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Avian Research 2024年第3期15卷 308-315页

作者： Siwei An Fenliang Kuang Wei Wu Chris J.Hassell Jonathan T.Coleman Zijing Gao Xuena Sun yue Yuan grace Maglio Kar-Sin K.leung Xuesong Feng Zhijun Ma Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Coastal Ecosystems Research Station of the Yangtze River EstuaryInstitute of Biodiversity ScienceSchool of Life SciencesFudan UniversityShanghai200433China School of Chemistry and Environment Yunnan Minzu UniversityKunming650504China Shanghai Chongming Dongtan Nature Reserve Administration Center ChongmingShanghai202183China Global Flyway Network PO Box 3089BroomeWA 6725Australia Australasian Wader Studies Group BroomeWA6725Australia Queensland Wader Study Group Shailer ParkQLD4128Australia Hong Kong Waterbirds Ringing Group Hong Kong999077China

Many migratory birds exhibit interannual consistency in migration schedules,routes and stopover *** the interannual consistency in spatiotemporal characteristics helps understand the maintenance of migration and enables the implementation of targeted conservation *** tracked the migration of Whimbrel(Numenius phaeopus)in the East Asian-Australasian Flyway and collected spatiotemporal data from individuals that were tracked for at least two *** non-parametric tests were used to compare the interannual variations in the dates of departure from and arrival at breeding/nonbreeding sites,and the inter-annual variation in the longitudes when the same individual across the same *** exhibited a high degree of consistency in the use of breeding,nonbreeding,and stopover sites between *** variation of arrival dates at nonbreeding sites was significantly larger than that of the departure dates from nonbreeding and breeding *** used stopover sites by the same individuals in multiple years were concentrated in the Yellow Sea coast during northward migration,but were more widespread during southward *** stopover duration at repeatedly used sites was significantly longer than that at sites used only *** flying across the Yellow Sea,Whimbrels breeding in Sakha(Yakutia)exhibited the highest consistency in migration routes in both autumn and ***,the consistency in migration routes of Yakutia breeding birds was generally higher than that of birds breeding in *** results suggest that the northward migration schedule of the Whimbrels is mainly controlled by endogenous factors,while the southward migration schedule is less affected by endogenous *** repeated use of stopover sites in the Yellow Sea coast suggests this region is important for the migration of Whimbrel,and thus has high conservation value.

关键词： Consistency Migration route Migration timing Shorebird

Immunoregulatory and Anti-cancer Activities of Combination Treatment of Novel Four-Herb Formula and Doxorubicin in 4T1-Breast Cancer Bearing Mice

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Chinese Journal of Integrative Medicine 2024年第4期30卷 311-321页

作者： Lea Ling-Yu Kan Ben Chung-Lap Chan grace Gar-Lee yue LI Pei-ting Sharon Sze-Man Hon HUANG Dan-qi Miranda Sin-Man Tsang Clara Bik-San Lau Ping-Chung leung Chun-Kwok Wong Institute of Chinese Medicine The Chinese University of Hong KongHong Kong SARChina State Key Laboratory of Research on Bioactivities and Clinical Applications of Medicinal Plants The Chinese University of Hong KongHong KongChina Department of Chemical Pathology The Chinese University of Hong KongHong Kong SARChina China-Australia International Research Centre for Chinese Medicine School of Health and Biomedical SciencesSTEM CollegeRMIT UniversityBundooraVictoriaAustralia Li Dak Sum Yip Yio Chin R&D Centre for Chinese Medicine The Chinese University of Hong Kong SARHong KongChina

