检索结果-南通市图书馆

Rational redesign of inhibitors of furin/kexin processing proteases by electrostatic mutations

Acta Pharmacologica Sinica 2004年第12期25卷 146-152页

作者： Xiao-hui CAI, Qing ZHANG, Da-fu DING2.Key Laboratory of Proteomics, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological sciences, chinese {2. of sciences, graduate school of the chinese {2. of sciences, Shanghai 2.003., China Key Laboratory of Proteomics Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai 200031 China

AIM: To model the three-dimensional structure and investigatethe interaction mechanism ofthe proprotein convertase furin/kexin and their inhibitors (eglin c mutants). METHODS: The three-dimensional complex structures of furin/ kexin with its inhibitors, eglin c mutants, were generated by modeller program using the newly published X-ray crystallographical structures of mouse furin and yeast kexin as templates. The electrostatic interaction energy of each complex was calculated and the results were compared with the experimentally determined inhibition con- stants to find the correlation between them. RESULTS: High quality models of furin/kexin-eglin c mutants were obtained and used for calculation of the electrostatic interaction energies between the proteases and their inhibitors. The calculated electrostaticenergies of interaction showeda linear correlation to the experimental inhibition constants. CONCLUSION: The modeled structures give good explanations of the specificity of eglin c mutants to furin/ kexin. The electrostatic interactions play important roles in inhibitory activity of eglin c mutants to furin/kexin. The results presented here provided quantitative structural and functional information concerning the role of the charge- charge interactions in the binding of furin/kexin and their inhibitors.

关键词： furin kexin eglin c drug design electrostatic mutation

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

A puzzle of the radio-quiet quasar PG 1407+2.5:Are optical and X-ray emissions produced from a relativistic jet?

引用

Science China(Physics,Mechanics & Astronomy) 2011年第1期54卷 183-186页

作者： CHEN Liang 1,2.3.& BAI JinMing 1,2.1 National Astronomical Observatories/Yunnan Observatory,chinese {3. of {2.,Kunming 650011,China 2.Key Laboratory for the Structure and Evolution of Celestial Objects,chinese {3. of {2.,Kunming 650011,China 3.graduate University of chinese {3. of {2.,Beijing 100049,China 1. National Astronomical Observatories/Yunnan Observatory Chinese Academy of Sciences Kunming 650011 China2. Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of Sciences Kunming 650011 China3. Graduate University of Chinese Academy of Sciences Beijing 100049 China

PG 1407+2.5 is a radio quiet quasar that has a relativistic *** this report,we show some peculiar properties of its optical and X-ray emissions,which indicate possible non-thermal origins produced from the *** use a simple synchrotron + synchrotron self Compton (SSC) model to fit the emissions with different ratios of energy densities between the magnetic field and electrons (η≡U B/U e),which predicts a different γ-ray *** First LAT AGN Catalog (1LAC) did not include PG 1407+2.5,which indicates an upper limit of γ-ray *** upper limit constrains the ratio to be unreasonably large (η≥10 4-5).This inversely indicates that the optical and X-ray emissions may not be produced from the beaming *** discuss the physical implications of these results.

关键词： active galactic nuclei jet non-thermal emission PG 1407+2.5

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Test on Different Types of the Time Curve of Hardness Ratio of Gamma-Ray Bursts based on the Curvature Effect

引用

chinese Journal of Astronomy and Astrophysics 2008年第4期8卷 451-464页

作者： Lan-Wei Jia National Astronomical Observatories/Yunnan Observatory,chinese academy of {2.,Kunming 650011,China {3.,Beijing 100049,China National Astronomical Observatories/ Yunnan Observatory Chinese Academy of Sciences Kunming 650011 China and graduate school of chinese academy of sciences Beijing 100049 China

We analyzed a sample of 66 gamma-ray bursts （GRBs） and statistically confirmed the prediction on the time curve of the hardness ratio of GRBs made by Qin et al. based on the curvature effect. In their analysis, GRB pulses are divided into three types according to the shape of their raw hardness ratio （RHR） time curves, defined as to include the background counts to the signal counts, so as to make use of counts within small time intervals. Of the three types, very hard sources exhibit a perfect pulse-like profile （type 1）, hard bursts possess a pulse-like profile with a dip in the decay phase （type 2., and soft bursts show no pulse-like profile but have only a dipped profile （type 3.. In terms of the conventional hardness ratio, type 3.sources are indeed generally softer than those of type 1 and type 2. in agreement with the prediction. We found that the minimum value of RHR is sensitive in distinguishing the different types. We propose that GRB pulses can be classified according to the minimum value of RHR and that the different type sources may be connected with different strengths of the shock or/and the magnetic field.

