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Morphodynamic signatures derived from daily surface elevation dynamics can explain the morphodynamic development of tidal flats

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Water Science and Engineering 2023年第1期16卷 14-25页

作者： Tim j.Grandjean jaco C.de Smit jim van Belzen gregory S.Fivash jeroen van Dalen Tom Ysebaert Tjeerd j.Bouma Department of Estuarine and Delta Systems Royal Netherlands Institute for Sea Research(NIOZ)4401 NT YersekeThe Netherlands Faculty of Geosciences Department of Physical GeographyUtrecht University3508 TC UtrechtThe Netherlands

Understanding the sensitivity of tidal flats to environmental changes is ***,most studies rely on process-based models to systematically explain the morphodynamic evolution of tidal *** this study,we proposed an alternative empirical approach to explore tidal flat dynamics using statistical indices based on long-term time series of daily surface elevation *** elevation dynamic(SED)indices focus on the magnitude and period of surface elevation changes,while morphodynamic signature(MDS)indices relate sediment dynamics to environmental *** statistical analyses were applied to an intervention site in the Netherlands to determine the effect of recently constructed groynes on the tidal *** these analyses,we were able to(1)detect a reduction in the daily SED and(2)determine that the changes in the daily SED were predominantly caused by the reduction in wave impact between the groynes rather than the reduction in tidal ***,the presented results showed that the combination of novel statistical indices provides new insights into the trajectories of tidal flats,ecosystem functioning,and sensitivity to physical drivers(wind and tides).Finally,we suggested how the SED and MDS indices may help to explore the future trajectories and climate resilience of intertidal habitats.

关键词： Surface elevation dynamics Tidal flat trajectories Morphodynamic development Morphodynamic signature Bed level dynamics

Determinants of the impact of blood pressure variability on neurological outcome after acute ischaemic stroke

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Stroke & Vascular Neurology 2017年第1期2卷 1-6页

作者： Adam de Havenon Alicia Bennett gregory j Stoddard Gordon Smith Lee Chung Steve O’Donnell j Scott McNally David Tirschwell jennifer j Majersik Department of Neurology University of UtahSaltLake CityUtahUSA University of Utah SaltLake CityUtahUSA University of Washington SeattleWashingtonUSA

Introduction: Increased blood pressure variability (BPV) is detrimental after acute ischaemic stroke, but the interaction between BPV and neuroimaging factors that directly influence stroke outcome has not been explored. Methods: We retrospectively reviewed inpatients from 2007 to 2014 with acute anterior circulation ischaemic stroke, CT perfusion and angiography at hospital admission, and a modified Rankin Scale (MRS) 30- 365 days after stroke onset. BPV indices included SD, coefficient of variation and successive variation of the systolic blood pressure between 0 and 120 hours after admission. Ordinal logistic regression models were fitted to MRS with predictor variables of BPV indices. Models were further stratified by CT perfusion volumetric measurements, proximal vessel occlusion and collateral score. Results: 110 patients met the inclusion criteria. The likelihood of a 1-point rise in the MRS increased with every 10 mm Hg increase in BPV (OR for the 3 BPV indices ranged from 2.27 to 5.54), which was more pronounced in patients with larger ischaemic core volumes (OR 8.37 to 18.0) and larger hypoperfused volumes (OR 6.02 to 15.4). This association also held true for patients with larger mismatch volume, proximal vessel occlusion and good collateral vessels. Conclusions: These results indicate that increased BPV is associated with worse neurological outcome after stroke, particularly in patients with a large lesion core volume, concurrent viable ischaemic penumbra, proximal vessel occlusion and good collaterals. This subset of patients, who are often not candidates for or fail acute stroke therapies such as intravenous tissue plasminogen activator or endovascular thrombectomy, may benefit from interventions aimed at reducing BPV.

