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lats基因在细胞周期和肿瘤发生中的作用

生物化学与生物物理进展 2001年第6期28卷 811-814页

作者：陈伟丽邓可京 T.s.gregory 许田上海复旦大学生命科学院发育生物学实验基地上海200433 Howard Hughes Medical Institute Yale UniversitySchool of MedicineDepartment of Genetics

lats基因 (largetumorsuppressorgene)最早在果蝇中发现 ,在小鼠和人中均有同源基因 .该基因的功能从果蝇到人是高度保守的 .lats基因的功能包括 :作为肿瘤抑制基因 ,其突变会导致肿瘤的发生 ;磷酸化的Lats与Cdc2结合 ,参与细胞周期的调... 详细信息

lats基因 (largetumorsuppressorgene)最早在果蝇中发现 ,在小鼠和人中均有同源基因 .该基因的功能从果蝇到人是高度保守的 .lats基因的功能包括 :作为肿瘤抑制基因 ,其突变会导致肿瘤的发生 ;磷酸化的Lats与Cdc2结合 ,参与细胞周期的调控 ;通过细胞细胞间的通讯 ,可能参与生物体个体大小的调控机制 .从果蝇到人lats基因功能的研究。

关键词： lats基因肿瘤抑制基因肿瘤发生细胞周期细胞周期因子大小调控果蝇模式生物

Acute colonic pseudo-obstruction: A systematic review of aetiology and mechanisms

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World Journal of Gastroenterology 2017年第30期23卷 5634-5644页

作者： Cameron I Wells gregory O’Grady Ian P Bissett Department of surgery University of Auckland Department of surgery Auckland District Health Board

To critically review the literature addressing the definition, epidemiology, aetiology and pathophysiology of acute colonic pseudo-obstruction (ACPO). METHODsA systematic search was performed to identify articles investigating the aetiology and pathophysiology of ACPO. A narrative synthesis of the evidence was undertaken. REsULTsNo consistent approach to the definition or reporting of ACPO has been developed, which has led to overlapping investigation with other conditions. A vast array of risk factors has been identified, supporting a multifactorial aetiology. The pathophysiological mechanisms remain unclear, but are likely related to altered autonomic regulation of colonic motility, in the setting of other predisposing factors. CONCLUsIONFuture research should aim to establish a clear and consistent definition of ACPO, and elucidate the pathophysiological mechanisms leading to altered colonic function. An improved understanding of the aetiology of ACPO may facilitate the development of targeted strategies for its prevention and treatment.

关键词： Acute colonic pseudoobstruction Acute colonic pseudo-obstruction Colonic Intestinal Pseudo obstruction Ogilvie’s syndrome Pseudo-Obstruction Pseudo-Obstruction

On a strongly Damped Wave Equation for the Flame Front

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Chinese Annals of Mathematics,series B 2010年第6期31卷 819-840页

作者： Claude-Michel BRAUNER Luca LORENZI gregory I. sIVAsHINsKY Chuanju XU school of Mathematical sciences Xiamen University 361005 Xiamen Fujian China Dipartimento di Matematica Università degli Studi di Parma Viale Parco Area delle Scienze 53/A 43124 Parma Italy school of Mathematical sciences Tel Aviv University 69978 Tel Aviv Israel

In two-dimensional free-interface problems, the front dynamics can be modeled by single parabolic equations such as the Kuramoto-sivashinsky equation (K-s). However, away from the stability threshold, the structure of the front equation may be more involved. In this paper, a generalized K-s equation, a nonlinear wave equation with a strong damping operator, is considered. As a consequence, the associated semigroup turns out to be analytic. Asymptotic convergence to K-s is shown, while numerical results illustrate the dynamics.

