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Seasonal Behavior of Aerosol Vertical Concentration in Dakar and Role Played by the Sea-Breeze

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Open Journal of Air Pollution 2020年第1期9卷 11-26页

作者： Habib Senghor éric Machu luis Durán gregory S. Jenkins Amadou Thierno Gaye laboratoire de Physique de l’Atmosphère et de l’Océan Siméon-Fongang (lPAO-SF) école Supérieure Polytechnique (ESP) Université Cheikh Anta Diop (UCAD) Dakar Sénégal laboratoire d’Océanographie Physique et Spatiale (lOPS) Institut Universitaire Européen de la Mer (IUEM) Plouzané France InterMET Madrid Spain Department of Meteorology and Atmospheric Science University Park State College PA USA

The Westward transport of mineral dust from the North Africa continent to Atlantic Ocean can produce poor air quality, low visibilities, and negatively impacting respiratory and cardiac health due to the optical and physical properties of aerosols. The dynamical impact of the sea-breeze on the dust vertical distribution in West Africa remains unknown. To investigate this issue, we have used in-situ measurements from lidar. We have focused on the attenuated backscatter of aerosols to study the effect of the local circulation on the vertical profile of mineral dust at land-sea transition. The results highlight a strong diurnal cycle of mineral dust associated with the nocturnal low-level jet (NllJ). The jet is located between 500 m and 1000 m and crucially affected by the dynamic of the sea-breeze circulation.

关键词： Aerosols Dust Sea-Breeze Circulation

Spontaneous Baroreflex Sensitivity in Normotensive African-American Men

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Open Journal of Molecular and Integrative Physiology 2019年第1期9卷 1-10页

作者： Peter l. latchman gregory J. Gates Robert Thiel Robert S. Axtell Weili Zhu Ally Morin-Viall Tianhong Yue Qin Yang Kenneth Gardner Ronald E. De Meersman Exercise Science Department Southern Connecticut State University New Haven CT USA Department of Pediatrics Albert Einstein College of Medicine Yeshiva University Bronx NY USA Capital University of Physical Education and Sports Beijing China G. C. Foster College of Physical Education and Sport Spanish Town Jamaica College of Medicine American University of Antigua Osbourn Antigua and Barbuda

Purpose: African-American men (AAM) have a greater risk of hypertension (HTN) than Caucasian men (CM). To reduce this risk, determining the differences in mechanisms involved in HTN and understanding the relationship between these mechanisms and factors affecting blood pressure (BP) in AAM and CM is necessary. One such mechanism is spontaneous baroreflex sensitivity (sBRS) and two factors are cardiorespiratory fitness (CRF) and arterial stiffness (AS). The aims of this study were to determine, firstly, whether there are differences in sBRS between young, normotensive AAM and CM, and secondly, to determine if CRF and AS are significant predictors of sBRS in young, normotensive AAM and CM. Methods: Twenty-three normotensive AAM and 36 CM were recruited from Southern Connecticut State University. Measures included anthropometric, sBRS (alpha-index), and CRF (maximal oxygen consumption [VO2max]), as well as AS (carotid-femoral pulse wave velocity [Cf-PWV]). Independent t-tests were used to determine differences between groups and multiple regression analysis was used to determine how much of the variation in sBRS was explained by CRF and AS. Results: The sBRS was significantly lower in AAM (10.3 ± 3.8 ms/mmHg) vs. CM (13.3 ± 5.7 ms/ mmHg), P = 0.03. CRF and AS were not significant predictors of sBRS in AAM (P = 0.25) and CM (P = 0.30). There was no relationship between, sBRS, CRF and AS;CRF was significantly reduced in AAM vs. CM (45.1 ± 6.3 vs. 52.1 ± 7.5 ml·kg?1·min?1, P ≤ 0.001). Conclusions: Young normotensive AAM demonstrated significantly lower sBRS vs. CM, irrespective of having fair CRF and normal BP. CRF and AS are not significant predictors of sBRS in young, normotensive AAM and CM. The attenuation in sBRS in AAM did not result in AAM having higher BP versus CM. This finding underscores the need for more detailed examination of the role of sBRS in the etiology of HTN in AAM.

