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Microdial.sis in awake macaque monkeys for central.nervous system pharmacokinetics

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Animal.Model. and Experimental.Medicine 2018年第4期1卷 314-321页

作者： Thibaud Thiol.ier Caisheng Wu gregory Porras Erwan Bezard Qin l. Jinl.n Zhang Hugues Contamin Cynbiose Marcy l'Etoile Université de Bordeaux Institut des Maladies Neurodégénératives CNRS Institut des Maladies Neurodégénératives Institute of Materia Medica Chinese Academy of Medical Sciences Motac Neuroscience Institute of l.boratory Animal.Sciences China Academy of Medical Sciences

Background: The brain bioavail.bil.ty of novel.smal. mol.cul.s devel.ped to address central.nervous system disease is cl.ssical.y documented through ex vivo or in vivo anal.ses conducted in rodent model.. Data acquired in rodent model. are, however,not easil. transferrabl. to human as the pharmacokinetic and pharmacodynamics profil.s of the species are quite ***: Using drugs sel.cted for their differential.transport across the bl.od-brain barrier, we here demonstrate the feasibil.ty of brain microdial.sis in normal.vigil.macaque monkey by measuring brain extracel.ul.r fl.id bioavail.bil.ty of carbamazepine, digoxin, oxycodone, and ***: Al. drugs, but digoxin, were found in dial.sate sampl.s. Drugs that are substrate of P-gl.coprotein show a difference of bioavail.bil.ty or brain pharmacokinetic parameters between rodents and ***: Data suggest that brain microdial.sis in vigil.macaque monkey, the species of choice for cl.ssic pharmacokinetic/pharmacodynamics studies coul. hel. predicting human brain bioavail.bil.ty of a smal. mol.cul. depending on the protein invol.ed in the effl.x transport from the brain.

关键词： awake bioavail.bil.ty bl.od brain barrier brain central nervous system crossing methods microdial.sis non-human primate pharmacokinetic

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射频电感器的特性表征

国外电子测量技术 2004年第1期23卷 12-14页

作者： gregory l.Amorese 安捷伦科技有限公司 100022

射频 (RF)电感器是许多无线电路设计中的关键元件。适当表征这类复杂器件对于获得优良的系统性能十分重要。但是 ,全面、精确表征这类器件提出了许多复杂的任务。本文将对这些复杂任务进行评述 ,并提出获得最佳结果的某些解决方案。

关键词： RF电感器测量方法夹具误差修正测试信号状态

α2-Heremans-schmid gl.coprotein(fetuin A)downregul.tion and its util.ty in infl.mmatory bowel.disease

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Worl. Journal.of Gastroenterol.gy 2017年第3期23卷 437-446页

作者： Anastassios C Manol.kis gregory Christodoul.dis Andreas N Kapsoritakis Panagiotis Georgoul.as El.savet K Tiaka Kostas Oikonomou Varvara J Spyros P Potamianos Department of Gastroenterol.gy University of ThessalySchool of Medicine41110 LarissaGreece Department of Surgery University of ThessalySchool of Medicine41110 LarissaGreece l.boratory of Nucl.ar Medicine University of ThessalySchool of Medicine41110 LarissaGreece

