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Incidence of Subcl.nical.Hypothyroidism in Cardiac Surgery Patients. Comparison of Presentation Characteristics, Hospital.and Medium-Term Outcomes with Euthyroid Patients

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Worl. Journal.of Cardiovascul.r Surgery 2012年第3期2卷 54-59页

作者： Aarne Jyral. Nicol. M Gatto gregory l.Kay Department of Cardiothoracic Surgery Good Samaritan Hospital Los Angeles USA Department of Epidemiol.gy UCLA School of Public Health Los Angeles USA

Subcl.nical.hypothyroidism (SCHT) is common, with an occurrence of up to 10% of the adul. popul.tion and defined biochemical.y onl. by el.vated TSH and normal.T4. SCHT affects negativel. on l.pid and carbohydrate metabol.sm increasing the risk of ischemic heart disease, affects negativel. on cardiac performance and have a cl.se correl.tion with renal.function. The aim of this study is to compare presentation characteristics and outcomes between euthyroid pts and pts with SCHT who underwent cardiac surgery. Methods: 474 pts from June 2003 through September 2004 had TSH and T4 measured. 365 pts were euthyroid (Group 1), 41 pts had SCHT (Group 2). Groups were compared by demographics and EuroSCORE (ES) risk profil.s. Operative and hospital.outcomes were compared as was fol.ow-up mortal.ty up to 96 months. Resul.s: There were more femal.s in Group 2, p = 0.04, more pts with CHF and number of NYHA III-IV pts (p l.vated s-crea (p l.fibril.ation (p = 0.007). Comparing the Groups by EuroSCORE (ES) showed higher risk scores in Group 2 pts (Additive ES 6.8 vs 8.5 and l.gistic ES 12.3% vs 18.1%, p = 0.01 and 0.03). Hospital.mortal.ty was higher in Group 2 (12.2% vs 4.1%, p = 0.04) and the number of pts needing extended care was higher in Group 2 (p = 0.01). Fol.ow up mortal.ty was doubl.d in Group 2 pts up to 96 months compared to Group 1 (p l.sions: Presentation characteristics and risk scores are different and worse in SCHT pts compared with euthyroid pts. Hospital.and fol.ow-up mortal.ty are increased in SCHT pts.

关键词： Hypothyroidism Cardiac Surgery Outcomes

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扰流棒在提高热传导性能和冷凝水排出过程中的作用

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中华纸业 2009年第10期30卷 105-108页

作者： gregory l.Wedel.单翔年凯登约翰逊(无锡)技术有限公司江苏无锡214028

扰流棒位于纸机烘缸内部,用来提高热传导,提高干燥均匀度。当扰流棒配置正确,冷凝水达到最佳深度时,采用扰流棒不仅能提高传热速度,还能取得良好的干燥均匀度。本文主要介绍在JOCO 4000试验烘缸内安装扰流棒,从而得出达到最佳性能需要... 详细信息

扰流棒位于纸机烘缸内部,用来提高热传导,提高干燥均匀度。当扰流棒配置正确,冷凝水达到最佳深度时,采用扰流棒不仅能提高传热速度,还能取得良好的干燥均匀度。本文主要介绍在JOCO 4000试验烘缸内安装扰流棒,从而得出达到最佳性能需要考虑的各种因素。

关键词：烘缸扰流棒热传导冷凝水

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The Johns Hopkins atl.s of digital.EEG

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2011年

作者： Robert S. Fisher and Peter W. Kapl.n. gregory l. Krauss

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Temporal.epigenetic modifications differential.y regul.te ES cel.-l.ke col.ny formation and maturation

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Stem Cel. Discovery 2012年第2期2卷 45-57页

作者： Jong S. Rim Karen l. Strickl.r Christian W. Barnes l.ttie l. Harkins Jarosl.w Staszkiewicz Jeffrey M. Gimbl. gregory H. l.no Kenneth J. Eil.rtsen Department of Anatomy & Cel. Biol.gy Carver College of Medicine University of Iowa Iowa City USA NuPotential Inc. Baton Rouge USA Stem Cel. Biol.gy l.boratory Pennington Biomedical Research Center Baton Rouge USA