关键词： African-American Men Spontaneous Baroreflex Sensitivity Cardiorespiratory Fitness Arterial Stiffness Hypertension

分子尺寸和形状对烷烃类聚合物热力学性质的影响

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分子尺寸和形状对烷烃类聚合物热力学性质的影响

Ⅲ期临床试验非盲延期阶段联合使用吡仑帕奈的局灶性癫痫患者的四年药物安全性、耐受性及发作结局:307号研究

2005年全国高分子学术论文报告会

作者：黄定海 Sindee l．Simon gregory B．McKenna 天津大学材料学院高分子材料与科学系 Department of Chemical Engineering Texas Tech UniversityLubbock79409 USA Department of Chemical Engineering Texas Tech UniversityLubbock79409 USA

＜正＞本文采用阶梯扫描DSC法对直链烷烃（从C5H12到C19H40）和环烷烃的热力学性质包括比热、相变熵等进行了精确的测定。同时还测量了直链和环状聚乙烯和聚苯乙烯的热力学性质。结果发现对于直链烷烃,在特定温度下平衡液态的比热随着... 详细信息

＜正＞本文采用阶梯扫描DSC法对直链烷烃（从C5H12到C19H40）和环烷烃的热力学性质包括比热、相变熵等进行了精确的测定。同时还测量了直链和环状聚乙烯和聚苯乙烯的热力学性质。结果发现对于直链烷烃,在特定温度下平衡液态的比热随着分子链长的增加而逐渐降低;当

关键词：分子尺寸比热相变熵热膨胀系数

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癫痫杂志 2020年第1期6卷 63-69页

作者： gregory l Krauss Emilio Perucca Patrick Kwan 覃英杰(译) 熊维希(审) 慕洁(审) 不详

评估307号研究(临床试验验证码:NCT00735397)Ⅲ期非盲延期阶段(OlEx)联合使用吡仑帕奈的局灶性癫痫患者的药物安全性、耐受性及痫性发作结局。患者在完成任一III期双盲试验后均可进入非盲延期阶段(Open-labelextension,OlEx)。对所有OlE... 详细信息

评估307号研究(临床试验验证码:NCT00735397)Ⅲ期非盲延期阶段(OlEx)联合使用吡仑帕奈的局灶性癫痫患者的药物安全性、耐受性及痫性发作结局。患者在完成任一III期双盲试验后均可进入非盲延期阶段(Open-labelextension,OlEx)。对所有OlEx队列中有同样最小吡伦帕奈暴露剂量的局灶性癫痫和继发全面性癫痫(Secondarily generalized seizures,SGS)的患者进行药物安全性及耐受性和痫性发作结局(每28 d中位痫性发作减少率、反应率和无发作率)的分析。另外,针对OlEx的早期失访进行了额外的敏感性分析。从1480例双盲试验中随机分组的患者共纳入1218例。大部分患者(65.4%~80.9%)仅用吡仑帕奈12 mg,每日一次,进行治疗,并在相同剂量下完成长期的检测,或是相对基线联合使用少量抗癫痫药物(AEDs)。长期的药物安全性及耐受性结果与双盲研究一致。导致超过1%的患者研究中断治疗的紧急不良反应事件(Treatment-emergent adverse events,TEAEs)包括眩晕、易激、疲劳。有临床意义的TEAEs稳定期为4年。所有队列中患者的痫性发作结局随时间持续改善。对于接受3年(n=436)、4年(n=78)药物治疗的患者28 d中位痫性发作减少率分别为62%、70.6%,相应的50%反应率为59.6%、67.9%。最大28 d中位痫性发作减少率发生于基线水平的SGS患者,接受3年(n=190)、4年(n=28)药物治疗分别为88.0%和100.0%。在这些队列中分别有40.0%和53.6%的患者达到了无SGS。排除早期失访后的28 d中位痫性发作减少率结果类似。长期吡仑帕奈联合用药(≤4年)不会导致新的药物安全性及耐受性问题,并且可以很大程度地减少痫性发作,特别是基线水平的SGS患者。

关键词：抗癫痫药物局灶性痫性发作长期安全性及耐受性吡仑帕奈继发全面性痫性发作

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用反循环法在荒漠地带和城市钻观测水井

西部探矿工程 1991年第4期3卷 35-37页

作者： Gerald Huerstel Gary l.Hix Frank Greyory David gregory 杜祥林

利用高于地面的移动循环槽的反循环钻进法,已被用来在美国西南部荒漠地区钻若干地下水观测水井,出于需要而研制出一种使钻探装备和工艺不寻常地结合起来,在变化较大的情况下从事观测水井钻进,它已经发展成为一种模式。样品收集良好而对... 详细信息

利用高于地面的移动循环槽的反循环钻进法,已被用来在美国西南部荒漠地区钻若干地下水观测水井,出于需要而研制出一种使钻探装备和工艺不寻常地结合起来,在变化较大的情况下从事观测水井钻进,它已经发展成为一种模式。样品收集良好而对环境影响最小证明了它的合理性。在改装后的菲灵(Failing)JED—A型钻机上增加四个长行程液压千斤顶,配有为气举反循环用的带空气管和丝扣连接的大直径钻管,浮动式转盘和为操作工人站立的操作台,证明这些改装都是成功的。这种钻探方法和装备已经在图森贝森(Tueson Basin)一地就钻了60多眼地下水观测井。

