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Highly elastic,Bioresorbable Polymeric Materials for Stretchable,Transient electronic Systems

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Nano-Micro Letters 2024年第6期16卷 1-13页

作者： Jeong‑Woong Shin Dong‑Je kim Tae‑Min Jang Won Bae Han Joong Hoon Lee Gwan‑Jin Ko Seung Min Yang Kaveti Rajaram Sungkeun Han Heeseok Kang Jun Hyeon Lim Chan‑Hwi eom Amay J.Bandodkar Hanul Min Suk‑Won Hwang KU‑KIST Graduate School of Converging Science and Technology Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea SK Hynix 2091Gyeongchung‑daeroBubal‑eupIcheon‑siGyeonggi‑do 17336Republic of Korea Hanwha Systems Co. Ltd.188Pangyoyeok‑roBundang‑guSeongnam‑siGyeonggi‑do 13524Republic of Korea Department of electrical and Computer engineering North Carolina State UniversityRaleighNC 27606USA Center for Advanced Self‑Powered Systems of Integrated Sensors and Technologies(ASSIST) North Carolina State UniversityRaleighNC 27606USA Department of Integrative energy engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea Biomaterials Research Center Korea Institute of Science and Technology(KIST)5 Hwarang‑ro 14‑gilSeongbuk‑guSeoul 02792Republic of Korea Semiconductor R&D Center Samsung Electronics Co.Ltd.Hwaseong‑siGyeonggi‑do 18448Republic of Korea Center for Advanced Biomolecular Recognition Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea

Substrates or encapsulants in soft and stretchable formats are key components for transient,bioresorbable electronic systems;however,elastomeric polymers with desired mechanical and biochemical properties are very limited compared to nontransient ***,we introduce a bioresorbable elastomer,poly(glycolide-co-ε-caprolactone)(PGCL),that contains excellent material properties including high elongation-at-break(esilience and toughness,and tunable dissolution *** of PGCLs as polymer matrices,in combination with conducing polymers,yields stretchable,conductive composites for degradable interconnects,sensors,and actuators,which can reliably function under external *** of device components with wireless modules demonstrates elastic,transient electronic suture system with on-demand drug delivery for rapid recovery of postsurgical wounds in soft,time-dynamic tissues.

关键词： Biodegradable elastomer Conductive polymer composites Biomedical device Transient electronics

The IBI1 Receptor ofβ-Aminobutyric Acid Interacts with VOZ Transcription Factors to Regulate Abscisic Acid Signaling and Callose-Associated Defense

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Molecular Plant 2020年第10期13卷 1455-1469页

作者： Roland e.Schwarzenbacher grace Wardell Joost Stassen emily Guest Peijun Zhang estrella Luna Jurriaan Ton P3 Institute for Plant and Soil Biology Department of Animal and Plant SciencesThe University of SheffieldSheffield S102TNUK School of Biosciences University of BirminghamBirmingham B152TTUK

extemal and internal signals can prime the plant immune system for a faster and/or stronger response to pathogen attack.β-aminobutyric acid(BABA)is an endogenous stress metabolite that induces broad-spectrum disease resistance in *** perception in Arabidopsis is mediated by the aspartyl tRNA synthetase IBI1,which activates priming of multiple immune responses,including callose-associated cell wall defenses that are under control by abscisic acid(ABA).However,the immediate signaling components after BABA perception by IBI1,as well as the regulatory role of ABA therein,remain ***,we have studied the early signaling events controlling IBI1-dependent BABA-induced resistance(BABAIR),using untargeted transcriptome and protein interaction *** analysis revealed that IBI1-dependent expression of BABA-IR against the biotrophic oomycete Hyaloperonospora arabidopsidis is associated with suppression of ABA-inducible abiotic stress *** interaction studies identified the VOZ1 and VOZ2 transcription factors(TFs)as IBI1-interacting partners,which are transcrip-tionally induced by ABA but suppress pathogen-induced expression of ABA-dependent ***,we show that VOZ TFs require nuclear localization for their contribution to BABA-IR by mediating augmented expression of callose-associated ***,our study indicates that the IBI1-VOZ signaling module channels pathogen-induced ABA signaling toward cell wall defense while simultaneously suppressing abiotic stress-responsive genes.