关键词： gamma-rays burst -- gamma-rays observations - methods statistical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessing the Carrying Capacity of Tourist Resorts: An Application of Tourists’ Spatial Behavior Simulator Based on GIS and Multi-Agent System

引用

Wuhan University Journal of Natural sciences 2005年第4期10卷 779-784页

作者： ZHANG Ren-jun 1,2.1. Institute of Mountain Hazards and Environment, chinese academy of {2., Chengdu 610041, Sichuan, China 2. {3.d school of the chinese academy of {2., Beijing 10003., China chinese academy of {2. Institute of Mountain Hazards and Environment Chengdu Sichuan China (GRID:grid.9227.e) (ISNI:***) graduated school of the {2. {3. of sciences Beijing China (GRID:grid.9227.e) (ISNI:***)

Based on the study of visitors' individual spatial behaviors, a tourists'spatial behavior simulator (TSBS) to assess the carrying capacity of tourist resorts was developed,TSBS employs GIS (Geographic Information System) to manage the spatial data,and Multi-Agent systemto simulate the actions of individual visitors. By utilizing TSBS, visitors' travel patterns such aslocation, cost, and state can be analyzed and predicted. Based on this analysis and prediction, themodel of assessing the carrying capacity of resorts is built. Our results show that TSBS will be aneffective tool to accurately assess the carrying capacity of tourist resorts.

关键词： tourist resort carrying capacity TSBS GIS Multi-Agent simulator

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of cosmological constant on motion of UHECR particles

引用

Science China(Physics,Mechanics & Astronomy) 2005年第1期48卷 44-56页

作者： CHEN Shaoxia & CHANG Zhe Institute of High Energy Physics, chinese academy of {2., Beijing 10003., China {3., Beijing 10003., China Institute of High Energy Physics Chinese Academy of Sciences Beijing 100039 China graduate school Chinese Academy of Sciences Beijing 100039 China

Recent astronomical observations manifest that about two-thirds of the whole energy in the Universe is contributed by a small positive cosmological constant A (> 0). Then, an asymptotically de Sitter spacetime is premised naturally. However, physics in the de Sitter spacetime is very different from that in the Minkowski spacetime. As the first step, a covariant formalism of the kinematics in the de Sitter spacetime is presented here. By solving exactly the equations of motion for a field, we obtain the dispersion relation of a free particle. It is noticed that the dispersion relation is dependent on the degree of freedom of angular momentum of the particle. We show the threshold anomaly of the ultra high energy cosmic ray disappears naturally in the framework of the de Sitter kinematics.

关键词： ultrahigh energy cosmic ray, cosmological constant, curved spacetime.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structure of augmentation quotients of finite homocyclic abelian groups

引用

Science China Mathematics 2007年第9期50卷 1280-1288页

作者： Guo-ping TANG school of Mathematical sciences,{2. University of {3. academy of sciences,Beijing 100049,China 1. school of Mathematical sciences Graduate University of Chinese Academy of Sciences Beijing 100049 China

Let G be a finite abelian group and its Sylow p-subgroup a direct product of copies of a cyclic group of order p r , i.e., a finite homocyclic abelian group. Let Δ n (G) denote the n-th power of the augmentation ideal Δ(G) of the integral group ring ?G. The paper gives an explicit structure of the consecutive quotient group Q n (G) = Δ n (G)/Δ n+1(G) for any natural number n and as a consequence settles a problem of Karpilovsky for this particular class of finite abelian groups.

关键词： integral group ring augmentation ideal consecutive quotient of augmentation ideal 16S3. 2.C05

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cloning and characterization of interferon stimulated genes Viperin and ISG15,and their promoters from snakehead Channa argus

引用

Progress in Natural Science:Materials International 2007年第12期17卷 1425-1435页

作者： Jia Weizhang1,2. Zhou Xiuxia1,2. Huang Rong1,2.and Guo Qionglin1(1. Institute of Hydrobiololgy, {3. academy of {2., Wuhan 43.072. China 2. {3. University of {3. academy of {2., Beijing 10003., China) Institute of Hydrobiololgy Chinese Academy of Sciences Wuhan 430072 China graduate University of chinese {2. of {3. Beijing 100039 China

By suppression subtractive hybridization, rapid amplification of cDNA ends and gene walking methods, interferon stimulated genes (ISGs), Viperin and ISG15, and their promoters have been cloned and characterized from snakehead Channa argus. The Viperin cDNA was found to be 1474 nt and contain an open reading frame (ORF) of 1059 nt that translates into a putative peptide of 3.2.amino acid (aa). The putative peptide of Viperin shows high identity to that in teleosts and mammals except for the N-terminal 70 aa. The ISG15 cDNA was found to be 758 nt and contain an ORF of 468 nt that translates into a putative peptide of 155 aa. The putative peptide of ISG15 is composed of two tandem repeats of ubiquitin-like (UBL) domains, and a canonical conjugation motif (LRGG) at C-terminal. Viperin and ISG15 promoter regions were characterized by the presence of interferon stimulating response elements (ISRE) and γ-IFN activation sites (GAS). ISRE is a feature of IFN-induced gene promoter and partially overlaps interferon regulatory factor (IRF) 1 and IRF2.recognition sites. GAS is responsible for the γ-IFN mediated transcription. One conserved site for NF-κB was found in the promoter region of Viperin. This is the first report of conservative binding motif for NF-κB in accordance with the consensus sequence (GGGRNNYYCC) among teleost ISG promoters. Moreover, there were also TATA, CAAT and Sp1 transcription factor sites in Viperin and ISG15 promoters. In 5′ untranslated region (UTR), snakehead ISG15 gene contains a single intron, which differs from Viperin gene. The transcripts of Vipeirn and ISG15 mRNA were mainly expressed in head kidney, posterior kidney, spleen and gill. The expression levels in liver were found to increase obviously in response to induction by IFN-inducer poly I∶C.

