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Cytotoxicity of carbon nanotubes

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Science china Chemistry 2008年第11期51卷 1021-1029页

作者： ZHU Ying1,2.& LI WenXin1 1 Laboratory of Nano-biology and Medicine, Shanghai Institute of Applied Physics, chinese academy of Sciences, Shanghai 2.1800, {2. 2.graduate school of chinese academy of Sciences, beijing 100049, {2. 1. Laboratory of Nano-biology and Medicine Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China 2. graduate school of {2. academy of Sciences Beijing 100049 China

With large-scale production and application at large scale, carbon nanotubes (CNTs) may cause ad-verse response to the environment and human health. Thus, study on bio-effects and safety of CNTs has attracted great attention from scientists and governments worldwide. This report briefly summa-rizes the main results from the in vitro toxicity study of CNTs. The emphasis is placed on the descrip-tion of a variety of factors affecting CNTs cytotoxicity, including species of CNTs, impurities contained, lengths of CNTs, aspect ratios, chemical modification, and assaying methods of cytotoxicity. However, experimental information obtained thus far on CNTs' cytotoxicity is lacking in comparability, and some-times there is controversy about it. In order to assess more accurately the potential risks of CNTs to human health, we suggest that care should be taken for issues such as chemical modification and quantitative characterization of CNTs in cytotoxicity assessment. More importantly, studies on physical and chemical mechanisms of CNTs' cytotoxicity should be strengthened; assaying methods and evaluating criteria characterized by nanotoxicology should be gradually established.

关键词： carbon nanotubes (CNTs) cell bio-security

Discovery of immune related factors in Fenneropenaeus chinensis by annotation of ESTs

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Progress in Natural Science:Materials International 2004年第1期14卷 48-55页

作者： SHEN Yaoqing 1,2. , XIANG Jianhai 1*, WANG Bing 1,2. , LI Fuhua 1 and TONG Wei 3(1. Experimental Marine Biology Laboratory, Institute of Oceanology, chinese academy of Sciences, Qingdao 2.6071,{2. 2. graduate school of the chinese academy of Sciences, beijing 100039, {2. 3. Genomics & Bioinformatics Institute, chinese academy of Sciences, beijing 101300, {2.) chinese Acad Sci Inst Oceanol Expt Marine Biol Lab Qingdao 266071 Peoples R China chinese Acad Sci Grad Sch Beijing 100039 Peoples R China chinese Acad Sci Geonom & Bioinformat Inst Beijing 101300 Peoples R China

A total of 10446 expressed sequence tags (ESTs) are obtained by a large scale sequencing of a cDNA library from cephalothorax of adult Fenneropenaeus chinensis . An EST analysis platform was built up based on local computers and bioinformatic techniques were used to annotate these ESTs in order to promptly find possible functional genes, especially for immune related factors. About 4% of the ESTs show similarity to the coding sequences of such factors, including lectin, serine protease, serpin, lysozyme, etc. These ESTs provide a partial profile of the immune system in F. chinensis and useful information for further study on these genes.

关键词： Fenneropenaeus chinensis bioinformatics ESTs immune factors

A formula on linear complexity of highest coordinate sequences from maximal periodic sequences over Galois rings

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Progress in Natural Science:Materials International 2006年第9期16卷 998-1001页

作者： HU Lei and SUN Nigang (State Key Laboratory of Information Security, graduate school of {2. academy of Sciences, beijing 100049, china) [a]State Key Laboratory of Information Security Graduate School of Chinese Academy of Sciences Beijing China

Using a polynomial expression of the highest coordinate map, we deduce an exact formula on the linear complexity of the highest coordinate sequence derived from a maximal periodic sequence over an arbitrary Galois ring of characteristic p2., where p is a prime. This generalizes the known result of Udaya and Siddiqi for the case that the Galois ring is Z4.

关键词： Galois ring highest coordinate sequence linear complexity.

Molecular cloning of growth hormone receptor (GHR) from common carp(Cyprinus carpio L.)and identification of its two forms of mRNA transcripts

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Progress in Natural Science:Materials International 2006年第11期16卷 1156-1163页

作者： SUN Xiaofeng~ 1,2., GUO Qionglin~1**, HU Wei~1, WANG Yaping~1 and ZHU Zuoyan~1(1. State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, chinese academy of Sciences, Wuhan 430072. {2. 2. graduate school of chinese academy of Sciences, beijing 100039, {2.) [a]State key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan China China [b]graduate school of {2. academy of sciences Beijing China

The cDNA of growth hormone receptor (GHR) was cloned from the liver of 2.year common carp (Cyprinus carpio L.) by reverse transcription-polymerase chain reaction (RT-PCR) and rapid amplification of cDNA end (RACE). Its open reading frame (ORF) of 1806 nucleotides is translated into a putative peptide of 602.amino acids, including an extracellular ligand-binding domain of 2.4 amino acids (aa), a single transmembrane domain of 2. aa and an intracellular signal-transduction domain of 334 aa. Sequence analysis indicated that common carp GHR is highly homologous to goldfish (Carassius auratus) GHR at both gene and protein levels. Using a pair of gene-specific primers, a GHR fragment was amplified from the cDNA of 2.year common carp, a 2.4 bp product was identified in liver and a 32. bp product in other tissues. The sequencing of the products and the partial genomic DNA indicated that the difference in product size was the result of a 97 bp intron that alternatively spliced. In addition, the 32. bp fragment could be amplified from all the tissues of 4-month common carp including liver, demonstrating the occurrence of the alternative splicing of this intron during the development of common carp. Moreover, a semi-quantitative RT-PCR was performed to analyze the expression level of GHR in tissues of 2.year common carp and 4-month common carp. The result revealed that in the tissues of gill, thymus and brain, the expression level of GHR in 2.year common carp was significantly lower than that of 4-month common carp.

