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soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第9期20卷 2585-2586页

作者： Andrew gregory Chengyun Tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzheimer's disease(AD)and Alzheimer's diseaserelated dementias(ADRD)represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词： Alzheimer population. drug

High Temperature Iron Ethylene Polymerization Catalysts Bearing N,N,N'-2-(1-(2,4-Dibenzhydryl-6-fluorophenylimino)ethyl)-6-(1-(arylphenylimino)ethyl)pyridines

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Chinese Journal of Polymer science 2024年第2期42卷 188-201,I0007页

作者： Chantsalnyam Bariashir Qiu-Yue Zhang Bayasgalan Ulambayar gregory A.solan Tong-Ling Liang Wen-Hua sun Institute of Chemistry and Chemical Technology Mongolian Academy of SciencesUlaanbaatar13330Mongolia Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular science Institute of ChemistryChinese Academy of SciencesBeijing100190China Department of Chemistry University of LeicesterUniversity RoadLeicesterLE17RHUK state Key Laboratory for Oxo synthesis and selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China

The N,N,N'-ferrous chloride complexes,[2-{CMeN(2,4-(CHPh)_(2)-6-FC_(6)H_(2))}-6-(CMeNAr)C_(5)H_(3)N]FeCl_(2)(Ar=2,6-Me_(2)C_(6)H_(3) Fe1,2,6-Et_(2)C_(6)H_(3)Fe2,2,6-^(i)Pr_(2)C_(6)H_(3) Fe3,2,4,6-Me_(3)C_(6)H_(2) Fe4 and 2,6-Et_(2)-4-MeC_(6)H_(2) Fe5),each possessing one N-2,4-dibenzhydryl-6-fluorophenyl group,were readily synthesized from their respective unsymmetrical bis(imino)pyridines,*** identification of Fe2 highlighted the variation in the steric properties provided by the dissimilar N-aryl *** pre-treatment with either MAO or MMAO,complexes Fe1-Fe5 all displayed,at an operating temperature of 80℃,high activities for ethylene polymerization with levels falling in the order:Fe4> Fe1> Fe5> Fe2> ***,Fe4/MAO displayed the highest activity of 1.94×10^(7) g_(PE)·mol_(Fe)^(-1)·h^(-1) of the study with only a modest loss in performance at 90℃.Generally,the resulting polyethylenes were highly linear(T_(m) range:122-132℃),narrowly disperse and of low molecular weight(M_(w) range:6.73-46.04kg·mol^(-1)),with the most sterically hindered Fe3 forming the highest molecular weight polymer of the ***-group analysis by ^(1)H-and ^(13)CNMR spectroscopy revealed saturated alkyl(n-propyl and i-propyl) and unsaturated vinyl chain ends indicative of the role of both β-H elimination and chain transfer to aluminum as termination *** comparison with previou sly reported iron precatalysts with similar tridentate ligand skeletons,it is evident that the introduction of a large benzhydryl group in combination with a fluorine as the ortho-substituents of one N-aryl group has the effect of enhancing thermal stability of the iron polymerization catalyst whilst maintaining appreciable polymer molecular weight.

关键词： Iron catalyst Ethylene polymerization Linear polyethylene Fluoride effect Thermal stability

soluble epoxide hydrolase:a next-generation drug target for Alzheimer's disease and related dementias

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Neural Regeneration Research 2025年第09期 2585-2586页

作者： Andrew gregory Chengyun Tang Fan Fan Department of Physiology Medical College of GeorgiaAugusta University

Alzheimer's disease(AD) and Alzheimer's diseaserelated dementias(ADRD) represent a significant public health challenge,with projections indicating a substantial increase in affected individuals due to the aging global *** the World Health Organization,AD/ADRD has affected more than 55 million individuals worldwide,with an additional 10 million cases diagnosed each year.

