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Diabetic peripheral neuropathy and neuromodulation techniques:a systematic review of progress and prospects

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Neural Regeneration Research 2025年第8期20卷 2218-2230页

作者： Rahul Mittal Keelin McKenna grant Keith Evan McKenna Joana R.N.Lemos Jeenu Mittal Khemraj Hirani Diabetes Research Institute University of Miami Miller School of MedicineMiamiFLUSA Department of Otolaryngology University of Miami Miller School of MedicineMiamiFLUSA Herbert wertheim College of Medicine Florida International UniversityMiamiFLUSA School of Medicine and Public Health University of WisconsinMadisonWIUSA

Neuromodulation for diabetic peripheral neuropathy represents a significant area of interest in the management of chronic pain associated with this *** peripheral neuropathy,a common complication of diabetes,is characterized by nerve damage due to high blood sugar levels that lead to symptoms,such as pain,tingling,and numbness,primarily in the hands and *** aim of this systematic review was to evaluate the efficacy of neuromodulatory techniques as potential therapeutic interventions for patients with diabetic peripheral neuropathy,while also examining recent developments in this *** investigation encompassed an array of neuromodulation methods,including frequency rhythmic electrical modulated systems,dorsal root ganglion stimulation,and spinal cord *** systematic review suggests that neuromodulatory techniques may be useful in the treatment of diabetic peripheral *** the advantages of these treatments will enable physicians and other healthcare providers to offer additional options for patients with symptoms refractory to standard pharmacologic *** these efforts,we may improve quality of life and increase functional capacity in patients suffering from complications related to diabetic neuropathy.

关键词： diabetes mellitus diabetic peripheral neuropathy neuromodulation neurostimulation therapy non-pharmacological treatment pain management

Competition for food in 2 populations of a wild-caught fish

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Current Zoology 2018年第5期64卷 615-622页

作者： Pierre J.C. CHUARD grant E. BROwN James w.A. grant Research School of Biology The Australian National University Canberra ACT 0200 Australia Departmentof Biology Concordia University 7141 Sherbrooke Street West Montreal Quebec Canada H4B 1R6

Aggressive behavior when competing for resources is expected to increase as the ratio of competitors-to-resource ratio （CRR） units increases. Females are expected to be more aggressive than males when competing for food when body size is more strongly related to reproductive suc- cess in females than in males, whereas aggression is predicted to decrease under high ambient predation risk by natural selection. Under the risk allocation model, however, individuals under high ambient predation risk are expected to be more aggressive, and forage more in the absence of imminent risk than their low risk counterparts. An interaction between adult sex ratio （i.e., adult males/females）, ambient predation risk （high vs. low）, and sex on intrasexual competition for mates in Trinidadian guppies Poecilia reticulata has been shown. The interaction suggested an increase in aggression rates as CRR increased, except for males from the high predation population. To compare the patterns of competition for food versus mates, we replicated this study by using food patches. we allowed 4 male or 4 female guppies from high and low predation populations to com- pete for 5, 3, or 1 food patches. The foraging rate was higher in a high rather than low ambient pre- dation risk population. Surprisingly, CRR, sex, and population of origin had no effect on aggression rates. Despite other environmental differences between the 2 populations, the effect of ambient predation risk may be a likely explanation for differences in foraging rates. These results highlight the importance for individuals to secure food despite the cost of competition and predation.

关键词： aggression competitor-to-resource ratio foraging Poecifia reticulata population differences predation risk sex

A rapid dehydration leaf assay reveals stomatal response differences in grapevine genotypes

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Horticulture Research 2014年第1期1卷 322-329页

作者： Daniel w Hopper Ryan Ghan grant R Cramer Department of Biochemistry and Molecular Biology University of NevadaRenoNV 89557USA.

