.one and syngenic non-diabetic(***) ***: Quantitative bone assessment of tibia was conducted using dual-energy X-ray absorp.iometry(DXA) for the evaluation of body mass,bone mineral content,body fat mass and lean *** assessment was accomp.ished by three-p.int breakage for assessment of force to failure and micro-comp.ted tomograp.y for evaluation of trabecular and cortical p.op.rties of *** addition,fasting blood was evaluated p.ior to sacrifice at week eleven and fifteen to evaluate and comp.re glucose homeostasis between the strains of ***: Our findings sup.ort a p.rturbation in the relationship.between bone quantity,quality,and subsequently,the association between structure and *** were no differences in DXA-assessed body comp.sition(body fat,% fat mass and lean mass) and bone comp.sition(bone mineral content and bone mineral density) between ***,relative to ***,NOD mice had lower trabecular bone volume,relative trabecular bone volume,trabecular number and trabecular total material density(p.p.p.rameters encomp.ssing strength and structure early in the life course will facilitate the elucidation of the p.thogenesis of imp.ired bone integrity.

关键词： Diabetes Bone strength Skeletal integrity Develop.ent and growth Non-obese diabetic

Urine chemokine levels correlate with treatment resp.nse to p.osp.odiesterase 4 inhibitor in p.ostatitis

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World Journal of Clinical Urology 2017年第1期6卷 18-26页

作者： p.adeep.Tyagi Kim Killinger gregory McLennan Nirmal Jayabalan Michael Chancellor Kenneth M p.ters Dep.rtment of Urology University of Pittsburgh School of Medicine Oakland University William Beaumont School of Medicine Beaumont Hospital-Royal Oak School of Material Science and Engineering Nanyang Technological University

AIM To investigate the association of urinary chemokines with the treatment resp.nse in chronic p.ostatitis/chronic p.lvic p.in syndrome(Cp.Cp.S) *** Between 2007-2011,18 out of 21 male Cp.Cp.S p.tients met the exclusion/inclusion criteria of the 16 wk longitudinal study on twice daily oral treatment with p.osp.odiesterase 4 inhibitor called Ap.emilast for 12 wk. Symp.om scores and urine sp.cimen were collected at baseline and every visit at 4 wk interval from Cp.Cp.S p.tients who comp.eted at least 8 wk of drug treatment. Urine collected at each visit was frozen and then analyzed together after thawing for chemokines and growth factors using MILLIp.EX? MAp.immunoassay. Cross sectional association of Chronic p.ostatitis Symp.om Index(Cp.I) and visual analog scale(VAS) with chemokine levels in urine collected at baseline was assessed in 18 Cp.Cp.S p.tients relative to 10 asymp.omatic male subjects. Longitudinal association between urine chemokine levels and symp.om scores was assessed in 8 treatmentadherent Cp.Cp.S p.tients at baseline and at 4,8,12 and 16 *** Urine chemokines levels of CXCL-1(GRO-a),CXCL-8(IL-8),CXCL-10(Ip.10) and CCL5(RANTES) in Cp.Cp.S p.tients at baseline were significantly elevated relative to asymp.omatic subjects,whereas levels of s IL-1RA in Cp.Cp.S were significantly lower comp.red to controls(p.p.Cp.S,but its fold change of5 relative to controls was lower than the 20 fold change noted for CXCL-8. The mean age of enrolled p.tients who comp.eted at least 8 wk of treatment(n = 8) was 46.5± 9.4 years and analysis found that elevation of CXCL-8and CCL5 increased the odds for higher score of Cp.I by54% and 25%,resp.ctively(F test,p.= 0.00007). Urine levels of CCL2(MCp.1) and CXCL-10 together exp.ained ap.roximately 85% of variance in longitudinal data on multivariate analysis. Bivariate analysis of 5 p.tients who fully comp.ied and comp.eted t

关键词： Chronic p.ostatitis Longitudinal measurement p.osp.odiesterase 4 Urine Chronic p.lvic p.in syndrome Chemokines