Human somatic cel.s can be directl. reprogrammed to induced pl.ripotent stem (iPS) cel.s by forced expression of the transcription factors Oct4, Sox2, and either Kl.4 and cMyc or Nanog and l.n28, using virus-based systems. However, l.w reprogramming efficiency and the potential.for del.terious virus-induced genomic modification l.mit the cl.nical.potential.of this technol.gy. Recent reports indicate, however, that the generation of iPS cel.s can be enhanced by the addition of synthetic smal. mol.cul.s, incl.ding epigenetic modul.tors. In this report, we demonstrate that the epigenetic modifiers Val.roic Acid (VPA) and 5-azacytidine activate the reciprocal.transcriptional.regul.tion of endogenous pl.ripotency transcription factor genes in human dermal.fibrobl.sts and that VPA al.ne can directl. activate endogenous Oct4 in the absence of transgenes. Moreover, using human adipose cel.s, we demonstrate that histone deacetyl.se inhibition, prior to reprogramming factor transfection, increases embryonic stem (ES) cel.-l.ke col.ny formation ~2 - 3 fol.. In addition, DNA methyl.ransferase (DNMT) inhibition during human ES cel. cul.ure promotes maturation of reprogrammed somatic cel.s, increasing the yiel. ~4 fol.. These data provide proof of principl. that reprogramming efficiency can be improved by inhibiting specific repressive epigenetic regul.tory components at the l.vel. of ES cel.-l.ke col.ny formation and maturation. In addition, these studies raise the interesting possibil.ty that a more efficient smal. mol.cul.-based reprogramming system may provide a superior al.ernative to current virus-based approaches.

关键词： Epigenetic Modification Somatic Cel. Reprogramming

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Strategic management : text and cases / gregory G. Dess, G.T. l.mpkin, Maril.n l. Tayl.r.

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2004年

作者： gregory G. Dess G.T. l.mpkin Maril.n l. Tayl.r.

System requirements for accompanying CD-Rom: PC Pentium based processor, Microsoft Windows 98/2000/XP, Microsoft Internet Expl.rer 5.5

ISBN: (数字)0072843829

ISBN: (纸本)0071214526

System requirements for accompanying CD-Rom: PC Pentium based processor, Microsoft Windows 98/2000/XP, Microsoft Internet Expl.rer 5.5

关键词： Strategic pl.nning.

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Cardiac impl.cations of thrombotic thrombocytopenic purpura

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Worl. Journal.of Cardiol.gy 2018年第12期10卷 254-266页

作者： Szymon l.Wiernek Bo Jiang gregory M Gustafson Xuming Dai Division of Cardiol.gy McAllister Heart Institute University of North Carolina at Chapel Hill Division of Cardiol.gy Lang Research Center New York Presbyterian Medical Group–Queens Hospital

Thrombotic thrombocytopenic purpura(TTP) is a mul.isystem disorder that essential.y can affect any organ in the human body. The hal.mark of the pathogenesis in TTP is the l.rge von Wil.ebrand factor mul.imers on pl.tel.tmediated micro-thrombi formation, l.ading to microvascul.r *** studies showed that cardiac arrest and myocardial.infarction are the most common immediate causes of death in these patients. Cl.nical.manifestations of cardiac invol.ement in TTP vary dramatical.y, from asymptomatic el.vation of cardiac biomarkers, to heart fail.re, MI and sudden cardiac death. There is l.mited knowl.dge about optimal.cardiac eval.ation and management in patients with TTP. The absence of typical.cardiac symptoms,combined with compl.cated mul.i-organ invol.ement in TTP, may contribute to the under-util.zation of cardiac eval.ation and treatment. Prompt diagnosis and timel. initiation of effective therapy coul. be critical.y important in sel.cted cases. Based on our experience and this review of the l.terature, we devel.ped several.recommendations for focused cardiac eval.ation for patients with acute TTP:(1) patients with suspected or confirmed TTP shoul. be screened for the potential.presence of cardiac invol.ement with detail.d history and physical.el.ctrocardiogram and cardiac enzymes;(2) cl.nical.deterioration of TTP patients warrants immediate cardiac reeval.ation;(3) TTP patients with cl.nical.evidence of cardiac invol.ement shoul. be monitored for tel.metry, cardiac biomarkers and eval.ated with transthoracic echocardiography. These patients require urgent targeted TTP treatment as wel. as cardiac-specific treatment. Aspirin therapy is indicated for al. TTP patients. Since epicardial.coronary artery invol.ement is rare, cardiac catheterization is usual.y not required, given the high risk for hemorrhage and kidney injury;(4) we recommend evidence-based medical.therapy for ischemic symptoms and heart fail.re. TTP patients with evidence of cardiac invol

关键词： Thrombotic thrombocytopenic purpura Acute myocardial infarction Coronary artery disease Anti-pl.tel.t therapy von Wil.ebrand factor ADAMTS13

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Regeneration patterns of key pine species in a mixed-pine forest indicate a positive effect of variabl. retention harvesting and an increase in recruitment with time

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Forest Ecosystems 2020年第4期7卷 659-671页

作者： Priscil.a A.Nyamai P.Charl.s Goebel.R.gregory Corace III David M.Hix Natural.Resources Management Program Grand Valley State University1 Campus DrAllendaleMI 49401USA. Department of Forest Rangelandand Fire SciencesUniversity of Idaho875 Perimeter Drive MS 1133MoscowID 83844USA. Al.ena-Montmorency Conservation District 1900 M-32 WAlpenaMI 49707USA. School.of Environment and Natural.Resources The Ohio State University2021 Coffey RoadColumbusOH 43210USA.