A simple and reliable way of phenotyping plant responses to dehydration was ***-developed leaves were detached and placed in a closed plastic box containing a salt solution to control the atmospheric water potential in the *** hours of dehydration(weight loss of the leaf)was optimal for measuring changes in stomatal response to *** of the plant hormone abscisic acid(ABA)prior to leaf detachment decreased the amount of water loss,indicating that the assay was able to detect differences based on a stomatal response to *** different Vitis genotypes(***,***,*** ***,*** *** and *** *** Sauvignon)with known differences in drought tolerance were screened for their dehydration response and the results obtained corresponded to previous reports of stomatal responses in the *** differences in stomatal density along with differences in the amount and rate of water lost indicate differences in dehydration sensitivity among the genotypes *** in stomatal response to ABA were also *** had the lowest stomatal density and the highest ABA sensitivity among the genotypes screened,yet Shiraz lost the most amount of water,indicating that it was the least sensitive to *** having the highest stomatal density and intermediate stomatal sensitivity to ABA,*** lost the smallest amount of water,indicating that it was the most sensitive to *** assay presented here represents a simple and reliable phenotyping method for plant responses to leaf dehydration.

关键词： smallest stomatal drought

Human induced pluripotent stem cell-derived therapies for regeneration after central nervous system injury

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Neural Regeneration Research 2025年第11期20卷 3063-3075页

作者： Stephen Vidman Yee Hang Ethan Ma Nolan Fullenkamp Giles w.Plant Department of Neuroscience Ohio State UniversityColumbusOHUSA

In recent years,the progression of stem cell therapies has shown great promise in advancing the nascent field of regenerative *** the non-regenerative nature of the mature central nervous system,the concept that“blank”cells could be reprogrammed and functionally integrated into host neural networks remained *** work has also demonstrated the ability of such cells to stimulate intrinsic growth programs in post-mitotic cells,such as *** embryonic stem cells demonstrated great potential in treating central nervous system pathologies,ethical and technical concerns *** barriers,along with the clear necessity for this type of treatment,ultimately prompted the advent of induced pluripotent stem *** advantage of pluripotent cells in central nervous system regeneration is multifaceted,permitting differentiation into neural stem cells,neural progenitor cells,glia,and various neuronal *** precise spatiotemporal application of extrinsic growth factors in vitro,in addition to microenvironmental signaling in vivo,influences the efficiency of this directed *** the pluri-or multipotency of these cells is appealing,it also poses the risk of unregulated differentiation and teratoma *** of the neuroectodermal lineage,such as neuronal subpopulations and glia,have been explored with varying degrees of *** the risk of cancer or teratoma formation is greatly reduced,each subpopulation varies in effectiveness and is influenced by a myriad of factors,such as the timing of the transplant,pathology type,and the ratio of accompanying progenitor ***,successful transplantation requires innovative approaches to develop delivery vectors that can mitigate cell death and support ***,host immune responses to allogeneic grafts must be thoroughly characterized and further developed to reduce the need for *** to a clinical setting wi

关键词： axon regeneration central nervous system regeneration induced pluripotent stem cells neurotrauma regenerative medicine spinal cord injury stem cell therapy

Strongly seasonal Proterozoic glacial climate in low palaeolatitudes:Radically different climate system on the pre-Ediacaran Earth

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Geoscience Frontiers 2016年第4期7卷 555-571页

作者： George E.williams Phillip w.Schmidt grant M.Young Department of Earth Sciences University of AdelaideSA 5005Australia CSIRO Mineral Resources Flagship PO Box 52North RydeNSW 16FOAustralia Department of Earth Sciences University of Western OntarioLondonOntario N6A 5B7Canada