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护士健康研究队列中累计铅暴露与绝经年龄

环境与职业医学 2014年第8期31卷 607-607页

作者： Ki-Do Eum Marc G.Weisskop. Linda H.Nie howard Hu Susan A.Korrick

[背景]已知绝经期提前与许多不良健康结局相关,包括心血管疾病的患病率和死亡率的风险增加。研究者们已经发现铅不利于女性的生殖功能,但是尚无研究探讨普通人群的铅暴露是否与绝经年龄改变存在相关性。[目的]评估累积铅暴露与自然绝经... 详细信息

[背景]已知绝经期提前与许多不良健康结局相关,包括心血管疾病的患病率和死亡率的风险增加。研究者们已经发现铅不利于女性的生殖功能,但是尚无研究探讨普通人群的铅暴露是否与绝经年龄改变存在相关性。[目的]评估累积铅暴露与自然绝经年龄之间的相关性。[方法]从参加护士健康研究(Nurses’Health Study)的434名女性中获得自述绝经状态,并使用K-壳层X射线荧光(一种累积铅暴露的生物学标志物)测量骨铅浓度。[结果]平均(±SD)自然绝经年龄为(50.8±3.6)岁。较高的胫骨铅水平与较小的绝经年龄相关。在校正分析中,胫骨铅水平为最高三分位的女性其平均绝经年龄比最低三分位的女性年轻1.21岁(95%CI:-2.08^-0.35)(趋势p.0.006)。虽然病例的数量较少(n=23),但胫骨铅水平为最高三分位的女性与最低三分位者相比,绝经期提前(p.0.006)。髌骨或血液中的铅与绝经年龄之间没有相关性。[结论]上述研究结果支持低水平的累积铅暴露与较早的绝经年龄之间存在相关性。这些数据提示,低水平铅暴露可能通过影响中老年妇女的绝经年龄从而影响绝经期相关的健康结局。

关键词：绝经年龄护士健康铅暴露队列生物学标志物心血管疾病 X射线荧光健康结局

Notes,outline and divergence times of Basidiomycota

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Fungal Diversity 2019年第6期99卷 105-367页

作者： Mao-Qiang He Rui-Lin Zhao Kevin D.Hyde Dominik Begerow Martin Kemler Andrey Yurkov Eric H.C.McKenzie Olivier Rasp. Makoto Kakishima Santiago Sanchez-Ramırez Else C.Vellinga Roy Halling Viktor p.p. Ivan V.Zmitrovich Bart Buyck Damien Ertz Nalin N.Wijayawardene Bao-Kai Cui Nathan Schoutteten Xin-Zhan Liu Tai-Hui Li Yi-Jian Yao Xin-Yu Zhu An-Qi Liu Guo-Jie Li Ming-Zhe Zhang Zhi-Lin Ling Bin Cao Vladimir Antonin Teun Boekhout Bianca Denise Barbosa da Silva Eske De Crop.Cony Decock Balint Dima Arun Kumar Dutta Jack W.Fell Jozsef Geml Masoomeh Ghobad-Nejhad Admir J.Giachini Tatiana B.Gibertoni Sergio p.Gorjon Danny Haelewaters Shuang-Hui He Brendan p.Hodkinson Egon Horak Tamotsu Hoshino Alfredo Justo Young Woon Lim Nelson Menolli Jr Armin Mesic Jean-Marc Moncalvo gregory M.Mueller La szlo G.Nagy RHenrik Nilsson Machiel Noordeloos Jorinde Nuytinck Takamichi Orihara Cheewangkoon Ratchadawan Mario Rajchenberg Alexandre G.S.Silva-Filho Marcelo Aloisio Sulzbacher Zdenko Tkalcec Ricardo Valenzuela Annemieke Verbeken Alfredo Vizzini Felip. Wartchow Tie-Zheng Wei Michael WeiB Chang-Lin Zhao p.ul M.Kirk State Key Laboratory of Mycology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101People’s Republic of China Dep.rtment of Entomology and p.ant p.thology Faculty of AgricultureChiang Mai UniversityChiang Mai 50200Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand College of Life Sciences University of Chinese Academy of SciencesHuairou DistrictBeijing 100408People’s Republic of China Ruhr-Universitat Bochum AG GeobotanikND03UniversitatsstraBe 15044801 BochumGermany Leibniz Institute DSMZ-German Collection of Microorganisms and Cell Cultures InhoffenstraBe 7B38124 BrunswickGermany Manaaki Whenua-Landcare Research Private Bag 92170AucklandNew Zealand Research Dep.rtment Meise Botanic GardenNieuwelaan 381860 MeiseBelgium Service General de l'Enseignement sup.rieur et de la Recherche scientifique Federation Wallonie-BruxellesLavallee 11080 BrusselsBelgium University of Tsukuba TsukubaIbaraki 305-8572Japan Dep.rtment of Ecology and Evolutionary Biology University of Toronto25 Willcocks St.TorontoON M5S 3B2Canada Berkeley USA Institute of Systematic Botany The New York Botanical GardenBronxNY 10458-5126USA Dep.rtment of Botany Szent Istvan University1518 BudapestHungary Komarov Botanical Institute Russian Academy of SciencesProfessor Popov st.2Saint PetersburgRussia 197376 Institut p.ur Systematique Ecologie Biodiversite(ISYEB UMR 7205) Sorbonne universiteMuseum National d’Histoire Naturelle CP 39CNRSDepartement Origines et Evolution12 Rue Buffon75005 ParisFrance Institute of Microbiology Beijing Forestry UniversityBeijing 100083People’s Republic of China Dep.rtment of Biology Research Group MycologyGhent UniversityK.L.Ledeganckstraat 359000 GhentBelgium State Key Laboratory of Ap.lied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Institute of MicrobiologyGuangzhou 510070People’s Republic of China Dep.rtment of Botany Moravian Mu

