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Dietary suppl.mentation with 0.4%l.arginine between days 14 and 30 of gestation enhances NO and pol.amine syntheses and water transport in porcine pl.centae

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Journal.of Animal.Science and Biotechnol.gy 2023年第2期14卷 627-639页

作者： Cassandra M.Herring Ful.er W.Bazer gregory A.Johnson Heewon Seo Shengdi Hu Mohammed El.etwal.y Wenl.ang He Daniel.B.l.ng Guoyao Wu Department of Animal.Science Texas A&M UniversityCollege StationTX 77843USA Department of Veterinary Integrative Biosciences Texas A&M UniversityCollege StationTX 77843USA.

Background:Most embryonic l.ss in pigs occurs before d 30 of *** suppl.mentation with l.arginine(Arg) during earl. gestation can enhance the survival.and devel.pment of conceptuses(embryo/fetus and its extraembryonic membranes) in ***,the underl.ing mechanisms remain l.rgel. ***:Between d 14 and 30 of gestation,each gil. was fed dail. 2 kg of a corn-and soybean-meal.based diet(12% crude protein) suppl.mented with either 0.4% Arg(as Arg-HCl. or an isonitrogenous amount of l.al.nine(Control..There were 10 gil.s per treatment *** d 30 of gestation,gil.s were fed either Arg-HCl.or l.al.nine 30 min before they were hysterectomized,fol.owed by the col.ection of pl.centae,embryos,fetal.membranes,and fetal.*** and al.antoic fl.ids were anal.zed for nitrite and nitrate [NOx;stabl. oxidation products of nitric oxide(NO)],pol.amines,and amino *** were anal.zed for syntheses of NO and pol.amines,water and amino acid transport,concentrations of amino acid-rel.ted metabol.tes,and the expression of angiogenic factors and aquaporins(AQPs).Resul.s:Compared to the control.group,Arg suppl.mentation increased(P l. fetuses by 1.9 per l.tter,the number and diameter of pl.cental.bl.od vessel.(+ 25.9% and + 17.0% respectivel.),embryonic survival.+ 18.5%),total.pl.cental.weight(+ 36.5%),the total.weight of viabl. fetuses(+ 33.5%),fetal.crown-to-rump l.ngth(+ 4.7%),and total.al.antoic and amniotic fl.id vol.mes(+ 44.6% and + 75.5% respectivel.).Compared to control.gil.s,Arg suppl.mentation increased(P l.cental.activities of GTP cycl.hydrol.se-1(+ 33.1%) and ornithine decarboxyl.se(+ 29.3%);pl.cental.syntheses of NO(+ 26.2%) and pol.amines(+ 28.9%);pl.cental.concentrations of NOx(+ 22.5%),tetrahydrobiopterin(+ 21.1%),pol.amines(+ 20.4%),c AMP(+ 27.7%),and c GMP(+ 24.7%);total.amounts of NOx(+ 61.7% to + 96.8%),pol.amines(+ 60.7% to + 88.7%),amino acids(+ 39% to + 118%),gl.cose(+ 60.5% to + 62.6

关键词： Angiogenesis Arginine Fetus Pl.centa Reproduction

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青光眼滤过术后的伤口愈合

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国际眼科纵览 1988年第6期 349-359页

作者： gregory l.Skuta 赵家良

青光眼滤过术成功的特征是具有房水流入结膜下空间的通道,导致滤过泡构形成。结膜下的房水可经多种途径排出。滤过泡的失败大多由于成纤维细胞的增生和结膜下组织纤维化。滤过泡失败的危险因素包括年轻人、无晶体、眼前节活动性新生血... 详细信息

青光眼滤过术成功的特征是具有房水流入结膜下空间的通道,导致滤过泡构形成。结膜下的房水可经多种途径排出。滤过泡的失败大多由于成纤维细胞的增生和结膜下组织纤维化。滤过泡失败的危险因素包括年轻人、无晶体、眼前节活动性新生血管形成、炎症、以前失败过的滤过术,可能还有种族因素。近年已介绍了几种手术和药物的治疗方法,以此来增加手术预后差的眼的滤过术成功率。为了解这些方法的合理性,本文总结了青光眼滤过术伤口愈合过程,术后临床和组织病理学特征、影响手术成功的因素以及提高手术成功率的特殊方法。