关键词： IBI1 priming abscisic acid β-aminobutyric acid callose e-MTAB-8720

嗓音障碍患者的普通话元音空间面积及其合理施测方式和语料研究

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听力学及言语疾病杂志 2024年第4期32卷 322-325页

作者：易彬郎晓康晓茜赵纹笙高少华 kim HaKyung 上海交通大学医学院附属第九医院耳鼻咽喉头颈外科上海200011 上海交通大学医学院耳科学研究所上海市耳鼻疾病转化医学重点实验室华东师范大学教育学部康复科学系香港大学教育学院沟通、发展与资讯科学部嗓音研究所中国

目的探究嗓音障碍患者的元音声学特征,以及普通话体系下的元音空间面积(vowel space area,VSA)合理的施测方式和语料。方法招募年龄和性别相匹配的嗓音障碍患者和正常健康对照组受试者各20例,在不同语料(单个元音/a/、/i/、/u/、/o/、/e... 详细信息

目的探究嗓音障碍患者的元音声学特征,以及普通话体系下的元音空间面积(vowel space area,VSA)合理的施测方式和语料。方法招募年龄和性别相匹配的嗓音障碍患者和正常健康对照组受试者各20例,在不同语料(单个元音/a/、/i/、/u/、/o/、/e/和长句)以及不同元音顶点个数(3个、4个、5个)下的VSA进行差异分析。结果嗓音障碍组与正常组之间在单元音和长句语料下VSA都有极显著差异,但两种语料类型间VSA差异不显著,两种语料均可用于VSA的测量。4个元音顶点与3个元音顶点及5个元音顶点下的VSA差异极显著,选择5个元音用于普通话体系下VSA的测量更加合适。结论嗓音障碍患者的元音发音较正常人清晰度下降。在普通话体系下采用5个元音顶点测量VSA相对较精准,更能测得口腔的运动能力。单个元音和连续语音两种语料均适用于VSA的测量。

关键词：嗓音障碍元音空间面积普通话声学分析

Generation of double knockout cattle via CRISPR-Cas9 ribonucleoprotein(RNP)electroporation

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Journal of Animal Science and Biotechnology 2024年第1期15卷 456-462页

作者： Gyeong-Min Gim Kyeong-Hyeon eom Dong-Hyeok Kwon Dae-Jin Jung Dae-Hyun kim Jun-Koo Yi Jae-Jung Ha Ji-Hyun Lee Seong-Beom Lee Woo-Jae Son Soo-Young Yum Won-Wu Lee Goo Jang Laboratory of Theriogenology and Biotechnology Department of Veterinary Clinical ScienceCollege of Veterinary Medicine and the Research Institute of Veterinary ScienceSeoul National UniversitySeoulRepublic of Korea LARTBio Co. Ltd.SeoulRepublic of Korea Gyeongsangbukdo Livestock Research Institute YeongjuRepublic of Korea Comparative Medicine Disease Research Center Seoul National UniversitySeoulRepublic of Korea

Background Genome editing has been considered as powerful tool in agricultural ***,genome editing progress in cattle has not been fast as in other mammal species,for some disadvantages including long gestational periods,single pregnancy,and high raising ***,technically demanding methods such as microinjection and somatic cell nuclear transfer(SCNT)are needed for gene editing in *** this point of view,electroporation in embryos has been risen as an *** First,editing efficiency of our electroporation methods were tested for *** of mutation on embryo was confirmed by T7e1 *** first combination,mutation rates for MSTN and PRNP were 57.6%±13.7%and 54.6%±13.5%,*** case of MSTN/BLG,mutation rates were 83.9%±23.6%for MSTN,84.5%±18.0%for ***,the double-KO embryos were transferred to surrogates and mutation rate was identified in resultant calves by targeted deep *** recipients were transferred for MSTN/PRNP,4 calves were delivered,and one calf underwent an induction for double *** surrogates were given double-KO embryos for MSTN/BLG,and four of the six calves that were born had mutations in both *** These data demonstrated that production of genome edited cattle via electroporation of RNP could be effectively ***,MSTN and PRNP from beef cattle and MSTN and BLG from dairy cattle have been born and they will be valuable resources for future precision breeding.