Objective To investigate the in vivo immunomodulatory and anti-tumor mechanisms of the combined treatment of novel Four-Herb formula(4HF)and doxorubicin in triple-negative breast cancer(TNBC).Methods Murine-derived triple-negative mammary carcinoma cell line,4T1 cells,was cultured and inoculated into mouse mammary ***-six mice were randomly assigned into 6 groups(n=11 in ench):naive,control,LD 4HF(low dose 4HF),HD 4HF(high dose 4HF),LD 4HF+D(low dose and doxorubicin),and D(doxorubicin).Apart from the naive group,each mouse received subcutaneous inoculation with 5×10^(5)4T1 cells resuspended in 100µL of normal saline in the mammary fat *** from the day of tumor cell inoculation,tumors were grown for 6 *** LD and HD groups received daily oral gavage of 658 and 2,630 mg/kg 4HF,*** LD 4HF+D group received daily oral gavage of 658 mg/kg 4HF and weekly intraperitoneal injection of doxorubicin(5 mg/kg).The D group received weekly intraperitoneal injections of doxorubicin(5 mg/kg).The treatment naive mice received daily oral gavage of 0.2 mL double distilled water and 0.1 mL normal saline via intraperitoneal injection once a *** control group received daily oral gavage of 0.2 mL double-distilled *** treatment period was 30 *** the end of treatment,mice organs were harvested to analyze immunological activities via immunophenotyping,gene and multiplex analysis,histological staining,and gut microbiota *** Mice treated with the combination of 4HF and doxorubicin resulted in significantly reduced tumor and spleen burdens(P<0.05),altered the hypoxia and overall immune lymphocyte landscape,and manipulated gut microbiota to favor the anti-tumor immunological ***,immunosuppressive genes,cytokines,and chemokines such as C-C motif chemokine 2 and interleukin-10 of tumors were significantly downregulated(P<0.05).4HF-doxorubicin combination treatment demonstrated synergetic activities and was most effective

关键词： adjunctivetherapy breast cancer cytokines Chinese medicine tumor microenvironment

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Individual consistency in spatiotemporal characteristics of migratory Whimbrels in the East Asian–Australasian Flyway

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Avian Research 2024年第3期 308-315页

作者： Siwei An Fenliang Kuang Wei Wu Chris J.Hassell Jonathan T.Coleman Zijing Gao Xuena Sun yue Yuan grace Maglio Kar-Sin K.leung Xuesong Feng Zhijun Ma Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Coastal Ecosystems Research Station of the Yangtze River Estuary Institute of Biodiversity Science School of Life Sciences Fudan University School of Chemistry and Environment Yunnan Minzu University Shanghai Chongming Dongtan Nature Reserve Administration Center Global Flyway Network Australasian Wader Studies Group Queensland Wader Study Group Hong Kong Waterbirds Ringing Group

Many migratory birds exhibit interannual consistency in migration schedules, routes and stopover sites. Detecting the interannual consistency in spatiotemporal characteristics helps understand the maintenance of migration and enables the implementation of targeted conservation measures. We tracked the migration of Whimbrel(Numenius phaeopus) in the East Asian–Australasian Flyway and collected spatiotemporal data from individuals that were tracked for at least two years. Wilcoxon non-parametric tests were used to compare the interannual variations in the dates of departure from and arrival at breeding/nonbreeding sites, and the interannual variation in the longitudes when the same individual across the same latitudes. Whimbrels exhibited a high degree of consistency in the use of breeding, nonbreeding, and stopover sites between years. The variation of arrival dates at nonbreeding sites was significantly larger than that of the departure dates from nonbreeding and breeding sites. Repeatedly used stopover sites by the same individuals in multiple years were concentrated in the Yellow Sea coast during northward migration, but were more widespread during southward migration. The stopover duration at repeatedly used sites was significantly longer than that at sites used only once. When flying across the Yellow Sea, Whimbrels breeding in Sakha(Yakutia) exhibited the highest consistency in migration routes in both autumn and spring. Moreover, the consistency in migration routes of Yakutia breeding birds was generally higher than that of birds breeding in Chukotka. Our results suggest that the northward migration schedule of the Whimbrels is mainly controlled by endogenous factors, while the southward migration schedule is less affected by endogenous factors. The repeated use of stopover sites in the Yellow Sea coast suggests this region is important for the migration of Whimbrel, and thus has high conservation value.