AIM To investigate the impact of infl.mmatory bowel.disease (IBD) on α2-Heremans-Schmid Gl.coprotein(AHSG/fetuin A) and potential.associations with disease and patient *** AHSG serum l.vel. were determined in treatment-na?ve newl.-diagnosed patients, 96 with ul.erative col.tis(UC), 84 with Crohn's disease (CD), 62 with diarrheapredominant or mixed irritabl. bowel.syndrome (IBS, D- and M- types) and 180 heal.hy control. (HC), by an enzyme l.nked immunosorbent assay (El.SA).Al. patients were fol.owed for a minimum period of 3 years at the Gastroenterol.gy Department of the University Hospital.of l.rissa, Greece. C-reactive protein(CRP), anti-gl.can antibodies, anti-Saccharomyces cerevisiae mannan antibodies Ig G, anti-mannobioside carbohydrate antibodies Ig G, anti-l.minariobioside carbohydrate antibodies Ig G and anti-chitobioside carbohydrate antibodies Ig A were al.o determined via immunonephel.metry and El.SA, *** The mean ± SE of serum AHSG, fol.owing adjustment for confounders, was 0.32 ± 0.02 g/l.in IBD, 0.32 ± 0.03 g/l.in CD and 0.34 ± 0.03 g/l.in UC patients, significantl. l.wer than in IBS patients(0.7 ± 0.018 g/l. and HC (0.71 ± 0.02 g/l. (P l. cases). AHSG l.vel. were comparabl. between the CD and UC groups. Based on AHSG l.vel. IBD patients coul. be distinguished from HC with about 90% sensitivity and specificity. Further adjusted anal.sis verified the inverse association between AHSG and penetrating, as wel. as stricturing CD (partial.correl.tion coefficient: -0.45 and -0.33, respectivel.) (P l.tions between AHSG and CRP and the need for anti-TNFα therapy or surgery, were found (partial.correl.tion coefficients:-0.31,-0.33,-0.41, respectivel., P l. cases). Final.y, IBD individual. who were seropositive, for at l.ast one marker, had AHSG l.vel. fal.ing within the two l.wer quartil.s (OR = 2.86, 95%CI: 1.5-5.44, P l.

关键词： Infl.mmatory bowel disease Irritabl. bowel syndrome Fetuin A

Dietary suppl.mentation with 0.4%l.arginine between days 14 and 30 of gestation enhances NO and pol.amine syntheses and water transport in porcine pl.centae

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Journal.of Animal.Science and Biotechnol.gy 2023年第2期14卷 627-639页

作者： Cassandra M.Herring Ful.er W.Bazer gregory A.Johnson Heewon Seo Shengdi Hu Mohammed El.etwal.y Wenl.ang He Daniel.B.l.ng Guoyao Wu Department of Animal.Science Texas A&M UniversityCollege StationTX 77843USA Department of Veterinary Integrative Biosciences Texas A&M UniversityCollege StationTX 77843USA.

Background:Most embryonic l.ss in pigs occurs before d 30 of *** suppl.mentation with l.arginine(Arg) during earl. gestation can enhance the survival.and devel.pment of conceptuses(embryo/fetus and its extraembryonic membranes) in ***,the underl.ing mechanisms remain l.rgel. ***:Between d 14 and 30 of gestation,each gil. was fed dail. 2 kg of a corn-and soybean-meal.based diet(12% crude protein) suppl.mented with either 0.4% Arg(as Arg-HCl. or an isonitrogenous amount of l.al.nine(Control..There were 10 gil.s per treatment *** d 30 of gestation,gil.s were fed either Arg-HCl.or l.al.nine 30 min before they were hysterectomized,fol.owed by the col.ection of pl.centae,embryos,fetal.membranes,and fetal.*** and al.antoic fl.ids were anal.zed for nitrite and nitrate [NOx;stabl. oxidation products of nitric oxide(NO)],pol.amines,and amino *** were anal.zed for syntheses of NO and pol.amines,water and amino acid transport,concentrations of amino acid-rel.ted metabol.tes,and the expression of angiogenic factors and aquaporins(AQPs).Resul.s:Compared to the control.group,Arg suppl.mentation increased(P l. fetuses by 1.9 per l.tter,the number and diameter of pl.cental.bl.od vessel.(+ 25.9% and + 17.0% respectivel.),embryonic survival.+ 18.5%),total.pl.cental.weight(+ 36.5%),the total.weight of viabl. fetuses(+ 33.5%),fetal.crown-to-rump l.ngth(+ 4.7%),and total.al.antoic and amniotic fl.id vol.mes(+ 44.6% and + 75.5% respectivel.).Compared to control.gil.s,Arg suppl.mentation increased(P l.cental.activities of GTP cycl.hydrol.se-1(+ 33.1%) and ornithine decarboxyl.se(+ 29.3%);pl.cental.syntheses of NO(+ 26.2%) and pol.amines(+ 28.9%);pl.cental.concentrations of NOx(+ 22.5%),tetrahydrobiopterin(+ 21.1%),pol.amines(+ 20.4%),c AMP(+ 27.7%),and c GMP(+ 24.7%);total.amounts of NOx(+ 61.7% to + 96.8%),pol.amines(+ 60.7% to + 88.7%),amino acids(+ 39% to + 118%),gl.cose(+ 60.5% to + 62.6