关键词：

晶粒长大对高纯Al{111}/{111}近奇异晶界的影响

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金属学报 2024年第1期60卷 80-94页

作者：冯小铮王卫国 gregory s.Rohrer 陈松洪丽华林燕王宗谱周邦新福建理工大学晶界工程研究所福州350118 福建理工大学材料科学与工程学院福州350118 Department of Materials science and Engineering Carnegie Mellon UniversityPittsburghPA 15213-3890USA 上海大学材料研究所上海200072

{111}/{111}近奇异晶界较比一般晶界更耐蚀,如何提高此类晶界比例以显著提高Al及其合金晶界腐蚀抗力是一个新课题。本工作选用99.99%(质量分数)高纯Al为研究对象,考察晶粒长大对{111}/{111}近奇异晶界的影响。样品经室温多向锻造和370... 详细信息

{111}/{111}近奇异晶界较比一般晶界更耐蚀,如何提高此类晶界比例以显著提高Al及其合金晶界腐蚀抗力是一个新课题。本工作选用99.99%(质量分数)高纯Al为研究对象,考察晶粒长大对{111}/{111}近奇异晶界的影响。样品经室温多向锻造和370℃再结晶退火后,再经500℃保温不同时间,采用基于EBsD和五参数分析的晶界界面匹配表征方法对样品进行测试和分析。结果表明,随着晶粒长大,{111}/{111}近奇异晶界的比例显著增加。当平均晶粒尺寸由38μm长大至77μm时,{111}/{111}近奇异晶界的比例由3.91%增加至6.56%。离线原位EBsD和晶界迹线分析表明,晶粒长大过程中,{111}/{111}近奇异晶界主要通过具有/θ(θ为取向差转角)取向差关系的两两晶粒吞并周边晶粒并相遇后形成;具有/θ取向差关系的相邻晶粒,其晶界通过再取向调整至{111}/{111}位置,亦可形成此类近奇异晶界。{111}/{111}近奇异晶界存在旋错结构,其原子排列有序度显著高于一般晶界,这是此类晶界比一般晶界更耐蚀的原因。

关键词：高纯Al 晶粒长大近奇异晶界晶界界面匹配

高温压缩变形Al-Zn-Mg-Cu合金动态再结晶后的{111}/{111}近奇异晶界

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金属学报 2024年第9期60卷 1165-1178页

作者：刘光辉王卫国 gregory s Rohrer 陈松林燕童芳冯小铮周邦新福建理工大学晶界工程研究所福州350118 福建理工大学材料科学与工程学院福州350118 Department of Materials science and Engineering Carnegie Mellon UniversityPittsburghPA15213-3890USA 上海大学材料研究所上海200072

提高{111}/{111}近奇异晶界比例可增强Al-Zn-Mg-Cu合金晶界腐蚀抗力,为了解此类晶界形成机理并探索其调控方法,本工作将470℃、12 h和520℃、6 h双级固溶及冷轧后再结晶的Al-Zn-Mg-Cu合金样品分别在450、480和520℃进行应变速率为0.001 ... 详细信息

提高{111}/{111}近奇异晶界比例可增强Al-Zn-Mg-Cu合金晶界腐蚀抗力,为了解此类晶界形成机理并探索其调控方法,本工作将470℃、12 h和520℃、6 h双级固溶及冷轧后再结晶的Al-Zn-Mg-Cu合金样品分别在450、480和520℃进行应变速率为0.001 s^(-1)、真应变为1.20的压缩变形,压缩后立即水冷。采用电子背散射衍射和基于五参数分析的晶界界面匹配定量表征方法对上述3个样品的显微组织和晶界特征分布进行观察分析。结果表明,高温压缩后的显微组织不均匀,存在间隔分明的细晶组织和粗晶组织,其中细晶组织中的晶界以小角度晶界(LAGB)为主,粗晶组织中的晶界以大角度晶界(HAGB)为主;粗、细晶组织中的{111}/{111}近奇异晶界({111}/{111}-NsB)比例均随压缩温度的升高而增大,其中经520℃压缩的试样,其LAGB中的{111}/{111}-NsB占总晶界的比例为8.77%,HAGB中的{111}/{111}-NsB占总晶界的比例为4.53%。进一步考察各试样的应力-应变曲线以及450℃压缩30%时的显微组织特征可见,应变介于0.05~0.70为稳态流变阶段,主要发生初次动态再结晶(DRX),其主要由粗晶及其HAGB构成。应变介于0.70~1.20为二次硬化阶段,主要发生二次DRX,其中不连续DRX(DDRX)和连续DRX(CDRX)同时进行,且优先发生在某些微区;不论是DDRX因形核和核心长大生成的HAGB,还是CDRX因亚晶合并引入的LAGB,均使对应微区的晶粒细化,导致样品总体流变应力急剧上升。二次DRX阶段,CDRX行为随压缩温度的提高而增强,{111}/{111}-NsB比例也随之增加,特别是LAGB中的{111}/{111}-NsB比例快速增加。