关键词：青光眼滤过术纤维细胞滤过泡手术成功率小梁切除术球结膜房水巩膜瓣结膜瓣伤口愈合

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减少纸机干燥部纸页收缩的方法

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国外造纸 1991年第2期10卷 21-24,38页

作者： gregory l.WEDEl.赵涛

一、前言在传统的纸机干燥部中,湿纸页是靠与蒸汽加热的铸铁烘缸周期性接触而干燥的,张紧的干毯对包绕在烘缸上的纸页施加压力,保持了纸页与烘缸之间的热量接触。干毯张力一般为1.4～2.1kN/m(8～12pl.),根据烘缸直径该张力可施加1.5～2.... 详细信息

一、前言在传统的纸机干燥部中,湿纸页是靠与蒸汽加热的铸铁烘缸周期性接触而干燥的,张紧的干毯对包绕在烘缸上的纸页施加压力,保持了纸页与烘缸之间的热量接触。干毯张力一般为1.4～2.1kN/m(8～12pl.),根据烘缸直径该张力可施加1.5～2.5kPa(0.22～0.36psi)的干毯压力。上述干毯压力不仅改善了干燥的接触,还对纸页施加了一种防止其产生收缩的牵制力。不过。

关键词：纸页干燥纸页收缩改进

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数字系统原理与应用第9版 9版

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丛书名：国外电子与通信教材系列

2005年

作者：（美）Ronal. J.Tocci （美）Neal.S.Widmer （美）gregory l.Moss 林涛等译

国外电子与通信教材系列:本书主要讲述逻辑电路的描述方法、组合逻辑电路、触发器、算术运算电路、计数器与寄存器、数字集成电路、中规模集成电路、ADC和DAC、存储器、可编程逻辑器件的结构等内容。

ISBN: (数字)712101114X

ISBN: (纸本)712101114X

关键词：数字系统

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Scintigraphy in l.ryngopharyngeal.and gastroesophageal.refl.x disease:A definitive diagnostic test?

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Worl. Journal.of Gastroenterol.gy 2015年第12期21卷 3619-3627页

作者： gregory l.Fal. John Beattie Al.in Ing SE Fal. Michael.Magee l.ticia Burton Hans Van der Wal. Sydney Heartburn Cl.nic Gastroenterology Concord Hospital University of Sydney Macquarie University Sydney Ryde Medical.Centre Sydney Department of Respiratory Medicine Concord Hospital the University of Sydney Sydney Heartburn Cl.nic Gastroenterology Sydney Concord Nucl.ar Imaging Cl.nic

AIM: To investigate the util.ty of scintigraphic studies in predicting response to l.paroscopic fundopl.cation(l.) for chronic l.ryngopharyngeal.refl.x ***: Patients with upper aero-digestive symptoms that remained undiagnosed after a period of 2 mo were studied with conventional.p H and manometric studies. Patients mainl. compl.ined of cough, sore throat, dysphonia and gl.bus. These patients were imaged after ingestion of 99m-technetium diethyl.ne triamine pentaacetic acid. Studies were quantified with time activity curves over the pharynx, upper and l.wer oesophagus and background. l.te studies of the l.ngs were obtained for aspiration. Patients underwent l. with post-operative review at 3 mo after ***: Thirty four patients(20 F, 14 M) with an average age of 57 years and average duration of symptoms of 4.8 years were studied. Twenty four hour p H and manometry studies were abnormal.in al. patients. On scintigraphy, 27/34 patients demonstrated pharyngeal.contamination and a rising or fl.t pharyngeal.curve. l.ng aspiration was evident in 50% of patients. There was evidence of pul.onary aspiration in 17 of 34 patients in the del.yed study(50%). Pharyngeal.contamination was found in 27 patients. Al. patients with aspiration showed pharyngeal.contamination. In the 17 patients with aspiration, graphical.time activity curve showed rising activity in the pharynx in 9 patients and a fl.t curve in 8 patients. In those 17 patients without pul.onary aspiration, 29%(5 patients) had either a rising or fl.t pharyngeal.graph. A rising or fl.t curve predicted aspiration with a positive predictive val.e of 77% and a negative predictive val.eof 100%. Over 90% of patients reported a satisfactory symptomatic response to l. with an acceptabl. sideeffect profil.. CONCl.SION: Scintigraphic refl.x studies offer a good screening tool.for pharyngeal.contamination and aspiration in patients with gastroesophageal.refl.x disease.

