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Risk of venous thromboembolic disease in postmenopausal women taking oral or transdermal hormone replacement therapy

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2011年第1期12卷 12-17页

作者： Barbara RUSZKOWSKA grazyna GADOMSKA Liliana BIELIS Marzena GRUSZKA Barbara GóRALCZYK Danuta RO grazyna ODROWAZ-sypniewska Department of Pathophysiology Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Department of Laboratory Medicine Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń Department of Laboratory Medicine Collegium Medicum in BydgoszczNicolaus Copernicus University in Toruń

Objective: The influence of hormone replacement therapy (HRT) on hemostasis processes depends on the type of hormone,the combination of doses,the time of taking HRT,and the route of administration (oral,transdermal,implanted).The aim of the current study was to assess some parameters of coagulation,especially tissue factor pathway inhibitor (TFPI) and tissue factor (TF) in postmenopausal women using oral or transdermal ***: The study was conducted on 76 healthy women,including 46 women aged 44–58 years who were taking oral (26) or transdermal (20) HRT,and 30 women aged 44–54 years who did not take HRT as the control *** concentrations of TF,TFPI,thrombin-antithrombin complex (TAT),and D-dimer were performed by enzyme-linked immunosorbent assay (ELISA).Moreover,the concentration of fibrinogen and activity of protein C were measured by chromogenic and chronometric ***: We observed a significantly higher concentration of TF and a significantly lower concentration of TFPI in women taking oral and transdermal HRT in comparison with the control *** also found a significantly lower concentration of fibrinogen in women taking oral HRT *** control ***,no statistically significant changes in concentrations of TAT and D-dimer,or activity of protein C were ***: In this study,the occurrence of an increased TF concentration simultaneously with a decreased concentration of TFPI in women taking HRT indicates *** significant modification of TAT or D-dimer occurred,and thus there may not be increased risk of thrombosis.

关键词： Menopause Coagulation Hormone replacement therapy

Microstructure and electrical resistivity in the GdNi_(5–x)Cu_x intermetallic series

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Journal of Rare Earths 2017年第1期35卷 71-78页

作者： Anna Bajorek grazyna Chelkowska A. Chelkowski Institute of Physics University of Silesia Katowice Poland Silesian Center for Education and Interdisciplinary Research University of Silesia Chorzow Poland

The effect of the Ni/Cu substitution on the electrical resistivity and microstructure of the polycrystalline GdNi5-xCux series was studied. The value of temperature of phase transition（T_（ph）） estimated from temperature dependence of electrical resistance varied non-linearly across copper doping from 32.5 K（x=0.0） to 29.1 K（x=5.0）. The value of residual resistivity（ρo） estimated at low temperature range decreased from 27.28 μΩcm（x=0.0） to 9.44 μΩcm（x=5.0）, which was discussed as the influence of microstructure. In order to describe the temperature dependence of resistivity ρ（T） a variety of approaches were applied due to different scattering mechanisms occurring at high and low temperature ranges. The change within ρ（T） curvature was evidenced at low temperature range across copper doping. The temperature variation of the resistivity was quite peculiar for Cu-rich compounds（x=4.8, x=5.0）, which might be correlated with the incommensurate magnetic structure derived from the weakly negative interaction between the nearest neighbours of Gd. The correlation between microstructure and resistivity was observed.

关键词： intermetallics rare earth alloys and compounds crystal structure electrical resistivity scanning electron microscopy

Thermal and radiative characteristics of oxyfluoride glass singly doped with lanthanide ions

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Journal of Rare Earths 2010年第6期28卷 893-898页

作者： Barbara KLIMESZ grazyna DOMINIAK-DZIK Witold RYBA-ROMANOWSKI Department of Physics Opole University of Technology Institute of Low Temperature and Structure Research Polish Academy of Sciences

Rare earths-doped oxyfluoride glasses based on germanium oxide and lead fluoride were prepared from commercial raw materials. The glasses with general composition of 50GeO2-(50-x-y)PbO-yPbF2-xLnF3 (Ln=Pr3+-Yb3+), contained different concentrations of optically active dopants (x=0.2 mol.% and 2 mol.%) and PbF2 (y≤15 mol.%). The differential thermal analysis (DTA) was used to determine both thermal characteristic and thermal stability properties of the glasses in the function of the kind of dopant, its concentration, and a glass composition. Characteristic glass temperatures such as glass transition temperature (Tg), glass crystallization temperature (Tc) and temperature corresponding to the maximum of the crystallization rate (Tpc) were evaluated. On the basis of obtained results, the thermal stabilities of glasses under study were evaluated using various thermal stability criteria (Dietzel factor ?T, Saad-Poulain factors H’ and S). It was found that the increase in rare earth fluoride contents influenced thermal characteristics when the characteristic temperatures of the individual glass was shifted towards higher values. The effect of the PbF2 content and the kind of rare earth impurity on the glass stability was observed. Absorption spectra of lanthanide-doped glasses were measured at room temperature and used to determine the phenomenological intensity parameters Ωt and next, to estimate radiative properties of lanthanide ions in this matrix. Radiative transition probabilities of luminescent states of Ln3+, branching ratios and radiative lifetimes were determined. The variation of the Ωt along the lanthanide series was presented and discussed.

