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Journal of Pharmacy and Pharmacology 2014年第4期2卷 231-242页

作者： Hans gregersen Asbjorn Mohr Drewes GIOME Center College of Bioengineering Chongqing University Chongqing 400030 China GIOME Institute GIOME Free Zone Enterprise Ras AI Khaimah 10055 United Arab Emirates Department of Gastroenterology Aalborg University Hospital Aalborg DK 9000 Denmark

Characterizations of pain and other sensory symptoms are very important for diagnosis and assessment of patient with gastrointestinal disorders. Methods to evoke and assess experimental pain have developed into a new area for multimodal assessment with electrical, mechanical, thermal and chemical stimulation of pain pathways in the human gut. Stimulation with this technology mimics to a large degree the pain experienced by patients seeking the health system for treatment. Multimodal methods have increased our understanding of peripheral receptors in the gut in health and disease. Combined with advanced muscle analysis, the methods have increased our understanding of receptors sensitive to mechanical, chemical and temperature stimuli in diseases such as systemic sclerosis and diabetes. Multimodal technology can also be used to unravel central pain mechanisms involved in allodynia, hyperalgesia and referred pain. Abnormalities in central pain mechanisms are often found in patients with chronic gut pain. Hence methods relying on multimodal pain stimulation may help to understand symptoms in these patients. In addition, multimodal methods have been used to gain more insight into the drug effects against pain. It is expected that multimodal methods represent a maj or step forward in the future characterization and treatment of patients with various gastrointestinal diseases.

关键词： Pain cut experimental allodynia hyperalgesia neurophysiology

EXPERIMENTAL STUDY OF THE MORPHOLOGY OF CEREBRAL BRIDGING VEIN

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Chinese Medical Sciences Journal 2001年第1期16卷 19-22页

作者：庞琦王成伟胡永生徐广明张珑郝晓光张庆林 Hans gregersen Department of Neurosurgery the Second Affiliated Hospital of Shandong Medical University Jinan 250033 Biomechanics Lab Institute of Experimental Clinical Research Arhus University Hospital Denmark

To investigate the morphological properties of pig cerebral bridging vein. Methods. The morphology and fibre arrangement of 15 cerebral bridging veins obtained from 7 Danish Yorkshire landrace pigs were observed. Results. There was a narrow region at the junction of the cerebral bridging veins and superior sagittal sinus termed“ outflow cuff segment". The diameter and length of outflow cuff segment were much smaller and the thickness was higher than those of the cerebral bridging veins (P0.05). Conclusions. There were differences in fibre arrangement and morphological properties between the outflow cuff segment and the cerebral bridging vein, just like a resistance valve, the outflow cuff segment may play an important role in stabilizing cerebral venous outflow and regulating intracranial pressure.

关键词： cerebral bridging vein morphology venous outflow

Effect of Tangweian Jianji on upper gastrointestinal remodeling in streptozotocin-induced diabetic rats

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World Journal of Gastroenterology 2012年第35期18卷 4875-4884页

作者： Gui-Fang Liu Jing-Bo Zhao Zhong Zhen Hong Sha Peng-Min Chen Min Li Jia-Cheng Zhang Ming-Ze Yuan Wen Gao Hans gregersen Xiao-Lin Tong Guang'anmen Hospital China Acad-emy of Chinese Medical Sciences Beijing 100053 China DK 9000 Aalborg and Instituteof Clinical Medicine Aarhus University DK8200 Aarhus NDenmark

AIM： To investigate the effect of Tangweian Jianji （TWAJJ） on the biomechanical and morphometrical remodeling of the upper gastrointestinal tract in diabetic rats. METHODS： Diabetes was induced in 27 rats by in- jecting streptozotocin （40 mg/kg body weight）, the animals were then divided into three groups （n = 9 in each group）, i.e., diabetic control （DM）; high dose （10 g/kg, T1） and low dose （5 g/kg, T2）. Another 10 rats acted as normal controls （Control）. TWAJJ was admin- istered by gavage once daily. Blood glucose and serum insulin levels were measured. Circumferential length, wall thickness and opening angle were measured from esophageal, duodenal, jejunal and ileal ring segments. The residual strain was calculated from the morpho- metric data. Step-wise distension was carried out on esophageal and jejunal segments. The obtained data on the length, diameter and pressure changes were then used to calculate the circumferential and longitu- dinal stresses and strains. Real-time reverse transcrip- tion polymerase chain reaction was used to detect the receptor of advanced glycation end-products （RAGE） mRNA level in jejunal tissues. RESULTS： At the end of the experiment, the blood glucose level was significantly higher and the serum insulin level was significantly lower in DM, T1 and T2 groups than in the control group （Glucose： 30.23 ± 0.41 mmol/L, 27.48 ± 0.27 mmol/L and 27.84 ± 0.29 mmol/ L vs 5.05 ± 0.04 mmol/L, P = 1.65 x 10-16, P = 5.89 x 1019 and P = 1.63 x 10-Is, respectively; Insulin： 1.47 ± 0.32 °tg/L, 2.66 ± 0.44 pg/L, 2.03 ± 0.29 pg/L and 4.17 ± 0.54 pg/L, P = 0.0001, P = 0.029 and P = 0.025, re- spectively）. However, these levels did not differ among the DM, T1 and T2 groups. The wet weight per unit length, wall thickness and opening angle of esophageal and intestinal segments in the DM group were signifi- cantly higher than those in the control group （from P = 0.009 to P = 0.004）. These parameters in the T1 group were significantly lower than those in th

