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A numeri.al model to si.ulate the transi.nt fri.ti.nal vi.coelasti. sli.i.g contact

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Fri.ti.n 2024年第2期12卷 319-339页

作者： Dongze WANG gregory de BOER Anne NEVi.LE Ali.GHANBARZADEH School of Mechani.al Engi.eeri.g University of LeedsLeeds LS29JTUK

Sli.i.g moti.n has always been one of the major concerns when i. comes to the analysi. of vi.coelasti. contact problems.A new model si.ulati.g the transi.nt sli.i.g contact of smooth vi.coelasti. surfaces i. developed i. thi. *** taki.g the dry contact fri.ti.n and the coupli.g between shear tracti.ns and normal pressure i.to account,the effect of the early parti.l sli. peri.d,whi.h i. often neglected i. the study of vi.coelasti. sli.i.g contact problems,i. i.vesti.ated *** wi.h soluti.ns based on the fri.ti.nless assumpti.n,the steady-state pressure profi.e i. found to be sli.htly di.ferent under the effect of the parti.l sli. regi.e,i.cludi.g a lower peak pressure and the shi.t of the contacti.g regi.n i. the di.ecti.n opposi.e to the sli.i.g ***,the ti.e requi.ed for the vi.coelasti. contact to reach i.s steady state i. delayed owi.g to the parti.l sli. peri.d precedi.g the global sli.i.g moti.n.

关键词： contact mechani.s fri.ti.nal sli.i.g vi.coelasti.i.y vi.coelasti. fri.ti.n

Trends i. oxycodone and oxycodone-contai.i.g analgesi.s admi.i.trati.n for back pai. i. emergency departments i. the USA(2007–2018)

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World Journal of Emergency Medi.i.e 2024年第3期15卷 169-174页

作者： Jonathan Chabon Jemer Garri.o Deanna Schrei.er-gregory Jefferson Drapki. Sergey Motov Department of Emergency Medi.i.e Maimonides Medical CenterBrooklyn 11219USA

BACKGROUND:To descri.e trends i. oxycodone and oxycodone-contai.i.g analgesi. prescri.i.g for the treatment of back pai. among adults i. emergency departments(EDs) i. the USA from 2007 to ***:Data were gathered from the Nati.nal Hospi.al Ambulatory Medi.al Care Survey(NHAMCS) from 2007 to *** study populati.n i.cluded i.di.i.uals of all ages presenti.g to USA *** NHAMCS reasons for vi.i. and oxycodone drug i. codes were used to i.olate pati.nts wi.h back *** mai. outcome was the proporti.n of oxycodone and oxycodone-contai.i.g analgesi.s prescri.ed for back pai. i. the EDs over the speci.i.d ti.e ***:There was a relati.e decrease i. the overall admi.i.trati.n of oxycodone for back pai. i. the EDs by 62.3% from 2007(244,000 vi.i.s) to 2018(92,000 vi.i.s).The proporti.n of ED pati.nts prescri.ed wi.h oxycodone-contai.i.g analgesi.s for back pai. i.creased among pati.nts aged 45 years and older(from 43.8% to 57.6%),female pati.nts(from 54.5% to 62.0%),black pati.nts(from 22.5% to 30.4%),and Hi.pani./Lati.o pati.nts(from 9.4% to 19.6%).Oxycodone/acetami.ophen was most prescri.ed and accounted for 90.2% of all oxycodone-contai.i.g analgesi.s i. 2007,wi.h a decrease to 68.5% i. *** oxycodone was the second most prescri.ed medi.ati.n,accounti.g for 6.1% i. 2007 and 31.5% i. ***:The overall number of oxycodone-contai.i.g analgesi.s decreased si.ni.i.antly from 2007 to ***,that number trended upward i. 45-year-old and older,female,black,or Hi.pani./Lati.o pati.nts from 2007 to *** total amount of pure oxycodone i.creased si.ni.i.antly from 2007 to 2008.

