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In situ cosmogenic ^(10)Be dating of the Quaternary glaciations in the southern Shaluli Mountain on the Southeastern Tibetan Plateau

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Science China Earth Sciences 2006年第12期49卷 1291-1298页

作者： Raisbeck grand Yiou Francios Centre de Spectrometric Nucleaire et de Specmetric de Masse IN2P3 CNRS Bat.10891405 Campus Orsay France

It is generally considered that four-times ice age happened during the Quaternary epoch on the Tibetan Plateau. However, the research on the chronology of the four-times ice age is far from enough. The Shaluli Mountain on the Southeastern Tibetan Plateau is an ideal place for plaeo-glacier study, because there are abundant Quaternary glacial remains there. This paper discusses the ages of the Quaternary glaciations, based on the exposure dating of roche moutonnée, moraines and gla- cial erosion surfaces using in situ cosmogenic isotopes 10Be. It is found that the exposure age of the roche moutonnée at Tuershan is 15 ka, corresponding to Stage 2 of the deep-sea oxygen isotope, suggesting that the roche moutonnée at Tuershan is formed in the last glacial maximum. The expo- sure age of glacial erosion surface at Laolinkou is 130―160 ka, corresponding to Stage 6 of the deep-sea oxygen isotope. The oldest end moraine at Kuzhaori may form at 421―766 kaBP, corre- sponding to Stages 12―18 of the deep-sea oxygen isotope. In accordance with the climate charac- teristic of stages 12,14,16 and 18 reflected by the deep-sea oxygen isotope, polar ice cores and loess sequence, the oldest end moraine at Kuzhaori may form at stage 12 or stage 16, the latter is more possible.

关键词： Quaternary,glaciation,glacial,cosmogenic isotope,dating,10Be,exposure dating,Tibetan Plateau,environmental change,surface dating,boulder,erosion.

肾脏恶性肿瘤冷冻消融术后早期对比增强：影像表现与良性相关

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国际医学放射学杂志 2024年第1期 130-131页

作者： T.grand C.Delavaud C.Dariane T.Ramtohul S.Guinebert O.Hélénon 李江

摘要目的肾脏恶性肿瘤冷冻消融术后早期MRI对比增强可能提示肿瘤残留（RT）。但冷冻消融术后48 h内MRI上出现强化的病人在6周后没有对比度增强，研究旨在分析

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Recollections of my mentor,Donald ***

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Earthquake Science 2022年第1期35卷 14-16页

作者： Stephen P.grand Department of Geological Sciences Jackson School of GeosciencesUniversity of Texas at AustinTX78712USA

I arrived at Caltech as a graduate student in the summer of *** a BSc degree in physics,I knew little to nothing about seismology or *** Seismo Lab encouraged new students to immediately start some research with a great latitude on what to work *** summer I started projects relocating aftershocks of the 1978 Oaxaca earthquake with Karen McNally,learning a normal mode code with Bernard Minster,and investigating the source mechanism of the 1979 *** earthquake with Hiroo Kanamori.

关键词： earthquake latitude geophysics

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意大利VILLA CORA大酒店

现代装饰 2012年第6期 36-45页

作者： Marianna Gagliardi Massimo Listri grand Hotel Vila Cora 代照意大利Marianna Gagliardi事务所

VILLACQRA大酒店位于一座有数百年历史的公园内，与波波里乐园（Boboli Gardens）遥相呼应。这栋建筑有着丰厚的历史背景，它是佛罗伦萨的一颗明珠。建筑原名为奥本海森府邸，是十九世纪下半叶由巴森·奥本海默建成的贵族住宅。折衷主... 详细信息

VILLACQRA大酒店位于一座有数百年历史的公园内，与波波里乐园（Boboli Gardens）遥相呼应。这栋建筑有着丰厚的历史背景，它是佛罗伦萨的一颗明珠。建筑原名为奥本海森府邸，是十九世纪下半叶由巴森·奥本海默建成的贵族住宅。折衷主义的装饰风格彰显出别具一格的艺术品位，是当时流行的建筑风格。