关键词： Front dynamics Wave equation Kuramoto-sivashinsky equation stability Analytic semigroups spectral method

Effects of Nitric Oxide Fumigation on Mortality of Light Brown Apple Moth, <i>Epiphyas postvittana</i>(Lepidoptera: Tortricidae)*

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Agricultural sciences 2021年第11期12卷 1286-1294页

作者： Yong-Biao Liu gregory s. simmons UsDA-ARs Salinas CA USA

Light brown apple moth, Epiphyas postvittana, is a quarantine pest in most countries and has established in California and, therefore, has potential to affect export of fresh products from infested areas. There is currently lack of effective treatment especially against eggs. Nitric oxide is a recently discovered fumigant for postharvest pest control and is evaluated in laboratory fumigations to determine its efficacy against different life stages of this pest. small scale fumigations with nitric oxide at 1.0%, 2.0%, 3.0%, and 5.0% concentrations were conducted under ultralow oxygen conditions at 2˚C against larvae, pupae, and eggs of light brown apple moth. Treatment times ranged from 4 to 24 h depending on nitric oxide concentration and life stage. Complete control of larvae and pupae was achieved in 8 h fumigation with 2.0% NO. Eggs were successfully controlled in 6, 12, and 24 h fumigations with 5.0%, 3.0%, and 2.0% NO respectively. The study demonstrated that nitric oxide fumigation was effective against all life stages of light brown apple moth and, therefore, has potential to be an alternative treatment to methyl bromide fumigation for postharvest control of light brown apple moth.

关键词： Quarantine Treatment Nitric Oxide Fumigation Light Brown Apple Moth

Optical tissue clearing enables rapid,precise and comprehensive assessment of three-dimensional morphology in experimental nerve regeneration research

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Neural Regeneration Research 2022年第6期17卷 1348-1356页

作者： simeon C.Daeschler Jennifer Zhang Tessa Gordon gregory H.Borschel sickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Division of Plastic and Reconstructive surgery the Hospital for Sick ChildrenTorontoONCanada Indiana University school of Medicine IndianapolisINUSA

Morphological analyses are key outcome assessments for nerve regeneration studies but are historically limited to tissue *** optical tissue clearing techniques enabling three-dimensional imaging of entire organs at a subcellular resolution have revolutionized morphological studies of the *** extend their applicability to experimental nerve repair studies we adapted these techniques to nerves and their motor and sensory targets in *** solvent-based protocols rendered harvested peripheral nerves and their target organs transparent within 24 hours while preserving tissue architecture and *** optical clearing was compatible with conventional laboratory techniques,including retrograde labeling studies,and computational image segmentation,providing fast and precise cell ***,optically cleared organs enabled three-dimensional morphometry at an unprecedented scale including dermatome-wide innervation studies,tracing of intramuscular nerve branches or mapping of neurovascular *** their wide-ranging applicability,rapid processing times,and low costs,tissue clearing techniques are likely to be a key technology for next-generation nerve repair *** procedures were approved by the Hospital for sick Children’s Laboratory Animal services Committee(49871/9)on November 9,2019.

关键词： histology image segmentation morphometry nerve regeneration outcome assessment peripheral nerve three-dimensional imaging tissue clearing

Holes in Fossil shells show Effects of Competition and Evolution

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当代外语研究 2005年第3期 22-21页

作者： gregory s.Herbert 张永红

化石能够或多或少地反映出当时生物及其生存环境的状况,这为人类了解生命的历史和地球上生态环境变迁的历史提供了重要的线索。一代又一代的科学家通过对不断发现的越来越多的生物化石的研究,根据它们形态特征上的异同来了解各门类生物... 详细信息

化石能够或多或少地反映出当时生物及其生存环境的状况,这为人类了解生命的历史和地球上生态环境变迁的历史提供了重要的线索。一代又一代的科学家通过对不断发现的越来越多的生物化石的研究,根据它们形态特征上的异同来了解各门类生物之间的亲缘关系。

关键词： Holes in Fossil shells show Effects of Competition and Evolution

Limbic system as immune tissue

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Acta Pharmacologica sinica 1999年第5期 80-81页

作者： gregory L FRICCHIONE Boston MA 02215 UsA Brigham and Women’s Hospital Harvard Medical school Medical Psychiatry service and Mind-Body Medical Institute