关键词： growth hormone receptor (GHR) molecular cloning transcript expression analysis common carp.

Explicit analytical solutions of the anisotropic Brinkman model for the natural convection in porous media(Ⅱ)

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Science china(Physics,Mechanics & Astronomy) 2005年第4期48卷 422-430页

作者： CAI Ruixian1, GOU Chenhua1, 2.& ZHANG Na1 1. Institute of Engineering Thermophysics, chinese academy of Sciences, {2. 100080, china 2. graduate school, chinese academy of Sciences, {2. 100080, china 1. Institute of Engineering Thermophysics Chinese Academy of Sciences 100080 Beijing China 2. graduate school Chinese Academy of Sciences 10080 Beijing China

Some algebraically explicit analytical solutions are derived for the anisotropic Brinkman model―an improved Darcy model―describing the natural convection in porous media. Besides their important theoretical meaning (for example, in analyzing the non-Darcy and anisotropic effects on the convection), such analytical solutions can be the benchmark solutions that can promote the development of computational heat and mass transfer. Some solutions considering the anisotropic effect of permeability have been given previously by the authors, and this paper gives solutions including the anisotropic effect of thermal conductivity and the effect of heat sources.

关键词： explicit analytical solution, porous medium, natural convection, Brinkman model, anisotropic.

Suprathermal particle events observed by WIND spacecraft in interplanetary space during 1995―1999 and their classification

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Science china(Technological Sciences) 2008年第9期51卷 1542-1553页

作者： SUN LingPeng1,2. WU DeJin1 & WANG DeYu1 1 Purple Mountain Observatory, chinese academy of Sciences, Nanjing 2.0008, {2. 2.graduate school of chinese academy of Sciences, beijing 100049, {2. Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China graduate school of {2. academy of Sciences Beijing 100049 China

Fifty-five suprathermal particle events were selected from WIND observations between 1995 and 1999. Based on systematic analysis on the observational characteristics of these events a two-parameter (the rising time and the flux ratio of electrons to protons in each event) classification method was proposed to classify these events. The three clas-sified classes are (1) impulsive electron events with the flux ratio of electrons to protons being bigger than 1 and rising time being shorter than 2.0 min, (2. impulsive proton events with the flux ratio being smaller than 1 and rising time being shorter than 2.0 min, and (3) gradual proton events with the flux ratio being smaller than 1 and the rising time being longer than 2.0 min. In the past, "impulsive solar electron events" were under in-tense research. However, because the selection standards of their velocity dispersions or pitch-angle distributions were inadequate, statistical surveys of selected events were dif-ferent from each other and even some conclusions were not consistent with the theory, for example, the relation of type-III solar radio bursts to the "impulsive solar electron events". The first class of impulsive electron events are associated with type-III radio bursts and with clear velocity dispersions; therefore they ought to originate from the Sun. The second class of the events, which have short continuance time and usually are not associated with type-III radio bursts and without velocity dispersion, are still far away from inter-planetary shocks and most of them do not one-to-one correspond to corrotating interact-ing regions (CIRs); such events are possible results of local interplanetary magnetic field reconnection or electromagnetic disturbances. Finally, about 2.3 gradual proton events of the third class occur with interplanetary shocks, the delay times of which are almost equal to the rising time. Some of these events can be understood as particle accelerations by shocks.

关键词： suprathermal particles solar wind plasma solar eruptive activity interplanetary active regions

Elemental and isotopic compositions of the hydrothermal sulfide on the East Pacific Rise near 13°N

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Science china Earth Sciences 2010年第2期53卷 253-266页

作者： ZENG ZhiGang1,CHEN DaiGeng1,2.YIN XueBo1,WANG XiaoYuan1,ZHANG GuoLiang1,2.& WANG XiaoMei1,2.1 Seafloor Hydrothermal Activity Laboratory of the Key Laboratory of Marine Geology and Environment,Institute of Oceanology,chinese academy of Sciences,Qingdao 2.6071,{2. 2.graduate school of chinese academy of Sciences,beijing 100049,{2. 1. Seafloor Hydrothermal Activity Laboratory of the Key Laboratory of Marine Geology and Environment Institute of Oceanology Chinese Academy of Sciences Qingdao 266071 China2. Graduate School of Chinese Academy of Sciences Beijing 100049 China