关键词： Biomechanics and morphometric remodel-ing Diabetes rats Gastrointestinal tract Mechanism Tangweian .]ianji

A Dietician’s Bedside Supervision in a Geriatric Ward Is Effective

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Health 2018年第9期10卷 1221-1232页

作者： Mikkel Erik Juul Jensen Jette Lindegaard Pedersen Merete gregersen Department of Geriatrics Aarhus University Hospital Aarhus Denmark

Introduction: Health professionals have greater focus on nutrition issues when having access to a dietician. The aim of this study was to examine the effect of having bed-side access to a clinical dietician in a geriatric ward. Methods: A follow-up study included consecutively all patients admitted in two geriatric wards during three time periods of 2½months each. The intervention was health professionals’ bed-side access to a clinical dietician. Patients hospitalized during the intervention period were compared to patients hospitalized before and after. Patients hospitalized ≤2 days and not screened were excluded. Data on nutritional screening, patients’ daily energy and protein intake, change in body weight from admission to discharge, and a nutrition plan and prescribed oral nutritional supplement at discharge were analysed using ANOVA analysis of variance and Chi-squared test. Results: A total of 554 patients (81%) were at nutritional risk. During the intervention period the compliance of diet registration was better. The patients’ protein and energy intake was higher during the intervention compared with that before and after the intervention (p = 0.04/p = 0.005). Fewer patients lost weight during and after the intervention. Length of hospital stay (LOS) was 1 median day longer in the period before the intervention compared with that during and after the intervention (7 days). LOS was associated with weight change. Conclusions: Health professionals’ access to a bedside dietician in a geriatric ward seems to improve protein and energy intake and thereby the older patients’ body weight, but not sufficiently. The dietician also enhances the staffs’ awareness of nutrition improvements after discharge.

关键词： Aged Malnutrition Dietician Geriatrics Hospitalization Protein Intake Energy Intake

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大鼠食道扭转生物力学特性

航天医学与医学工程 2004年第2期17卷 126-129页

作者：杨坚廖东华高松曾衍钧赵静波 H.gregersen 北京工业大学生物力学与医学信息研究所北京100022 Biomechanics Lab Aalborg UnivesityDenmark

目的食道的主要功能与力学性质密切相关 ,通过对食道进行拉伸、充压、扭转 ,定量地测量食道被动扭转生物力学特性。方法应力应变的计算采用薄壁筒模型 ,认为食道在轴向和环向两个方向的应力沿壁厚均匀分布 ,而忽略径向的应力和其他横向... 详细信息

目的食道的主要功能与力学性质密切相关 ,通过对食道进行拉伸、充压、扭转 ,定量地测量食道被动扭转生物力学特性。方法应力应变的计算采用薄壁筒模型 ,认为食道在轴向和环向两个方向的应力沿壁厚均匀分布 ,而忽略径向的应力和其他横向剪应力。结果实验表明 ,在一定的伸长比和内压下 ,扭矩和扭转角度呈线性关系 ,剪切模量可由扭矩、扭转角度以及在此状态下的极惯量计算而得 ;剪切模量不随剪应力和剪应变的变化而变化 ,改变轴向伸长比和透壁压将使剪切模量产生变化。结论在伸长比一定的充压过程中 ,剪切模量与透壁压、轴向应力呈线性关系。在透壁压一定的伸长过程中 ,剪切模量与轴向伸长比、轴向应变呈非线性关系。

关键词：食道生物力学特征扭转模量应变能方程

Experiences of Social Isolation in Older Hospitalized Patients with COVID-19 and Their Close Relatives: A Qualitative Study

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Health 2023年第7期15卷 758-770页

作者： Karin Bundgaard Lone Winther Lietzen Peter Errboe Jensen Merete gregersen Clinical Nursing Research Unit Aalborg University Hospital & Department of Clinical Medicine Aalborg University Aalborg Denmark Department of Geriatrics Aarhus University Hospital Aarhus Denmark Nursing School VIA University College Aarhus Denmark

