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lipopolysaccharide Modified liposomes for Amyotropic lateral Sclerosis Therapy: Efficacy in SOD1 Mouse Model

2004 7th International Conference on Solid-State and Integrated Circuits Technology（ICSICT 2004）

作者： gregory l.Snider Alexei O.Orlov Ravi Kummamuru John Timler Geza Toth Gary H.Bernstein Craig S.lent Department of Electrical Engineering University of Notre DameNotre DameIN 46556

＜正＞An introduction to of quantum-dot cellular automata （QCA） is *** is a transistorless nanoelectronic computation paradigm that addresses the issues of device and power density which are becoming increasingly important in the electronics *** of CMOS is expected to come to an end in the next 10-15 years,with perhaps the most important limiting problem being the power density and the resulting heat generated. QCA offers the possibility of circuitry that dissipates many orders of magnitude less power than CMOS,is scalable to molecular dimensions,and provides the power gain necessary to restore signal *** cells are scalable to molecular dimensions and initial measurements have demonstrated single-electron switching within a molecule.

关键词： Quantum dots Quantum cellular automata Polarization Electrons FETs Stationary state Nanoscale devices Switches Power engineering computing Electronics industry

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Advances in Nanoparticles 2012年第3期1卷 44-53页

作者： Nicholas J. Wiley A. B. Madhankumar Ryan M. Mitchell Elizabeth B. Neely Elias Rizk gregory l. Douds Zachary Simmons James R. Connor Department of Neurology Pennsylvania State University College of Medicine/Milton S. Hershey Medical Center Hershey USA George M. leader Family laboratory Department of Neurosurgery Pennsylvania State University College of Medicine/Milton S. Hershey Medical Center Hershey USA

Activation of microglia is a histological feature observed in neurodegenerative diseases like AlS. The oral administration of minocycline has been demonstrated to have minimal neuroprotection ability in the animal models and is also associated with inadvertent toxicity due to non-specific oral absorption of the drug. Nonetheless, the drug itself shows promise in a number of disease models suggesting it could be effective if delivered optimally. Thus, we utilized lPS modified liposomes to target TlR4 receptor on the microglia in SOD1G93A mice and compared its efficacy with non- targeted nanoliposomes. The in vitro results indicate that targeting the TlR4 receptor on microglia significantly increases (p G93A mouse model of AlS, targeted and non-targeted minocycline treatment significantly increased (p G93A mice, the non- targeted nanovesicles significantly increased the latency to rotarod failure and both targeted and non-targeted nanovesicles significantly delayed disease endpoints.

关键词： Amyotrophic lateral Sclerosis Minocycline liposomes Microglia TlR4 lipopolysaccharides

Intentionality as Creativity: A Communicological Critique of Muddle-Headed Mindfulness in Pragmatics of Human Communication

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language and Semiotic Studies 2019年第1期5卷 21-44页

作者： Richard l.lanigan International Communicology Institute

Jürgen Ruesch and gregory Bateson were dedicated to the research paradigm that asserts the successful Axiom of Communication Theory: The Intentionality Code of "You Both Can And Cannot Communicate"(Make up Your Mind and Change Your Mind—You can learn!). Ruesch and Bateson's axiomatic view of Codes critiques the failed Intentionality Messages, i.e., the failed Postulate of Information Theory: The Behavior of "You Cannot Not Communicate" raised to the status of a fetish in the American speech communication discipline by the publication of Paul Watzlawick, Janet Helmick Beavin, and Don J. Jackson, Pragmatics of Human Communication: A Study of Interactional Patterns, Pathologies, and Paradoxes(New York, NY: W. W. Norton & Co., Inc., 1967). Although dedicated "To gregory Bateson, Friend and Mentor", this book(hereafter cited as WBJ) is not co-authored by Bateson and its publication was vigorously opposed by him for many reasons, including the argument of the present analysis that shows a fundamental misunderstanding and gross misapplication of Information Theory(Shannon & Weaver) in place of Communication Theory(Weiner & Bateson) and the mathematical logic(Edmund Husserl & Bertrand Russell) upon which the distinction is based.