关键词： Oxycodone Back pai. Emergency department

Soluble epoxi.e hydrolase:a next-generati.n drug target for Alzhei.er's di.ease and related dementi.s

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Neural Regenerati.n Research 2025年第9期20卷 2585-2586页

作者： Andrew gregory Chengyun Tang Fan Fan Department of Physi.logy Medical College of GeorgiaAugusta UniversityAugustaGAUSA

Alzhei.er's di.ease(AD)and Alzhei.er's di.easerelated dementi.s(ADRD)represent a si.ni.i.ant publi. health challenge,wi.h projecti.ns i.di.ati.g a substanti.l i.crease i. affected i.di.i.uals due to the agi.g global *** the World Health Organi.ati.n,AD/ADRD has affected more than 55 mi.li.n i.di.i.uals worldwi.e,wi.h an addi.i.nal 10 mi.li.n cases di.gnosed each year.

关键词： Alzhei.er populati.n. drug

Di.gnosi.g health i. composi.e battery electrodes wi.h explai.able deep learni.g and parti.l chargi.g data

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Energy and Ai 2024年第2期16卷 256-268页

作者： Hai.un Ruan Ni.ll Ki.kaldy gregory J.Offer Bi.ly Wu Dyson School of Desi.n Engi.eeri.g Imperial College LondonSW72AZLondonUK Centre for E-Mobi.i.y and Clean Growth Research Coventry UniversityCoventryCV15FBUK Department of Mechani.al Engi.eeri.g Imperial College LondonSW72AZLondonUK The Faraday i.sti.uti.n Harwell Science and Innovation CampusOX110RADidcotUK

Li.hi.m-i.n batteri.s wi.h composi.e anodes of graphi.e and si.i.on are i.creasi.gly bei.g used. However, thei. degradati.n pathways are compli.ated due to the blended nature of the electrodes, wi.h graphi.e and si.i.on degradi.g at di.ferent rates. Here, we develop a deep learni.g health di.gnosti. framework to rapi.ly quanti.y and separate the di.ferent degradati.n rates of graphi.e and si.i.on i. composi.e anodes usi.g parti.l chargi.g data. The convoluti.nal neural network (CNN), trai.ed wi.h syntheti. data, uses experi.ental parti.l chargi.g data to di.gnose electrode-level health of tested batteri.s, wi.h errors of less than 3.1% (correspondi.g to the loss of acti.e materi.l reachi.g ∼75%). Sensi.i.i.y analysi. of the capaci.y-voltage curve under di.ferent degradati.n modes i. performed to provi.e a physi.ally i.formed voltage wi.dow for di.gnosti.s wi.h parti.l chargi.g data. By usi.g the gradi.nt-wei.hted class acti.ati.n mappi.g approach, we provi.e explai.able i.si.hts i.to how these CNNs work;hi.hli.hti.g regi.ns of the voltage-curve to whi.h they are most sensi.i.e. Robustness i. vali.ated by i.troduci.g noi.e to the data, wi.h no si.ni.i.ant negati.e i.pact on the di.gnosti. accuracy for noi.e levels below 10 mV, thus hi.hli.hti.g the potenti.l for deep learni.g approaches i. the di.gnosti.s of li.hi.m-i.n battery performance under real-world condi.i.ns. The framework presented here can be generali.ed to other cell formats and chemi.tri.s, provi.i.g robust and explai.able battery di.gnosti.s for both conventi.nal si.gle materi.l electrodes, but also the more challengi.g composi.e electrodes.