Background: Proximity between older patients and their close relatives is essential during hospitalisation. During the first wave of the pandemic, the Danish Patient Safety Authority restricted no hospital visitors. Aim: To explore how older patients with COVID-19 and their close relatives experienced physical separation during hospitalization. Method: A qualitative study using semi-structured interviews and thematic analysis was employed. Findings: Six interviews were conducted: three patients with a mean age of 81 years and three close relatives—two daughters and one spouse. The patients felt boredom, loneliness, and a sense of imprisonment, yet they felt safe and satisfied. Isolation was known beforehand from the media. Close relatives emphasised that information, involvement, and collaboration with hospital staff were crucial. Conclusion: Although older patients with COVID-19 and their close relatives widely accept their situation during hospitalization, they experience negative consequences from social isolation.

关键词： Aged COVID-19 Nursing Staff Hospital Personal Protective Equipment Social Isolation Visitors to Patients

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糖基化终末产物及其受体在胃肠道中的分布

世界华人消化杂志 2012年第36期20卷 3638-3643页

作者：陈朋民赵静波 Hans gregersen Mech-Sense Aalborg Hospital 中日友好医院临床医学研究所生化与分子生物学研究室北京市100029 Sino-Danish Centre for Education and Research

目的:研究糖基化终末产物(advanced glycation end products,AGE)及其受体(receptor for advanced glycation end products,RAGE)在胃肠道中的分布,为进一步探索其在慢性糖尿病胃肠功能紊乱中的作用奠定基础.方法:分别对成年Wistar大鼠... 详细信息

目的:研究糖基化终末产物(advanced glycation end products,AGE)及其受体(receptor for advanced glycation end products,RAGE)在胃肠道中的分布,为进一步探索其在慢性糖尿病胃肠功能紊乱中的作用奠定基础.方法:分别对成年Wistar大鼠食管、胃、十二指肠、空肠、回肠、结肠及直肠组织进行AGE及RAGE免疫组织化学染色.结果:(1)食管:AGE及RAGE主要分布在横纹肌的肌细胞及黏膜的鳞状上皮细胞;(2)胃:AGE在壁细胞为强阳性.RAGE在主细胞、肥大细胞、神经细胞为强阳性,在壁细胞为中等强度阳性,在表面黏液细胞为弱阳性;(3)小肠:AGE及RAGE在绒毛及固有层上皮细胞为阳性或强阳性.RAGE在肠道的神经细胞亦为强阳性;(4)结肠及直肠:AGE及RAGE在黏膜上皮细胞为弱阳性,RAGE在神经细胞为强阳性.结论:AGE及RAGE广泛分布于肠道上皮细胞及食管的横纹肌细胞,AGE亦分布于胃的壁细胞,RAGE亦分布于胃的壁细胞、主细胞、表面黏液细胞、肥大细胞及胃肠道的神经细胞.

关键词：糖尿病胃肠道合并症糖基化终末产物糖基化终末产物受体

Unrestricted Weight Bearing as a Method for Assessment of Nociceptive Behavior in a Model of Tibiofemoral Osteoarthritis in Rats

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Journal of Behavioral and Brain Science 2013年第3期3卷 306-314页

作者： Lise Skott gregersen Turid Rosland Lars Arendt-Nielsen Garth Whiteside Michele Hummel Center for Sensory-Motor Interaction Aalborg UniversityAalborgODenmark Purdue Pharma LP CranburyUSA

Background: Novel preclinical models for prediction of osteoarthritis-like pain are necessary for the elucidation of osteoarthritis (OA) pathology and for assessment of novel analgesics. A widely used behavioral test in rat models of tibiofemoral OA is hind limb weight bearing (WB). However, this method evaluates WB in an unnaturally restricted manner. The aim of this study was therefore to characterize the Tekscan Pressure Measurement System as a means to assess OA-like tibiofemoral pain in rats by determination of plantar pressure distribution in a more natural and unrestricted position, defined as unrestricted WB. Methods: Intra-articular injections of 1 mg monosodium iodoacetate (MIA) or saline were administrated in the left hind knee of 84 male Sprague Dawley rats. Changes in unrestricted WB between ipsilateral and contralateral hindlimbs were determined. Morphine (5 mg/kg administered subcutaneously) and naproxen (60 mg/kg per-oral) were examined for their ability to reverse WB changes. Results: Changes in hind limb unrestricted WB were observed 14 (P P P Conclusion: This study indicated that unrestricted WB assessed by the Tekscan system can be utilized as a clinically relevant method to assess aberrations in WB induced by intra-articular MIA injections in rodents. Therefore, this system may be useful for understanding the mechanisms of OA pain in humans and may also assist in the discovery of novel pharmacological agents.