关键词： interferon interferon stimulated gene (ISG) Viperin ISG15 snakehead (Channa argus).

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Application of the moist vorticity vector in the analysis of a heavy rainfall event in North China

引用

Progress in Natural Science:Materials International 2007年第12期17卷 1457-1465页

作者： Zhao Yu1,2.3. Wang Jianguo4 and Xue Deqiang2.1. Laboratory of Cloud-Precipitation Physics and Severe Storms, Institute of Atmospheric Physics, chinese {3. of {2., Beijing 10002., China 2. Shandong Provincial Meteorological Observatory, Jinan 2.003., China 3. {3. University of chinese {3. of {2., Beijing 10003., China 4. Shandong Provincial Meteorological Bureau, Jinan 2.003., China) Laboratory of Cloud-Precipitation Physics and Severe Storms Institute of Atmospheric Physics Chinese Academy of Sciences Beijing 100029 China Shandong Provincial Meteorological Observatory Jinan 250031 China graduate University of chinese {2. of {3. Beijing 100039 China Shandong Provincial Meteorological Bureau Jinan 250031 China

The moist vorticity vector (MVV), defined as (ζa×▽qv)/ρ introduced by Gao et al. is used to study a heavy rainfall event in North China. The MVV has zonal, meridional and vertical components in a three-dimensional framework. Analysis of domain-mean and mass-integrated quantities shows that the variation of the vertical component of the MVV closely follows the variation of the cloud hydrometeors, with a linear correlation coefficient of 0.95, indicating that the vertical component of the MVV is strongly associated with midlatitude convection. Further analysis shows that the vertical component of the MVV reflects the interaction between the horizontal vorticity and the horizontal specific humidity gradient, which can associate dynamic and thermodynamic processes with cloud microphysical processes. Thus, this study can help to understand how the interaction between circulations and clouds aids the development of convection, and the MVV can be used to trace the development and evolution of heavy rainfall.

关键词： moist vorticity vector heavy rainfall modeling study.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Cytotoxicity of carbon nanotubes

引用

Science China Chemistry 2008年第11期51卷 1021-1029页

作者： ZHU Ying1,2.& LI WenXin1 1 Laboratory of Nano-biology and Medicine, Shanghai Institute of Applied Physics, chinese academy of {2., Shanghai 2.1800, China 2.{3., Beijing 100049, China 1. Laboratory of Nano-biology and Medicine Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China 2. graduate school of chinese academy of sciences Beijing 100049 China

With large-scale production and application at large scale, carbon nanotubes (CNTs) may cause ad-verse response to the environment and human health. Thus, study on bio-effects and safety of CNTs has attracted great attention from scientists and governments worldwide. This report briefly summa-rizes the main results from the in vitro toxicity study of CNTs. The emphasis is placed on the descrip-tion of a variety of factors affecting CNTs cytotoxicity, including species of CNTs, impurities contained, lengths of CNTs, aspect ratios, chemical modification, and assaying methods of cytotoxicity. However, experimental information obtained thus far on CNTs' cytotoxicity is lacking in comparability, and some-times there is controversy about it. In order to assess more accurately the potential risks of CNTs to human health, we suggest that care should be taken for issues such as chemical modification and quantitative characterization of CNTs in cytotoxicity assessment. More importantly, studies on physical and chemical mechanisms of CNTs' cytotoxicity should be strengthened; assaying methods and evaluating criteria characterized by nanotoxicology should be gradually established.

关键词： carbon nanotubes (CNTs) cell bio-security

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Recent advances in the data analysis method of functional magnetic resonance imaging and its applications in neuroimaging

引用

Progress in Natural Science:Materials International 2006年第8期16卷 785-795页

作者： TIAN Jie, YANG Lei and HU Jin (Institute of Automation, chinese academy of {2., Beijing 100080, China {3., Beijing 10003., China) [a]chinese academy of {2. Institute of Automation Beijing China [b]graduate school of chinese academy of sciences Beijing China

Functional magnetic resonance imaging (fMRI) has opened a new area to explore the human brain. The fMRI can reveal the deep insights of spatial and temporal changes underlying a broad range of brain function, such as motor, vision, memory and emotion, all of which are helpful in the clinical investigation. In this paper, we introduce some recent-developed algorithms for fMRI signal detection such as model-driven method (general linear model, deconvolution model, non-linear model, etc. ) and data-driven method (principle component analysis, independent component analysis, self-organization mapping, clustered constrained non-negative matrix factorization, etc. ). We also propose several important applications of neuroimaging and point out their shortcomings and future perspectives.

关键词： fMR1 data analysis neuroimaging.

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：