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Quantitative and qualitative subgenomic RNA profiles of SARS-CoV-2 in respiratory samples: A comparison between Omicron BA.2 and non-VOC-D614G

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Virologica Sinica 2024年第2期39卷 218-227页

作者： Zigui Chen Rita Way Yin Ng grace Lui Lowell Ling Agnes S.Y.leung Chit Chow Siaw Shi Boon Wendy C.S.Ho Maggie Haitian Wang Renee Wan Yi Chan Albert Martin Li David Shu Cheong Hui Paul Kay Sheung Chan Department of Microbiology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anaesthesia and Intensive Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Paediatrics Faculty of MedicineThe Chinese University of Hong KongHong KongChina Department of Anatomical and Cellular Pathology Faculty of MedicineThe Chinese University of Hong KongHong KongChina Jockey Club School of Public Health and Primary Care Faculty of MedicineThe Chinese University of Hong KongHong KongChina Stanley Ho Centre for Emerging Infectious Diseases Faculty of MedicineThe Chinese University of Hong KongHong KongChina

The SARS-CoV-2 Omicron variants are notorious for their transmissibility,but little is known about their subgenomic RNA(sgRNA)*** study applied RNA-seq to delineate the quantitative and qualitative profiles of canonical sgRNA of 118 respiratory samples collected from patients infected with Omicron BA.2 and compared with 338 patients infected with non-variant of concern(non-VOC)-D614G.A unique characteristic profile depicted by the relative abundance of 9 canonical sgRNAs was reproduced by both BA.2 and non-VOCD614G regardless of host gender,age and presence of ***,such profile was lost in samples with low viral load,suggesting a potential application of sgRNA pattern to indicate viral activity of individual patient at a specific time point.A characteristic qualitative profile of canonical sgRNAs was also reproduced by both BA.2 and *** presence of a full set of canonical sgRNAs carried a coherent correlation with crude viral load(AUC¼0.91,95%CI 0.88–0.94),and sgRNA ORF7b was identified to be the best surrogate marker allowing feasible routine application in characterizing the infection status of individual *** potentials in using sgRNA as a target for vaccine and antiviral development are worth pursuing.

关键词： Coronavirus SARS-CoV-2 Omicron BA.2 Non-VOC-D614G RNA-seq Subgenomic RNA(sgRNA)

Validation model of fibrosis-8 index score to predict significant fibrosis among patients with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2022年第15期28卷 1563-1573页

作者： Thaninee Prasoppokakorn Wah-Kheong Chan Vincent wai-Sun Wong Panyavee Pitisuttithum Sanjiv Mahadeva Nik Raihan Nik Mustapha grace Lai-Hung Wong Howard Ho-wai leung Pimsiri Sripongpun Sombat Treeprasertsuk Department of Medicine Division of GastroenterologyFaculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand Department of Medicine Division of GastroenterologyDivision of Gastroenterology and Hepatology UnitFaculty of MedicineUniversity of MalayaKuala Lumpur 50603Malaysia Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Department of Medicine Division of General Internal MedicineFaculty of MedicineChulalongkorn University and King Chulalongkorn Memorial HospitalThai Red Cross SocietyBangkok 10330Thailand Department of Pathology Hospital Sultanah BahiyahAlor SetarKedah 05460Malaysia Department of Anatomical and Cellular Pathology The Chinese University of Hong KongHong KongChina Department of Internal Medicine Prince of Songkla UniversityHat Yai 90110Thailand Department of Medicine Division of Gastroenterology and HepatologyStanford University School of MedicinePalo AltoCA 94305United States

BACKGROUND Identifying hepatic fibrosis is crucial for nonalcoholic fatty liver disease(NAFLD)*** fibrosis-8(FIB-8)score,recently developed by incorporating four additional variables into the fibrosis-4(FIB-4)score,showed better performance in predicting significant fibrosis in *** To validate the FIB-8 score in a biopsy-proven NAFLD cohort and compare the diagnostic performance of the FIB-8 and FIB-4 scores and NAFLD fibrosis score(NFS)for predicting significant *** We collected the data of biopsy-proven NAFLD patients from three Asian centers in three *** the patients with available variables for the FIB-4 score(age,platelet count,and aspartate and alanine aminotransferase levels)and FIB-8 score(the FIB-4 variables plus 4 additional parameters:The body mass index(BMI),albumin to globulin ratio,gamma-glutamyl transferase level,and presence of diabetes mellitus)were *** fibrosis stage was scored using nonalcoholic steatohepatitis CRN criteria,and significant fibrosis was defined as at least fibrosis stage *** A total of 511 patients with biopsy-proven NAFLD and complete data were included for *** these 511 patients,271(53.0%)were female,with a median age of 51(interquartile range:41,58)*** median BMI was 29(26.3,32.6)kg/m2,and 268(52.4%)had *** the 511 NAFLD patients,157(30.7%)had significant fibrosis(≥F2).The areas under the receiver operating characteristic curves of the FIB-8 and FIB-4 scores and NFS for predicting significant fibrosis were 0.774,0.743,and 0.680,*** FIB-8 score demonstrated significantly better performance for predicting significant fibrosis than the NFS(P=0.001)and was also clinically superior to FIB-4,although statistical significance was not reached(P=0.073).The low cutoff point of the FIB-8 score for predicting significant fibrosis of 0.88 showed 92.36%sensitivity,and the high cutoff point of the FIB-8 score for predicting significant fibrosis of 1.

