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Non-Immunosuppressant Medication Use in Heart Transplant Patients: A Guide for Pharmacists

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Pharmacology & Pharmacy 2014年第10期5卷 950-958页

作者： gregory Egan Glen j. Pearson University of British Columbia Vancouver British Columbia Canada University of Alberta Division of Cardiology Edmonton Alberta Canada Mazankowski Alberta Heart Institute Edmonton Alberta Canada

For heart transplant patients, there are a number of non-immunosuppressant medications that are routinely prescribed to mitigate the side-effects of immunosuppression, treat the related complications, and improve long-term survival. This review focuses on the medications used to prevent and manage cardiac allograft vasculopathy (CAV), hypertension, dyslipidemia and osteoporosis. The rationale and evidence supporting their use are summarized and the immunosuppressant drugs are only discussed briefly, as they relate to each of these medical issues. Pharmacy practitioners are likely to encounter patients post-cardiac transplant in a variety of clinical settings;therefore, a concise appreciation of the principles for the long-term medical management of these patients is important when providing collaborative care.

关键词： Cardiac Transplant Cardiac Allograft Vasculopathy Calicneurin Inhibitors Hypertension Dyslipiemia Osteoporisis

Current advancements on charge selective contact interfacial layers and electrodes in flexible hybrid perovskite photovoltaics

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journal of Energy Chemistry 2021年第3期30卷 151-173页

作者： Gopalan Saianand Prashant Sonar gregory j.Wilson Anantha-Iyengar Gopalan Vellaisamy A.L.Roy Gautam E.Unni Khan Mamun Reza Behzad Bahrami K.Venkatramanan Qiquan Qiao Global Centre for Environmental Remediation(CCER) Faculty of ScienceThe University of NewcastleCallaghan 2308New South WalesAustralia CSIRO Energy Newcastle Energy Centre10 Murray Dwyer CctMayfield WestNSW 2304Australia School of Chemistry and Physics Queensland University of Technology(QUT)2 George StreetBrisbaneQLD 4001Australia Centre for Material Science Queensland University of Technology(QUT)BrisbaneQLD 4000Australia Daegyeong Regional Infrastructure Technology Development Center Kyungpook National UniversityDaegu 41566Republic of Korea james Watt School of Engineering University of GlasgowG128QQUnited Kingdom Facufty of Engineering and Built Environment The University of NewcastleCallaghan 2308New South WalesAustralia Department of Electrical Engineering Center for Advanced PhotovoltaicsSouth Dakota State UniversityBrookings 57007South DakotaUSA Department of Physics SCSVMV Deemed UniversityKanchipuram 631561Tamil NaduIndia

Perovskite-based photovoltaic materials have been attracting attention for their strikingly improved performance at converting sunlight into *** beneficial and unique optoelectronic characteristics of perovskite structures enable researchers to achieve an incredibly remarkable power conversion *** hybrid perovskite photovoltaics promise emerging applications in a myriad of optoelectronic and wearable/portable device applications owing to their inherent intriguing physicochemical and photophysical properties which enabled researchers to take forward advanced research in this growing *** perovskite photovoltaics have attracted significant attention owing to their fascinating material properties with combined merits of high efficiency,light-weight,flexibility,semitransparency,compatibility towards roll-to-roll printing,and large-area mass-scale *** perovskite-based solar cells comprise of 4 key components that include a flexible substrate,semi-transparent bottom contact electrode,perovskite(light absorber layer)and charge transport(electron/hole)layers and top(usually metal)*** these components,interfacial layers and contact electrodes play a pivotal role in influencing the overall photovoltaic *** this comprehensive review article,we focus on the current developments and latest progress achieved in perovskite photovoltaics concerning the charge selective transport layers/electrodes toward the fabrication of highly stable,efficient flexible *** a concluding remark,we briefly summarize the highlights of the review article and make recommendations for future outlook and investigation with perspectives on the perovskite-based optoelectronic functional devices that can be potentially utilized in smart wearable and portable devices.