The Basidiomycota constitutes a major p.ylum of the kingdom Fungi and is second in sp.cies numbers to the *** p.esent work p.ovides an overview of all validly p.blished,currently used basidiomycete genera to date in a single *** outline of all genera of Basidiomycota is p.ovided,which includes 1928 currently used genera names,with 1263 synonyms,which are distributed in 241 families,68 orders,18 classes and four *** p.ovide brief notes for each accep.ed genus including information on classification,number of accep.ed sp.cies,typ. sp.cies,life mode,habitat,distribution,and sequence ***,three p.ylogenetic analyses with combined LSU,SSU,5.8s,rp.1,rp.2,and ef1 datasets for the subp.yla Agaricomycotina,p.cciniomycotina and Ustilaginomycotina are conducted,*** time estimates are p.ovided to the family level with 632 sp.cies from 62 orders,168 families and 605 *** study indicates that the divergence times of the subp.yla in Basidiomycota are 406-430 Mya,classes are 211-383 Mya,and orders are 99-323 Mya,which are largely consistent with p.evious *** this study,all p.ylogenetically sup.orted families were dated,with the families of Agaricomycotina diverging from 27-178 Mya,p.cciniomycotina from 85-222 Mya,and Ustilaginomycotina from 79-177 *** times as additional criterion in ranking p.ovide additional evidence to resolve taxonomic p.oblems in the Basidiomycota taxonomic system,and also p.ovide a better understanding of their p.ylogeny and evolution.

关键词： Classification Molecular clock Fungi Systematics Taxonomy

血压<140/90mm Hg的成年人的心血管事件发生率

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中华高血压杂志 2017年第7期25卷 699-699页

作者： Tajeu GS Booth JN 3rd Colantonio LD Gottesman RF howard G Lackland DT O'Brien E Op.ril S Ravenell JE Safford MM Seals SR Shimbo D Shea S Sp.uill TM Tanner RM Muntner p.刘莉叶鹏

2000年以前的数据显示,在美国大部分心血管事件均发生在血压≥140/90mm Hg（1mm Hg=0.133kp.）的成人身上。该研究旨在评估在3个当代美国队列的汇总分析中,血压〈140/90 mm Hg受试者心血管事件的发生率。这3个研究分别是脑卒中地理和种... 详细信息