关键词： Nonalcoholic fatty liver disease Fibrosis-8 score Fibrosis-4 score Nonalcoholic fatty liver disease fibrosis score

Proactive infection control measures to prevent nosocomial transmission of carbapenem-resistant Enterobacteriaceae in a non-endemic area

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Chinese Medical Journal 2013年第23期126卷 4504-4509页

作者： CHENG Vincent Chi-Chung CHAN Jasper Fuk-Woo WONG Sally Cheuk-Ying CHEN Jonathan Hon-Kwan TAI Josepha wai-Ming YAN Mei-Kum KWAN grace See-wai TSE Herman TO Kelvin Kai-Wang HO Pak-leung yueN Kwok-Yung Department of Microbiology Queen Mary Hospital Hong KongChina Infection Control Team Queen Mary Hospital Hong Kong China

Background Identification of hospitalized carbapenem-resistant Enterobacteriaceae （CRE）-positive patient is important in preventing nosocomial *** objective of this study was to illustrate the implementation of proactive infection control measures in preventing nosocomial transmission of CRE in a healthcare region of over 3200 beds in Hong Kong between October 1,2010 and December 31,*** The program included active surveillance culture in patients with history of medical tourism with hospitalization and surgical operation outside Hong Kong within 12 months before admission,and ＂added test＂ as an opportunistic CRE screening in all fecal specimens submitted to the *** investigation and contact tracing were conducted for CRE-positive *** quantitative culture was performed on CRE-positive patients and the duration of fecal carriage of CRE was *** During the study period,a total of 6533 patients were screened for CRE,of which 76 patients were positive （10 from active surveillance culture,65 from ＂added test＂,and 1 secondary case from contact tracing of 223 patients with no nosocomial outbreak）,resulting in an overall rate of CRE fecal carriage of 1.2％.The median time of fecal carriage of CRE was 43 days （range,13-119 days）.Beta-lactam-beta-lactamase-inhibitors,cephalosporins,and fluoroquinolones were associated significantly with high fecal bacterial load when used 90 days before CRE detection,while use of cephalosporins,carbapenems,and fiuoroquinolones after CRE detection are significantly associated with longer duration of *** duration of fecal carriage of CRE also correlates significantly with the initial fecal bacterial load （Pearson correlation：0.53; P=0.02）.Conclusion Proactive infection control measures by enhanced surveillance program identify CRE-positive patients and data obtained are useful for the planning of and resource allocation for CRE control.

关键词： surveillance nosocomial transmission carbapenem-resistant Enterobacteriaceae

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Clinical features and treatment outcomes of endogenous Klebsiella endophthalmitis:a 12-year review

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International Journal of Ophthalmology(English edition) 2020年第12期13卷 1933-1940页

作者： Chun yue Mak Mary Ho Lawrence Pui-leung Iu Helena Pui-yee Sin Li Jia Chen grace Lui Marten Erik Brelen Alvin Lerrmann Young Department of Ophthalmology and Visual Sciences Prince of Wales HospitalNew TerritoriesHong KongChina Department of Ophthalmology and Visual Sciences the Chinese University of Hong KongNew TerritoriesHong KongChina Division of Infectious Diseases Department of Medicine and Therapeuticsthe Chinese University of Hong KongNew TerritoriesHong KongChina

