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Single-cell Analysis Technologies for Immuno-oncology Research:from Mechanistic Delineation to Biomarker Discovery

Genomics, Proteomics & Bioinformatics 2021年第2期19卷 191-207页

作者： Zhiliang Bai graham su Rong Fan Department of Biomedical Engineering Yale UniversityNew HavenCT 06511USA State Key Laboratory of Precision Measurement Technology and Instrument Tianjin UniversityTianjin 300072China Yale Stem Cell Center and Yale Cancer Center Yale School of MedicineNew HavenCT 06511USA Human and Translational Immunology Yale School of MedicineNew HavenCT 06511USA

The successes with immune checkpoint blockade(ICB)and chimeric antigen receptor(CAR)-T-cell therapy in treating multiple cancer types have established immunotherapy as a powerful curative option for patients with advanced ***,many patients do not derive benefit or long-term responses,highlighting a pressing need to perform complete investigation of the underlying mechanisms and the immunotherapy-induced tumor regression or *** recent years,a large number of single-cell technologies have leveraged advances in characterizing immune system,profiling tumor microenvironment,and identifying cellular heterogeneity,which establish the foundations for lifting the veil on the comprehensive crosstalk between cancer and immune system during *** this review,we introduce the applications of the most widely used single-cell technologies in furthering our understanding of immunotherapies in terms of underlying mechanisms and their association with therapeutic *** also discuss how single-cell analyses help to deliver new insights into biomarker discovery to predict patient response rate,monitor acquired resistance,and support prophylactic strategy development for toxicity ***,we provide an overview of applying cutting-edge single-cell spatial-omics to point out the heterogeneity of tumor–immune interactions at higher level that can ultimately guide to the rational design of next-generation immunotherapies.

关键词： Single-cell analysis Immunotherapy Biomarker discovery Checkpoint blockade CAR-T

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Electrospun ZnSnO_(3)/PVDF‑HFP Nanofibrous Triboelectric Films for Efficient Mechanical Energy Harvesting

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Advanced Fiber Materials 2023年第5期5卷 1685-1698页

作者： Venkata Siva Kavarthapu Sontyana Adonijah graham Punnarao Manchi Mandar Vasant Paranjape Jae su Yu Department of Electronics and Information Convergence Engineering Institute for Wearable Convergence ElectronicsKyung Hee University1732 Deogyeong‑daeroGiheung‑guYongin‑SiGyeonggi‑do 17104Republic of Korea

Nowadays,triboelectric nanogenerators(TENGs)are one of the most emerging technologies owing to their easy and costeffective device *** can harvest mechanical energy from our living ***,we synthesized dielectric zinc tin oxide(ZnSnO_(3))nanoparticles(NPs)by a hydrothermal *** ZnSnO_(3)NPs provide a dielectric and piezoelectric effect,which can efficiently enhance the output electrical performance of the proposed *** prepared ZnSnO_(3)NPs were embedded into a polyvinylidene fluoride hexafluoropropylene(PVDF-HFP)polymer to prepare ZnSnO_(3)/PVDF-HFP nanofibrous films to fabricate a *** output performance of TENG was investigated and optimized by varying the loading concentration of ZnSnO_(3)NPs in PVDF-HFP fibrous *** highest voltage,current,charge density,and power density from the fabricated TENG were achieved as~138 V,~5μA,~52μC/m2,and~1.6 W/m2,***,the robustness of the TENG was studied via the long-term mechanical stability ***,the practical and real-time application of the TENG was demonstrated by harvesting mechanical energy to power low-power portable electronic ***,the materials used in the TENG were combined into a skipping rope to harvest biomechanical/mechanical energy while exercising.