Proterozoic （pre-Ediacaran） glaciations occurred under strongly seasonal climates near sea level in low palaeolatitudes. Metre-scale primary sand wedges in Cryogenian periglacial deposits are identical to those actively forming, through the infilling of seasonal （winter） thermal contraction-cracks in perma- frost by windblown sand, in present-day polar regions with a mean monthly air temperature range of 40 ~C and mean annual air temperatures of -20 ~C or lower. Varve-like rhythmites with dropstones in Proterozoic glacial successions are consistent with an active seasonal freeze-thaw cycle. The seasonal （annual） oscillation of sea level recorded by tidal rhythmites in Cryogenian glacial successions indicates a significant seasonal cycle and extensive open seas. Palaeomagnetic data determined directly for Prote- rozoic glacial deposits and closely associated rocks indicate low palaeolatitudes： Cryogenian deposits in South Australia accumulated at 〈10% most other Cryogenian deposits at 〈20~ and Palaeoproterozoic deposits at 〈15~ palaeolatitude. Palaeomagnetic data imply that the Proterozoic geomagnetic field approximated a geocentric axial dipole, hence palaeolatitudes represent geographic latitudes. The Cry- ogenian glacial environment included glacier-flee, continental permafrost regions with ground frozen on a kyr time-scale, aeolian sand-sheets, extensive and long-lived open seas, and an active hydrological cycle. This palaeoenvironment confiicts with the ＇snowball Earth＇ and ＇slushball Earth＇ hypotheses, which cannot accommodate large seasonal changes of temperature near the equator. Consequently, their proponents have attempted to refute the evidence for strong seasonality by introducing Popperian ＇auxiliary assumptions＇. However, non-actualistic arguments that the Cryogenian sand wedges indicate diurnal or weakly seasonal temperature changes are based on misunderstandings of periglacial pro- cesses. Modelling of a strongly seasonal climate for a frozen-over Ear

关键词： Proterozoic Glaciation Periglacial structures Varves Paleoclimate Paleomagetism

Spatially-Structured Sharing Technique for Multimodal Problems

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Journal of Computer Science & Technology 2008年第1期23卷 64-76页

作者： grant Dick Peter whigham Department of Information Science University of OtagoDunedin

Spatially-structured populations are one approach to increasing genetic diversity in an evolutionary algorithm （EA）. However, they are susceptible to convergence to a single peak in a multimodal fitness landscape. Niching methods, such as fitness sharing, allow an EA to maintain multiple solutions in a single population, however they have rarely been used in conjunction with spatially-structured populations. This paper introduces local sharing, a method that applies sharing to the overlapping demes of a spatially-structured population. The combination of these two methods succeeds in maintaining multiple solutions in problems that have previously proved difficult for sharing alone （and vice-versa）.

关键词： evolutionary algorithm multimodal problem domain sharing spatially-structured population

Studying the genetic basis of speciation in high gene flow marine invertebrates

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Current Zoology 2016年第6期62卷 643-653页

作者： grant H. POGSON Department of Ecology and Evolutionary Biology University of California Santa Cruz CA 95064 USA

A growing number of genes responsible for reproductive incompatibilities between species （barrier loci） exhibit the signals of positive selection. However, the possibility that genes experiencing positive selection diverge early in speciation and commonly cause reproductive incompatibilities has not been systematically investigated on a genome-wide scale. Here, I outline a research program for studying the genetic basis of speciation in broadcast spawning marine invertebrates that uses a priori genome-wide information on a large, unbiased sample of genes tested for positive selection. A targeted sequence capture approach is proposed that scores single-nucleotide polymorphisms （SNPs） in widely separated species populations at an early stage of allopatric divergence. The targeted capture of both coding and non-coding sequences enables SNPs to be characterized at known locations across the genome and at genes with known selective or neutral histories. The neutral coding and non-coding SNPs provide robust background distributions for identifying Fsm-outliers within genes that can, in principle, identify specific mutations experiencing diversifying selection. If natural hybridization occurs between species, the neutral coding and noncoding SNPs can provide a neutral admixture model for genomic clines analyses aimed at finding genes exhibiting strong blocks to introgression. Strongylocentrotid sea urchins are used as a model system to outline the approach but it can be used for any group that has a complete reference genome available.

关键词： barrier loci Bobzhansky-Muller incompatibilities FsToutliers genome scan introgression positive selection sequence capture speciation.