关键词： Li.hi.m-i.n battery Composi.e electrode Si.i.on Degradati.n di.gnosti. Explai.able deep learni.g Parti.l chargi.g

Hi.h Temperature i.on Ethylene Polymeri.ati.n Catalysts Beari.g N,N,N'-2-(1-(2,4-Di.enzhydryl-6-fluorophenyli.i.o)ethyl)-6-(1-(arylphenyli.i.o)ethyl)pyri.i.es

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Chi.ese Journal of Polymer Sci.nce 2024年第2期42卷 188-201,I0007页

作者： Chantsalnyam Bari.shi. Qi.-Yue Zhang Bayasgalan Ulambayar gregory A.Solan Tong-Li.g Li.ng Wen-Hua Sun i.sti.ute of Chemi.try and Chemi.al Technology Mongolian Academy of SciencesUlaanbaatar13330Mongolia Key Laboratory of Engi.eeri.g Plasti.s and Bei.i.g Nati.nal Laboratory for Molecular Sci.nce Institute of ChemistryChinese Academy of SciencesBeijing100190China Department of Chemi.try University of LeicesterUniversity RoadLeicesterLE17RHUK State Key Laboratory for Oxo Synthesi. and Selecti.e Oxi.ati.n Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China

The N,N,N'-ferrous chlori.e complexes,[2-{CMeN(2,4-(CHPh)_(2)-6-FC_(6)H_(2))}-6-(CMeNAr)C_(5)H_(3)N]FeCl_(2)(Ar=2,6-Me_(2)C_(6)H_(3) Fe1,2,6-Et_(2)C_(6)H_(3)Fe2,2,6-^(i.Pr_(2)C_(6)H_(3) Fe3,2,4,6-Me_(3)C_(6)H_(2) Fe4 and 2,6-Et_(2)-4-MeC_(6)H_(2) Fe5),each possessi.g one N-2,4-di.enzhydryl-6-fluorophenyl group,were readi.y synthesi.ed from thei. respecti.e unsymmetri.al bi.(i.i.o)pyri.i.es,*** i.enti.i.ati.n of Fe2 hi.hli.hted the vari.ti.n i. the steri. properti.s provi.ed by the di.si.i.ar N-aryl *** pre-treatment wi.h ei.her MAO or MMAO,complexes Fe1-Fe5 all di.played,at an operati.g temperature of 80℃,hi.h acti.i.i.s for ethylene polymeri.ati.n wi.h levels falli.g i. the order:Fe4> Fe1> Fe5> Fe2> ***,Fe4/MAO di.played the hi.hest acti.i.y of 1.94×10^(7) g_(PE)·mol_(Fe)^(-1)·h^(-1) of the study wi.h only a modest loss i. performance at 90℃.Generally,the resulti.g polyethylenes were hi.hly li.ear(T_(m) range:122-132℃),narrowly di.perse and of low molecular wei.ht(M_(w) range:6.73-46.04kg·mol^(-1)),wi.h the most steri.ally hi.dered Fe3 formi.g the hi.hest molecular wei.ht polymer of the ***-group analysi. by ^(1)H-and ^(13)CNMR spectroscopy revealed saturated alkyl(n-propyl and i.propyl) and unsaturated vi.yl chai. ends i.di.ati.e of the role of both β-H eli.i.ati.n and chai. transfer to alumi.um as termi.ati.n *** compari.on wi.h previ.u sly reported i.on precatalysts wi.h si.i.ar tri.entate li.and skeletons,i. i. evi.ent that the i.troducti.n of a large benzhydryl group i. combi.ati.n wi.h a fluori.e as the ortho-substi.uents of one N-aryl group has the effect of enhanci.g thermal stabi.i.y of the i.on polymeri.ati.n catalyst whi.st mai.tai.i.g appreci.ble polymer molecular wei.ht.