关键词： s ZnSnO_(3)nanoparticles ZnSnO_(3)/PVDF-HFP fibrous films Triboelectric nanogenerators Mechanical energy harvesting

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Abundant Production of Reactive Water Radical Cations under Ambient Conditions

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CCS Chemistry 2022年第4期4卷 1224-1231页

作者： Meng Wang Xiao-Fei Gao Rui su Peng He Yuan-Yuan Cheng Ke Li Dongbo Mi Xiaoping Zhang Xinglei Zhang Huanwen Chen R.graham Cooks Jiangxi Key Laboratory for Mass Spectrometry and Instrumentation East China University of TechnologyNanchang 330013 State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of ChemistryJilin UniversityChangchun 130012 Department of Chemistry and Center for Analytical Instrumentation Development Purdue UniversityWest LafayetteIN 47907

Water radical cations,the crucial intermediates in many aqueous reactions and biochemical processes,are difficult to investigate experimentally due to their short lifetime ***,ahomemade device based on energy-tunable discharge was employed to deposit suitable amounts of energy to atmospheric pressure pure water vapor for abundant production of water radical cations,stabilized as(H_(2)O)n^(+·)(n=2-5)with a maximal abundance of≥8.3×10^(6) cps for(H_(2)O)_(2)^(+·),characterized by mass spectrometry(MS).The abundance of water radical cations was optimized by adjusting the experimental parameters such as the discharge voltage(2.5 kV),temperature of the MS inlet(140℃),carrier gas flow(20mL/min),and the distance between the discharge tip and MS inlet(12 mm).The ambient formation of water radical cationswas further confirmedby thehigh reactivity of as-prepared water radical cations,which reacted with benzene,ethyl acetate,and dimethyl disulfide instantly,showing rich chemistry with ionic and radical ***,the computations usingCCSD(T)//MP2 method and density functional theory confirmed that the O-O single-electron bound dimer(B),as well as the hydronium hydroxyl radical complex(A),accounted for the unusual chemistry of the water radical cations,providing a facile approach to access the high reactivity ofwater radical cations under the ambient conditions.

关键词： water radical cation mass spectrometry O-O single-electron bound dimer of water radical cation hydronium hydroxyl dimer of water radical cation

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Preparation of large-size Al_(2)O_(3)/GdAlO_(3)/ZrO_(2)ternary eutectic ceramic rod by laser directed energy deposition and its microstructure homogenization mechanism

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Journal of Materials Science & Technology 2021年第26期85卷 218-223页

作者： Haifang Liu Haijun su Zhonglin Shen Di Zhao Yuan Liu Yinuo Guo Min Guo Jun Zhang Lin Liu Hengzhi Fu State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an710072China

Laser 3D printing based on melt growth has great potential in rapid preparation of Al_(2)O_(3)-based eutectic ce *** this work,la rge-scale Al_(2)O_(3)/GdAlO_(3)/ZrO_(2)ternary eutectic ceramic rod with diameter of 4-5 mm and height higher than 250 mm was additively manufactured by laser directed energy ***,heat treatment was applied to eliminate the microstructure heterogeneity in the as-deposited eutectic ceramic,and the microstructure homogenization mechanism was studied in *** results indicate that colonies and banded structures completely disappear after the heat treatment,producing a homogeneous network eutectic *** microstructure homogenization is revealed to experience three stages of discontinuous coarsening,continuous coarsening and microstructure ***,it is found that the eutectic spacing linearly increases with the heat treatment time,meaning that the coarsening behavior of the laser 3D-printed Al_(2)O_(3)/GdAlO_(3)/ZrO_(2)eutectic ceramic satisfies well with the graham-Kraft model.

关键词： Oxide eutectic ceramic Laser 3D printing Melt growth Heat treatment Microstructure homogenization

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论《洼地》中的历史创伤书写

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外国文学研究 2009年第1期31卷 81-87页

作者：苏忱浙江大学外语学院

《洼地》是当代英国小说家格雷厄姆.斯威夫特颇受评论界关注的一部作品。评论者大都认为小说对历史叙事和历史哲学的思考呼应了以海登.怀特为代表的新历史主义学家的诸多观点。然而,《洼地》不仅展现了"史学元小说"的某些特点,而且小说... 详细信息