关键词： oxyfluoride glasses rare earths DTA thermal stability of glasses radiative transition probabilities radiative lifetimes

Tufted Hairgrass(Deschampsia caespitosa)Exhibits a Lower Photosynthetic Plasticity than Antarctic Hairgrass(***)

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Journal of Integrative Plant Biology 2009年第6期51卷 593-603页

作者： grazyna Bystrzejewska-Piotrowska Pawel L.Urban Isotope Laboratory Faculty of Biology University of Warsaw02-096 Warsaw Miecznikowa 1 Poland

The aim of our work was to assess photosynthetic plasticity of two hairgrass species with different ecological origins （a temperate zone species, Deschampsia caespitosa （L.） Beauv. and an Antarctic species, D. antarctica） and to consider how the anticipated climate change may affect vitality of these plants. Measurements of chlorophyll fluorescence showed that the photosystem Ⅱ （PSⅡ） quantum efficiency of D. caespitosa decreased during 4 d of incubation at 4℃ but it remained stable in D. antarctica. The fluorescence half-rise times were almost always lower in D. caespitosa than in D. antarctica, irrespective of the incubation temperature. These results indicate that the photosynthetic apparatus of D. caespitosa has poorer performance in these conditions. D. caespitosa reached the maximum photosynthesis rate at a higher temperature than D. antarctica although the values obtained at 8 ℃ were similar in both species. The photosynthetic water-use efficiency （photosynthesis-to-transpiration ratio, PIE） emerges as an important factor demonstrating presence of mechanisms which facilitate functioning of a plant in non-optimal conditions. Comparison of the PiE values, which were higher in D. antarctica than in D. caespitosa at low and medium temperatures, confirms a high degree of adjustability of the photosynthetic apparatus in D. antarctica and unveils the lack of such a feature in D. caespitosa.

关键词： chlorophyll fluorescence climate change Deschampsia photosynthesis photosynthetic water-use efficiency.

Culturomics and metagenomics: In understanding of environmental resistome

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Frontiers of Environmental Science & Engineering 2019年第3期13卷 29-40页

作者： Monika Nowrotek Lukasz Jalowiecki Monika Harnisz grazyna Anna Plaza Microbiology Unit Institute for Ecology of Industrial Areas Kossutha 6 Str. 40-844 Katowice Poland Department of Environmental Microbiology Faculty of Environmental Sciences University of Warmia and Mazuiy Prawochenskiego 1 Str. 10-720 Olsztyn Poland Silesian University of Technology Faculty of Organization and Management Institute of Engineering Production Roosevelta 26 Str. 41-800 Zabrze Poland

Pharmaceutical residues, mainly antibiotics, have been called "emerging contaminants" in the environment because of their increasing frequency of detection in aquatic and terrestrial systems and their sublethal ecological effects. Most of them are undiscovered. Both human and veterinary pharmaceuticals, including antibiotics, are introduced into the environment via many different routes, including discharges from municipal wastewater treatment plants and land application of animal manure and biosolids to fertilize croplands. To gain a comprehensive understanding of the widespread problem of antibiotic resistance, modem and scientific approaches have been developed to gain knowledge of the entire antibiotic-resistant microbiota of various ecosystems, which is called the resistome. In this review, two omics methods, i.e. culturomics, a new approach, and metagenomics, used to study antibiotic resistance in environmental samples, are described. Moreover, we discuss how both omics methods have become core scientific tools to characterize microbiomes or resistomes, study natural communities and discover new microbes and new antibiotic resistance genes from environments. The combination of the method for get better outcome of both culturomics and metagenomics will significantly advance our understanding of the role of microbes and their specific properties in the environment.

关键词： Culturomics Metagenomics Antibiotic resistance Resistome

Coexistence of hepatocellular carcinoma and gastrointestinal stromal tumor:A case report

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World Journal of Gastroenterology 2006年第4期12卷 665-667页

作者： RadoslawJaworski TomaszJastrzebski MaciejSwierblewski KamilDrucis grazyna Kobierska-Gulida Department of Surgical Oncology Medical University of GdanskPoland Department of Pathology Medical University of GdanskPoland

Malignant gastrointestinal stromal tumors （GIST） are rare mesenchymal tumors originating from the wall of the gastrointestinal tract. Their coexistence with other tumors originating from other germ layers is unique. We have reported a case of a 63-year-old GIST patient presenting as an epigastric mass associated with hepatic tumor. Histologically, the mesenteric tumor was composed of spindle cells showing both neural and smooth muscle differentiation. Immunohistochemical examination showed positive staining for CDl17, vimentin, S-100, and SMA, while CD34 antigen was negative. The hepatic tumor was diagnosed as hepatocellular carcinoma （HCC）. To the best of our knowledge, this is the first case of GIST and HCC coexistence. The rarity of the case, however, should not lead to ignoring such a possibility in differential diagnosis.