关键词： Beta-lactoglobulin Cattle CRISPR-Cas9 electroporation Knockout MSTN PRNP

Mechanisms for amplified mediator release from colonic mast cells:Implications for intestinal inflammatory diseases

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World Journal of Gastroenterology 2004年第5期10卷 617-619页

作者： kim e.Barrett Division of Gastroenterology Department of MedicineUniversity of CaliforniaSan DiegoSchool of Medicine San DiegoCA 92103USA

The mast cell is an enigmatic cell type whose physiological function has preoccupied large numbers of investigators for decadest. Some have concluded that the absence of mast cells is incompatible with life, at least in humans, because no human conditions have been documented where these cells are absent from the body. On the other hand, mice harboring specific mutations in certain growth factors, or their receptors, that

关键词： Colon Humans Inflammation Mediators Mast Cells Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs

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Bio-Design and Manufacturing 2024年第3期7卷 240-261页

作者： Seol-Ha Jeong Jarno Hiemstra Patrick V.Blokzijl Rebeca Damian-Ferrara Danilo Martins dos Santos Jéssica H.L.da Fonseca Min-Ho Kang Jihyun kim Dilara Yilmaz-Aykut Mei L.L.Cham-Pérez Jeroen Leijten Su Ryon Shin Division of engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolBostonMA 02139USA Leijten Lab Department of Developmental BioEngineeringFaculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteDrienerlolaan 57522 NB EnschedeThe Netherlands Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoSao CarlosSao Paulo 13560-970Brazil Department of Biomedical-Chemical engineering The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea Department of Biotechnology The Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do 14662Republic of Korea

ensuring a sufficient oxygen supply is pivotal for the success of bioprinting applications since it fosters tissue integration and natural *** in oxygen concentration among diverse tissues necessitates the precise recreation of tissue-specific oxygen levels in imprinted constructs to support the survival of targeted *** oxygen-releasing biomaterials,such as oxygen-generating microparticles(OMPs),have shown promise for enhancing the oxygen supply of microenvironments in injured tissues,whether this approach is scalable for large tissues and whether tissue-specific bioinks with varying OMP concentrations remain printable remain *** study addresses this critical gap by introducing an innovative class of engineered oxygenated bioinks that combine colloidal-based microgels with *** report that incorporating nanosized calcium peroxide(nCaO_(2))and manganese oxide nanosheets(nMnO_(2))into hydrophobic polymeric microparticles enables precise modulation of oxygen release while controlling hydrogen peroxide ***,the fabrication of oxygenating and cytocompatible colloidal gels is achieved using an aqueous two-phase *** study thoroughly evaluates the fundamental characteristics of the resulting bioink,including its rheological behaviors,printability,shape fidelity,mechanical properties,and oxygen release ***,this study demonstrates the macroscopic scalability and cytocompatibility of printed constructs produced via cell-laden oxygenating colloidal *** showcasing the effectiveness of extrusion-based bioprinting,this study underscores how it can be used to fabricate biomimetic tissues,indicating its potential for new *** findings presented here advance the bioprinting field by achieving scalability with both high cell viability and the possibility of mimicking specifically oxygenated *** work thereby offers a promising avenue for the development of functional tissues with e

关键词： 3D bioprinting Bioink Colloidal gels extrusion printing Oxygen-generating microparticle

不同地域和性别受试者的普通话元音空间面积的差异研究

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听力学及言语疾病杂志 2024年

作者：曹艳静郎晓刘晓明 kim HaKyung 雷俊卿靳令经华东师范大学康复科学系北京联合大学特殊教育学院长沙民政职业技术学院唯听助听器上海有限公司同济大学附属养志康复院