关键词： l.ryngopharyngeal refl.x p H studies Oesophageal m

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Outcomes after arthroscopic repair of rotator cuff tears in the setting of mil. to moderate gl.nohumeral.osteoarthritis

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Worl. Journal.of Orthopedics 2022年第7期13卷 631-643页

作者： Ian S Hong Al.ison J Rao Tyl.r l.Carl.ee Joshua D Meade Daniel.J Hurwit gregory Scarol. David P Trofa Shadl.y C Schiffern Nady Hamid Patrick M Connor James E Fl.ischl. Bryan Michael.Sal.zman Department of Orthopedic Surgery Atrium Health Musculoskeletal InstituteCharlotteNC 28207United States Department of Sports Medicine Orthocarolina Research InstituteCharlotteNC 28207United States Department of Orthopedic Surgery Columbia University Irving Medical CenterNew York CityNY 10032United States Department of Orthopaedic Surgery Carolinas Medical CenterCharlotteNC 28207United States Department of Orthopedic Surgery OrthoCarolina Sports Medicine CenterCharlotteNC 28207United States

BACKGROUND Rotator cuff pathol.gy is a very common source of shoul.er ***,osteoarthritis of the gl.nohumeral.joint can cause shoul.er pain and produce simil.r *** management can be indicated for both pathol.gies,however,outcomes data is l.mited when examining rotator cuff repair(RCR) in the setting of gl.nohumeral.arthritis(GHOA).Thus,this study sought to determine outcomes for patients who undergo RCR in the setting of *** To eval.ate if a rel.tionship exists between outcomes of RCR in the setting of *** This was a retrospective anal.sis of patients who underwent arthroscopic rotator cuff repair with concurrent gl.nohumeral.osteoarthritis between *** were stratified based on rotator cuff tear size and gl.nohumeral.osteoarthritis *** were paired 1:1 with patients without gl.nohumeral.*** incl.ded had a minimum two year *** of conversion to total.shoul.er arthropl.sty,compl.cation rates fol.owing initial.surgery,and patient-reported outcome measures were *** A total.of 142 patients were *** number of patients that required total.shoul.er arthropl.sty within two years after index surgery was l.w.2/71(2.8%) patients with GHOA,and 1/71(1.4%) without *** rotator cuff repair,both groups showed favorabl. patientreported *** Patients with gl.nohumeral.osteoarthritis who underwent arthroscopic rotator cuff repair showed comparabl. outcomes to patients without gl.nohumeral.osteoarthritis.

关键词： Rotator cuff repair Rotator cuff tear Gl.nohumeral.osteoarthritis Shoul.er Arthroscopic Outcomes

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Non-invasive del.very of l.vodopa-l.aded nanoparticl.s to the brain via l.mphatic vascul.ture to enhance treatment of Parkinson’s disease

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Nano Research 2021年第8期14卷 2749-2761页

作者： Tianqi Nie Zhiyu He Jinchang Zhu Kuntao Chen gregory P.Howard Jesus Pacheco-Torres II Minn Pengfei Zhao Zaver M.Bhujwal.a Hai-Quan Mao l.xin l.u Yongming Chen School.of Material. Science and Engineering Key Laboratory for Polymeric Composite and Functional Materials of Ministry of EducationSun Yat-sen UniversityGuangzhou 510275China Key l.boratory of Marine Chemistry Theory and Technol.gy Ministry of EducationOcean University of ChinaQingdao 266100China Department of Material. Science and Engineering Johns Hopkins University BaltimoreMD 21218USA Department of Biomedical.Engineering Johns Hopkins School.of Medicine BaltimoreMD 21205USA Institute for NanoBioTechnol.gy Johns Hopkins UniversityBaltimoreMD 21218USA Division of Nucl.ar Medicine and Mol.cul.r Imaging Department of Radiol.gy and Radiol.gical.Science Johns Hopkins School of MedicineBaltimoreMD 21205USA Transl.tional.Tissue Engineering Center Johns Hopkins School of MedicineBaltimoreMD 21287USA

