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Optical tissue clearing enables rapid,precise and comprehensive assessment of three-dimensional morphology in experimental nerve regeneration research

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Neural Regeneration Research 2022年第6期17卷 1348-1356页

作者： Simeon C.Daeschler Jennifer Zhang Tessa Gordon gregory h.borschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Indiana University School of Medicine IndianapolisINUSA

Morphological analyses are key outcome assessments for nerve regeneration studies but are historically limited to tissue *** optical tissue clearing techniques enabling three-dimensional imaging of entire organs at a subcellular resolution have revolutionized morphological studies of the *** extend their applicability to experimental nerve repair studies we adapted these techniques to nerves and their motor and sensory targets in *** solvent-based protocols rendered harvested peripheral nerves and their target organs transparent within 24 hours while preserving tissue architecture and *** optical clearing was compatible with conventional laboratory techniques,including retrograde labeling studies,and computational image segmentation,providing fast and precise cell ***,optically cleared organs enabled three-dimensional morphometry at an unprecedented scale including dermatome-wide innervation studies,tracing of intramuscular nerve branches or mapping of neurovascular *** their wide-ranging applicability,rapid processing times,and low costs,tissue clearing techniques are likely to be a key technology for next-generation nerve repair *** procedures were approved by the hospital for Sick Children’s Laboratory Animal Services Committee(49871/9)on November 9,2019.

关键词： histology image segmentation morphometry nerve regeneration outcome assessment peripheral nerve three-dimensional imaging tissue clearing

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Science Bulletin 2024年第7期69卷 850-852页

作者：周晓东 gregory Y.h.Lip 郑明华 Department of Cardiovascular Medicine the Heart Centerthe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Liverpool Centre for Cardiovascular Science at University of Liverpool Liverpool John Moores University and Liverpool Heart&Chest HospitalLiverpool L693BXUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark MAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China Institute of hepatology Wenzhou Medical UniversityWenzhou 325000China Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province Wenzhou 325000China

heart failure with preserved ejection fraction(hFpEF)has an estimated incidence rate of approximately 27 cases per 10,000 person-year[1].Furthermore,the prevalence of hFpEF is on the rise and is expected to exceed that of heart failure with reduced ejection fraction(hFr EF)[2].In the near future,hFpEF is expected to become the predominant subtype of heart failure[2].

关键词： predominant fraction 射血分数保留型

high Temperature Iron Ethylene Polymerization Catalysts Bearing N,N,N'-2-(1-(2,4-Dibenzhydryl-6-fluorophenylimino)ethyl)-6-(1-(arylphenylimino)ethyl)pyridines

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Chinese Journal of Polymer Science 2024年第2期42卷 188-201,I0007页

作者： Chantsalnyam Bariashir Qiu-Yue Zhang Bayasgalan Ulambayar gregory A.Solan Tong-Ling Liang Wen-hua Sun Institute of Chemistry and Chemical Technology Mongolian Academy of SciencesUlaanbaatar13330Mongolia Key Laboratory of Engineering Plastics and Beijing National Laboratory for Molecular Science Institute of ChemistryChinese Academy of SciencesBeijing100190China Department of Chemistry University of LeicesterUniversity RoadLeicesterLE17RHUK State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou730000China

The N,N,N'-ferrous chloride complexes,[2-{CMeN(2,4-(ChPh)_(2)-6-FC_(6)h_(2))}-6-(CMeNAr)C_(5)h_(3)N]FeCl_(2)(Ar=2,6-Me_(2)C_(6)h_(3) Fe1,2,6-Et_(2)C_(6)h_(3)Fe2,2,6-^(i)Pr_(2)C_(6)h_(3) Fe3,2,4,6-Me_(3)C_(6)h_(2) Fe4 and 2,6-Et_(2)-4-MeC_(6)h_(2) Fe5),each possessing one N-2,4-dibenzhydryl-6-fluorophenyl group,were readily synthesized from their respective unsymmetrical bis(imino)pyridines,*** identification of Fe2 highlighted the variation in the steric properties provided by the dissimilar N-aryl *** pre-treatment with either MAO or MMAO,complexes Fe1-Fe5 all displayed,at an operating temperature of 80℃,high activities for ethylene polymerization with levels falling in the order:Fe4> Fe1> Fe5> Fe2> ***,Fe4/MAO displayed the highest activity of 1.94×10^(7) g_(PE)·mol_(Fe)^(-1)·h^(-1) of the study with only a modest loss in performance at 90℃.Generally,the resulting polyethylenes were highly linear(T_(m) range:122-132℃),narrowly disperse and of low molecular weight(M_(w) range:6.73-46.04kg·mol^(-1)),with the most sterically hindered Fe3 forming the highest molecular weight polymer of the ***-group analysis by ^(1)h-and ^(13)CNMR spectroscopy revealed saturated alkyl(n-propyl and i-propyl) and unsaturated vinyl chain ends indicative of the role of both β-h elimination and chain transfer to aluminum as termination *** comparison with previou sly reported iron precatalysts with similar tridentate ligand skeletons,it is evident that the introduction of a large benzhydryl group in combination with a fluorine as the ortho-substituents of one N-aryl group has the effect of enhancing thermal stability of the iron polymerization catalyst whilst maintaining appreciable polymer molecular weight.

