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a.functiona. ta.rolimus-relea.ing nerve wra. for enha.cing nerve regenera.ion following surgica. nerve repa.r

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Neura. Regenera.ion Resea.ch 2025年第1期20卷 291-304页

作者： Simeon C.Da.schler Ka.elyn J.W.So Konsta.tin Feinberg Ma.ina.Ma.ora. Jenny Cheung Jennifer Zha.g Ka.eh Mirmoeini JPa.l Sa.terre Tessa.Gordon gregory HBorschel SickKids Resea.ch Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Bioma.eria.s a.d Biomedica. Engineering University of TorontoTorontoONCanada India.a.University School of Medicine IndianapolisINUSA Division of Pla.tic a.d Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Tra.sla.iona. Biology a.d Engineering Progra. Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

a.ona. regenera.ion following surgica. nerve repa.r is slow a.d often incomplete,resulting in poor functiona. recovery which sometimes contributes to lifelong ***,there a.e no FDa.a.proved thera.ies a.a.la.le to promote nerve *** a.celera.es a.ona. regenera.ion,but systemic side effects presently outweigh its potentia. benefits for periphera. nerve *** a.thors describe herein a.biodegra.a.le polyuretha.e-ba.ed drug delivery system for the susta.ned loca. relea.e of ta.rolimus a. the nerve repa.r site,with suita.le properties for sca.a.le production a.d clinica. a.plica.ion,a.ming to promote nerve regenera.ion a.d functiona. recovery with minima. systemic drug *** is enca.sula.ed into co-a.ia.ly electrospun polyca.bona.e-uretha.e na.ofibers to genera.e a. impla.ta.le nerve wra. tha. relea.es thera.eutic doses of bioa.tive ta.rolimus over 31 *** a.d drug loa.ing a.e a.justa.le for a.plica.ions in sma.l a.d la.ge ca.iber nerves,a.d the wra. degra.es within 120 da.s into biocompa.ible *** relea.ed from the nerve wra. promotes a.on elonga.ion in vitro a.d a.celera.es nerve regenera.ion a.d functiona. recovery in preclinica. nerve repa.r models while off-ta.get systemic drug exposure is reduced by 80%compa.ed with systemic *** its surgica. suita.ility a.d preclinica. effica.y a.d sa.ety,this system ma. provide a.rea.ily tra.sla.a.le a.proa.h to support a.ona. regenera.ion a.d recovery in pa.ients undergoing nerve surgery.

关键词： biodegra.a.le loca. drug delivery nerve injury nerve regenera.ion nerve wra. ta.rolimus

The enduring link between forest cover a.d ra.nfa.l： a.historica. perspective on science a.d policy discussions

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Forest Ecosystems 2018年第1期5卷 53-61页

作者： Brett M. Bennett gregory a. ba.ton School of Huma.ities a.d Communica.ion a.ts Western Sydney UniversityLocked Bag 1797PenrithNSW 2751Australia Depa.tment of Historica. Studies Faculty of HumanitiesUniversity of JohannesburgC-Ring 2-Orange Block(Kingsway Campus)Corner Kingsway and University RoadAuckland ParkSouth Africa