Precambrian supercontinents,glaciations,atmospheric oxygenation,metazoan evolution and an impact that may have changed the second half of Earth history

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Geoscience Frontiers 2013年第3期4卷 247-261页

作者： grant M.Young Department of Earth Sciences Western University1151 Richmond Street NLondonOntarioCanada N6A 5B7

In more than 4 Ga of geological evolution, the Earth has twice gone through extreme climatic perturba- tions, when extensive glaciations occurred, together with alternating warm periods which were accom- panied by atmospheric oxygenation. The younger of these two episodes of climatic oscillation preceded the Cambrian ＂explosion＂ of metazoan life forms, but similar extreme climatic conditions existed between about 2.4 and 2.2 Ga. Over long time periods, changing solar luminosity and mantle temperatures have played important roles in regulating Earth＇s climate but both periods of climatic upheaval are associated with supercontinents. Enhanced weathering on the orogenically and thermally buoyed supercontinents would have stripped CO2 from the atmosphere, initiating a cooling trend that resulted in continental glaciation. Ice cover prevented weathering so that CO2 built up once more, causing collapse of the ice sheets and ushering in a warm climatic episode. This negative feedback loop provides a plausible explanation for multiple glaciations of the Early and Late Proterozoic, and their intimate association with sedimentary rocks formed in warm climates. Between each glacial cycle nutrients were flushed into world oceans, stimulating photosynthetic activity and causing oxygenation of the atmosphere. Accommodation for many ancient glacial deposits was provided by rifting but escape from the climatic cycle was predicated on break- up of the supercontinent, when flooded continental margins had a moderating influence on weathering. The geochemistry of Neoproterozoic cap carbonates carries a strong hydrothermal signal, suggesting that they precipitated from deep sea waters, overturned and spilled onto continental shelves at the termination of glaciations. Paleoproterozoic （Huronian） carbonates of the Espanola Formation were probably formed as a result of ponding and evaporation in a hydrothermally influenced, restricted rift setting. why did metazoan evolution not take off a

关键词： Proterozoic supercontinents Glaciations Impacts Oxygenation Metazoa

Did prolonged two-stage fragmentation of the supercontinent Kenorland lead to arrested orogenesis on the southern margin of the Superior province?

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Geoscience Frontiers 2015年第3期6卷 419-435页

作者： grant M.Young Department of Earth Sciences University of Western Ontario

Recent geochronological investigations reinforce the early suggestion that the upper part of the Paleoproterozoic Huronian Supergroup of Ontario, Canada is present in the Animikie Basin on the south shore of Lake Superior. These rocks, beginning with the glaciogenic Gowganda Formation, are interpreted as passive margin deposits. The absence of the lower Huronian （rift succession） from the Animikie Basin may be explained by attributing the oldest Paleoroterozoic rocks in the Animikie Basin （Chocolay Group） to deposition on the upper plate of a north-dipping detachment fault, which lacks sediments of the rift phase. Following thermal uplift that led to opening of the Huronian Ocean on the south side of what is now the Superior province, renewed uplift （plume activity） caused large-scale gravitational folding of the Huronian Supergroup accompanied by intrusion of the Nipissing diabase suite and Senneterre dikes at about 2.2 Ga. Termination of passive margin sedimentation is normally followed by ocean closure but in the Huronian and Animikie basins there was a long hiatus - the Great Stratigraphic Gap - which lasted for about 350 Ma. This hiatus is attributed to a second prolonged thermal uplift of part of Kenorland that culminated in complete dismemberment of the supercontinent shortly before 2.0 Ga by opening of the Circum-Superior Ocean. These events caused regional uplift （the Great Stratigraphic Gap） and delayed completion of the Huronian wilson Cycle until a regional compressional tectonic episode, including the Penokean orogeny, belatedly flooded the southern margin of the Superior province with foreland basin deposits, established the limits of the Superior structural province and played an important role in constructing Laurentia.

关键词： Paleoproterozoic Glaciation Plate tectonics Mantle plumes Supercontinents