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Transforming growth factor-β and toll-like receptor-4 polymorphisms are not associated with fibrosis in haemochromatosis

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World Journal of Gastroenterology 2013年第48期19卷 9366-9376页

作者： Marnie J Wood Lawrie W Powell Jeannette L Dixon V Nathan Subramaniam grant a ramm Hepatic Fibrosis Group QIMR Berghofer Medical Research Institute Brisbane 4006Australia Faculty of Medicine and Biomedical Sciences The University of Queensland Brisbane 4006 Australia Department of Gastroenterology and Hepatology Royal Brisbane and Women’s HospitalBrisbane 4029 Australia Centre for the Advancement of Clinical Research Royal Brisbane and Women’s Hospital and the University of Queensland Centre for Clinical Research Brisbane 4029 Australia Iron Metabolism Laboratory QIMR Berghofer Medical Research Institute Brisbane 4006 Australia Membrane Transport Laboratory QIMR Berghofer Medical Research Institute Brisbane 4006 Australia

AIM:To investigate the role of genetic polymorphisms in the progression of hepatic fibrosis in hereditary ***:A cohort of 245 well-characterised C282Y homozygous patients with haemochromatosis was studied,with all subjects having liver biopsy data and DNA available for *** study assessed the association of eight single nucleotide polymorphisms(SNPs)in a total of six genes including toll-like receptor 4(TLR4),transforming growth factor-beta(TGF-β),oxoguanine DNA glycosylase,monocyte chemoattractant protein 1,chemokine C-C motif receptor 2 and interleukin-10 with liver disease *** was performed using high resolution melt analysis and *** results were analysed in relation to the stage of hepatic fibrosis in multivariate analysis incorporating other cofactors including alcohol consumption and hepatic iron ***:There were significant associations between the cofactors of male gender(P=0.0001),increasing age(P=0.006),alcohol consumption(P=0.0001),steatosis(P=0.03),hepatic iron concentration(P<0.0001)and the presence of hepatic *** the candidate gene polymorphisms studied,none showed a significant association with hepatic fibrosis in univariate or multivariate analysis incorporating *** also specifically studied patients with hepatic iron loading above threshold levels for cirrhosis and compared the genetic polymorphisms between those with no fibrosis vs cirrhosis however there was no significant effect from any of the candidate genes ***,in this large,well characterised cohort of patients there was no association between SNPs for TGF-βor TLR4and the presence of fibrosis,cirrhosis or increasing fibrosis stage in multivariate ***:In our large,well characterised group of haemochromatosis subjects we did not demonstrate any relationship between candidate gene polymorphisms and hepatic fibrosis or cirrhosis.

关键词： Haemochromatosis Genetic polymorphism Liver fibrosis Toll-like receptor 4 Interleukin 10 Monocyte chemoattractant protein 1 Chemokine(C-C motif) ligand 2 Transforming growth factor beta 8-oxoguanine DNA glycosylase

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Role of iron in hepatic fibrosis: One piece in the puzzle

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World Journal of Gastroenterology 2007年第35期13卷 4746-4754页

作者： Marie A Philippe Richard G Ruddell grant a ramm Hepatic Fibrosis Group The Queensland Institute of Medical ResearchPO Royal Brisbane and Women's HospitalBrisbane 4029Australia

Iron is an essential element involved in various biological pathways. When present in excess within the cell, iron can be toxic due to its ability to catalyse the formation of damaging radicals, which promote cellular injury and cell death. Within the liver, iron related oxidative stress can lead to fibrosis and ultimately to cirrhosis. Here we review the role of excessive iron in the pathologies associated with various chronic diseases of the liver. We also describe the molecular mechanism by which iron contributes to the development of hepatic fibrosis.

关键词： Iron Fibrosis Oxidative stress Hepatic stellate cell Haemochromatosis Hepatitis C Non-alcoholic fatty liver disease Alcoholic liver disease

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Paediatric cholestatic liver disease:Diagnosis,assessment of disease progression and mechanisms of fibrogenesis

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World Journal of Gastrointestinal Pathophysiology 2010年第2期1卷 69-84页

作者： Tamara N Pereira Meagan J Walsh Peter J Lewindon grant a ramm The Hepatic Fibrosis Group The Queensland Institute of Medical Research Department of Gastroenterology Royal Children's Hospital

Cholestatic liver disease causes significant morbidity and mortality in *** diagnosis and management of these diseases can be complicated by an inability to detect early stages of fibrosis and a lack of adequate interventional *** is no single gold standard test that accurately reflects the presence of liver disease,or that can be used to monitor fibrosis progression,particularly in conditions such as cystic *** has lead to controversy over how suspected liver disease in children is detected and *** review discusses the challenges in using commonly available methods to diagnose hepatic fibrosis and monitor disease progression in children with cholestatic liver *** addition,the review examines the mechanisms hypothesised to be involved in the development of hepatic fibrogenesis in paediatric cholestatic liver injury which may ultimately aid in identifying new modalities to assist in both disease detection and therapeutic intervention.

关键词： Cystic fibrosis Biliary atresia Liver biopsy Ultrasound Hepatic fibrosis Cirrhosis Hepatic stellatecell Bile acid Chemotaxis Monocyte chemotaxis protein-1

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The Forgotten Nutrient——The Role of Nitrogen in Permafrost Soils of Northern China

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Advances in Atmospheric Sciences 2020年第8期37卷 793-799页

作者： Elisabeth ramm Chunyan LIU Xianwei WANG Hongyu YUE Wei ZHANG Yuepeng PAN Michael SCHLOTER Silvia GSCHWENDTNER Carsten W.MUELLER Bin HU Heinz RENNENBERG Michael DANNENMANN Institute of Meteorology and Climate Research Atmospheric Environmental Research(IMK-IFU)Karlsruhe Institute of Technology(KIT)Garmisch-Partenkirchen 82467Germany State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry(LAPC) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory of Wetland Ecology and Environment Northeast Institute of Geography and AgroecologyChinese Academy of SciencesChangchun 130102China Chair of Soil Science Science Center WeihenstephanDepartment of Ecology and Ecosystem ManagementTechnical University MunichFreising 85354Germany Research Unit for Comparative Microbiome Analyses Helmholtz Zentrum MünchenOberschleissheim 85764Germany Center of Molecular Ecophysiology(CMEP) College of Resources and EnvironmentSouthwest UniversityChongqing 400715China Department of Geosciences and Natural Resource Management University of CopenhagenCopenhagen DK-1350Denmark

***:permafrost carbon and nitrogen feedback to climate change Permafrost refers to any ground,including soils,sediments and rocks,with a temperature at or below the freezing point of water(0℃)for two or more consecut... 详细信息

关键词： ground climate freezing

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