Ba.kground： This a.ticle tra.es the history of scientific idea. connecting forest cover with ra.nfa.l to inform ongoing deba.es a.out whether forests a.e net users or producers of wa.er in the hydrologica. cycle. Schola.s of the supply-side school a.gue tha. forests a.e net producers a.d ma.nifiers tha. increa.e ra.nfa.l a. regiona. sca.es. Supply-side schola.s seek to cha.lenge the domina.ce of dema.d-side thinking. The dema.d-side school empha.izes tha. trees a.e net users of wa.er within a.ca.chment tha. decrea.e overa.l wa.er a.a.la.le for other users. This scientific deba.e ha. significa.t implica.ions for the development of policies to ma.a.e forests a.d wa.er. Results： Scientists ha.e deba.ed the question of whether forests improve or worsen wa.er ba.a.ce for over two hundred yea.s. Connections between forests a.d ra.nfa.l ga.ned prominence in scientific circles during the second ha.f of the nineteenth century a.d a.a.n during the pa.t three deca.es. The popula.ity of forest- ra.nfa.l connections ha. pa.a.leled societa. a.d scientific interest in a.thropogenic clima.e cha.ge a.d deforesta.ion. Theories connecting forests with ra.nfa.l pea.ed in popula.ity in the 1850s to 1880s, a.period when scientists expressed a.a.m tha. deforesta.ion ca.sed regiona. declines in precipita.ion. Forests were understood to crea.e ra.n within a.loca.ity a.d region. Scientific consensus shifted by the ea.ly twentieth century to the view tha. forests did not pla. a.significa.t role in determining ra.nfa.l. The forest-ra.nfa.l connection reemerged in the 1980s a.ongside a.va.ces in clima.e modelling a.d growing fea.s of a.thropogenic globa. wa.ming a.d tropica. deforesta.ion. Using new da.a.a.d theories, supply-side a.voca.es ha.e once a.a.n pla.ed a.strong forest-ra.nfa.l connection into scientific prominence. Conclusion： Supply-side ma.a.ement policies ha.e a.checkered history tha. should elicit ca.tion, while dema.d-side policies, which a.e ba.ed on a.most a.century of hydrolog

关键词： Clima.e cha.ge Environmenta. history Forests Hydrology Ra.n Wa.er

Endophytic fungi a.ter sucking bug responses to cotton reproductive structures

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Insect Science 2017年第6期24卷 1003-1014页

作者： gregory a. Sword a.hley Tessnow Ma.ia.Julissa.Ek-Ra.os Depa.tment of Entomology Texas A&M University College Station Texas USA Ecology a.d Evolutiona.y Biology Interdisciplina.y Progra. Texas A&M University College Station Texas USA La.ora.orio de Inmunologia.y Virologia Facultad de Ciencias BiolSgicas Universidad Autonoma de Nuevo Leon San Nicolas de los Garza Nuevo Leon Mexico

a.l pla.ts including cotton host a.wide ra.ge of microorga.isms a. endophytes. There is a.growing a.precia.ion of the preva.ence, ecologica. significa.ce a.d ma.a.ement potentia. of fa.ulta.ive funga. endophytes in protecting pla.ts from pests, pa.hogens a.d environmenta. stressors. Hemiptera. sucking bugs ha.e emerged a. ma.or pests a.ross the U.S. cotton belt, reducing yields directly by feeding on developing reproductive structures a.d indirectly by vectoring pla.t pa.hogens. We used no-choice a.d simulta.eous choice a.sa.s to exa.ine the host selection beha.ior of western ta.nished pla.t bugs （Lygus hesperus） a.d southern green stink bugs （Neza.a.viridula. in response to developing flower buds a.d fruits from cotton pla.ts colonized by 1 of 2 ca.dida.e beneficia. funga. endophytes, Phia.emonium infla.um or Bea.veria.ba.sia.a. Both insect species exhibited strong nega.ive responses to flower buds （L. hesperus） a.d fruits （N. viridula. from pla.ts tha. ha. been colonized by ca.dida.e endophytic fungi rela.ive to control pla.ts under both no-choice a.d choice conditions. Beha.iora. responses of both species indica.ed tha. the insects were deterred prior to conta.t with pla.t tissues from endophyte-colonized pla.ts, suggesting a.puta.ive role for vola.ile compounds in media.ing the nega.ive response. Our results highlight the role of funga. endophytes a. pla.t mutua.ists tha. ca. ha.e positive effects on pla.t resista.ce to pests.

关键词： beha.ior endophyte fungi Hemiptera mutua.ism sucking bug

Optica. monitoring of pa.ticle a.grega.es

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Journa. of Environmenta. Sciences 2009年第1期21卷 2-7页

作者： John gregory Depa.tment of Civil Environmental and Geomatic EngineeringUniversity College London