关键词： impaired perfusion cerebral

Ordered SrTiO_3 Nanoripples Induced by Focused Ion Beam

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Nano-Micro Letters 2012年第4期4卷 243-246页

作者： jiang Wu Gang Chen Zhaoquan Zeng Shibin Li Xingliang Xu Zhiming M.Wang gregory j.Salamo State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of China Institute of Intelligent Optoelectronic Technology Zhejiang University of Technology Institute for Nanoscience and Engineering University of Arkansas

Ordered nanoripples on the niobium-doped SrTiO_3 surfaces were fabricated through focused ion beam bombardment. The surface morphology of the SrTiO_3 nanoripples was characterized using in situ focused ion beam/scanning electron microscopy. The well-aligned SrTiO_3 nanostructures were obtained under optimized ion irradiation conditions. The characteristic wavelength was measured as about 210 nm for different ion beam currents. The relationship between the ion irradiation time and current and SrTiO_3 surface morphology was analyzed. The presented method will be an effective supplement for fabrication of SrTiO_3 nanostructures that can be used for ferroelectric and electronic applications.

关键词： SrTiO3 focused ion beam nanoripple self-assembly

A survey of high resolution image processing techniques for cereal crop growth monitoring

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Information Processing in Agriculture 2022年第2期9卷 300-315页

作者： Sanaz Rasti Chris j.Bleakley N.M.Holden Rebecca Whetton David Langton gregory O’Hare School of Computer Science University College DublinDublinIreland School of Agriculture and Food Science University College DublinDublinIreland School of Biosystems and Food Engineering University College DublinDublinIreland Origin Enterprises plc DublinIreland

This paper presents a survey of image processing techniques proposed in the literature forextracting key cereal crop growth metrics from high spatial resolution, typically proximalimages. The descriptive crop growth metrics considered are: crop canopy cover, aboveground biomass, leaf area index (including green area index), chlorophyll content, andgrowth stage. The paper includes an overview of relevant fundamental image processingtechniques including camera types, colour spaces, colour indexes, and image segmentation. The descriptive crop growth metrics are defined. Reference methods for groundtruth measurement are described. Image processing methods for metric estimation aredescribed in detail. The performance of the methods is reviewed and compared. The surveyreveals limitations in image processing techniques for cereal crop monitoring such as lackof robustness to lighting conditions, camera position, and self-obstruction. Directions forfuture research to improve performance are identified.

关键词： Crop canopy cover Above ground biomass Leaf area index Chlorophyll content Growth stage Cereal image processing

GoldCLIP： Gel-omitted Ligation-dependent CLIP

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Genomics, Proteomics & Bioinformatics 2018年第2期16卷 136-143页

作者： jiaqi Gu Ming Wang Yang Yang Ding Qiu Yiqun Zhang jinbiao Ma Yu Zhou gregory j. Hannon Yang Yu State Key Laboratory of Genetic Engineering Department of Biochemistry School of Life Sciences Fudan University Shanghai 200438 China CAS Key Laboratory of RNA Biology Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China Hubei Key Laboratory of Cell Homeostasis College of Life Sciences Wuhan University Wuhan 430072 China Cancer Research UK Li Ka Shing Centre University of Cambridge Cambridge CB2 ORE United Kingdom

Protein-RNA interaction networks are essential to understand gene regulation control. Identifying binding sites of RNA-binding proteins （RBPs） by the UV-crosslinking and immunoprecipitation （CLIP） represents one of the most powerful methods to map protein RNA interactions in vivo. However, the traditional CLIP protocol is technically challenging, which requires radioactive labeling and suffers from material loss during PAGE-membrane transfer procedures. Here we introduce a super-efficient CLIP method （GoldCLIP） that omits all gel purification steps. This nonisotopic method allows us to perform highly reproducible CLIP experiments with polypyrimidine tract-binding protein （PTB）, a classical RBP in human cell lines. In principle, our method guarantees sequencing library constructions, providing the protein of interest can be successfully crosslinked to RNAs in living cells. GoldCLIP is readily applicable to diverse proteins to uncover their endogenous RNA targets.

关键词： RNA binding protein UV crosslinking CLIP HaloTag PTB

Variation in resource competition traits among Microcystis strains is affected by their microbiomes

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mLife 2023年第4期2卷 401-415页

作者： Dylan Baker Casey M.Godwin Muhtamim Khanam Ashley M.Burtner gregory j.Dick Vincent j.Denef Department of Ecology and Evolutionary Biology University of MichiganAnn ArborMichiganUSA Cooperative Institute for Great Lakes Research School for Environment and SustainabilityUniversity of MichiganAnn ArborMichiganUSA Department of Earth and Environmental Sciences University of MichiganAnn ArborMichiganUSA