AIM:To identify the clinical features and treatment outcomes of endogenous Klebsiella pneumoniae endophthalmitis and investigate prognostic factors of poor visual ***:The clinical records of all patients diagnosed with endogenous Klebsiella endophthalmitis between January 2007 to December 2018 in Prince of Wales Hospital,Hong Kong,China were retrospectively *** ophthalmological examination findings were recorded in the case note,including visual acuity testing,slit-lamp examination,indirect ophthalmoscopy and B-scan ultrasonography if media opacity precluded fundus ***:A total of 18 eyes in 14 patients were *** involvement was noted in 4 patients(28.6%).Hepatobiliary sepsis was the source in 9 patients(64.3%).Culture of intraocular fluid was positive in 5 out of 18 eyes(27.8%).Mortality was noted in 2 patients(14.3%).Mean final visual acuity was 20/*** out of 16 eyes had total loss of sight(37.5%)and 3 eyes required evisceration(18.8%).Multivariate linear regression revealed poor presenting visual acuity(P=0.031)and lack of fundus view due to vitritis(P=0.02)as prognostic factors of poor visual ***:Visual outcome of endogenous Klebsiella endophthalmitis is *** presenting visual acuity and lack of fundus view predict poor visual *** index of suspicion for endophthalmitis is important in Klebsiella sepsis patients with complaints of ocular *** screening is recommended in noncommunicable patients with Klebsiella sepsis.

关键词： Klebsiella pneumoniae endogenous endophthalmitis screening liver abscess sepsis

Detecting the non-breeding region and migration route of Whimbrels(Numenius phaeopus rogachevae)in the East Asian–Australasian Flyway

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Avian Research 2022年第1期13卷 72-77页

作者： Fenliang Kuang Wei Wu David Li Chris J.Hassell grace Maglio Kar-Sin K.leung Jonathan T.Coleman Chuyu Cheng Pavel S.Tomkovich Zhijun Ma Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering National Observations and Research Station for Wetland Ecosystems of the Yangtze EstuaryInstitute of Eco-ChongmingSchool of Life SciencesFudan UniversityShanghai200433China School of Resources Environment and Chemistry Chuxiong Normal UniversityChuxiongYunnan675000China Shanghai Chongming Dongtan National Nature Reserve Shanghai202183China National Parks Board Singapore718925Singapore Global Flyway Network PO Box 3089BroomeWA6725Australia Australasian Wader Studies Group BroomeWA6725Australia Hong Kong Waterbirds Ringing Group Hong Kong999077China Queensland Wader Study Group 22 Parker StreetShailer ParkQLD4128Australia Zoological Museum Lomonosov Moscow State UniversityBolshaya Nikitskaya Str.2Moscow125009Russia

Determining the migration routes and connections of migratory birds at the population level helps clarify intraspecific differences in *** subspecies have been recognized in the Whimbrel(Numenius phaeopus)in *** is the most recently described *** breeds in Central Siberia,while its non-breeding region and migration routes are still *** tracked the migration of Eurasian Whimbrels captured at three non-breeding sites(Moreton Bay in east coast of Australia,Roebuck Bay in Northwest Australia and Sungei Buloh Wetland in Singapore)and two migration stopover sites(Chongming Dongtan and Mai Po Wetland in China).We determined the breeding sites and inferred the subspecies of the tagged birds in the East Asian–Australasian Flyway(EAAF)based on the known breeding distribution of each *** the 30 tagged birds,6 and 21 birds bred in the breeding range of *** and variegatus,respectively;one bred in the presumed transition area between the breeding range of *** and rogachevae,and two bred in the region between the breeding range of *** and *** birds that bred in the *** breeding range spent their non-breeding season in the northern Sumatra,Singapore,East Java and Northwest Australia and mainly stopped over along China's coasts during *** of our birds bred in the exclusive breeding range of the phaeopus *** studies have predicted that rogachevae whimbrels migrate along the Central Asian Flyway and spend the non-breeding season in West India and East *** found that at least some rogachevae whimbrels migrate along the EAAF and spend the non-breeding season in Southeast Asia and *** *** is at best sparsely distributed in the EAAF in the west region,or possibly does not occur at all.

关键词： Migratory connectivity Non-breeding area Numenius phaeopus Satellite tracking Stopover site Subspecies

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In vitro investigations on the effects of a natural cyclopeptide,RA-V on cell adhesion in human breast cancer cells

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In vitro investigations on the effects of a natural cyclopep...