《洼地》是当代英国小说家格雷厄姆.斯威夫特颇受评论界关注的一部作品。评论者大都认为小说对历史叙事和历史哲学的思考呼应了以海登.怀特为代表的新历史主义学家的诸多观点。然而,《洼地》不仅展现了"史学元小说"的某些特点,而且小说叙述者在作品中对历史创伤的反复回忆,小说叙事所呈现的多元化特点,以及作家对"人造历史"和"自然历史"、"历史"和"此处现在"等概念的区分,都展现了斯威夫特在遭遇历史书写困境之时,对如何还原历史之真,再现历史创伤的探索与思考。

关键词：《洼地》格雷厄姆·斯威夫特历史叙事创伤

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斯维夫特小说《糖果铺店主》的叙事心理与叙事策略

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当代外国文学 2009年第1期30卷 103-109页

作者：苏忱浙江大学外国语言文化与国际交流学院师资博士后

叙述者的叙事心理往往决定了他所采用的叙事策略。斯维夫特的小说《糖果铺店主》的叙述者威利在历史叙事的建构中为了规避其中的创伤事件,对创伤经验保持沉默、以"拜物式"的叙事置换真实的创伤经历、或者在历史的回忆中建构怀旧的叙事... 详细信息

叙述者的叙事心理往往决定了他所采用的叙事策略。斯维夫特的小说《糖果铺店主》的叙述者威利在历史叙事的建构中为了规避其中的创伤事件,对创伤经验保持沉默、以"拜物式"的叙事置换真实的创伤经历、或者在历史的回忆中建构怀旧的叙事。由叙事心理决定的叙事策略构成了小说叙事独有的特点。

关键词：格雷厄姆·斯维夫特创伤不可靠叙述

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铝阳极化黑色染液中铝离子含量与添补染料浓度的关系

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电镀与涂饰 2018年第11期37卷 503-507页

作者：江富诚苏逸焕张政乾林舜得台湾永光化学工业股份有限公司台湾桃园33759

探讨了黑色染液中铝离子的质量浓度对铝阳极化染色的影响。通过统计分析,得到了上色力度与染料添补浓度的关系式。

关键词：铝合金阳极化黑色染料铝离子上色力度

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The Principal Component Analysis of Element Contents in Chinese Herbs of the Caine Kidney Mixture

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Engineering（科研） 2012年第10期4卷 39-42页

作者： Shurong su Xiaoxi Yang Yi Xie Weiqun Tian Shirley Z Shen Biology Base Class2 College of Life Sciences at Wuhan University Luo-jia-shan Wuhan 430072 P. R. China Department of Biomedical Engineering Wuhan University School of Basic Medical Sciences 185 Donghu Rd.Wuhan 430071 P. R. China Division of Materials Science and Engineering CSIRO 37 Graham Rd. Highett VIC 3190 Australia Wuhan University School of Mathematics and Statistics Luo-jia-shan Wuhan 430072 P. R. China

Objective: This research compares the nature of 11 kinds of Chinese herbs in the caine kidney mixture, and provides a theoretical way to concentrated prescriptions. Methods: Based on the principal component analysis of element contents in Chinese herbs, the effects of 25 chemical elements in the 11 kinds of Chinese herbs in the caine kidney mixture have been analyzed. Results: The traditional Chinese medicines of rehmannia, astragalus, mulberry, salvia miltiorrhiza, rhubarb in the caine kidney mixture play a major role in the treatment of chronic renal failure. Conclusion: The principal component analysis is very practical in the compatibility of medicines and concentrated prescriptions.

关键词： Chemical Element Principal Com- ponent Analysis the Caine Kidney Mixture Concentrated Prescriptions

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活塞用铝合金材料蠕变本构模型对比

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内燃机学报 2022年第4期40卷 364-370页

作者：何联格周蓝苏建强张斌石文军重庆理工大学汽车零部件先进制造技术教育部重点实验室重庆400054 重庆理工大学车辆工程学院重庆400054 重庆青山工业有限责任公司重庆402761

为对比时效硬化和修正graham两种蠕变本构模型在活塞蠕变分析上的应用,在不同温度和应力状态下对Al-Si-Cu系合金进行了蠕变时效试验,根据试验结果拟合两种蠕变本构模型所需参数.将两种蠕变本构模型用于活塞热机耦合强度计算中,对比两种... 详细信息

