检索结果-南通市图书馆

Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2024年第2期137卷 172-180页

作者： Jing Lin Deyong Long Chenxi Jiang Caihua Sang Ribo Tang Songnan Li Wei Wang Xueyuan Guo Man Ning Zhaoqing Sun Na yang yongchen hao Jun Liu Jing Liu Xin Du Louise Morgan Gregg C.Fonarow Sidney C.Smith Jr gregory y.h.lip Dong Zhao Jianzeng Dong Changsheng Ma On behalf of CCC-AF investigators Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China National Clinical Research Center for Cardiovascular Diseases Beijing 100029 China Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China International Quality Improvement Department American Heart AssociationDallasTX 07076USA Division of Cardiology Geffen School of Medicine at University of CaliforniaLos Angeles CA 90024USA Division of Cardiology University of North CarolinaChapel HillNC 27599USA Department of Cardiology Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpool L143PEUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark 不详

Background:Oral anti-coagulants(OAC)are the intervention for the prevention of stroke,which consistently improve clinical outcomes and survival among patients with atrial fibrillation(AF).The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in ***:Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation(CCC-AF)registry,guideline-recommended OAC use in eligible patients was ***:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low *** admission,only 20.0%(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking *** use of pre-hospital OAC on admission was associated with a lower risk of new-onset ischemic stroke/transient ischemic attack among the diagnosed AF population(adjusted odds ratio:0.54,95%confidence interval:0.43-0.68;Pharge,the prescription rate of OAC was 45.2%(16,757/37,087)in eligible patients with high stroke risk and 60.7%(2778/4578)in eligible patients with low stroke *** utilization in patients with high stroke risk on admission or at discharge both increased largely over time(all Pysis showed that OAC utilization at discharge was positively associated with in-hospital rhythm control strategies,including catheter ablation(adjusted odds ratio[OR]11.63,95%confidence interval[CI]10.04-13.47;Phythmic drug use(adjusted OR 1.45,95%CI 1.38-1.53;Phospitals participated in the CCC-AF project,>70%of AF patients were at a high risk of *** poor performance on guideline-recommended OAC use was found in this study,over time the CCC-AF project has made progress in stroke prevention in the Chinese AF ***

关键词： Atrial fibrillation Oral anti-coagulants OAC Stroke prevention Contraindication

Frailty and Anticoagulant Therapy in Patients Aged 65 years or Older with Atrial Fibrillation

在线全文

学校读者我要写书评

暂无评论

Cardiovascular Innovations and Applications 2020年第1期4卷 153-161页

作者： Jiapeng Liu Xin Du Mengmeng Li Zhaoxu Jia Shangxin Lu Sanshuai Chang Ribo Tang Rong Bai Jianzeng Dong gregory y.h.lip Changsheng Ma Department of Cardiology Beijing Anzhen HospitalCapital Medical University and National Clinical Research Center for Cardiovascular DiseasesBeijingChina heart health Research Center BeijingChina University of New South Wales SydneyAustralia Department of Cardiology The First Affi liated Hospital of Zhengzhou UniversityZhengzhouChina Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart and Chest HospitalLiverpoolUK Aalborg Thrombosis Research Unit Department of Clinical MedicineAalborg UniversityAalborgDenmark

Background:Elderly adults with atrial fi brillation(AF)are at increased risk of frailty and thromboembolic ***,studies on the prevalence of frailty in AF patients and data on the relationship between frailty and the use of anticoagulants are ***:We conducted a cross-sectional study involving 500 *** aged 65 years or older were consecutively selected from the Chinese Atrial Fibrillation Registry *** patient’s frailty status was assessed with use of the Canadian Study of health and Aging Clinical Frailty *** assessed the prevalence of and factors associated with frailty,and how frailty affects anticoagulant ***:In 500 elderly adults with AF(age 75.2±6.7 years;51.6%female),201 patients(40.2%)were *** prevalence of frailty was higher in females(P=0.002)and increased with age and ChA 2 DS 2-VASc score(P for trend less than 0.001 for both).The factors associated with frailty were a history of heart failure(odds ratio[OR]2.40,95%confi dence interval[CI]1.39–4.14),female sex(OR 2.09,95%CI 1.27–3.43),and advanced age(OR 1.13,95%CI 1.09–1.17).Frail patients were signifi cantly less likely to have ever been prescribed anticoagulants compared with nonfrail patients(81.7 vs.54.9%,Py is prevalent in elderly adults with AF,especially in females,those of advanced age,and those with heart *** status has a signifi cant impact on prescription of anticoagulants for high-risk AF patients.