关键词： Perovskite photovoltaics Charge transport layers Contact interface layer Contact electrodes Printable electronics

SYNTHESIS AND POLYMERIZATION OF OLIGO (OXYETHYLENE) MACROMONOMER

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Chinese journal of Polymer Science 1993年第3期11卷 262-266页

作者：张升水刘庆国杨蕾玲 FARRINGTON gregory C. Laboratory of Solid State Ionics University of Science and Technology Beijing Beijing 100083 Beijing Research Institute of Chemical Industry Beijing 100013 Department of Materials Science and Engineering University of Pennsylvania Philadelphia PA 19104 USA.

This paper reports the synthesis of methoxyoligo (oxyethylene) methacrylate (MEO_n , n is the repeating unit number of (CH_2CH_2O) in the macromonomer), and its polymerization in different solvents. MEO_n is prepared through such two independent reactions as (1) anionic polymerization of oxirane initiated by potassium alkoxide and (2) end-capping of methoxy oligo(oxyethylene) by methacrylic group. The n value can be conveniently controlled over the range of 5 ～ 30 by varying the molar ratio of oxirane to initiator and the molecular weight distribution of MEO_n be narrowed by increasing reaction time only in step (1). MEO_n thus obtained shows a rapid polymerization in water and benzene respectively, and both give water-soluble polymers as long as suitable conditions are used.

关键词： M acromonomer Oligo (oxyethylene) Amphiphilic monomer Free-radical Polymerization

One decade(2011–2020)of European agricultural water stress monitoring by MSG-SEVIRI:workflow implementation on the Virtual Earth Laboratory(VLab)platform

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International journal of Digital Earth 2022年第1期15卷 730-747页

作者： Bagher Bayat Carsten Montzka Alexander Graf gregory Giuliani Mattia Santoro Harry Vereecken Institute of Bio-and Geosciences:Agrosphere (IBG-3) Forschungszentrum Jülich GmbHJülichGermany Institute for Environmental Sciences EnviroSPACE labUniversity of GenevaGenevaSwitzerland Institute of Atmospheric Pollution Research National Research Council of Italy (CNR)Sesto FiorentinoItaly

Cloud computing facilities can provide crucial computing support for processing the time series of satellite data and exploiting their spatio-temporal information ***,dedicated efforts are still required to develop workflows,executable on cloud-based platforms,for ingesting the satellite data,performing the targeted processes,and generating the desired *** this study,an operational workflow is proposed,based on monthly Evaporative Stress Index(ESI)anomaly,and implemented in cloud-based online Virtual Earth Laboratory(VLab)platform,as a demonstration,to monitor European agricultural water *** this end,daily time-series of actual and reference evapotranspiration(ETa and ET0),from the Spinning Enhanced Visible and Infrared Imager(SEVIRI)sensor,were used to execute the proposed workflow successfully on *** execution of the workflow resulted in obtaining one decade(2011–2020)of European monthly agricultural water stress maps at 0.04˚spatial resolution and corresponding stress reports for each *** support open science,all the workflow outputs are stored in GeoServer,documented in GeoNetwork,and made available through *** enables creating a dashboard for better visualization of the results for *** results from this study demonstrate the capability of VLab platform for water stress detection from time series of SEVIRI-ET data.

关键词： ET SEVIRI ESI water stress workflow Europe VLab demonstration

Theoretical Simulation on a Nonlinear Photonics Process of Er(1%)Yb(8%):FOV Oxyfluoride Nanophase Vitroceramics

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Communications in Computational Physics 2010年第3期7卷 580-596页

作者： Ce Wang Xiaobo Chen gregory j.Salamo Naruhito Sawanobori Chenjuan He Hongyu Zhou Hongmei jing Yongzhi Zeng Song Li Xiaoling Xu Applied Optics Beijing Area Major Laboratory Beijing Normal UniversityBeijing100875China Applied Optics Beijing Area Major Laboratory Department of Physics&Material CollegeBeijing Normal UniversityBeijing100875China Department of Physics University ArkansasFayettevilleAR 72701USA Sumita Optical Glass Inc.4-7-25 HarigayaUrawaSaitama338Japan Department of Physics Fuzhou UniversityFuzhouFujian350002China

We numerically simulate a photonics phenomenon of what we call intensity inversion between red and green fluorescence in oxyfluoride nanophase vitroceramics Er(1%)Yb(8%):FOV through the integration of whole fluorescence’s *** found that it is essential to introduce a coefficient presenting the difference between the Stokes energy transfer and anti-Stokes energy transfer processes in nano-material when calculating the energy transfer *** this consideration,and with the total crystallized volume ratio set to be 17.6%,the simulation results of the population probabilities values of all energy levels of Er^(3+) ion are coincident with the experimental result perfectly.