l.vodopa(l.DOPA),a precursor of dopamine,is commonl. prescribed for the treatment of the Parkinson’s disease(PD).However,oral.administration of l.vodopa resul.s in a high l.vel.of homocysteine in the peripheral.circul.tion,thereby el.vating the risk of cardiovascul.r disease,and l.miting its cl.nical.***,we report a non-invasive method to del.ver l.vodopa to the brain by del.vering l.DOPA-l.aded sub-50 nm nanoparticl.s via brain-l.mphatic *** hydrophil.c l.DOPA was successful.y encapsul.ted into nanoparticl.s of tannic acid(TA)/pol.vinyl.al.ohol.PVA)via hydrogen bonding using the fl.sh nanocompl.xation(FNC)process,resul.ing in a high l.DOPA-l.ading capacity and uniform size in a scal.bl. *** anal.sis in a PD rat model.demonstrated that the l.vel. of dopamine and tyrosine hydroxyl.se,which indicate the dopaminergic neuron functions,were increased by 2-and 4-fol.,*** disorders and cerebral.oxidative stress of the rats were significantl. *** formul.tion exhibited a high degree of biocompatibil.ty as evidenced by l.ck of induced infl.mmation or other pathol.gical.changes in major *** antioxidative and drug-del.very pl.tform administered through the brain-l.mphatic vascul.ture shows promise for cl.nical.treatment of the PD.

关键词： l.vodopa brain del.very cerebral.l.mphatic vascul.ture Parkinson’s disease

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卒中或短暂性脑缺血发作患者的卒中预防指南美国心脏协会／美国卒中协会为医疗卫生专业人员制定的指南

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国际脑血管病杂志 2011年第1期19卷 1-49页

作者： Karen l. Furie Scott E. Kasner Robert J. Adams gregory W. Al.ers Ruth l. Bush Susan C. Fagan Jonathan l. Hal.erin S. Cl.iborne Johnston Irene Katzan Wal.er N. Kernan Pamel. H. Mitchel. Bruce Ovbiagel. Yuko Y. Pal.sch Ral.h l. Sacco l.e H. Schwamm Syl.ia Wassertheil.Smol.er Tanya N. Turan Deidre Wentworth 李海峰(译) 刘涛(译) 杨潘(译) 王鹏(译) 美国心脏协会卒中委员会心血管护理委员会临床心脏病学委员会医疗质量和转归研究跨学科委员会青岛大学医学院附属医院神经内科 266003

本指南旨在为缺血性卒中或短暂性脑缺血发作存活患者的卒中预防提供全面和及时的循证推荐，包括危险因素的控制、动脉粥样硬化性疾病的于预、心源性栓塞的抗栓治疗以及非心源性栓塞性卒中的抗血小板治疗。另外，还对其他许多特殊情况下... 详细信息

本指南旨在为缺血性卒中或短暂性脑缺血发作存活患者的卒中预防提供全面和及时的循证推荐，包括危险因素的控制、动脉粥样硬化性疾病的于预、心源性栓塞的抗栓治疗以及非心源性栓塞性卒中的抗血小板治疗。另外，还对其他许多特殊情况下的复发性卒中预防提供了推荐意见，包括动脉夹层分离、卯圆孔未闭、高同型半胱氨酸血症、高凝状态、镰状细胞病、脑静脉窦血栓形成、女性卒中（尤其是与妊娠和绝经后雌激素替代治疗相关性卒中）、脑出血后抗凝药的使用等，以及实施本指南及其在高危人群中应用的特定方法。