关键词： Bateson Watzlawick Communicology creativity Double Bind pragmatics

Plant Programmed Cell Death Caused by an Autoactive Form of Prf Is Suppressed by Co-Expression of the Prf lRR Domain

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Molecular Plant 2012年第5期5卷 1058-1067页

作者： Xinran Du Min Miao Xinrong Ma Yongsheng liu Joseph C. Kuhl gregory B. Martin Fangming Xiao Department of Plant. Soil and Entomoloqical Sciences University of Idaho Moscow ID 83844. USA Ministry of Education Key laboratory for Bio-Resource and Eco-Environment College of Life Science and State Key Laboratory of Hydraulics and Mountain River Engineering Sichuan University Chengdu 610064 China Chengdu Institute of Biology Chinese Academia of Sciences Chengdu 610064 China School of Biotechnology and Food Engineering Hefei University of Technology Hefei 230009 China Boyce Thompson Institute for Plant Research and Department of Plant Pathology and Plant-Microbe Biology Cornell University Ithaca NY 14853 USA

In tomato, the NBARC-lRR resistance （R） protein Prf acts in concert with the Pto or Fen kinase to determine immunity against Pseudomonas syringae pv. tomato （Pst）. Prf-mediated defense signaling is initiated by the recognition of two sequence-unrelated Pst-secreted effector proteins, AvrPto and AvrPtoB, by tomato Pto or Fen. Prf detects these inter- actions and activates signaling leading to host defense responses including localized programmed cell death （PCD） that is associated with the arrest of Pst growth. We found that Prf variants with single amino acid substitutions at D1416 in the IHD motif （isoleucine-histidine-aspartic acid） in the NBARC domain cause effector-independent PCD when transiently expressed in leaves of Nicotiana benthamiana, suggesting D1416 plays an important role in activation of Prf. The N-ter- minal region of Prf （NPrf） and the lRR domain are required for this autoactive Prf cell death signaling but dispensable for accumulation of the PrfD1416V protein. Significantly, co-expression of the Prf lRR but not NPrf, with PrfD1416v, AvrPto/Pto, AvrPtoB/Pto, an autoactive form of Pro （PtoY207D）, or Fen completely suppresses PCD. However, the Prf lRR does not in- terfere with PCD caused by Rpi-blblD475v a distinct R protein-mediated PCD signaling event, or that caused by overex- pression of MAPKKKα, a protein acting downstream of Prf. Furthermore, we found the PrfD1416V protein is unable to accumulate in plant cells when co-expressed with the Prf lRR domain, likely explaining the cell death suppression. The mechanism for the lRR-induced degradation of PrfD1416V is unknown but may involve interference in the intramo- lecular interactions of Prf or to binding of the unattached lRR to other host proteins that are needed for Prf stability.

关键词： NBARC-lRR resistance protein Prf Pto Fen AvrPto AvrPtoB cell death.

人免疫缺陷病毒Ⅰ型gag、env、rev mRNA检测

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中华检验医学杂志 2002年第5期25卷 296-298页

作者：姜拥军尚红康辉 gregory F.Burton 王亚男中国医科大学第一临床学院艾滋病研究室沈阳110001 UT Brigham Young University

目的　动态检测人免疫缺陷病毒Ⅰ型 (HIV 1)基因gag、env、revmRNA水平。方法　将插入有HIV 1竞争模板的pSPI质粒DNA转化入感受态菌STBl 2 ,进行扩增。以T7RNA聚合酶体外转录出HIV 1mRNA竞争模板。用 3对引物对HIV 1RNA标本进行定量竞... 详细信息

目的　动态检测人免疫缺陷病毒Ⅰ型 (HIV 1)基因gag、env、revmRNA水平。方法　将插入有HIV 1竞争模板的pSPI质粒DNA转化入感受态菌STBl 2 ,进行扩增。以T7RNA聚合酶体外转录出HIV 1mRNA竞争模板。用 3对引物对HIV 1RNA标本进行定量竞争聚合酶链反应 (QC RT PCR) ,检测HIV 1gag、env、revmRNA水平。结果　HIV 1ⅢB感染的标本中 ,HIV 1gag、env和revmRNA的水平分别为 36 0 0 0拷贝 / μl,980 0拷贝 / μl和 910 0拷贝 / μl。此方法可动态定量检测HIV 1gag、env、revmRNA水平。结论　该方法简便易行 ,费用低廉 ,适用于实验室HIV致病机理、药物筛选和病毒复制状况的研究。

关键词：人免疫缺陷病毒-Ⅰ 病毒基因信使核糖核酸艾滋病 AIDS

本土化压力管理与心身增弹训练(SMART-C)对提升教师心理弹性与睡眠质量的作用研究

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世界睡眠医学杂志 2018年第7期5卷 808-812页