为对比时效硬化和修正graham两种蠕变本构模型在活塞蠕变分析上的应用,在不同温度和应力状态下对Al-Si-Cu系合金进行了蠕变时效试验,根据试验结果拟合两种蠕变本构模型所需参数.将两种蠕变本构模型用于活塞热机耦合强度计算中,对比两种蠕变本构模型对活塞在热-机械负荷耦合作用下的强度影响,以及蠕变应变的差异.结果表明:时效硬化蠕变本构模型对活塞强度计算结果影响较大,修正graham蠕变本构模型较适用于活塞在高温热-机械负荷下的蠕变时效分析.

关键词：活塞铝合金热机耦合高温蠕变本构模型

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国际白菜基因组测序项目中的参考遗传图

国际白菜基因组测序项目中的参考遗传图

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第十二届国际油菜大会

作者： su Ryun Choi graham R.Teakle Prikshit Plaha Jeong Hee Kim Charlotte J.Allender Elena Beynon Zhong Yun Piao Tae Ho Han graham J.King Guy C.Barker Paul Hand Derek J.Lydiate Jacqui Batley Dave Edwards Thomas C.Osborn Dal Hoe Koo Jae Wook Bang Beom-Seok Park Yong Pyo Lim Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Saskatoon Research Centre Agriculture and Agri-Food Canada107 Science PlaceSaskatoonSKS7N3V3Canada Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea Department of Applied Plant Science Chonnam National UniversityGwangju 500-757Korea Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Warwick HRI University of WarwickWellesbourneWarwickCV35 9EFUK Saskatoon Research Centre Agriculture and Agri-Food Canada107 Science PlaceSaskatoonSKS7N3V3Canada Plant Biotechnology Centre Primary Industries Research VictoriaLa Trobe UniversityBundooraVictoria 3086Australia Plant Biotechnology Centre Primary Industries Research VictoriaLa Trobe UniversityBundooraVictoria 3086Australia Seminis Vegetable Seeds Inc. 37437 State Highway 16woodlandCA 95695USA Department of Biology Chungnam National UniversityDaejeon 305-764Korea Department of Biology Chungnam National UniversityDaejeon 305-764Korea Brassica Genomics Team National Institute of Agricultural BiotechnologySuwon 441-707Korea Department of Horticulture Genome Research CenterChungnam National UniversityDaejeon 305-764Korea

我们目前正在构建的大白菜遗传连锁图是国际白菜基因组测序项目作为骨架图,将用来序列重叠群的锚定工作。图谱是基于以遗传差异大的两个中国大白菜品种---“Chiifu”和”Kenshin”杂交得到的F1经花药培养而得到78个DH系构建的。目前,图...

我们目前正在构建的大白菜遗传连锁图是国际白菜基因组测序项目作为骨架图,将用来序列重叠群的锚定工作。图谱是基于以遗传差异大的两个中国大白菜品种---“Chiifu”和”Kenshin”杂交得到的F1经花药培养而得到78个DH系构建的。目前,图谱上一共定位了556个标记,其中包括278个AFLP、235个SSR、25个RAPD和18个ESTP、STS、CAPS标记。对本遗传图谱和甘蓝型油菜遗传图谱中的通用SSR标记进行了位置和方向比较,从而把确定的10个连锁群分别记为R1-R10,并与甘蓝型油菜的N1-N10相对应。同时,通过定位的235个通用SSR标记,我们还可以对来自白菜的A基因组和来自甘蓝型油菜的A基因组进行比较分析。通过与拟南芥基因组序列进行比较,选出了500个BAC克隆,作为部分最小跨度克隆。对这些BAC的测序工作已完成,并成为设计和发展SSR引物的一个重要序列来源。用这些BAC序列发展而来的SSR标记已被定位到了参考遗传图上——CKDH图谱。这些做为锚定用的SSR标记,将在遗传图和物理图的整合中起重要作用,同时也为随后BAC-BY-BAC的测序策略中构建重叠群提供种子BAC。这样一个参考图谱的成功构建将对国际社会中改良白菜以及其它芸薹属作物起重要作用。

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