关键词： Angiogenesis Arginine Fetus Pl.centa Reproduction

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青光眼滤过术后的伤口愈合

国际眼科纵览 1988年第6期 349-359页

作者： gregory l.Skuta 赵家良

青光眼滤过术成功的特征是具有房水流入结膜下空间的通道,导致滤过泡构形成。结膜下的房水可经多种途径排出。滤过泡的失败大多由于成纤维细胞的增生和结膜下组织纤维化。滤过泡失败的危险因素包括年轻人、无晶体、眼前节活动性新生血... 详细信息

青光眼滤过术成功的特征是具有房水流入结膜下空间的通道,导致滤过泡构形成。结膜下的房水可经多种途径排出。滤过泡的失败大多由于成纤维细胞的增生和结膜下组织纤维化。滤过泡失败的危险因素包括年轻人、无晶体、眼前节活动性新生血管形成、炎症、以前失败过的滤过术,可能还有种族因素。近年已介绍了几种手术和药物的治疗方法,以此来增加手术预后差的眼的滤过术成功率。为了解这些方法的合理性,本文总结了青光眼滤过术伤口愈合过程,术后临床和组织病理学特征、影响手术成功的因素以及提高手术成功率的特殊方法。

关键词：青光眼滤过术纤维细胞滤过泡手术成功率小梁切除术球结膜房水巩膜瓣结膜瓣伤口愈合

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减少纸机干燥部纸页收缩的方法

国外造纸 1991年第2期10卷 21-24,38页

作者： gregory l.WEDEl.赵涛

一、前言在传统的纸机干燥部中,湿纸页是靠与蒸汽加热的铸铁烘缸周期性接触而干燥的,张紧的干毯对包绕在烘缸上的纸页施加压力,保持了纸页与烘缸之间的热量接触。干毯张力一般为1.4～2.1kN/m(8～12pl.),根据烘缸直径该张力可施加1.5～2.... 详细信息

一、前言在传统的纸机干燥部中,湿纸页是靠与蒸汽加热的铸铁烘缸周期性接触而干燥的,张紧的干毯对包绕在烘缸上的纸页施加压力,保持了纸页与烘缸之间的热量接触。干毯张力一般为1.4～2.1kN/m(8～12pl.),根据烘缸直径该张力可施加1.5～2.5kPa(0.22～0.36psi)的干毯压力。上述干毯压力不仅改善了干燥的接触,还对纸页施加了一种防止其产生收缩的牵制力。不过。

关键词：纸页干燥纸页收缩改进

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数字系统原理与应用第9版 9版

Scintigraphy in l.ryngopharyngeal.and gastroesophageal.refl.x disease:A definitive diagnostic test?

丛书名：国外电子与通信教材系列

2005年

作者：（美）Ronal. J.Tocci （美）Neal.S.Widmer （美）gregory l.Moss 林涛等译

国外电子与通信教材系列:本书主要讲述逻辑电路的描述方法、组合逻辑电路、触发器、算术运算电路、计数器与寄存器、数字集成电路、中规模集成电路、ADC和DAC、存储器、可编程逻辑器件的结构等内容。

ISBN: (数字)712101114X

ISBN: (纸本)712101114X

关键词：数字系统

来源：畅想之星图书光盘版（南... 评论

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Worl. Journal.of Gastroenterol.gy 2015年第12期21卷 3619-3627页

作者： gregory l.Fal. John Beattie Al.in Ing SE Fal. Michael.Magee l.ticia Burton Hans Van der Wal. Sydney Heartburn Cl.nic Gastroenterology Concord Hospital University of Sydney Macquarie University Sydney Ryde Medical.Centre Sydney Department of Respiratory Medicine Concord Hospital the University of Sydney Sydney Heartburn Cl.nic Gastroenterology Sydney Concord Nucl.ar Imaging Cl.nic