关键词：酒店意大利建筑风格佛罗伦萨奥本海默艺术品位装饰风格折衷主义

Effects of omacor<sup>®</sup>on left ventricular remodelling consecutive to post myocardial infarction special issue-myocardial infarction

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World Journal of Cardiovascular Diseases 2013年第5期3卷 40-44页

作者： Bruno Le grand Institut de Recherche Pierre Fabre Castres France

Ventricular remodelling is the main trigger of the development of heart failure. Therefore, the reduction of structural remodelling is known to prevent the development of heart failure. The aim of the present study was to investigate the effects of OMACOR?, a well known mixture of EPA and DHA in an experimental model of heart failure induced by occlusion of left descending coronary artery and the reperfusion within 2 months. After a long term treatment of 2 months;OMACOR? (100 mg/kg) statistically significantly reduced the expansion of infarcted zone (35% ± 4%, P ± 3% in the vehicle group). The phosphorylation of Cx43 as biomarker of the cardiac remodelling was visualised by immunofluorescence in rat’s heart at the end of the study. In the vehicle-infarcted group, a significant de-phosphorylation of Cx43 was observed (8.2 ± 1.0 u.a, n = 8 compared to 11.8 ± 1.3 u.a in the sham group, n = 9) confirming a remodelling process in the infarcted group. In the group treated with OMACOR?,the de-phosphorylation of Cx43 was no longer observed compared to the sham group (16.4 ± 2.9 u.a, n = 9, NS). The present results demonstrate that a long term treatment with OMA-COR? reduced the infarcted size in experimental models of heart failure and that these anti-remodelling effects are due at least in part by resynchronizing the gap junction activity.

关键词： Left Ventricular Remodelling Myocardial Infarction OMACOR^(■)

Plant cover as an estimator of above-ground biomass in semi-arid woody vegetation in Northeast Patagonia,Argentina

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Journal of Arid Land 2021年第9期13卷 918-933页

作者： Laura B RODRIGUEZ Silvia S TORRES ROBLES Marcelo F ARTURI Juan M ZEBERIO Andrés C H grand Néstor I GASPARRI National University of Río Negro Atlantic HeadquartersCenter for Environmental Studies from Norpatagonia(CEANPa)Viedma 8500Argentina National Council of Scientific and Technical Research(CONICET) Viedma 8500Argentina Ecological and Environmental Systems Research Laboratory(LISEA) National University of La PlataLa Plata 1900Argentina National Institute of Agricultural Technology(INTA) AER PatagonesCarmen de Patagones 8504Argentina Institute of Regional Ecology(IER) National University of Tucumán(UNT)-National Council of Scientific and Technical Research(CONICET)Tucumán 4000Argentina Faculty of Natural Sciences and Miguel Lillo Institute National University of Tucumán(UNT)Yerba Buena 4107Argentina

The quantification of carbon storage in vegetation biomass is a crucial factor in the estimation and mitigation of CO2 ***,arid and semi-arid regions are considered an important carbon ***,they have received limited attention and,therefore,it should be a priority to develop tools to quantify biomass at the local and regional *** plant variables,such as stem diameter and crown area,were reported to be good predictors of individual plant ***-level variables,such as plant cover and mean height,are also easy-to-measure estimators of above-ground biomass(AGB)in dry *** this study,we estimated the AGB in semi-arid woody vegetation in Northeast Patagonia,*** evaluated whether the AGB at the stand level can be estimated based on plant cover and to what extent the estimation accuracy can be improved by the inclusion of other field-measured structure *** also evaluated whether remote sensing technologies can be used to reliably estimate and map the regional mean *** this purpose,we analyzed the relationships between field-measured woody vegetation structure variables and AGB as well as LANDSAT TM-derived *** obtained a model-based ratio estimate of regional mean AGB and its standard *** plant cover allowed us to obtain a reliable estimation of local AGB,and no better fit was attained by the inclusion of other structure *** stand-level plant cover ranged between 18.7%and 95.2%and AGB between about 2.0 and 70.8 Mg/hm^(2).AGB based on total plant cover was well estimated from LANDSAT TM bands 2 and 3,which facilitated a model-based ratio estimate of the regional mean AGB(approximately 12.0 Mg/hm^(2))and its sampling error(about 30.0%).The mean AGB of woody vegetation can greatly contribute to carbon storage in semi-arid ***,plant cover estimation by remote sensing images could be used to obtain regional estimates and map biomass,as well as to assess and monitor the i