Methods for monitoring pa.ticle a.grega.ion a.e briefly reviewed. Most of the techniques a.e ba.ed on some form of light sca.tering a.d ma. be grea.ly dependent on the optica. properties of a.grega.es, which a.e not genera.ly known. a. fra.ta. a.grega.es grow la.ger their density ca. become very low a.d this ha. importa.t pra.tica. consequences for light sca.tering. For insta.ce, the sca.tering coefficient ma. be much less tha. for solid objects, which mea.s tha. the a.grega.es ca. a.pea. much sma.ler tha. their a.tua. size by a.light tra.smission method. a.so, for low-density objects, a.high proportion of the sca.tered light energy is within a.sma.l a.gle of the incident bea., which ma. a.so be releva.t for mea.urements with a.grega.es. Using the ＂turbidity fluctua.ion＂ technique a. a. exa.ple, it is shown how the a.pa.ent size of hydroxide flocs depends ma.nly on the included impurity pa.ticles, ra.her tha. the hydroxide precipita.e itself. Results using cla. suspensions with hydrolyzing coa.ula.ts a.d polymeric floceula.ts under different string conditions a.e discussed.

关键词： monitoring method floccula.ion turbidity fluctua.ion

Time-first a.proa.h for la.d cover ma.ping using big Ea.th observa.ion da.a.time-series in a.da.a.cube-a.ca.e study from the La.e Geneva.region(Switzerla.d)

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Big Ea.th Da.a 2024年第3期8卷 435-466页

作者： gregory Giulia.i Institute for Environmenta. Sciences EnviroSPACE labUniversity of GenevaGenevaSwitzerland United Na.ions Environment Progra.me Division of Early Warning and AssessmentGenevaSwitzerland

a.cura.e,consistent,a.d high-resolution La.d Use&Cover(LUC)informa.ion is funda.enta. for effectively monitoring la.dsca.e dyna.ics a.d better a.prehending drivers,pressures,sta.e,a.d impa.ts on la.d ***,the a.a.la.ility of such na.iona. products with high thema.ic a.cura.y is still limited a.d consequently resea.chers a.d policyma.ers a.e constra.ned to work with da.a.tha. do not necessa.ily reflect on-the-ground rea.ities impending to correctly ca.ture deta.ls of la.dsca.e fea.ures a. well a. limiting the identifica.ion a.d qua.tifica.ion of drivers a.d ra.e of ***,we took a.va.ta.e of the Switzerla.d’s officia. LUC sta.istica. sa.pling survey a.d dense time-series of Sentinel-2 da.a.combining them with Ma.hine a.d Deep Lea.ning methods to produce a. a.cura.e a.d high spa.ia. resolution la.d cover ma. over the La.e Geneva.*** suggest tha. time-first a.proa.h is a.va.ua.le a.terna.ive to spa.e-first a.proa.hes,a.counting for the intra.a.nua. va.ia.ility of cla.ses,hence improving cla.sifica.ion *** demonstra.e tha. Deep Lea.ning methods outperform more tra.itiona. Ma.hine Lea.ning ones such a. Ra.dom Forest,providing more a.cura.e predictions with lower *** produced la.d cover ma. ha. a.high a.cura.y,a. improved spa.ia. resolution,while a. the sa.e time preserving the sta.istica. significa.ce(*** proportion)of the officia. na.iona. *** work pa.es the wa. towa.ds the objective to produce a.yea.ly high resolution la.d cover ma. of Switzerla.d a.d potentia.ly implement a.continuous la.d cha.ge monitoring *** further work is required to properly a.dress cha.lenges such a. the need for increa.ed tempora. resolution for LUC informa.ion or the qua.ity of tra.ning sa.ples.

关键词： La.d cover Sentinel-2 timeseries SITS a.ea.sta.istik

Globa. weirding a. ma.s extinction horizons

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Na.iona. Science Review 2024年第1期11卷 10-12页

作者： gregory J.Reta.la.k Depa.tment of Ea.th Sciences University of Oregon

a.strong motiva.ion for studying ma.s extinctions is understa.ding how current clima.ic a.d biodiversity crises will a.fect crea.ures living on la.d such a. ourselves. Perha.s the question is: how ba. ca. it get? In tha. ca.e, terrestria. Permia.-Tria.sic ma.s extinctions a.e a. irresistible worst-ca.e scena.io [1].

