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Comparative Analysis of Different Evaluation Functions for Protein Structure Prediction Under the HP Model

Journal of Computer Science & Technology 2013年第5期28卷 868-889页

作者： Mario Garza-Fabre Eduardo Rodriguez-Tello gregorio toscano-pulido Information Technology Laboratory CINVESTAV-Tamaulipas Km.5.5 Carretera Ciudad Victoria-Soto La Marina 87130 Ciudad Victoria Tamaulipas México

The HP model for protein structure prediction abstracts the fact that hydrophobicity is a dominant force in the protein folding process. This challenging combinatorial optimization problem has been widely addressed through metaheuristics. The evaluation function is a key component for the success of metaheuristics; the poor discrimination of the conventional evaluation function of the HP model has motivated the proposal of alternative formulations for this component. This comparative analysis inquires into the effectiveness of seven different evaluation functions for the HP model. The degree of discrimination provided by each of the studied functions, their capability to preserve a rank ordering among potential solutions which is consistent with the original objective of the HP model, as well as their effect on the performance of local search methods are analyzed. The obtained results indicate that studying alternative evaluation schemes for the HP model represents a highly valuable direction which merits more attention.

关键词： evaluation function protein structure prediction metaheuristics combinatorial optimization bioinformatics

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Skeletal cystic angiomatosis:A rare cause of unilateral lytic bone lesions

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Case Reports in Clinical Medicine 2013年第7期2卷 381-385页

作者： Lia Marques Elisa Vedes Miguel toscano Rico Servico de Medicina III Hospital Pulido ValenteCentro Hospitalar Lisboa NorteLisboaPortugal Unidade de Cuidados Intensivos Hospital da LuzLisboaPortugal Servico de Medicina Hospital de Santa MartaCentro Hospitalar Lisboa CentralLisboaPortugal

Cystic angiomatosis is a rare, benign, multifocal disorder of bone and viscera. Angiomatous deposits result in bone lysis and organ dysfunction. Bony cystic lesions occur in the axial and proximal appendicular skeleton. Lesions may cause bone pain or pathological fracture. Diagnosis is difficult, of exclusion and demands a biopsy. The prognosis varies upon whether the lesions are solely skeletal or there is visceral involvement. A 71-year-old man reports increasing symptoms of painful swelling in the right thoracic wall for over a month. The swelling was bony hard in consistency. Except for his bony swelling, the patient’s physical examination was within normal limits, as were all his laboratory studies. X-ray imagery showed multicystic expansive lytic areas involving the right ribs. Computerized tomography, magnetic resonance imagery and gallium bone scan revealed lytic lesions of multiple right ribs, and cervical, dorsal, lumbar and sacrum iliac spine. A right rib biopsy has shown a cystic formation with endothelial walls. Five years later, the patient remained stable, with no clinical, laboratory or imagilogic progression of disease and without visceral involvement. This case is presented in his rarity and differential diagnosis challenge.

关键词： Cystic Angiomatosis Bone Lytic Lesions Histiocitosis X

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