关键词： Osteoarthritis Pain Monosodium Iodoacetate Unrestricted Weight Bearing Morphine Naproxen

肠润通对糖尿病大鼠结肠转化生长因子β1及其受体表达的干预作用

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中华中医药杂志 2017年第10期32卷 4444-4447页

作者：赵东沙洪廖东华仝小林 Hans gregersen 赵静波中日友好医院老年医学科北京100029 Department of Clinical Medicine Aarhus University 重庆大学生物工程学院重庆400044 中国中医科学院广安门医院北京100053

目的:探讨肠润通对糖尿病大鼠结肠生物力学重构的影响是否与转化生长因子β1(TGF-β1)及其受体的表达相关。方法:雄性SD大鼠40只,随机分为正常组、模型组及肠润通高、低剂量组。模型组及肠润通高、低剂量组一次性注射链脲佐菌素(40mg/kg... 详细信息

目的:探讨肠润通对糖尿病大鼠结肠生物力学重构的影响是否与转化生长因子β1(TGF-β1)及其受体的表达相关。方法:雄性SD大鼠40只,随机分为正常组、模型组及肠润通高、低剂量组。模型组及肠润通高、低剂量组一次性注射链脲佐菌素(40mg/kg)诱发糖尿病。肠润通高、低剂量组分别灌胃给药肠润通50、25g/kg,每日1次,周期为60d。定期检测其血糖和体质量,免疫组织化学染色检测TGF-β1及其受体在结肠肠壁各层组织的表达。采用线性回归方法分析检测TGF-β1及其受体的表达与上述参数的相关关系。结果:模型组TGF-β1及其受体在结肠肠壁各层组织的表达明显高于正常组(P<0.05,P<0.01),且与形态组织学和生物力学重构参数高度正相关。经肠润通治疗后,肠润通高剂量组处理能显著降低TGF-β1及其受体在结肠肠壁各层的表达(P<0.05,P<0.01),但肠润通低剂量组处理无显著作用。结论:TGF-β1及其受体的表达水平与糖尿病结肠生物力学重构高度相关,高剂量肠润通能够通过抑制糖尿病结肠肠壁TGF-β1及其受体在肠壁表达来改善结肠生物力学重构。

关键词：肠润通转化生长因子β1 受体糖尿病

肠润通对糖尿病大鼠结肠糖基化终末产物及其受体表达的干预作用

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中华中医药杂志 2016年第2期31卷 479-483页

作者：赵东沙洪廖东华仝小林 Hans gregersen 赵静波中日友好医院北京100029 Department of Clinical Medicine Aarhus University 重庆大学生物工程学院重庆400044 中国中医科学院广安门医院北京100053

目的:本研究通过糖尿病大鼠结肠生物力学重构与糖基化终末产物表达的相关性来探讨肠润通的干预作用机制。方法:将成年健康SD大鼠40只,每组10只随机分为空白对照组,糖尿病对照组,肠润通高(50g/kg)、低(25g/kg)剂量治疗组。肠润通每日1次... 详细信息

目的:本研究通过糖尿病大鼠结肠生物力学重构与糖基化终末产物表达的相关性来探讨肠润通的干预作用机制。方法:将成年健康SD大鼠40只,每组10只随机分为空白对照组,糖尿病对照组,肠润通高(50g/kg)、低(25g/kg)剂量治疗组。肠润通每日1次经灌胃给药,定期检测血糖和体重,实验周期为60d。实验结束时,通过免疫组织化学染色方法观测各组糖基化终末产物(AGEs)及其受体(RAGE)在结肠肠壁各层的分布表达,利用图像分析软件对其表达进行定量分析。结肠管壁的湿重,壁厚、展开角、残余应变以及应力应变等形态学和生物力学参数取自本课题组之前相关研究报道的结果。采用线性回归方法对上述两组参数进行相关统计分析。结果:糖尿病对照组AGEs和RAGE在结肠肠壁各层的表达明显高于空白对照组(P<0.05,P<0.01)且与形态组织学和生物力学重构参数高度正相关。经肠润通治疗后,高剂量肠润通处理能显著降低AGEs和RAGE在结肠肠壁各层的表达(P<0.05,P<0.01),但低剂量肠润通处理无显著作用。结论:AGEs和RAGE在肠壁各层组织的表达与糖尿病结肠生物力学特性重构高度相关,高剂量肠润通对AGEs-RAGE表达的抑制作用是糖尿病结肠生物力学特性重构机制改善的有效途径之一。

关键词：结肠生物力学重构糖基化终末产物糖尿病肠润通干预