关键词： atrial fi brillation frailty anticoagulant elderly adults

Optimal INR level in elderly and non-elderly patients with atrial fibrillation receiving warfarin: a report from the COOL-AF nationwide registry in Thailand

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2020年第10期17卷 612-620页

作者： Rungroj Krittayaphong Rapeephon Kunjara-Na-Ayudhya Pornchai Ngamjanyaporn Smonporn Boonyaratavej Chulalak Komoltri Ahthit yindeengam Piyamitr Sritara gregory yhlip Division of Cardiology Department of MedicineFaculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Department of Cardiology Vichaiyut Hospital and Medical CenterBangkokThailand Department of Cardiology Chonburi HospitalChonburiThailand Division of Cardiology Department of MedicineFaculty of MedicineChulalongkorn UniversityBangkokThailand Department of Research Promotion Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand her Majesty Cardiac Center Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand Division of Cardiology Department of MedicineFaculty of Medicine Ramathibodi HospitalMahidol UniversityBangkokThailand Liverpool Centre for Cardiovascular Science University of Liverpool and Liverpool Heart&Chest HospitalLiverpoolUnited Kingdom Aalborg Thrombosis Research Unit Department of Clinical MedicineAalborg UniversityAalborgDenmark

Background Asian population are at increased risk of bleeding during the warfarin treatment,so the recommended optimal international normalized ratio(INR)level may be lower in Asians than in *** aim of this prospective multicenter study was to determine the optimal INR level in Thai patients with non-valvular atrial fibrillation(NVAF).Methods Patients with NVAF who were on warfarin for stroke prevention were recruited from 27 hospitals in the nationwide COOL-AF registry in *** collected demographic data,medical history,risk factors for stroke and bleeding,concomitant disease,electrocardiogram and laboratory data including INR and antithrombotic *** measurements included ischemic stroke/transient ischemic attack(TIA)and major *** INR level was assessed by the calculation of incidence density for six INR ranges(hemic stroke/TIA and 112 major bleeding *** lowest prevalence of ischemic stroke/TIA and major bleeding events occurred within the INR range of 2.0–2.99 for patientsyears and 1.5–2.99 for patients≥70 *** The INR range associated with the lowest risk of ischemic stroke/TIA and bleeding in the Thai population was 2.0–2.99 for patientsyears and 1.5–2.99 for patients≥70 *** rates of major bleeding and ischemic stroke/TIA were both higher than the rates reported in Western population.

关键词： Bleeding Ischemic stroke Non-valvular atrial fibrillation Optimal international normalized ratio Thailand Warfarin

Semimartingale dynamics for a backward exchange rate process

在线全文

学校读者我要写书评

暂无评论

Probability, Uncertainty and Quantitative Risk 2024年第3期9卷 371-388页

作者： gregory Gagnon Department of Economics University of Toronto Mississauga3359 Mississauga RoadMississaugaOntarioL5L 1C6Canada

Via a forward SDE solution(k_(t),t≥O)that captures money supply dynamics,a macroeconomic model known as the monetary model generates a backward exchange rate process(y_(t),t≥0).For any t≥0,y_(t)=k_(t)+α^(-1)μ_(t) where(μ_(t),t≥0)is a backward process andα>0 is a ***,(y_(t),t≥O)does not satisfy a conventional *** paper proves(y_(t),t≥O)is a continuous semimartingale when restrictions on the SDE for(k_(t),t≥O)capture anti-inflationary *** new result in economic dynamics does not require the filtration to be the Brownian filtration.