关键词： Malignant GIST Hepatocellular carcinoma Coexistence of GIST and HCC

TT virus infection and pancreatic cancer: Relationship or accidental coexistence

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World Journal of Gastroenterology 2005年第18期11卷 2847-2849页

作者： Krzysztof Tomasiewicz Roma Modrzewska Anna Lyczak grazyna Krawczuk Department of Infectious Diseases Medical University of Lublin Biernackiego 9 20-089 Lublin Poland

TT virus (TTV) was first isolated in 1997 from the patient with acute post-transfusion hepatitis. This fact led to the conclusion that the virus was hepatotropic and could be one of the causative agents of acute hepatitis. Afterwards, however, the virus was found in other human tissues and serological studies revealed that it was widespread. Multiple tropisms of TTV and the fact of its high incidence in general population are considered to indicate no medical significance of TTV in human pathology. Here we present a report of two cases of TTV infection in patients who developed pancreas cancer. The patients were hospitalized at the Department of Infectious Diseases due to hepatitis of unknown origin. Since serological and virological markers of common primary and secondary hepatotropic viruses were negative, TTV-DNA was found in serum and was believed to be the only causative agent with probable hepatotropic action. The patients later developed pancreas cancer and they underwent operation. The relationship is difficult to confirm, however the cases we present should be treated as a preliminary report and a comment on the real role of TTV in human pathology.

关键词： TT virus Hepatitis Pancreas cancer Hepatotropic viruses

Loss of FHIT expression in gastric mucosa of patients with family histories of gastric cancer and Helicobacter pylori infection

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World Journal of Gastroenterology 2005年第1期11卷 17-21页

作者： Krystyna Stec-Michalska Slawomir Antoszczyk grazyna Klupinska Barbara Nawrot Clinic of Gastroenterology and Internal Diseases Centre of Molecular and Macromolecular Studies of the Polish Academy of Sciences

AIM: To answer the question whether FHIT gene expression is affected by the family history of gastric carcinoma and the presence of Helicobacter pylori (Hpylori) in the gastric mucosa of patients with ***: FHIT gene expression in two different topographic sites of the gastric mucosa of twenty-one patients with dyspepsia and with or without familial gastric carcinoma, infected or not infected with H pylori, was evaluated by reverse transcription-PCR (RT-PCR) and IMAGE QUANT methods. A rapid urease test and histopathological examination were used to determine H pylori ***: In the gastric mucosa of patients with family histories of gastric carcinoma, the amount of FHIT protein mRNA was reduced down to 32%, and for patients with H pylori colonization, to 24% in comparison to controls with dyspepsia and without cancer in the family. FHIT expression was independent of the topography of specimens (corpus vsantrum), and for the control patients it was less sensitive to infection with H pylori. A considerable statistical difference in FHIT levels was observed in the gastric mucosa from the corpus of patients with family histories of gastric carcinoma in respect to H pylori colonization (P = 0.06). Macroscopic evaluation of the gastric mucosa demonstrated that pathologic changes classified according to the Sydney system had no significant influence on FHIT expression within each tested group of ***: Loss of FHIT expression was observed in patients with dyspepsia and family histories of gastric carcinoma, especially those infected with H pylori. Such results may constitute an early indication of the development of gastric carcinoma, which is associated with family factors including heredity and H pylori infection. The loss of the FHIT gene may serve as a marker for early diagnosis and prevention of gastric carcinoma, especially in context of early monitoring of H pylori infection in individuals with a record of familial stomach ca

关键词： Gastric cancer Helicobacter pylori infection FHIT protein

Sensitivity of the area method with mono isotopic fission chambers to reactivity changes in subcritical nuclear reactors

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Nuclear Science and Techniques 2021年第10期32卷 166-176页

作者： Jerzy A.Janczyszyn grazyna Domanska Przemysław Stanisz Faculty of Energy and Fuels AGH University of Science and Technologyal.Mickiewicza 3030-0591 KrakowPoland

High-level waste is an important safety issue in the development of nuclear power.A proposed solution is the transmutation of waste in fast *** exclusion of the risk of supercriticality by using subcritical reactors is currently under *** the subcriticality level in such reactors presents difficulties.A problem is posed by the so-called space effect observed when using in reactors many neutron detectors in different locations of the core and *** obtained from measure-ments,for example,by the Sjo¨strand method,differs by nonnegligible *** corrections can partially improve this *** use of a monoisotopic fission chamber set,designed for a given reactor,when each chamber is intended for a specific position in the system,can improve the situation.A question arises about the sensitivity of the results to reactivity *** issue is analyzed by computer simulation for possible fissionable and fissile nuclides for the total range of control rod insertion,changes in reactor fuel enrichment,and fuel *** tested sensitivity was satisfactory at most levels from several dozen to several hundred pcm.A case study was conducted using the VENUS-F core model.

关键词： Subcriticality Simulation Sjostrand method Fission chambers Space effect