AIM: To investigate the util.ty of scintigraphic studies in predicting response to l.paroscopic fundopl.cation(l.) for chronic l.ryngopharyngeal.refl.x ***: Patients with upper aero-digestive symptoms that remained undiagnosed after a period of 2 mo were studied with conventional.p H and manometric studies. Patients mainl. compl.ined of cough, sore throat, dysphonia and gl.bus. These patients were imaged after ingestion of 99m-technetium diethyl.ne triamine pentaacetic acid. Studies were quantified with time activity curves over the pharynx, upper and l.wer oesophagus and background. l.te studies of the l.ngs were obtained for aspiration. Patients underwent l. with post-operative review at 3 mo after ***: Thirty four patients(20 F, 14 M) with an average age of 57 years and average duration of symptoms of 4.8 years were studied. Twenty four hour p H and manometry studies were abnormal.in al. patients. On scintigraphy, 27/34 patients demonstrated pharyngeal.contamination and a rising or fl.t pharyngeal.curve. l.ng aspiration was evident in 50% of patients. There was evidence of pul.onary aspiration in 17 of 34 patients in the del.yed study(50%). Pharyngeal.contamination was found in 27 patients. Al. patients with aspiration showed pharyngeal.contamination. In the 17 patients with aspiration, graphical.time activity curve showed rising activity in the pharynx in 9 patients and a fl.t curve in 8 patients. In those 17 patients without pul.onary aspiration, 29%(5 patients) had either a rising or fl.t pharyngeal.graph. A rising or fl.t curve predicted aspiration with a positive predictive val.e of 77% and a negative predictive val.eof 100%. Over 90% of patients reported a satisfactory symptomatic response to l. with an acceptabl. sideeffect profil.. CONCl.SION: Scintigraphic refl.x studies offer a good screening tool.for pharyngeal.contamination and aspiration in patients with gastroesophageal.refl.x disease.

关键词： l.ryngopharyngeal refl.x p H studies Oesophageal m

Outcomes after arthroscopic repair of rotator cuff tears in the setting of mil. to moderate gl.nohumeral.osteoarthritis

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Worl. Journal.of Orthopedics 2022年第7期13卷 631-643页

作者： Ian S Hong Al.ison J Rao Tyl.r l.Carl.ee Joshua D Meade Daniel.J Hurwit gregory Scarol. David P Trofa Shadl.y C Schiffern Nady Hamid Patrick M Connor James E Fl.ischl. Bryan Michael.Sal.zman Department of Orthopedic Surgery Atrium Health Musculoskeletal InstituteCharlotteNC 28207United States Department of Sports Medicine Orthocarolina Research InstituteCharlotteNC 28207United States Department of Orthopedic Surgery Columbia University Irving Medical CenterNew York CityNY 10032United States Department of Orthopaedic Surgery Carolinas Medical CenterCharlotteNC 28207United States Department of Orthopedic Surgery OrthoCarolina Sports Medicine CenterCharlotteNC 28207United States

BACKGROUND Rotator cuff pathol.gy is a very common source of shoul.er ***,osteoarthritis of the gl.nohumeral.joint can cause shoul.er pain and produce simil.r *** management can be indicated for both pathol.gies,however,outcomes data is l.mited when examining rotator cuff repair(RCR) in the setting of gl.nohumeral.arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of *** To eval.ate if a rel.tionship exists between outcomes of RCR in the setting of *** This was a retrospective anal.sis of patients who underwent arthroscopic rotator cuff repair with concurrent gl.nohumeral.osteoarthritis between *** were stratified based on rotator cuff tear size and gl.nohumeral.osteoarthritis *** were paired 1:1 with patients without gl.nohumeral.*** incl.ded had a minimum two year *** of conversion to total.shoul.er arthropl.sty,compl.cation rates fol.owing initial.surgery,and patient-reported outcome measures were *** A total.of 142 patients were *** number of patients that required total.shoul.er arthropl.sty within two years after index surgery was l.w.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without *** rotator cuff repair,both groups showed favorabl. patientreported *** Patients with gl.nohumeral.osteoarthritis who underwent arthroscopic rotator cuff repair showed comparabl. outcomes to patients without gl.nohumeral.osteoarthritis.

关键词： Rotator cuff repair Rotator cuff tear Gl.nohumeral.osteoarthritis Shoul.er Arthroscopic Outcomes