The purpose of this review is to examine the interaction of the limbic system and the cellular immune system from the perspective of evolutionary biology. While the limbic system exerts a level of control over the stress response systems, the cellular immune system spearheaded by the monocyte-macrophage is responsible for the acute phase response to *** potential role of the macrophage in certain neuropsychiatric and psychosomatic disorders,including dementia,delirium, schizophrenia, depression and autoimmune disease will be

关键词： Limbic system as immune tissue

Recent Advancements on Three‑Dimensional Electrospun Nanofiber scaffolds for Tissue Engineering

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Advanced Fiber Materials 2022年第5期4卷 959-986页

作者： Yujie Chen Xutao Dong Muhammad shafiq gregory Myles Norbert Radacsi Xiumei Mo shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative Medicine State Key Laboratory for Modification of Chemical Fibers and Polymer MaterialsCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversitySongjiangShanghai 201600China school of Engineering Institute for Materials and ProcessesThe University of EdinburghKing’s BuildingsEdinburgh EH93FBUnited Kingdom

Electrospinning is widely accepted as a technique for the fabrication of nanofibrous three-dimensional(3D)scaffolds which mimic extracellular matrix(ECM)microenvironment for tissue engineering(TE).Unlike normal densely-packed two-dimensional(2D)nanofibrous membranes,3D electrospun nanofiber scaffolds are dedicated to more precise spatial control,endowing the scaffolds with a sufficient porosity and 3D environment similar to the in vivo settings as well as optimizing the properties,including injectability,compressibility,and ***,the 3D morphology regulates cellular interaction and mediates growth,migration,and differentiation of cell for matrix *** variation among scaffold structures,functions and applications depends on the selection of electrospinning materials and methods as well as on the post-processing of electrospun *** review summarizes the recent new forms for building electrospun 3D nanofiber scaffolds for TE applications.A variety of approaches aimed at the fabrication of 3D electrospun scaffolds,such as multilay-ering electrospinning,sacrificial agent electrospinning,wet electrospinning,ultrasound-enhanced electrospinning as well as post-processing techniques,including gas foaming,ultrasonication,short fiber assembly,3D printing,electrospraying,and so on are discussed,along with their advantages,limitations and ***,the current challenges and prospects of 3D electrospun scaffolds are rationally discussed,providing an insight into developing the vibrant fields of biomedicine.

关键词： Electrospun Nanofibers Three-dimensional Tissue engineering Regenerative medicine scaffold Polymer

Improving simulations of sulfate aerosols during winter haze over Northern China： the impacts of heterogeneous oxidation by NO2

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Frontiers of Environmental science & Engineering 2016年第5期10卷 165-175页

作者： Meng Gao gregory R. Carmichael Yuesi Wang Dongsheng Ji Zirui Liu Zifa Wang Center for Global and Regional Environmental Research University of Iowa Iowa City IA 52242 USA state Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry (LAPC) Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China

We implemented the online coupled WRF-Chem model to reproduce the 2013 January haze event in North China, and evaluated simulated meteorological and chemical fields using multiple observations. The comparisons suggest that temperature and relative humidity （RH） were simulated well （mean biases are 0.2K and 2.7%, respectively）, but wind speeds were overestimated （mean bias is 0.5 m.s -1）. At the Beijing station, sulfur dioxide （sO2） concentrations were overpredicted and sulfhte concentrations were largely underpredicted, which may result from uncertainties in sO2 emissions and missing heterogeneous oxidation in current model. We conducted three parallel experiments to examine the impacts of doubling sO2 emissions and incorporating heterogeneous oxidation of dissolved sO2 by nitrogen dioxide （NO2） on sulfate formation during winter haze. The results suggest that doubling sO2 emissions do not significantly affect sulthte concentrations, but adding heterogeneous oxidation of dissolved sO2 by NO, substantially improve simulations of sulfate and other inorganic aerosols. Although the enhanced sO2 to sulfate conversion in the Hets （heterogeneous oxidation by NO2） case reduces sO2 concentrations, it is still largely overestimated by the model, indicating the overestimations of sO2 concentrations in the North China Plain （NCP） are mostly due to errors in sO2 emission inventory.

关键词： sulfate aerosols Winter haze WRF-Chem Northern China