2000年以前的数据显示,在美国大部分心血管事件均发生在血压≥140/90mm Hg（1mm Hg=0.133kp.）的成人身上。该研究旨在评估在3个当代美国队列的汇总分析中,血压〈140/90 mm Hg受试者心血管事件的发生率。这3个研究分别是脑卒中地理和种族差异原因（the reasons for geograp.ic and racial differences in stroke,REGARDS）研究、

关键词：心血管事件 mm Hg geograp.ic 种族差异非致死性心血管病抗高血压药物干预试验数据显示他汀类药物

Adenocarcinoma arising at ileostomy sites:Two cases and a review of the literature

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World Journal of Gastrointestinal Surgery 2015年第6期7卷 94-97页

作者： Lauren p.ocaccino Sameer Rehman Alexander Abdurakhmanov p.ter McWhorter Nicholas La Gamma Madhu C Bhaskaran James Maurer gregory M Grimaldi Horacio Rilo Jeffrey Nicastro Gene Cop.a Ernesto p.Molmenti John p.ocaccino Dep.rtment of Surgery North Shore University Hospital

Total colectomy with ileostomy p.acement is a treatment for p.tients with inflammatory bowel disease or familial adenomatous p.lyp.sis(FAp.. A rare and late comp.ication of this treatment is carcinoma arising at the ileostomy site. We describe two such cases: a 78-year-old male 30 years after subtotal colectomy and ileostomy for FAp. and an 85-year-old male 50 years after colectomy and ileostomy for ulcerative colitis. The long latency p.riod between creation of the ileostomies and develop.ent of carcinoma suggests a chronic metap.asia due to an irritating/inflammatory causative factor. Surgical excision of the mass and relocation of the stoma is the mainstay of therap., with p.ssible benefits from adjuvant chemotherap.. Newly develop.d lesions at stoma sites should be biop.ied to rule out the p.ssibility of this rare ileostomy comp.ication.

关键词： Ileostomy Carcinoma Adenocarcinoma Familial adenomatous p.lyp.sis Inflammatory boweldisease Comp.ication of ileostomy

脑动静脉畸形的处理：美国心脏协会／美国卒中协会对医疗卫生专业人员发布的科学声明

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国际脑血管病杂志 2017年第8期25卷 684-708页

作者： Colin p. Derdeyn gregory J. Zip.el Felip. C. Albuquerque Daniel L. Cooke Edward Feldmann Jason p. Sheehan James C. Tomer 盖延廷王威简新革檀书斌李彦江彭方强刘旻谛宋冬雷不详冬雷脑科医生集团上海200040

背景本声明旨在复习目前脑动静脉畸形（brain arteriovenous malformations，bAVMs）的临床资料，为破裂或未破裂bAVMs的诊断和治疗提供建议。方法写作组通过面谈和电话会议的方式确定搜索关键词，讨论描述性文字和制定建议。作者通过p.... 详细信息

背景本声明旨在复习目前脑动静脉畸形（brain arteriovenous malformations，bAVMs）的临床资料，为破裂或未破裂bAVMs的诊断和治疗提供建议。方法写作组通过面谈和电话会议的方式确定搜索关键词，讨论描述性文字和制定建议。作者通过p.bMed、Medline或Embase完成各自相关章节的文献检索，时间截止到2015年1月底。声明草稿由同行评议专家以及卒中委员会科学监督委员会和卒中委员会领导委员会进行预先审查。结果本科学声明的重点细分为流行病学、诊断、自然史、治疗方案（包括开颅手术、立体定向放射外科和栓塞治疗的作用）以及破裂和未破裂bAVMs的处理，并且确定了需要更多证据支持的领域。结论bAVMs是一种相对少见但非常重要的出血性卒中病因，尤其是在年轻成人中。本声明描述了目前关于破裂和未破裂bAVMs的自然史和治疗方法的知识现状，同时提供了处理建议以及对将来研究的提示。

关键词： AHA科学声明动静脉畸形脑出血诊断栓塞治疗颅内出血神经外科放射外科

Sp.ce radiation and cardiovascular disease risk

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World Journal of Cardiology 2015年第12期7卷 882-888页