关键词：钻探水井观测反循环法

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基于自组织映射的增材制造中数据驱动式微观组织和显微硬度设计

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Engineering 2019年第4期 295-306页

作者：甘政涛李恒阳 Sarah J.Wolff Jennifer l.Bennett gregory Hyatt gregory J.Wagner 曹简 Wing Kam liu Department of Mechanical Engineering Northwestern University DMG MORI Hoffman Estates

为了在镍基高温合金的增材制造(AM)中设计微观组织和显微硬度,本研究提出了一种新的数据驱动方法,该方法结合了物理模型、实验测量和数据挖掘方法。该模拟基于计算热流体动力学(Ct FD)模型,可以获得热行为、凝固参数(如冷却速度)和凝固... 详细信息

为了在镍基高温合金的增材制造(AM)中设计微观组织和显微硬度,本研究提出了一种新的数据驱动方法,该方法结合了物理模型、实验测量和数据挖掘方法。该模拟基于计算热流体动力学(Ct FD)模型,可以获得热行为、凝固参数(如冷却速度)和凝固层的稀释率。根据计算出的热信息,可利用经过充分测试的力学模型估算枝晶臂间距和显微硬度。通过实验测定试样的微观结构和显微硬度,与模拟值进行比较验证。为了实现过程-组织-性能(PSP)关系的可视化,模拟及实验数据集被输入到数据挖掘模型——自组织映射(SOM)中。在多目标下,工艺参数的设计窗口可以从可视化映射中得到。这种被提出的方法可用于AM和其他数据密集型工艺过程。过程、组织和性能之间的数据驱动联系可能会有利于在线过程监控控制,从而获得理想的微观组织和力学性能。

关键词：增材制造数据科学多重物理建模自组织映射微观组织显微硬度镍基高温合金

The singer of tales / 2nd ed.

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Superior Conjugative Plasmids Delivered by Bacteria to Diverse Fungi

2000年

作者： Albert B. lord Stephen Mitchell and gregory Nagy

来源：畅想之星图书光盘版（南... 评论

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BioDesign Research 2022年第1期2022卷 151-165页

作者： Ryan R.Cochrane Arina Shrestha Mariana M.Severo de Almeida Michelle Agyare-Tabbi Stephanie l.Brumwell Samir Hamadache Jordyn S.Meaney Daniel P.Nucifora Henry Heng Say Jehoshua Sharma Maximillian P.M.Soltysiak Cheryl Tong Katherine Van Belois Emma J.l.Walker Marc-Andrélachance gregory B.Gloor David R.Edgell Rebecca S.Shapiro Bogumil J.Karas Department of Biochemistry Schulich School of Medicine and DentistryThe University of Western OntarioLondonONCanada N6A 5C1 Department of Molecular and Cellular Biology University of GuelphGuelphONCanada N1G 2W1 Department of Biology The University of Western OntarioLondonOntarioCanada N6A 5B7

Fungi are nature’s recyclers,allowing for ecological nutrient cycling and,in turn,the continuation of life on *** fungi inhabit the human microbiome where they can provide health benefits,while others are opportunistic pathogens that can cause ***,members of the fungal kingdom,have been domesticated by humans for the production of beer,bread,and,recently,medicine and ***,the great untapped potential exists within the diverse fungal ***,many yeasts are intractable,preventing their use in biotechnology or in the development of novel treatments for pathogenic ***,as a first step for the domestication of new fungi,an efficient DNA delivery method needs to be ***,we report the creation of superior conjugative plasmids and demonstrate their transfer via conjugation from bacteria to 7 diverse yeast species including the emerging pathogen Candida *** create our superior plasmids,derivatives of the 57 kb conjugative plasmid pTA-Mob 2.0 were built using designed gene deletions and insertions,as well as some unintentional ***,a cluster mutation in the promoter of the conjugative gene traJ had the most significant effect on improving conjugation to *** addition,we created Golden Gate assembly-compatible plasmid derivatives that allow for the generation of custom plasmids to enable the rapid insertion of designer genetic ***,we demonstrated that designer conjugative plasmids harboring engineered restriction endonucleases can be used as a novel antifungal agent,with important applications for the development of next-generation antifungal therapeutics.

关键词： insertion continuation harbor

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完美风暴

汽车与运动 2015年第1期 84-85页

作者： HENRY CATCHPOlE NICK TROTT BEN MI l lER RICHARD MEADEN ASTON PARROTT GUS gregory

2014十佳年度性能车的面对面较量即将展开,为了这场难得一遇的碰撞,我们等来了一个典型的英国式"风暴"天气。但无论如何,令人垂涎的evo年度性能车头衔只有一个,不如我们赌上—把?

关键词：令人垂涎英国式 “风暴”

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