关键词： Iron catalyst Ethylene polymerization Linear polyethylene Fluoride effect Thermal stability

高温压缩变形Al-Zn-Mg-Cu合金动态再结晶后的{111}/{111}近奇异晶界

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金属学报 2024年第9期60卷 1165-1178页

作者：刘光辉王卫国 gregory S Rohrer 陈松林燕童芳冯小铮周邦新福建理工大学晶界工程研究所福州350118 福建理工大学材料科学与工程学院福州350118 Department of Materials Science and Engineering Carnegie Mellon UniversityPittsburghPA15213-3890USA 上海大学材料研究所上海200072

提高{111}/{111}近奇异晶界比例可增强Al-Zn-Mg-Cu合金晶界腐蚀抗力,为了解此类晶界形成机理并探索其调控方法,本工作将470℃、12 h和520℃、6 h双级固溶及冷轧后再结晶的Al-Zn-Mg-Cu合金样品分别在450、480和520℃进行应变速率为0.001 ... 详细信息

提高{111}/{111}近奇异晶界比例可增强Al-Zn-Mg-Cu合金晶界腐蚀抗力,为了解此类晶界形成机理并探索其调控方法,本工作将470℃、12 h和520℃、6 h双级固溶及冷轧后再结晶的Al-Zn-Mg-Cu合金样品分别在450、480和520℃进行应变速率为0.001 s^(-1)、真应变为1.20的压缩变形,压缩后立即水冷。采用电子背散射衍射和基于五参数分析的晶界界面匹配定量表征方法对上述3个样品的显微组织和晶界特征分布进行观察分析。结果表明,高温压缩后的显微组织不均匀,存在间隔分明的细晶组织和粗晶组织,其中细晶组织中的晶界以小角度晶界(LAGB)为主,粗晶组织中的晶界以大角度晶界(hAGB)为主;粗、细晶组织中的{111}/{111}近奇异晶界({111}/{111}-NSB)比例均随压缩温度的升高而增大,其中经520℃压缩的试样,其LAGB中的{111}/{111}-NSB占总晶界的比例为8.77%,hAGB中的{111}/{111}-NSB占总晶界的比例为4.53%。进一步考察各试样的应力-应变曲线以及450℃压缩30%时的显微组织特征可见,应变介于0.05~0.70为稳态流变阶段,主要发生初次动态再结晶(DRX),其主要由粗晶及其hAGB构成。应变介于0.70~1.20为二次硬化阶段,主要发生二次DRX,其中不连续DRX(DDRX)和连续DRX(CDRX)同时进行,且优先发生在某些微区;不论是DDRX因形核和核心长大生成的hAGB,还是CDRX因亚晶合并引入的LAGB,均使对应微区的晶粒细化,导致样品总体流变应力急剧上升。二次DRX阶段,CDRX行为随压缩温度的提高而增强,{111}/{111}-NSB比例也随之增加,特别是LAGB中的{111}/{111}-NSB比例快速增加。

关键词： Al-Zn-Mg-Cu合金近奇异晶界晶界界面匹配连续动态再结晶

轧制变形及再结晶00Cr12铁素体不锈钢中的{011}/{011}近奇异晶界

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中国科学：技术科学 2024年第3期54卷 459-476页

作者：黄新宇王卫国 ROhRER gregory S 徐刚陈松冯小铮张厚安陈文哲周邦新福建理工大学晶界工程研究所福州350118 福建理工大学材料科学与工程学院福州350118 Department of Materials Science and Engineering Carnegie Mellon UniversityPittsburgh 15213-3890USA 厦门理工学院材料科学与工程学院厦门361024 上海大学材料研究所上海200072

不同于低层错能面心立方结构的奥氏体不锈钢,高层错能体心立方结构的铁素体不锈钢在形变及再结晶等组织重构过程中很难形成结构稳定且十分耐蚀的奇异晶界(共格孪晶界).研究{011}/{011}近奇异晶界的影响因素和形成机理,将有可能为改善铁... 详细信息