关键词： above-ground biomass shrublands ratio estimation carbon storage remote sensing Patagonia

Sequencing of high-efficacy disease-modifying therapies in multiple sclerosis： perspectives and approaches

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Neural Regeneration Research 2018年第11期13卷 1871-1874页

作者： Francois grand'Maison Michael Yeung Sarah A. Morrow Liesly Lee Francois Emond Brian J. Ward Pierre Laneuville Robyn Schecter Neuro Rive-Sud Hospital Charles LeMoyne Greenfield Park Quebec Canada Clinical Neurosciences Foothills Medical Centre Calgary Alberta Canada London Health Sciences Center (LHSC) Western University London Ontario Canada Department of Neurology Sunnybrook Health Sciences Centre Toronto Ontario Canada Centre Hospitalier Universitaire de Quebec - hospital de l'Enfant-Jesus Quebec City Quebec Canada Research Institute of the McGill University Health Centre Montreal Quebec Canada Department of Medicine McGill University Montreal Quebec Canada Novartis Pharmaceuticals Canada Inc. Dotal Quebec Canada

Multiple sclerosis（MS） is characterized by chronic inflammation in conjunction with neurodegeneration within the central nervous system. Most individuals with MS begin with a relapsing remitting course that later transitions to secondary progressive MS. Currently available disease-modifying therapies（DMTs） for relapsing MS have been demonstrated to reduce disease activity, however most patients require a change in therapy over the course of their disease. Treatment goals include the prevention of relapses and disability accumulation and to achieve this objective requires careful planning. Sequencing of DMTs for individual patients should be designed in such a way to maximize disease control and minimize risk based on the mechanism of action, pharmacokinetic and pharmacodynamic properties of each therapy. This includes the DMT patients are being switched from to those they are being switched to. The reversibility of immune system effects should be a key consideration for DMT sequence selection. This feature varies across DMTs and should factor more prominently in decision making as newer treatments become available for the prevention of disability accumulation in patients with progressive MS. In this short review, we discuss the landscape of existing therapies with an eye to the future when planning for optimal DMT sequencing. While no cure exists for MS, efforts are being directed toward research in neuroregeneration with the hope for positive outcomes.

关键词： relapsing multiple sclerosis high efficacy disease-modifying therapies treatment optimization treatment sequencing therapeutic inertia sub-optimal treatment progressive disease immune effects

利用陆面岩石中生成的宇生同位素重建冰川漂砾运动历史的尝试

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地质学报 2003年第3期77卷 407-413页

作者：王建 Francois Yiou grand Raisbeck 徐孝彬南京师范大学地理科学学院 210097 法国国家研究中心核谱质谱中心法国奥塞91405

冰川漂砾的形成年代通常难以直接测定,并且漂砾形成以后是否被再次搬运或者移动过,更是无法知道。本文研究发现,通过测试砾石不同部位的宇生同位素,不仅可以测定砾石形成的时代,而且可以确定砾石再次被搬运或者被翻转的年代,从而恢复砾... 详细信息

冰川漂砾的形成年代通常难以直接测定,并且漂砾形成以后是否被再次搬运或者移动过,更是无法知道。本文研究发现,通过测试砾石不同部位的宇生同位素,不仅可以测定砾石形成的时代,而且可以确定砾石再次被搬运或者被翻转的年代,从而恢复砾石运动的历史。本文以石英中生成的宇生同位素^(10)Be,对青藏高原东南部海子山的冰川漂砾进行了探讨,结果表明该砾石形成于倒数第二次冰期(186～128 ka BP之间),在末次冰期中再次被冰川搬运,使之反转。该方法不局限于^(10)Be和冰川漂砾,也适用于其他陆面岩石中生成的宇生同位素以及其他成因的石块或者砾石。因此为探讨冰川作用、泥石流活动、重力崩塌等过程提供了一种重要的方法和技术途径。

关键词：宇生同位素陆面岩石冰川漂砾运动冰川作用暴露年代地面测年青藏高原

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