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a.sessing risks from mining-induced ground movements nea. ga. wells

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Interna.iona. Journa. of Mining Science a.d Technology 2020年第1期30卷 11-16页

作者： Christopher Ma.k gregory M.Rumba.gh Mine Sa.ety a.d Hea.th a.ministra.ion PittsburghPAUSA

The prolifera.ion of unconventiona. ga. well development in the Northern a.pa.a.hia. coa.fields ha. ra.sed a.number of mine sa.ety *** wells,which extra.t ga. from deep sha.e forma.ions,a.e cha.a.terized by ga. volumes a.d pressures tha. a.e significa.tly higher tha. those observed a. ma.y conventiona. *** ga. is composed la.gely of metha.e a. well a. other *** of pla.ned a.d a.tively producing wells penetra.e protective coa. pilla.s or ba.riers within a.tive mine bounda.ies,including cha.n pilla.s loca.ed between longwa.l *** relea.ed from a.well da.a.ed by mining-induced ground movements could pose a.risk to miners by flowing into the mine *** mining-induced ground movements tha. ma. ca.se well da.a.e include conventiona. subsidence,non-conventiona. subsidence(*** pla.e slip),pilla. fa.lure,a.d floor *** pa.er describes the known risk fa.tors for ea.h of the four fa.lure *** includes a.fra.ework tha. ca. guide the risk a.sessment process when mining ta.es pla.e nea. ga. or oil wells.

关键词： Ga. well Subsidence Coa. protection pilla. Risk ma.rix Longwa.l mining

From common ga.dens to ca.dida.e genes:a. elega.t ca.e of homoploid hybrid specia.ion

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Molecula. Pla.t 2021年第2期14卷 200-201页

作者： gregory L.Owens Depa.tment of Biology University of VictoriaVictoriaBCCanada

Homoploid hybrid specia.ion(HHS),where genetic contributions from two species combine to produce a.third species without a.cha.ge in pioidy,rema.ns a. intriguing a.d enigma.ic evolutiona.y *** studies in the pa.t deca.e ha.e shown tha. introgression a.d a.mixture between species is common,a.d yet well documented ca.es of HHS rema.n ra.e(Schumer et a..,2014;Ma.ques et a..,2019).This strikes a. a.key fea.ure of HHS;it is a.fa. higher ba. to prove tha. hybridiza.ion wa. critica. for specia.ion tha. it is to show tha. introgression *** former requires us to know how reproductive isola.ion(RI)is a.hieved,identify hybrid a.cestry,a.d definitively link hybrid a.cestry with reproductive *** this in mind,the work by Wa.g et a..(2020)fully documenting a.ca.e of HHS is pa.ticula.ly impressive in terms of both the scope a.d cla.ity of the results.

关键词： a.. combine intro

Introducing RiverProfilea.p,a.web a.plica.ion for nea.-globa.,explora.ory,longitudina. river profile a.a.ysis

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Interna.iona. Journa. of Digita. Ea.th 2022年第1期15卷 679-689页

作者： gregory a.Ruetenik Czech a.a.emy of Sciences Institute of GeophysicsPragueCzech Republic

River profile a.a.ysis ha. been used extensively in the ea.th sciences. Commonly,explora.ion of river profiles requires downloa.ing a.d processing Digita. Eleva.ion Models (DEMs) for specific a.ea.,which limits the scope of explora.ory a.a.ysis. Presented here is a.web a.plica.ion designed to a.a.yze river profiles a. 90m resolution a. a.nea.-globa. sca.e. The a.p a.lows users to quickly query downstrea. or upstrea. from selected points a.ywhere within ±60 degrees la.itude,in order to intera.tively a.a.yze corresponding river profiles. River profile a.a.ysis ca. be performed in both dista.ce a.d χ spa.e,where χ is a.metric tha. is proportiona. to the presumed stea.y-sta.e sha.e of the river profile. River loca.ions a.e ba.ed on the HydroSHEDS 90m dra.na.e direction grid,a. well a. custom computed D8 dra.na.e direction a.d void-filled SRTM DEMs. RiverProfilea.p is open source,a.d a.though currently it is designed a. a. explora.ory tool,more functions ca. be ea.ily a.ded via.community contributions a.d/or from existing toolsets. It is a.a.la.le from ***.

关键词： River profile a.a.ysis geomorphology big da.a science communica.ion