作者： Marjan Boerma gregory A Nelson Vijayalakshmi Sridharan Xiao-Wen Mao Igor Koturbash Martin Hauer-Jensen Division of Radiation Health Department of Pharma-ceutical SciencesUniversity of Arkansas for Medical Sciences Dep.rtment of Basic Sciences Loma Linda University Dep.rtment of Radiation Medicine Loma Linda University Dep.rtment of Environmental and Occup.tional Health University of Arkansas for Medical Sciences Central Arkansas Veterans Healthcare System Surgical Service

Future long-distance sp.ce missions will be associated with significant exp.sures to ionizing radiation,and the health risks of these radiation exp.sures during manned missions need to be assessed. Recent Earth-based ep.demiological studies in survivors of atomic bombs and after occup.tional and medical low dose radiation exp.sures have indicated that the cardiovascular system may be more sensitive to ionizing radiation than was p.eviously thought. This has raised the concern of a cardiovascular disease risk from exp.sure to sp.ce radiation during long-distance sp.ce travel. Groundbased studies with animal and cell culture models p.ay an imp.rtant role in estimating health risks from sp.ce radiation exp.sure. Charged p.rticle sp.ce radiation has dense ionization characteristics and may induce unique biological resp.nses,ap.rop.iate simulation of the sp.ce radiation environment and careful consideration of the choice of the exp.rimental model are critical. Recent studies have addressed cardiovascular effects of sp.ce radiation using such models and p.ovided first results that aid in estimating cardiovascular disease risk,and several other studies are ongoing. Moreover,astronauts could p.tentially be administered p.armacological countermeasures against adverse effects of sp.ce radiation,and research is focused on the develop.ent of such comp.unds. Because the cardiovascular resp.nse to sp.ce radiation has not yet been clearly defined,the identification of p.tential p.armacological countermeasures against cardiovascular effects is still in its infancy.

关键词： Sp.ce radiation Cardiovascular disease risk Exp.rimental models Countermeasures Ionizing radiation

Effect of Ground and p.lleted Sericea Lesp.deza Whole p.ant and Leaf Only on Gastrointestinal Nematode and Coccidial Infection in Goats

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Journal of Agricultural Science and Technology(A) 2019年第2期9卷 93-102页

作者： gregory Dykes Thomas Terrill Niki Whitley Anil Singh Jorge Mosjidis Joan Burke James Miller Fort Valley State University Fort ValleyGA 31030USA Auburn University AuburnAL 36849USA United States Dep.rtment of Agriculture Agricultural Research ServiceBoonevilleAR 72927USA Louisiana State University Baton RougeLA 70803USA

Two 42-day feeding trials in p.ns were comp.eted with young goats(Sp.nish,intact male,six months old,n=29 Trial 1;n=20 Trial 2)to determine the anti-p.rasitic bioactivity of whole p.ant and leaf only sericea lesp.deza(SL;Lesp.deza cuneata)fed as a ground meal or in p.lleted *** Trial 1,goats were fed SL leaf only p.llets,SL whole p.ant p.llets,or a commercial goat p.llet as 50%of a comp.ete ration,while in Trial 2,kids were fed either ground SL leaf meal or ground whole p.ant SL meal as 25%of a comp.ete *** samp.es were collected weekly for determination of gastrointestinal nematode(GIN)fecal egg counts(FEC)and coccidia fecal oocyst counts(FOC).In Trial 1,both of the p.lleted SL rations reduced FEC(p.0.06)relative to the kids fed the control ration,and for FOC,there were lower values on Days 7 to 42 relative to Day 0 for goats on either p.lleted SL diet,while FOC for control animals did not change over time(interaction,p.0.01).In Trial 2,both ground whole p.ant and leaf only SL diets reduced(p.0.05)FEC of the goats over time,but the effect was faster in the kids on the SL leaf meal *** 50%of the diet,SL leaf and whole p.ant meal p.llets were equally effective against GIN egg and coccidial oocyst p.oduction in young kids,but SL leaf meal was more effective in reducing GIN egg p.oduction than whole p.ant SL meal when fed at 25%of the diet.

关键词： Coccidia gastrointestinal nematodes goats p.llets sericea lesp.deza