The mineralogical,elemental,and isotopic characteristics of a hydrothermal sulfide sample from one dredge station (12.42.30’N,103°54.48’W,water depth 2.55 m) on the East Pacific Rise near 13°N were *** hydrothermal sulfide was composed mainly of sphalerite,chalcopyrite,and pyrite and was a Zn-rich sulfide;in layer ep-s-1,goethite formed by secondary oxidation was *** concentrations of rare elements,such as Li (0.15×10-6-0.30×10-6),Be (0.01×10-6-0.05×10-6),Zr (73.8×10-9-1344×10-9),Nb (8.14×10-9-64.7×10-9),Hf (2.54×10-9-2..0×10-9),and Ta (0.2.3×10-9-1.2.×10-9),were far lower in the hydrothermal sulfide than in the ocean crust,whereas the content of Au was higher and the contents of Co,Ni,Sr,Cs,Ba,Bi,and U were *** correlations between Zn and Cr,Cd and Ga,Cu and P,P and In (R2.> 0.8) were positive,whereas those between Zn and Fe,Cu,and Ba (R2.> 0.8) were distinctly *** low-temperature mineral assemblages to high-temperature mineral assemblages,the spatial distributions of dispersive and rare elements (***,Li,Cs) in the hydrothermal sulfide displayed corresponding *** variations observed in some elements (e.g.,Cd,Cs,P) are controlled by Zn,Fe,and Cu sulfides,*** weathering accounts for the enrichment of V,Mn,and rare earth elements (REE) in the henna sulfide-oxidation layer that bears the secondary oxide mineral,leading to identical REE patterns for this layer (ep-s-1) and *** weathering also distinctly affects the correlations between the element ratios of the hydrothermal *** high-temperature mineral assemblages to low-temperature mineral assemblages,Fe content and δ 34S value of the hydrothermal sulfide increase gradually,and Zn content and lead isotopic ratios decrease gradually on the contrary,which indicate the influences of seawater on elements and the sulfur and lead isotopic compositions enhance gradually during the formation of hydrothermal sulfides.

关键词： variation element isotopic composition hydrothermal sulfide East Pacific Rise 13oN

Structures and physical properties of rigid polyurethane foams with water as the sole blowing agent

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Science china Chemistry 2006年第4期49卷 363-370页

作者： LI Xiaobin1,2. CAO Hongbin1 & ZHANG Yi1 1. Institute of Process Engineering, chinese academy of Sciences, {2. 100080, china 2. graduate school of the chinese academy of Sciences, {2. 100039, china 1. Institute of Process Engineering Chinese Academy of Sciences Beijing 100080 China 2. graduate school of the {2. academy of Sciences Beijing 100039 China

Rigid polyurethane foams blown by varying water level were prepared in this study. The structures and physical properties of rigid polyurethane foams blown by water were measured with FT-IR, universal testing machine (Instron3365), scanning electron microscope (SEM) and differential scanning calorimeter (DSC). The results show that polyurea and polybiuret were the typical charac- teristics, and the cream time and gel time were shorter for the fully water blown rigid foams than that for the fully cyclopentane blown foams. The density of foam samples decreased from 45.0 kg/m3 to 2..4 kg/m3 with the increase of water level from 3 pph to 7 pph. Compressive strength exhibited the similar behavior with density. The average cell size of foam samples ranged from 2.1 μm to 356 μm with the increase of water level from 3 pph to 7 pph, respectively. At the same time, poorer dimen- sional stability was encountered with the increase of average cell size due to fast diffusion rate of CO2.out of the foam. The results of thermal analysis show that the glass transition temperature (Tg) shifted to a higher temperature with the increase of isocyanate level when more water was used as chemical blowing agent.

关键词： polyether polyol, polyurethane rigid foam, compressive strength, dimensional stability, cell size, glass transition temperature.

A 12.bit multichannel ADC for pixel detectors in particle physics and nuclear imaging

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Science china(Technological Sciences) 2010年第5期53卷 1208-1214页

作者： WEI Wei1,2.3,WANG Zheng1,3 & ZHAO JingWei1,3 1 Institute of High Energy Physics,chinese academy of Sciences,{2.,china 2.graduate University of chinese academy of Sciences,{2.,china 3 Key Lab of Nuclear Detection Technology and Nuclear Electronics of chinese academy of Sciences,{2.,china 1. Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China2. Graduate University of Chinese Academy of Sciences Beijing 100049 China3. Key Lab of Nuclear Detection Technology and Nuclear Electronics of Chinese Academy of Sciences Beijing 100049 China

Modern pixel detectors in nuclear and particle physics experiments and also in nuclear imaging,starve for highly integrated application specified integrated circuit(ASIC),whereas in china the study of ASIC still stays far away from practical *** lack of ASIC strictly limits the research and development of domestic high energy physics field.A 12.bit multichannel ADC designed for high density readout is introduced as a major candidate for solution.A precise model is discussed and the simulation fully agrees with the model,which indicates a key principle of *** is performed according to the given rule,and novel layout techniques are carried *** results in all aspects are also obtained,showing an excellent real performance,which satisfies the practical requirement.

关键词： application specified integrated circuit high density readout Wilkinson ADC multi-channel ADC