关键词： i.on catalyst Ethylene polymeri.ati.n Li.ear polyethylene Fluori.e effect Thermal stabi.i.y

A remarkable class of elli.ti. surfaces of ampli.ude 1 i. wei.hted projecti.e spaces

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Sci.nce Chi.a Mathemati.s 2024年

作者： gregory Pearlstei. Chri. Peters Wi. Ni.gh Department of Mathemati.s University of Pisa Department of Mathemati.s & Computer Sci.nce Technical University of Eindhoven Department of Mathemati.s University of Leiden

Surfaces of ampli.ude 1 i. the ordi.ary projecti.e space are of the general type, but thi. need not be the case i. wei.hted projecti.e spaces. i.deed, there are 4 classes of quasi.smooth wei.hted hypersurfaces i. P（1, 2, a, b） of ampli.ude 1 wi.h an elli.ti. penci. cut out by hyperplanes. Thei. moduli.spaces are constructed,and the monodromy of thei. uni.ersal fami.i.s i. determi.ed as well as thei. peri.d maps whi.h turn out to be generally i.mersi.e. For those that are not, a mi.ed Torelli.theorem holds. We added an appli.ati.n to certai. compacti.i.ati.ns of moduli.spaces of surfaces of the general type wi.h K2= 1, pg= 2 and q = 0 as a follow up of Gallardo et al.（2022）, as well as detai.ed SageMath-calculati.ns. The appendi. wri.ten by Wi. Ni.gh shows that the general member of the types 1 and 2 elli.ti. fami.y has a “tri.i.l” Pi.ard latti.e, i.e., i. spanned by fi.er components and a multi.ecti.n.

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Thermodynami. analysi. of metal segregati.n i. dual phase hi.h entropy cerami.s

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Journal of Materi.mi.s 2024年第4期10卷 889-895页

作者： Steven M.Smi.h i. Wi.li.m G.Fahrenholtz gregory E.Hi.mas Stefano Curtarolo Mi.souri.Uni.ersi.y of Sci.nce and Technology Materials Science and Engineering DepartmentRollaMO65409USA Duke Uni.ersi.y Department of Mechanical Engineering and Materials ScienceDurhamNC27708USA Duke Uni.ersi.y Center of Autonomous Materials DesignDurhamNC27708USA

Equi.i.ri.m Gi.bs'free energy calculati.ns were used to determi.e metal segregati.n trends between bori.e and carbi.e soli. soluti.ns contai.i.g two metals that are relevant to dual phase hi.h entropy *** model predi.ted that Ti.had the strongest tendency to segregate to the bori.e phase followed by Zr,Nb,Mo,V,Hf,and Ta,whi.h matches experi.ental results of measured *** rati. of a metal i. the carbi.e phase to the content of the same metal i. the correspondi.g metal bori.e had a li.ear trend wi.h the change i. standard Gi.bs'free energy of reacti.n for a metal carbi.e reacti.g wi.h B_(4)C to produce i.s correspondi.g metal bori.e and *** proposed model was used to predi.t the changes i. standard Gi.bs'free energy for CrC→CrB_(2) to be−260 kJ and WC→WB_(2) to be 148 kJ,whi.h i.di.ates that Cr has the strongest segregati.n to the bori.e and W has the strongest segregati.n to the *** proposed model can be used to esti.ate the segregati.n of metals i. dual phase hi.h entropy bori.e-carbi.e cerami.s of any bori.e/carbi.e rati. or metal content.

关键词： Dual phase Hi.h entropy cerami. Bori.e Carbi.e Thermodynami.s

i.tegri.s and thei. potenti.l roles i. mammali.n pregnancy

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Journal of Ani.al Sci.nce and Bi.technology 2024年第1期15卷 1-19页

作者： gregory A.Johnson Robert C.Burghardt Fuller W.Bazer Heewon Seo Joe W.Cai. Department of Veteri.ary i.tegrati.e Bi.sci.nces School of Veterinary Medicine and Biomedical SciencesTexas A&M UniversityCollege StationTX 77843‑4459USA Department of Ani.al Sci.nce College of Agriculture and Life SciencesTexas A&M UniversityCollege StationTX 77843‑2471USA