关键词： Energy transfer theoretical simulation Stokes and anti-Stokes processes rare earth ions oxyfluoride nanophase vitroceramics

Modeling process-structure-property relationships for additive manufacturing

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Frontiers of Mechanical Engineering 2018年第4期13卷 482-492页

作者： Wentao YAN Stephen LIN Orion L. KAFKA Cheng YU Zeliang LIU Yanping LIAN Sarah WOLFF jian CAO gregory j. WAGNER Wing Kam LIU Department of Mechanical Engineering Northwestern University Evanston IL 60201 USA

This paper presents our latest work on comprehensive modeling of process-structure-property relationships for additive manufacturing （AM） materials, including using data-mining techniques to close the cycle of design-predict-optimize. To illustrate the process- structure relationship, the multi-scale multi-physics pro- cess modeling starts from the micro-scale to establish a mechanistic heat source model, to the meso-scale models of individual powder particle evolution, and finally to the macro-scale model to simulate the fabrication process of a complex product. To link structure and properties, a high- efficiency mechanistic model, self-consistent clustering analyses, is developed to capture a variety of material response. The model incorporates factors such as voids, phase composition, inclusions, and grain structures, which are the differentiating features of AM metals. Furthermore, we propose data-mining as an effective solution for novel rapid design and optimization, which is motivated by the numerous influencing factors in the AM process. We believe this paper will provide a roadmap to advance AM fundamental understanding and guide the monitoring and advanced diagnostics of AM processing.

关键词： additive manufacturing thermal fluid flow data mining material modeling

The Influence of Biological Maturity on Dynamic Force-Time Variables and Vaulting Performance in Young Female Gymnasts

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journal of Science in Sport and Exercise 2020年第4期2卷 319-329页

作者： Sylvia Moeskops jon L.Oliver Paul j.Read john B.Cronin gregory D.Myer G.gregory Haff Isabel S.Moore Rhodri S.Lloyd Youth Physical Development Centre Cardiff School of Sport and Health SciencesCardiff Metropolitan UniversityCyncoed CampusCyncoed RoadCardiffCF52YBUK Sports Performance Research Institute New Zealand(SPRINZ) AUT UniversityAuckland 1142New Zealand Centre for Sport Science and Human Performance Waikato Institute of TechnologyHamilton 3240New Zealand Athlete Health and Performance Research Centre Aspetar Orthopaedic and Sports Medicine HospitalDohaQatar Division of Sports Medicine Cincinnati Children’s HospitalCincinnatiOH45229USA Department of Pediatrics and Orthopaedic Surgery College of MedicineUniversity of CincinnatiCincinnatiOH 45267USA The Micheli Center for Sports Injury Prevention WalthamMA 02453USA Centre for Exercise and Sports Science Edith Cowan UniversityJoondalupWA 6027Australia Australian Centre for Research into Injury in Sport and Its Prevention(ACRISP) Edith Cowan UniversityJoondalupWA 6027Australia University of Gloucestershire GloucesterGL502RHUK

Purpose This cross-sectional study investigated dynamic force-time variables and vaulting performance in young female gymnasts of different maturity *** 120 gymnasts aged 5-14 years were sub-divided into maturity groupings using percent of predicted adult height(%PAH)*** performed three jumping protocols,the squat jump(Sj),countermovement jump(CMj)and drop jump(Dj),before completing straight jump vaults that were recorded using two-dimensional *** jumping performance improved with biological maturity evidenced by the most mature gymnasts’producing sig-nificantly more absolute force(P0.78),impulse(P0.75)and power(P0.91)than the least mature group,resulting in the greater jump heights(P0.70).While,no significant differences were observed in relative peak force across multiple tests,measures of relative peak power did significantly increase with *** upon regression analyses,maturation was found to influence vertical take-off velocity during vaulting,explaining 41%of the variance in each jumping *** all tests,the Dj was found to have the highest predictive ability of vaulting vertical take-off velocity,explaining 55%of the total *** Biological maturation impacts jump height and underpinning mechanical variables in young female *** vertical take-off velocity appears to be influenced by maturation and various dynamic force-time variables,par-ticularly those during Dj,which had the highest explained total variance.