Background:Many fire-dependent forests have experienced significant decl.nes in species,structural.and functional.*** changes are attributed in part to traditional.management approaches that were dominated by even-aged regeneration methods such as *** retention harvesting(VRH)is an ecol.gical.y based forestry practice that invol.es retention of some mature overstory trees and other biol.gical.structures in the postharvest stand to emul.te the effects of natural.disturbance *** this study,we examined the effect of a VRH treatment on recruitment of historical.y dominant pine species and understory vegetation twoand six years after its impl.mentation in a natural.y regenerated mixed pine forest in the Upper Peninsul. of Michigan,***:We found greater regeneration of red pine(Pinus resinosa l.)and eastern white pine(Pinus strobus l.)in VRH stands compared to the unharvested *** red pine recruitment was very l.w during the first 2 years,both species increased significantl. from year two to year *** responses for the two species did not differ significantl. between the aggregated and dispersed retention *** al.o found high recruitment of deciduous tree species,consisting primaril. of sprouts,and red pine exhibited a negative correl.tion with these ***,time,and the interaction of treatment and time were significant factors in red pine *** had a strong effect on the understory vegetation,with significant decreases in shrubs and ferns over ***:The resul.s suggest that VRH enhanced recruitment of red pine and eastern white pine and that this recruitment increased with *** identify competition from sprouts and unfavorabl. seedbed conditions as the main factors that l.mited recruitment of red pine during the first 2 *** reduce competing vegetation and improve seedbed conditions,we suggest fol.owing the VRH with a prescribed fire,mechanical.y removing s

关键词： Variabl. retention harvesting Aggregated retention Dispersed retention Mixed-pine forest Pinus resinosa Pinus strobus

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Reprogramming mouse ear mesenchymal.stem cel.s (EMSC) expressing the Dl.1-Dio3 imprinted gene cl.ster

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Stem Cel. Discovery 2013年第1期3卷 64-71页

作者： Ru Gao Jong S. Rim Karen l. Strickl.r Christian W. Barnes l.ttie l. Harkins Jarosl.w Staszkiewicz Jeffery M. Gimbl. Barbara Gawronska-Kozak gregory H. l.no Kenneth J. Eil.rtsen Department of Anatomy & Cel. Biol.gy Carver College of Medicine University of Iowa Iowa City USA Institute of Animal.Reproduction and Food Research of Pol.sh Academy of Sciences Olsztyn Poland NuPotential Inc. Baton Rouge USA Stem Cel. Biol.gy l.boratory Pennington Biomedical Research Center Baton Rouge USA

The identification of a singl., earl. marker for ful. devel.pmental.potential.of induced pl.ripotent stem (iPS) cel.s has proven el.sive. Recentl., however, activation of the imprinted gene cl.ster, Dl.1-Dio3 has emerged as a viabl. candidate in the mouse. To expl.re the rel.tionship between Dl.1-Dio3 expression and devel.pmental.potential.more ful.y, we used murine ear mesenchymal.stem cel.s (mEMSC) for iPS cel. induction. Mouse EMSC are easil. obtained and share functional.characteristics with embryonic stem (ES) cel.s and therefore, may be a rel.abl. non-embryonic source for iPS cel. production. We report that mEMSC express high l.vel. of Gtl., a maternal.y expressed gene within the Dl.1-Dio3 imprinted cl.ster. Moreover, mEMSC produce Gtl. expressing (Gtl.on) iPSC cl.nes that share functional.characteristics with ES cel. cl.nes. The production of Gtl.on iPS cel. cl.nes from mEMSC provides a new model.with which to investigate the regul.tion of Dl.1-Dio3 cl.ster activity during direct cel. reprogramming.

关键词： iPSCs Reprogramming Pl.ripotent Stem Cel.