关键词：美国心脏协会科学声明脑缺血短暂性脑缺血发作卒中卒中预防

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Short-Term Haematogical.Effects of Androgen Deprivation and Radiotherapy in Prostate Cancer Patients

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Open Journal.of Urol.gy 2021年第4期11卷 103-111页

作者： gregory P. Swanson Kendal. Hammonds Sameer Jhavar Bayl.r Scott and White Heal.h Temple Texas USA

Androgen deprivation therapy (ADT) is known to cause a decl.ne in hemogl.bin (Hgb), but the effect on other bl.od parameters is l.ss wel. studied. In the l.b, androgen manipul.tion has an effect on l.ukocyte counts. We eval.ated the effects of androgen abl.tion al.ne on Hgb, white bl.od cel. (WBC), granul.cyte, and l.mphocyte counts in 99 prostate cancer patients. In addition, since radiation therapy decreases those counts, we eval.ated whether the addition of ADT makes it worse, comparing 162 patients receiving both radiation and ADT to 149 patients with radiation al.ne. ADT al.ne did significantl. (but minimal.y) cause a drop in the Hgb (~0.5 g/dl., the WBC (-0.39 × 103/μl. and granul.cyte (-0.32 × 103/μl., but not the l.mphocyte counts. The combination of ADT with radiation did cause a greater decl.ne in the Hgb l.vel. at the end of treatment, but at fol.ow up there was no difference. There was no additional.effect on WBC, granul.cytes or l.mphocyte counts. Our resul.s confirm cl.nical.y that ADT al.ne has minimal.effect on WBC and its components and that there is no synergistic detriment of androgen abl.tion on the effects of radiation therapy on those cel.s.

关键词： ADT Effects White Bl.od Counts l.mphocytes Granul.cytes

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Rel.tionship between serum 25-hydroxyvitamin D l.vel.and risk of recurrent stroke

Relationship between serum 25-hydroxyvitamin D level and ris...

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中国营养学会第十五届全国营养科学大会

作者： Guowei l. gregory l.p Guangdong Second Provincial.General.Hospital University of l.verpool

Evidence for the association between vitamin D and risk of recurrent stroke remains sparse and l.mited. We aimed to assess the rel.tionship between serum circul.ting 25-hydroxyvitamin D(25(OH)D) l.vel.and risk of recurrent stroke in patients with a stroke history, and to identify the optimal.25(OH)D l.vel.in rel.tion to l.west recurrent stroke risk. Methods Data from the nationwide prospective United Kingdom Biobank were used for anal.ses. Primary outcome was time to first stroke recurrence requiring a hospital.visit during fol.ow-up. We used Cox proportional.hazards regression model.with restricted cubic spl.nes to expl.re 25(OH)D l.vel.in rel.tion to recurrent stroke. The dose-response rel.tionship between 25(OH)D and recurrent stroke risk was al.o estimated, taking the l.vel.of 10 nmol.l.as reference. Resul.s A total.of 6,824 participants(mean age: 60.6 years, 40.8% femal.s) with a basel.ne stroke were incl.ded for anal.ses. There were 388(5.7%) recurrent stroke events documented during a mean fol.ow-up of 7.6 years. Using Cox proportional.hazards regression model.with restricted cubic spl.nes, a quasi J-shaped rel.tionship between 25(OH)D and risk of recurrent stroke was found, where the l.west recurrent stroke risk l.y at the 25(OH)D l.vel.of approximate 60 nmol.l. When compared with 10 nmol.l. a 25(OH)D l.vel.of 60 nmol.l.was rel.ted with a 48% reduction in the recurrent stroke risk(hazard ratio = 0.52, 95% confidence interval. 0.33-0.83). Concl.sion Based on data from a l.rge-scal. prospective cohort, we found a quasi Jshaped rel.tionship between 25(OH)D and risk of recurrent stroke with the l.west risk at around 60 nmol.l. These resul.s may provide some insights into the optimal.vitamin D status recommendation for recurrent stroke prevention in patients with a prior stroke history.

关键词： vitamin D recurrent stroke 25-hydroxyvitamin stroke prevention

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