关键词： Backward process Semimartingale Anti-inflationary SDE policy

心房颤动和高血压：我们需要知道什么(续前)

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中华高血压杂志 2013年第5期21卷 403-406页

作者： GUO yu-tao gregory y.h.lip 英国伯明翰大学心血管科学中心英国伯明翰中国人民解放军总医院老年心血管科

由于高血压只轻度增加脑卒中和出血风险（其在ChA2DS2-VASc和hAS-BLED评分中各占1分，见表3），所以在评估心房颤动患者的脑卒中和出血风险时还需要结合其他危险因素及评分，评估临床净获益情况。

关键词：心房颤动患者高血压危险因素脑卒中评分风险出血评估

心房颤动和高血压：我们需要知道什么(待续)

在线全文

学校读者我要写书评

暂无评论

中华高血压杂志 2013年第4期21卷 304-307页

作者： GUO yu-tao gregory y.h.lip 张刘锋(编译) 谢良地(审校) 英国伯明翰大学心血管科学中心英国伯明翰中国人民大学解放军总医院老年心血管科不详

高血压增加心房颤动和心房颤动相关并发症(包括脑卒中/血栓栓塞、严重出血和死亡)的发生风险。在心房颤动患者中,高血压增加2倍风险的脑卒中/血栓栓塞事件。在ChA2DS2-VASc脑卒中评分系统和hAS-BLED出血评分系统中高血压各占1分,综合风... 详细信息

高血压增加心房颤动和心房颤动相关并发症(包括脑卒中/血栓栓塞、严重出血和死亡)的发生风险。在心房颤动患者中,高血压增加2倍风险的脑卒中/血栓栓塞事件。在ChA2DS2-VASc脑卒中评分系统和hAS-BLED出血评分系统中高血压各占1分,综合风险还应结合其他危险因素进行评估。血管紧张素转换酶抑制剂和血管紧张素受体拮抗剂被推荐用于原发性高血压患者一级预防心房颤动发生。应在综合评估脑卒中和出血风险及临床净获益的基础上考虑给予口服抗凝药物治疗,包括使用华法林或新的口服抗凝药。

关键词：高血压心房颤动脑卒中出血预防

In-hospital direct costs for thromboembolism and bleeding in Chinese patients with atrial fibrillation

在线全文

学校读者我要写书评

暂无评论

Chronic Diseases and Translational Medicine 2018年第2期4卷 127-134页

作者： San-Shuai Chang Jia-hui Wu yi Liu Ting Zhang Xin Du Jian-Zeng Dong gregory y.h. lip Chang-Sheng Ma Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityNational Clinical Research Centre for Cardiovascular DiseasesBeijing 100029China Department of Cardiology Xuzhou Center HospitalXuzhouJiangsu 221000China University of Birmingham Institute of Cardiovascular Sciences City HospitalBirmingham B18 7QHUnited Kingdom

Objective: Limited data are available on the direct costs of hospitalization owing to thromboembolism and bleeding in patients with atrial fibrillation (AF) in China. Such data are essential for policy development, service planning, and cost-effectiveness analysis of new therapeutic strategies. This study aimed to provide detailed data regarding in-hospital direct costs for these pa-tients, compare the costs at different scenarios, and identify independent factors that may predict the costs. Methods: We collected data regarding in-hospital direct costs among patients with AF who were hospitalized owing to ischemic stroke (IS), transient ischemic attack (TIA), intracranial hemorrhage (ICh), or major gastrointestinal bleeding. All data were collected from 7 representative tertiary referral hospitals and 3 secondary care hospitals from December 2009 to October 2014. Results: In total, 312 eligible patients with thromboembolism and 143 patients with major bleeding were identified, and their hospital charts were reviewed. The median in-hospital direct costs were 17,857 Chinese yuan (CNy) for IS and 16,589 CNy for TIA (equivalent to 2907 US dollars and 2701 US dollars, respectively). For patients with major bleeding, the costs were 27,924 CNy for ICh and 18,196 CNy for major gastrointestinal bleeding (equivalent to 4546 US dollars and 2962 US dollars, respec-tively). The direct costs were mainly driven by medications, which accounted for approximately 33.4%-36.1% in different groups of patients. The direct costs were highly related to the hospital level and National Institutes of health Stroke Scale scores in patients with thromboembolism; in patients with ICh, the factors included hospital level, warfarin treatment before admission, and prior hospitalization for stroke. Conclusions: Given the high prevalence, AF-related thromboembolism and bleeding impose considerable economic burden on the Chinese society. Efforts to improve the management of AF may confer substantial e