不同于低层错能面心立方结构的奥氏体不锈钢,高层错能体心立方结构的铁素体不锈钢在形变及再结晶等组织重构过程中很难形成结构稳定且十分耐蚀的奇异晶界(共格孪晶界).研究{011}/{011}近奇异晶界的影响因素和形成机理,将有可能为改善铁素体不锈钢,特别是低Cr铁素体不锈钢晶间腐蚀性能提供晶界工程新思路.本文选用经固溶处理和组织均匀化处理的00Cr12低Cr铁素体不锈钢为实验材料,5个平行试样分别在350℃,500℃,580℃,650℃和690℃进行厚度减缩量为70%的单向轧制变形后,立即进行750℃、2 h再结晶退火处理.使用基于电子背散射衍射和五参数分析的晶界界面匹配表征方法对上述样品进行测试和分析发现,轧制温度对00Cr12铁素体不锈钢再结晶{011}/{011}近奇异晶界比例有显著影响,再结晶后的{011}/{011}近奇异晶界比例随再结晶退火前轧制温度的升高先上升再下降,其中经650℃轧制的样品,其再结晶后{011}/{011}近奇异晶界比例达到极大值6.82%.取向分布函数(ODF)和重叠极图晶界迹线分析表明,经650℃轧制的样品,其再结晶组织中形成了强的{011}织构;具有{011}及其漫散取向的晶粒之间较多地存在/θ取向差关系(θ为绕的旋转角),其关联晶界为{011}/{011}近奇异晶界,这是经650℃轧制的样品,其再结晶后{011}/{011}近奇异晶界比例达到极大值的原因.离线原位表面侵蚀实验表明,{011}/{011}近奇异晶界的腐蚀抗力显著高于一般晶界.因此,基于本文研究结果,进一步调控并提高{011}/{011}近奇异晶界的比例将有助于从根本上显著改善00Cr12铁素体不锈钢晶间腐蚀性能.

关键词： 00Cr12铁素体不锈钢近奇异晶界晶界界面匹配晶间腐蚀

Forecast hesitancy: Why are People Reluctant to Believe, Accept, or Respond to Various Weather, Water, and Climate hazard-Related Forecasts?

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International Journal of Disaster Risk Science 2021年第4期12卷 600-609页

作者： Michael h.Glantz gregory E.Pierce Consortium for Capacity Building(CCB) Institute for Arctic and Alpine Research(INSTAAR)University of ColoradoBoulderCO80301USA

Current discussions of the social phenomenon of“vaccine hesitancy”with regard to Covid-19 provide an opportunity to use hesitancy as a means to shift thinking about untimely and delayed responses to forecasts of hydrometeorological ***,that is,provides a paradigm through which such regrettably delayed responses to hydromet hazards might be better understood and effectively *** exaggeration,just about every hydromet event provides an example of how hesitancy hinders individual,community,and national government risk-reducing preventive and mitigative responses to forecasts of foreseeable,relatively near-term climate,water,or weather *** for such hesitancy(for vaccine and forecast use alike)include—among others—lack of trust in the science,lack of confidence in government,and persistent concern about the uncertainties that surround forecasting—both meteorological and public *** such,a better understanding of the causes that lead to individual and group hesitancy can better inform hydromet forecasters and affected communities about ways in which beneficial actions in response to timely forecasts are often *** better understanding will facilitate,where necessary,targeted interventions to enhance the societal value of forecasting by reducing this long-observed challenge of“forecast hesitancy.”First,this article focuses on incidents of“vaccine hesitancy”that,for various reasons,people around the world are even now experiencing with regard to several now-available,and confirmed efficacious,Covid-19 *** of such incidents of indecisiveness first increased dramatically over the first few months of 2021,despite the strong scientific confidence that vaccination would significantly lower personal risk of contracting as well as spreading the ***,the notion of forecast hesitancy with regard to hydrometeorological hazards is discussed.

关键词： Disaster risk reduction Forecast Forecast hesitancy hesitancy hydromet hazards Vaccine hesitancy

Oral anti-coagulants use in Chinese hospitalized patients with atrial fibrillation

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Chinese Medical Journal 2024年第2期137卷 172-180页

作者： Jing Lin Deyong Long Chenxi Jiang Caihua Sang Ribo Tang Songnan Li Wei Wang Xueyuan Guo Man Ning Zhaoqing Sun Na Yang Yongchen hao Jun Liu Jing Liu Xin Du Louise Morgan Gregg C.Fonarow Sidney C.Smith Jr gregory Y.h.Lip Dong Zhao Jianzeng Dong Changsheng Ma On behalf of CCC-AF investigators Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China National Clinical Research Center for Cardiovascular Diseases Beijing 100029 China Department of Epidemiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of HeartLung and Blood Vessel DiseasesBeijing 100029China International Quality Improvement Department American Heart AssociationDallasTX 07076USA Division of Cardiology Geffen School of Medicine at University of CaliforniaLos Angeles CA 90024USA Division of Cardiology University of North CarolinaChapel HillNC 27599USA Department of Cardiology Liverpool Centre for Cardiovascular ScienceUniversity of Liverpool and Liverpool Heart&Chest HospitalLiverpool L143PEUK Department of Clinical Medicine Aalborg UniversityAalborg 9000Denmark 不详