关键词： Youth Maturation Squat jump Countermovement jump Drop jump Gymnastics

Magnetic resonance imaging-guided focused ultrasound to increase localized blood-spinal cord barrier permeability

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Neural Regeneration Research 2017年第12期12卷 2045-2049页

作者： Allison H.Payne gregory W.Hawryluk Yoshimi Anzai Henrik Odéen Megan A.Ostlie Ethan C.Reichert Amanda j.Stump Satoshi Minoshima Donna j.Cross Department of Radiology and Imaging Sciences University of Utah Salt Lake City UT USA Department of Neurosurgery University of Utah Salt Lake City UT USA

Spinal cord injury（SCI） affects thousands of people every year in the USA, and most patients are left with some permanent paralysis. Therapeutic options are limited and only modestly affect outcome. To address this issue, we used magnetic resonance imaging-guided focused ultrasound（MRg FUS） as a non-invasive approach to increase permeability in the blood-spinal cord barrier（BSCB）. We hypothesize that localized, controlled sonoporation of the BSCB by MRg FUS will aid delivery of therapeutics to the injury. Here, we report our preliminary findings for the ability of MRg FUS to increase BSCB permeability in the thoracic spinal cord of a normal rat model. First, an excised portion of normal rat spinal column was used to characterize the acoustic field and to estimate the insertion losses that could be expected in an MRg FUS blood spinal cord barrier opening. Then, in normal rats, MRg FUS was applied in combination with intravenously administered microbubbles to the spinal cord region. Permeability of the BSCB was indicated as signal enhancement by contrast administered prior to T1-weighted magnetic resonance imaging and verified by Evans blue dye. Neurological testing using the Basso, Beattie, and Breshnahan scale and the ladder walk was normal in 8 of 10 rats tested. Two rats showed minor impairment indicating need for further refinement of parameters. No gross tissue damage was evident by histology. In this study, we have opened successfully the blood spinal cord barrier in the thoracic region of the normal rat spine using magnetic resonance-guided focused ultrasound combined with microbubbles.

关键词： focused ultrasound spinal cord magnetic resonance imaging contrast-enhanced blood-spinalcord barrier

Coherent-interface-induced strain in large lattice-mismatched materials:A new approach for modeling Raman shift

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Nano Research 2022年第3期15卷 2405-2412页

作者： Andrian V.Kuchuk Fernando Mde Oliveira Pijush K.Ghosh Yuriy I.Mazur Hryhorii V.Stanchu Marcio D.Teodoro Morgan E.Ware gregory j.Salamo Institute for Nanoscience and Engineering University of ArkansasFayettevilleAR 72701USA Departamento de Física Universidade Federal de São CarlosSão CarlosSP 13565-905Brazil Department of Electrical Engineering University of ArkansasFayettevilleAR 72701USA

Strain engineering as one of the most powerful techniques for tuning optical and electronic properties of III-nitrides requires reliable methods for strain *** this work,we reveal,that the linear model based on the experimental data limited to within a small range of biaxial strains(<0.2%),which is widely used for the non-destructive Raman study of strain with nanometer-scale spatial resolution is not valid for the binary wurtzite-structure group-III nitrides GaN and ***,we found that the discrepancy between the experimental values of strain and those calculated via Raman spectroscopy increases as the strain in both GaN and AlN ***,a new model has been developed to describe the strain-induced Raman frequency shift in GaN and AlN for a wide range of biaxial strains(up to 2.5%).Finally,we proposed a new approach to correlate the Raman frequency shift and strain,which is based on the lattice coherency in the epitaxial layers of superlattice structures and can be used for a wide range of materials.

关键词： Raman spectroscopy strain lattice coherency III-nitrides high-resolution X-ray diffraction(HRXRD)