目的探讨不同地域和性别受试者的普通话元音空间面积的差异。方法各选取62例常住北京(男32例,女30例)和上海(男32例,女30例)的健康大学生为研究对象,分别以六个中文元音/a/、/i/、/e/、/u/、/o/、/ü/和短文《假期》为语料,测试其普... 详细信息

目的探讨不同地域和性别受试者的普通话元音空间面积的差异。方法各选取62例常住北京(男32例,女30例)和上海(男32例,女30例)的健康大学生为研究对象,分别以六个中文元音/a/、/i/、/e/、/u/、/o/、/ü/和短文《假期》为语料,测试其普通话元音空间面积(vowel space area,VSA)。结果不同性别的VSA差异极其显著(P<0.001),女性的VSA明显大于男性。语料和地区的简单效应检验显示,当语料为连续语音时,北京和上海的受试者的VSA显示没有显著差异;但当语料为单元音时,上海受试者的VSA显著大于北京受试者(P=0.003,P<0.01)。结论普通话体系下,成年女性的VSA比男性大,女性的前元音更趋前,后元音更趋后。不同地域受试者VSA的差异并不显著。

关键词：声学元音空间声学分析元音三角形普通话

迈向高效、智能、绿色制造时代WINTeC携全新注塑机系列亮相2024年中国国际橡塑展

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上海化工 2024年第3期49卷 41-41页

作者： grace 不详

eNGeL集团成员——WIN-TeC携两款全新注塑机(t-winSe液压二板注塑机和e-winSe全电动高精密注塑机)以及数字化解决方案i Qweightcontrol亮相2024年中国国际橡塑展,全方位展示了成立10年来WINTeC在注塑成型领域的先进技术。WINTeC的两款... 详细信息

eNGeL集团成员——WIN-TeC携两款全新注塑机(t-winSe液压二板注塑机和e-winSe全电动高精密注塑机)以及数字化解决方案i Qweightcontrol亮相2024年中国国际橡塑展,全方位展示了成立10年来WINTeC在注塑成型领域的先进技术。WINTeC的两款全新注塑机可满足汽车、家电、医疗、电子和技术注塑等行业对塑料制品的生产和应用要求.

关键词：注塑机注塑成型塑料制品全电动绿色制造全方位展示 eC

Bile acid homeostasis in female mice deficient in Cyp7a1 and Cyp27a1

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3847-3856页

作者： Daniel Rizzolo Bo Kong Rulaiha e.Taylora Anita Brinker Michael Goedken Brian Buckley grace L.Guo Department of Pharmacology and Toxicology School of PharmacyRutgers UniversityPiscatawayNJ 08854USA environmental and Occupational Health Institute Rutgers UniversityPiscatawayNJ 08854USA Office of Research and economic Development Research Pathology ServicesRutgers UniversityPiscatawayNJ 08854USA Rutgers Center of Lipid Research Rutgers UniversityNew BrunswickNJ 08901USA Department of Veterans Affairs New Jersey Health Care System East OrangeNJ 07018USA

Bile acids(BAs) are amphipathic molecules important for metabolism of cholesterol,absorption of lipids and lipid soluble vitamins,bile flow,and regulation of gut *** are over 30 different BA species known to exist in humans and mice,which are endogenous modulators of at least 6 different membrane or nuclear *** diversity of ligands and receptors play important roles in health and disease;however,the full functions of each individual BA in vivo remain *** generated a mouse model lacking the initiating enzymes,CYP7 A1 and CYP27 A1,in the two main pathways of BA *** females are more susceptible to BA related diseases,such as intrahepatic cholestasis of pregnancy,we expanded this model into female *** null mice of Cyp7 a1 and Cyp27 a1 were crossbred to create double knockout(DKO) *** concentrations in female DKO mice had reductions in serum(63%),liver(83%),gallbladder(94%),and small intestine(85%),as compared to WT *** low BA levels,DKO mice had a similar expression pattern to that of WT mice for genes involved in BA regulation,synthesis,conjugation,and ***,through treatment with a synthetic FXR agonist,GW4064,female DKO mice responded to FXR activation similarly to WT mice.

关键词： Bile acids Farnesoid X receptor Female Fibroblast growth factor 15 CYP7A1 CYP27A1