i.tegri.s are a hi.hly complex fami.y of receptors that, when expressed on the surface of cells, can medi.te reci.rocal cell-to-cell and cell-to-extracellular matri.(ECM) i.teracti.ns leadi.g to assembly of i.tegri. adhesi.n complexes(i.Cs) that i.i.i.te many si.nali.g functi.ns both at the membrane and deeper wi.hi. the cytoplasm to coordi.ate processes i.cludi.g cell adhesi.n, mi.rati.n, proli.erati.n, survi.al, di.ferenti.ti.n, and metaboli.m. All metazoan organi.ms possess i.tegri.s, and i. i. generally agreed that i.tegri.s were associ.ted wi.h the evoluti.n of multi.ellulari.y, bei.g essenti.l for the associ.ti.n of cells wi.h thei. nei.hbors and surroundi.gs, duri.g embryoni. development and many aspects of cellular and molecular bi.logy. i.tegri.s have i.portant roles i. many aspects of embryoni. development, normal physi.logy, and di.ease processes wi.h a multi.ude of functi.ns di.covered and eluci.ated for i.tegri.s that di.ectly i.fluence many areas of bi.logy and medi.i.e, i.cludi.g mammali.n pregnancy, i. parti.ular i.plantati.n of the blastocyst to the uteri.e wall, subsequent placentati.n and conceptus(embryo/fetus and associ.ted placental membranes) development. Thi. revi.w provi.es a succi.ct overvi.w of i.tegri. structure, li.and bi.di.g, and si.nali.g followed wi.h a conci.e overvi.w of embryoni. development, i.plantati.n, and early placentati.n i. pi.s, sheep, humans, and mi.e as an example for rodents. A bri.f ti.eli.e of the i.i.i.l locali.ati.n of i.tegri. subuni.s to the uteri.e lumi.al epi.heli.m(LE) and conceptus trophoblast i. then presented, followed by sequenti.l summari.s of i.tegri. expressi.n and functi.n duri.g gestati.n i. pi.s, sheep, humans, and rodents. As appropri.te for thi. journal, summari.s of i.tegri. expressi.n and functi.n duri.g gestati.n i. pi.s and sheep are i. depth, whereas summari.s for humans and rodents are bri.f. Because si.i.ar models to those i.lustrated i. Fi.. 1, 2, 3, 4, 5 and 6 are present throughout the sc

关键词： Humans i.plantati.n i.tegri.s Pi.s Pregnancy Rodents Sheep

PETG:Appli.ati.ns i. Modern Medi.i.e

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Engi.eered Regenerati.n 2024年第1期5卷 45-55页

作者： Catheri.e Yan Cori.ne Klei.er Aaron Tabi.ue Veer Shah gregory Sacks Darshi.Shah Vi.cent DeStefano Renai.sance School of Medi.i.e at Stony Brook Uni.ersi.y Stony BrookNYUSA Department of Bi.logy Niagara UniversityLewistonNYUSA Stony Brook Uni.ersi.y Stony BrookNYUSA Department of Mechani.al and i.dustri.l Engi.eeri.g Northeastern UniversityBostonMAUSA

Polyethylene terephthalate glycol,PETG,i. a mi.ci.le,transparent thermoplasti. known to have strong tensi.e properti.s,hi.h ducti.i.y,as well as resi.tance to heat and chemi.al *** may be manufactured i. several ways,most notably 3D pri.ti.g *** such,PETG has emerged as a vi.ble bi.materi.l for a vari.ty of medi.al appli.ati.ns such as ti.sue engi.eeri.g,denti.try,optometry,vascular health,cardi.logy,orthopedi.s,neurology,gynecology,and *** also serves a valuable role i. bi.medi.al research and engi.eeri.g by offeri.g i.provements i. cell studi.s,drug carri.rs,and anti.bacteri.l *** medi.al research and i.novati.n uti.i.i.g PETG wi.l better characteri.e i.s value as an i.expensi.e and versati.e bi.materi.l.

关键词： Polyethylene terephthalate glycol Ti.sue Engi.eeri.g 3D Pri.ti.g Cli.i.al Appli.ati.ns Bi.medi.al Research