Freshwater harmful algal blooms are often dominated by Microcystis,a phylogenetically cohesive group of cyanobacteria marked by extensive genetic and physiological *** have previously shown that this genetic diversity and the presence of a microbiome of heterotrophic bacteria influences competitive interactions with eukaryotic *** this study,we sought to explain these observations by characterizing Monod equation parameters for resource usage(maximum growth rateμmax,half-saturation value for growth Ks,and quota)as a function of N and P levels for four strains(NIES-843,PCC 9701,PCC 7806[WT],and PCC 7806ΔmcyB)in presence and absence of a microbiome derived from Microcystis isolated from Lake *** indicated limited differences in maximum growth rates but more pronounced differences in half-saturation values among Microcystis *** largest impact of the microbiome was reducing the minimal nitrogen concentration sustaining growth and reducing half saturation values,with variable results depending on the Microcystis *** strains also differed from each other in their N and P quotas and the extent to which microbiome presence affected *** data highlight the importance of the microbiome in altering Microcystis-intrinsic traits,strain competitive hierarchies,and thus bloom *** quota,μmax,and Ks are commonly used in models for harmful algal blooms,our data suggest that model improvement may be possible by incorporating genotype dependencies of resource-use parameters.

关键词： cultivation-dependent fitness harmful algal blooms host-microbe interactions phytoplankton

Circumcision of Infants and Children: Short-Term Trauma and Long-Term Psychosexual Harm

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Advances in Sexual Medicine 2015年第2期5卷 22-38页

作者： gregory j. Boyle Australian Institute of Psychology Fortitude Valley Queensland Australia

Non-therapeutic infant male circumcision is a permanent surgical alteration to the penis that may cause significant physical, sexual and psychological harm. Physical harms include unintended adverse effects of the surgery itself (e.g., complications such as bleeding, infection, excessive removal of foreskin leaving insufficient shaft skin to accommodate erections, etc.), as well as the inherent loss of healthy, functional tissue. Sexual harms that necessarily follow from circumcision include the loss of all sensation in the foreskin itself, and the loss of all sexual functions that involve the physical manipulation of the foreskin. Additional sexual harms that may follow circumcision include reduced sexual sensation in the remaining penile structures, difficulty with masturbation, increased chafing in both the circumcised man and his sexual partner, as well as reduced overall psychosexual/psychological tension relief and subjective satisfaction. Psychological harms include short-term trauma as well as the potential for long-term emotional disturbances, including sadness, frustration, distress, and anger—akin to post-traumatic stress disorder (PTSD). In this paper, the extent and severity of these various harms are considered and it is argued that they are more serious and more widespread than is commonly believed.

关键词： Circumcision Sexual Reduction Surgery Circumcision-Related Deaths Male Genital Mutilation

Does Male Circumcision Adversely Affect Sexual Sensation, Function, or Satisfaction? Critical Comment on Morris and Krieger (2013)

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Advances in Sexual Medicine 2015年第2期5卷 7-12页

作者： gregory j. Boyle Australian Institute of Psychology Fortitude Valley Queensland Australia

Morris and Krieger (2013) have argued that male circumcision does not impact adversely on sexual sensation, satisfaction, and/or function. In the present paper, it is argued that such a view is untenable. By selectively citing Morris’ own non-peer-reviewed letters and opinion pieces purporting to show flaws in studies reporting evidence of negative effects of circumcision, and by failing adequately to account for replies to these letters by the authors of the original research (and others), Morris and Krieger give an incomplete and misleading account of the available literature. Consequently, Morris and Krieger reach an implausible conclusion that is inconsistent with what is known about the anatomy and functions of the penile foreskin, and the likely effects of its surgical removal.

关键词： Circumcision Sexual Dysfunction

China＇s ＂Peaceful Rise＂： Rhetoric or Reality7

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Fudan journal of the Humanities and Social Sciences 2010年第4期3卷 132-137页

作者： gregory j. Moore

With the astonishing growth in China＇s economy over the past thirty years and the concomitant growth in China＇s power and influence in international affairs have come a number of new ＂China＇s rise＂ books, for very understandable reasons. Among the more notable examples are those by Taylor Fravel, David Kang and David （Mike） Lampton,

关键词：中国经济发展发展战略市场分析