作者：王芳冯帆 John W.Denniger Herbert Benson gregory l.Fricchione 中国中医科学院广安门医院睡眠心理科北京100053 哈佛大学医学院麻省总医院本森亨利心身医学研究所波士顿02114

目的:探索本土化压力管理心身增弹训练(SMART-C)对于教师群体的应对压力能力以及睡眠质量的改善作用,为进一步完善压力情绪管理应用于教育方案(RS-C)提供依据。方法:通过本土化压力管理心身增弹训练(SMART-C)对北京市东城区38位教师进... 详细信息

目的:探索本土化压力管理心身增弹训练(SMART-C)对于教师群体的应对压力能力以及睡眠质量的改善作用,为进一步完善压力情绪管理应用于教育方案(RS-C)提供依据。方法:通过本土化压力管理心身增弹训练(SMART-C)对北京市东城区38位教师进行干预,采用心理弹性量表、匹兹堡睡眠质量指数判定效果。结果:参与团体的教师在心理弹性的忍受消极情感和精神影响方面有所改善,睡眠方面在睡眠质量、入睡时间、睡眠时间、睡眠效率、日间功能等方面所有改善。结论:本土化压力管理心身增弹训练(SMART-C)对于教师群体的应对压力能力以及睡眠质量有改善作用。

关键词：本土化压力管理与心身增弹训练教师心身弹性睡眠质量

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视觉心理学 1

视觉心理学

本土化压力管理与心身增弹训练(SMART-C)对提升教师心理弹性与睡眠质量的作用研究

丛书名：世界大学丛书

1986年

作者：（英）格列高里（gregory R.l.）彭聃龄杨__译

本书介绍了视觉心理学的基本知识

ISBN: (纸本)7243·328

本书介绍了视觉心理学的基本知识

关键词：视觉

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世界睡眠医学杂志 2017年第7期 808-812页

作者：王芳冯帆 John W.Denniger Herbert Benson gregory l.Fricchione

关键词：本土化压力管理与心身增弹训练教师心身弹性睡眠质量

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正常阴道分娩后肛门括约肌的定量肌电图评价

世界核心医学期刊文摘（妇产科学分册） 2005年第9期1卷 40-41页

作者： gregory W.T. Stuyvesant A. Clark A.l. 王雅楠 Obstetrics and Gynecology Div. Urogynecol./Reconstr. Pelvic S. Oregon Health and Science University 3181 SW Sam Jackson Park Road Portland OR 97239 United States Dr.

OBJECTIVE: Fecal incontinence in women is thought to be associated with sphi nc ter laceration or pudendal nerve damage. A prolonged pudendal nerve terminal mot or latency is evidence of profound nerve damage, but pudendal nerve terminal mot or latency can be normal even when nerve injury has been sustained. We performed quantitative electromyography (EMG) to compare multiple motor unit action poten tial parameters between recently postpartum women and nulliparous women. METHODS : Standardized examinations were prospectively performed on 2 groups: 1) healthy nulliparous women without pelvic floor disorders (n=28) and 2) asymptomatic wom en who were postpartum following vaginal delivery of their first child (n = 23). The examinations included pelvic organ prolapse quantification measurements, e ndoanal ultrasonography, pudendal nerve terminal motor latency, sacral reflexes, and concentric needle EMG using multiple motor unit action potential analysis. RESUlTS: A mean of 11.5 (standard deviation [SD] 1.1) weeks had elapsed since fi rst vaginal deliveries in the postpartum group. The mean fetal weight at deliver y was 3,495 (SD 458) grams. There were no sphincter defects seen by ultrasonogra phy. Compared with the nulliparous women, pudendal nerve terminal motor latency and sacral reflexes (clitoral-anal reflex, urethral-anal reflex) were not incr eased in the postpartum group. Each of the quantitative parameters (duration, am plitude, area, turns, and phases), measured from motor unit action potentials in the postpartum group, were larger than in the nulliparous group (P ≤.004, nest ed analysis of variance [ANOVA]). CONClUSION: Quantitative EMG using multiple mo tor unit action potential analysis can detect the presence after vaginal childbi rth of subtle nerve injury not demonstrable by pudendal nerve terminal motor lat ency. Even asymptomatic women show evidence of pelvic floor nerve injury after u ncomplicated deliveries.

关键词：阴道分娩会阴神经电冲动经产妇未产妇正常分娩盆腔器官动作电位大便失禁常规检查