Background:Oral anti-coagulants(OAC)are the intervention for the prevention of stroke,which consistently improve clinical outcomes and survival among patients with atrial fibrillation(AF).The main purpose of this study is to identify problems in OAC utilization among hospitalized patients with AF in ***:Using data from the Improving Care for Cardiovascular Disease in China-Atrial Fibrillation(CCC-AF)registry,guideline-recommended OAC use in eligible patients was ***:A total of 52,530 patients with non-valvular AF were enrolled from February 2015 to December 2019,of whom 38,203 were at a high risk of stroke,9717 were at a moderate risk,and 4610 were at a low *** admission,only 20.0%(6075/30,420)of patients with a diagnosed AF and a high risk of stroke were taking *** use of pre-hospital OAC on admission was associated with a lower risk of new-onset ischemic stroke/transient ischemic attack among the diagnosed AF population(adjusted odds ratio:0.54,95%confidence interval:0.43-0.68;Pharge,the prescription rate of OAC was 45.2%(16,757/37,087)in eligible patients with high stroke risk and 60.7%(2778/4578)in eligible patients with low stroke *** utilization in patients with high stroke risk on admission or at discharge both increased largely over time(all Phowed that OAC utilization at discharge was positively associated with in-hospital rhythm control strategies,including catheter ablation(adjusted odds ratio[OR]11.63,95%confidence interval[CI]10.04-13.47;Phythmic drug use(adjusted OR 1.45,95%CI 1.38-1.53;Phospitals participated in the CCC-AF project,>70%of AF patients were at a high risk of *** poor performance on guideline-recommended OAC use was found in this study,over time the CCC-AF project has made progress in stroke prevention in the Chinese AF ***

关键词： Atrial fibrillation Oral anti-coagulants OAC Stroke prevention Contraindication

Covariation in Insular Life-history Traits of the Rice Frog(Fejervarya limnocharis)in Eastern China

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Asian herpetological Research 2013年第1期4卷 28-35页

作者： Feng XU gregory h.ADLER Yiming LI Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of Sciences Key Laboratory of Biogeography and Bioresource in Arid Land Xinjiang Institute of Ecology and GeographyChinese Academy of Sciences Department of Biology and Microbiology University of Wisconsin-Oshkosh

Although shifts in life-history traits of insular vertebrates, as compared with mainland populations, have been observed in many taxa, few studies have examined the relationships among individual life-history traits on islands. Lifehistory theory also predicts that there is a trade-off between body size and reproductive effort, and between egg size and clutch size. We surveyed the rice frog, Fejervarya limnocharis, on 20 islands within the Zhoushan Archipelago and two nearby sites on the mainland of China to compare differences in life-history traits and to explore relationships among those traits. Rice frog females reached a greater body size on half of the smaller islands among the total 20 surveyed islands, and larger egg size, decreased clutch size and reduced reproductive effort on most of the islands when compared to the two mainland sites. Insular body size was negatively correlated with reproductive effort. There was a negative correlation between egg size and clutch size. Results suggest that life-history theory provides a good explanation for co-variation between body size and reproductive effort, and between egg size and clutch size in rice frogs on the islands.

关键词： island syndrome life-history traits trade-off body size egg size clutch size reproductive effort

Facile synthesis of nanosized sodium magnesium hydride,NaMgh3

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Progress in Natural Science:Materials International 2013年第3期23卷 343-350页

作者： hazel Reardon Natalia Mazur Duncan h.gregory WestChEM School of ChemistryJoseph Black BuildingUniversity of GlasgowGlasgow G12 8QQ ScotlandUK Department of Materials Science and Engineering Norwegian University of Science and TechnologyN-7491 TrondheimNorway

The ternary magnesium hydride NaMgh 3 has been synthesised via reactive milling *** method employed neither a reactive h2 atmosphere nor high pressure sintering or other post-treatment *** formation of the ternary hydride was studied as a function of milling time and ball:powder *** purity NaMgh 3 powder(orthorhombic space group Pnma,a 5.437(2),b 7.705(5),c 5.477(2) ;Z 4) was prepared in 5 h at high ball:powder ratios and characterised by powder X-ray diffraction(PXD),Raman spectroscopy and scanning electron microscopy/energy dispersive X-ray spectroscopy(SEM/EDX).The products formed sub-micron scale(typically 200-400 nm in size) crystallites that were approximately isotropic in *** dehydrogenation behaviour of the ternary hydride was investigated by temperature programmed desorption(TPD).The nanostructured hydride releases hydrogen in two steps with an onset temperature for the first step of 513 K.

关键词： hydride Mechanochemistry Structure hydrogen storage Raman