关键词： Atrial fibrillation Ischemic stroke Bleeding In-hospital direct costs

Animal models of amyotrophic lateral sclerosis： a comparison of model validity

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2018年第12期13卷 2050-2054页

作者： Jessica R.Morrice Cheryl y.gregory-Evans Christopher A.Shaw Experimental Medicine Program University of British Columbia Vancouver Canada Department of Ophthalmology and Visual Sciences University of British Columbia Vancouver Canada Neuroscience Program University of British Columbia Vancouver Canada Department of Pathology. University of British Columbia Vancouver Canada

Animal models are necessary to investigate the pathogenic features underlying motor neuron degeneration and for therapeutic development in amyotrophic lateral sclerosis（ALS）. Measures of model validity allow for a critical interpretation of results from each model and caution from over-interpretation of experimental models. Face and construct validity refer to the similarity in phenotype and the proposed causal factor to the human disease, respectively. More recently developed models are restricted by limited phenotype characterization, yet new models hold promise for novel disease insights, thus highlighting their importance. In this article, we evaluate the features of face and construct validity of our new zebrafish model of environmentally-induced motor neuron degeneration and discuss this in the context of current environmental and genetic ALS models, including C9 orf72, mutant Cu/Zn superoxide dismutase 1 and TAR DNA-binding protein 43 mouse and zebrafish models. In this mini-review, we discuss the pros and cons to validity criteria in each model. Our zebrafish model of environmentally-induced motor neuron degeneration displays convincing features of face validity with many hallmarks of ALS-like features, and weakness in construct validity. however, the value of this model may lie in its potential to be more representative of the pathogenic features underlying sporadic ALS cases, where environmental factors may be more likely to be involved in disease etiology than single dominant gene mutations. It may be necessary to compare findings between different strains and species modeling specific genes or environmental factors to confirm findings from ALS animal models and tease out arbitrary strain-and overexpression-specific effects.

关键词： amyotrophic lateral sclerosis motor neuron degeneration face validity construct validity zebrafish models mouse models genetic models environmental models

RNA-based therapies in animal models of Leber congenital amaurosis causing blindness

在线全文

学校读者我要写书评

暂无评论

Precision Clinical Medicine 2020年第2期3卷 113-126页

作者： Xia Wang Xianghong Shan Kevin gregory-Evans Cheryl y.gregory-Evans Department of Ophthalmology and Visual Sciences University of British ColumbiaVancouver BC V5Z 3N9Canada

Leber congenital amaurosis(LCA)is a severe,genetically heterogeneous recessive eye disease in which∼35%of genemutations are in-frame nonsensemutations coding for loss-of-function premature termination codons(PTCs)*** suppression therapy allows read-through of PTCs leading to production of full-length protein.A limitation of nonsense suppression is that nonsense-mediated decay(NMD)degrades PTC-containing RNA *** purpose of this study was to determine whether inhibition of NMD could improve nonsense suppression efficacy in *** a high-throughput approach in the recessive cep290 zebrafish model of LCA(cep290;Q1223X),we first tested the NMD inhibitor Amlexanox in combination with the nonsense suppression drug *** observed reduced retinal cell death and improved visual *** these positive data,we next investigated whether this strategy was also applicable across species in two mammalianmodels:Rd12(rpe65;R44X)and Rd3(rd3;R107X)mouse models of *** the Rd12 model,cell death was reduced,RPE65 protein was produced,and in vivo visual function testing was *** establish for the first time that the mechanism of action of Amlexanox in Rd12 retina was through reduced UPF1 *** the Rd3 model,however,no beneficial effect was observed with Ataluren alone or in combination with *** variation in response establishes that some forms of nonsensemutation LCA can be targeted by RNA therapies,but that this needs to be verified for each *** implementation of precision medicine by identifying better responders to specific drugs is essential for development of validated retinal therapies.

关键词： precision medicine Ataluren Amlexanox nonsense suppression RPE65 CEP290 RD3