关键词： Al-Zn-Mg-Cu合金近奇异晶界晶界界面匹配连续动态再结晶

轧制变形及再结晶00Cr12铁素体不锈钢中的{011}/{011}近奇异晶界

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中国科学：技术科学 2024年第3期54卷 459-476页

作者：黄新宇王卫国 ROHRER gregory s 徐刚陈松冯小铮张厚安陈文哲周邦新福建理工大学晶界工程研究所福州350118 福建理工大学材料科学与工程学院福州350118 Department of Materials science and Engineering Carnegie Mellon UniversityPittsburgh 15213-3890USA 厦门理工学院材料科学与工程学院厦门361024 上海大学材料研究所上海200072

不同于低层错能面心立方结构的奥氏体不锈钢,高层错能体心立方结构的铁素体不锈钢在形变及再结晶等组织重构过程中很难形成结构稳定且十分耐蚀的奇异晶界(共格孪晶界).研究{011}/{011}近奇异晶界的影响因素和形成机理,将有可能为改善铁... 详细信息

不同于低层错能面心立方结构的奥氏体不锈钢,高层错能体心立方结构的铁素体不锈钢在形变及再结晶等组织重构过程中很难形成结构稳定且十分耐蚀的奇异晶界(共格孪晶界).研究{011}/{011}近奇异晶界的影响因素和形成机理,将有可能为改善铁素体不锈钢,特别是低Cr铁素体不锈钢晶间腐蚀性能提供晶界工程新思路.本文选用经固溶处理和组织均匀化处理的00Cr12低Cr铁素体不锈钢为实验材料,5个平行试样分别在350℃,500℃,580℃,650℃和690℃进行厚度减缩量为70%的单向轧制变形后,立即进行750℃、2 h再结晶退火处理.使用基于电子背散射衍射和五参数分析的晶界界面匹配表征方法对上述样品进行测试和分析发现,轧制温度对00Cr12铁素体不锈钢再结晶{011}/{011}近奇异晶界比例有显著影响,再结晶后的{011}/{011}近奇异晶界比例随再结晶退火前轧制温度的升高先上升再下降,其中经650℃轧制的样品,其再结晶后{011}/{011}近奇异晶界比例达到极大值6.82%.取向分布函数(ODF)和重叠极图晶界迹线分析表明,经650℃轧制的样品,其再结晶组织中形成了强的{011}织构;具有{011}及其漫散取向的晶粒之间较多地存在/θ取向差关系(θ为绕的旋转角),其关联晶界为{011}/{011}近奇异晶界,这是经650℃轧制的样品,其再结晶后{011}/{011}近奇异晶界比例达到极大值的原因.离线原位表面侵蚀实验表明,{011}/{011}近奇异晶界的腐蚀抗力显著高于一般晶界.因此,基于本文研究结果,进一步调控并提高{011}/{011}近奇异晶界的比例将有助于从根本上显著改善00Cr12铁素体不锈钢晶间腐蚀性能.

关键词： 00Cr12铁素体不锈钢近奇异晶界晶界界面匹配晶间腐蚀

Criteria for selecting Carbon subsurface and Ocean storage site in Developing Countries: A Review

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American Journal of Climate Change 2024年第2期13卷 103-139页

作者： gregory Mwenketishi Hadj Benkreira Nejat Rahmanian school of Engineering Faculty of Engineering and Digital Technologies University of Bradford Bradford UK

Important first phases in the process of implementing CO2 subsurface and ocean storage projects include selecting of best possible location(s) for CO2 storage, and site selection evaluation. sites must fulfill a number of criteria that boil down to the following basics: they must be able to accept the desired volume of CO2 at the rate at which it is supplied from the CO2 source(s);they must as well be safe and reliable;and must comply with regulatory and other societal requirements. They also must have at least public acceptance and be based on sound financial analysis. site geology;hydrogeological, pressure, and geothermal regimes;land features;location, climate, access, etc. can all be refined from these basic criteria. In addition to aiding in site selection, site characterization is essential for other purposes, such as foreseeing the fate and impacts of the injected CO2, and informing subsequent phases of site development, including design, permitting, operation, monitoring, and eventual abandonment. According to data from the IEA, in 2022, emissions from Africa and Asias emerging markets and developing economies, excluding Chinas, increased by 4.2%, which is equivalent to 206 million tonnes of CO2 and were higher than those from developed economies. Coal-fired power generation was responsible for more than half of the rise in emissions that were recorded in the region. The difficulty of achieving sustainable socio-economic progress in the developing countries is entwined with the work of reducing CO2 emissions, which is a demanding project for the economy. Organisations from developing countries, such as Bangladesh, Cameroon, India, and Nigeria, have formed partnerships with organisations in other countries for lessons learned and investment within the climate change arena. The basaltic rocks, coal seams, depleted oil and gas reservoirs, soils, deep saline aquifers, and sedimentary basins that developing countries (Bangladesh, Cameroon, India, and Nigeria etc.