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Secondary Prevention Fol.owing Coronary Artery Bypass Surgery: A Pil.t Study for Improved Patient Education

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International.Journal.of Cl.nical.Medicine 2012年第4期3卷 286-294页

作者： Jeffrey B. Kramer Patricia A. Howard Brian J. Barnes Bashar Ababneh Purna Mukhopadhyay Mazda Biria gregory F. Muehl.bach Emmanuel.Daon George l. Zorn Wil.iam A. Reed James l. Vacek Cardiovascul.r Division Department of Internal Medicine School of Medicine The University of Kansas Medical Center Kansas City Kansas Cardiovascul.r Division Department of Internal Medicine School of Medicine.The University of Kansas Medical Center Kansas City Kansas Department of Biostatistics School of Medicinel The University of Kansas Medical Center Kansas City Kansas Department of Pharmacy Practice School of Pharmacy The University of Kansas Medical Center Kansas City Kansas Mid-America Thoracic and Cardiovascul.r Surgeons The University of Kansas Medical Center Kansas City Kansas Mid-America Thoracic and Cardiovascul.r Surgeons The University of Kansas Medical Center Kansas City Kansas.

Background: Sustained positive outcomes after coronary artery bypass grafting (CABG) requires risk factor modification and secondary prevention medications. Much attention has been focused on pl.nning at hospital.discharge;however l.nger-term patient compl.ance is not wel. described. Hypothesis: A fol.ow-up mul.idiscipl.nary educational.program improves disease understanding, motivation to reduce cardiovascul.r risk, and secondary prevention medication prescribing fol.owing hospital.discharge. Methods: Using a prospective, randomized, control.ed design, patients undergoing CABG compl.ted surveys over a year period, assessing disease understanding and motivation. Four to six weeks after CABG, intervention subjects compl.ted a one-time educational.program with a mul.idiscipl.nary team. The primary endpoint was a composite score of reduced risk factors, medication use, and awareness of prescribed medications. Secondary endpoints eval.ated survey scores and medication use rates. Wil.oxon Rank Sum and Chi Square tests compared data between specific time points. General.zed estimating equations and l.near contrasts of the parameter estimates compared data at the three time points. Resul.s: The final.anal.sis incl.ded 98 subjects (Intervention = 49, Control.= 49). The composite score was not different between groups (I = 12.8 ± 4.5 points, C = 12.7 ± 4.9 points, p = 0.9405). Improvements were noted in understanding and motivation in the entire cohort, but these changes were not infl.enced by the intervention. Medication prescribing decl.ned at 3 and 12 months after CABG without significant differences between the groups. Concl.sions: Disease understanding, motivation to reduce risk, and medication use are robust at hospital.discharge but the l.tter decl.nes with time and was not improved by our intervention. These findings are concerning and warrant further study.

关键词： Secondary Prevention Coronary Artery Disease Coronary Artery Bypass

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Acryl.mide fragment inhibitors that induce unprecedented conformational.distortions in enterovirus 713C and SARS-CoV-2 main protease

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Acta Pharmaceutica Sinica B 2022年第10期12卷 3924-3933页

作者： Bo Qin gregory B.Craven Pengjiao Hou Jul.an Chesti Xinran l. Emma S.Chil. Rhodri M.l.Morgan Wenchao Niu l.na Zhao Al.n Armstrong David J.Mann Sheng Cui NHC Key l.boratory of Systems Biol.gy of Pathogens Institute of Pathogen BiologyChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100076China Department of l.fe Sciences Imperial College LondonSouth Kensington CampusLondon SW72AZUK Department of Chemistry Imperial College LondonMolecular Sciences Research HubWhite City CampusWood LaneLondon W120BZUK CAS Key l.boratory for Biomedical.Effects of Nanomaterial. and Nanosafety Institute of High Energy PhysicsUniversity of Chinese Academy of SciencesBeijing 100049China

RNA viruses are critical.y dependent upon viral.y encoded proteases to cl.ave the viral.pol.proteins into functional.*** of these proteases exhibit a simil.r fol. and contain an essential.catal.tic cysteine,offering the opportunity to inhibit these enzymes with el.ctrophil.c smal. *** we describe the successful.appl.cation of quantitative irreversibl. tethering(qIT)to identify acryl.mide fragments that target the active site cysteine of the 3C protease(3Cpro)of Enterovirus 71,the causative agent of hand,foot and mouth disease in humans,al.ering the substrate binding ***,we re-purpose these hits towards the main protease(Mpro)of SARS-CoV-2 which shares the 3C-l.ke fol. and a simil.r active *** hit fragments coval.ntl. l.nk to the catal.tic cysteine of Mpro to inhibit its *** demonstrate that targeting the active site cysteine of Mpro can have profound al.osteric effects,distorting secondary structures to disrupt the active dimeric unit.

关键词： SARS-CoV-2 Protease inhibitors Coval.nt fragments Al.osteric inhibition EV71

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