关键词： Aquifer CCUs site selection Carbon Dioxide Capture and storage (CCs) CO2 sequestration CCs Governmental Regulation CO2 Environment Impact Geological storage

室温和深冷轧制对纯Al再结晶{111}/{111}近奇异晶界的影响

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金属学报 2024年

作者：李振想王卫国 gregory s Rohrer 洪丽华陈松林燕周邦新福建理工大学材料科学与工程学院福建理工大学晶界工程研究所上海大学材料研究所 Department of Material science and Engineering Carnegie Mellon University

{111}/{111}近奇异晶界比一般晶界更耐蚀，研究此类晶界的形成条件、影响因素和生成机制，设法调控此类晶界并提高其比例是改善相关铝合金晶界腐蚀性能的根本途径。为了解铝合金生成{111}/{111}近奇异晶界的本征行为，本工作选择高纯Al ... 详细信息

{111}/{111}近奇异晶界比一般晶界更耐蚀，研究此类晶界的形成条件、影响因素和生成机制，设法调控此类晶界并提高其比例是改善相关铝合金晶界腐蚀性能的根本途径。为了解铝合金生成{111}/{111}近奇异晶界的本征行为，本工作选择高纯Al (99.99%)为实验材料，首先经室温反复多向锻造和370℃再结晶退火获得晶粒尺寸均匀、平均晶粒尺寸约为20μm且晶粒取向随机分布的组织均匀化初始样品；再将初始样品分别在室温(25℃)和-196℃深冷进行厚度减缩量为80%的轧制变形，及370℃、30 min再结晶退火处理。采用EBsD和基于五参数分析的晶界界面匹配定量表征方法对两样品进行测试和分析。结果表明，经-196℃深冷轧制并再结晶的样品，其{111}/{111}近奇异晶界比例达到6.0%，相比室温轧制并再结晶的样品提升了120%。XRD、EBsD及硬度结果表明，经室温和-196℃深冷轧制的样品中均形成了较强的{011}形变织构；较比室温轧制，经-196℃深冷轧制的样品内残余压应力更大，晶粒碎化更严重、储能更高。在后续370℃退火过程中，经室温和-196℃深冷轧制的样品，其再结晶机制均以{011}取向生长为主；较比于室温轧制，经-196℃深冷轧制的样品可提供更大的晶界迁移驱动力，其样品再结晶组织的平均晶粒尺寸更大且{011}再结晶织构更强。统计结果表明，{011}取向晶粒与其他取向的晶粒毗连所形成的晶界中存在较高比例的{111}/{111}近奇异晶界；同时，为{011}取向晶粒与其相邻的且具有{011}漫散取向的晶粒间也形成较多的{111}/{111}近奇异晶界，这是导致经-196℃深冷轧制及再结晶的样品中{111}/{111}近奇异晶界比例较高的主要原因。

关键词：高纯Al 深冷轧制近奇异晶界晶界界面匹配择尤取向

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science Bulletin 2024年第7期69卷 850-852页

作者：周晓东 gregory Y.H.Lip 郑明华 Department of Cardiovascular Medicine the Heart Centerthe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Liverpool Centre for Cardiovascular science at University of Liverpool Liverpool John Moores University and Liverpool Heart&Chest HospitalLiverpool L693BXUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark MAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Institute of Hepatology Wenzhou Medical UniversityWenzhou 325000China Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province Wenzhou 325000China

Heart failure with preserved ejection fraction(HFpEF)has an estimated incidence rate of approximately 27 cases per 10,000 person-year[1].Furthermore,the prevalence of HFpEF is on the rise and is expected to exceed that of heart failure with reduced ejection fraction(HFr EF)[2].In the near future,HFpEF is expected to become the predominant subtype of heart failure[2].

关键词： predominant fraction 射血分数保留型