检索结果-南通市图书馆

ethyl acetate fraction of Sargassum pallidum extract attenuates particulate matter-induced oxidative stress and inflammation in keratinocytes and zebrafish

引用

Asian Pacific Journal of Tropical Biomedicine 2024年第4期14卷 137-146页

作者： Wook Chul kim Ji-Won Park Bohyun Yun WonWoo Lee Kyung-Min Choi Seung-Hong Lee Department of Medical Science Soonchunhyang UniversityAsan 31538Republic of Korea Honam National Institute of Biological Resources 99Gohadoan-gilMokpo-siJeollanam-do 58762Republic of Korea Department of Pharmaceutical engineering Soonchunhyang UniversityAsan 31538Republic of Korea

Objective:To evaluate the effect of the ethyl acetate fraction derived from Sargassum pallidum extract against particulate matter(PM)-induced oxidative stress and inflammation in HaCaT cells and ***:HaCaT cells and zebrafish were used to evaluate the protective effects of the ethyl acetate fraction of Sargassum pallidum extract against PM-induced oxidative stress and *** production of nitric oxide(NO),intracellular ROS,prostaglandin e_(2)(PGe_(2)),and pro-inflammatory cytokines,and the expression levels of COX-2,iNOS,and NF-κB were evaluated in PM-induced HaCaT ***,the levels of ROS,NO,and lipid peroxidation were assessed in the PM-exposed zebrafish ***:The ethyl acetate fraction of Sargassum pallidum extract significantly decreased the production of NO,intracellular ROS,and PGe_(2) in PM-induced HaCaT *** addition,the fraction markedly suppressed the levels of pro-inflammatory cytokines and inhibited the expression levels of COX-2,iNOS,and NF-κ***,it displayed remarkable protective effects against PM-induced inflammatory response and oxidative stress,represented by the reduction of NO,ROS,and lipid peroxidation in ***:The ethyl acetate fraction of Sargassum pallidum extract exhibits a protective effect against PM-induced oxidative stress and inflammation both in vitro and in vivo and has the potential as a candidate for the development of pharmaceutical and cosmeceutical products.

关键词： Particulate matter Inflammation Oxidative stress Sargassum pallidum ethyl acetate fraction Zebrafish

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Factor analysis of recent major heatwaves in east Asia

引用

Geoscience Frontiers 2024年第1期15卷 374-383页

作者： Arim Yoon Jeongwon kim Jooyeop Lee Hyun Min Sung Je-Woo Hong Seung-Ki Min Junhong Lee Jinkyu Hong ecosystem-Atmosphere Process Laboratory Department of Atmospheric SciencesYonsei UniversitySeoul 03722Republic of Korea National Institute of Meteorological Sciences Jeju 63568Republic of Korea Korea Adaptation Center for Climate Korea Environment InstituteSejong 30121Republic of Korea Division of environmental Science and engineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Max Planck Institute for Meteorology Hamburg 20146Germany Institute for Convergence Research and education in Advanced Technology Yonsei UniversitySeoulRepublic of Korea

Heatwaves(HWs)present a major hazard to our society and more extreme heatwaves are expected with future climatic ***,it is important to improve our understanding of the underlying processes that drive HWs,in order to boost our socioeconomic-ecological *** this study,we quantified the influences of key driving factors(large-scale atmospheric circulation,soil moisture,and sea surface temperature)and their synergies on recent heatwaves in east *** conducted a factor separation analysis for three recent HW events by constraining the key factors in the regional Weather Research and Forecasting model with their climatologies or pseudo-observations in different *** study showed distinct spatial variations in the HW-controlling factors in east *** synergistic interaction of large-scale circulation and soil moisture was the most important factors in the 2013 Chinese *** the 2018 HWs in Korea and Japan,the same stagnant large-scale atmospheric circulation played a dominant role in driving the HW *** land-atmosphere coupling via soil moisture,its interaction with circulation,and SST exhibited stronger influences during the Korean HW than the Japanese *** analysis also revealed temporal variations in the factors driving Korean and Chinese HWs due to typhoon passage and other multiple processes over heterogeneous surfaces(i.e.,topographically induced Foehn winds,large-scale warm advection from the warm ocean,spatial differences in soil moisture).Our findings suggest that future heatwave-related studies should consider interactive contributions of key factors,their interplay with surface heterogeneities of complex terrain.

关键词： Heatwave east Asia Large-scale circulation Soil moisture Sea surface temperature Synergistic impacts

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Indolocarbazole-Based Small Molecule Cathode-Active Material exhibiting Double Redox for High-Voltage Li-Organic Batteries

引用

energy & environmental Materials 2024年第5期7卷 90-98页

作者： Hyunji Park Hyojin Kye Jong-Sung Lee Young-Chang Joo Dong Joo Min Bong-Gi kim Soo Young Park Ji eon Kwon Laboratory for Supramolecular Optoelectronic Materials (LSOM) Department of Materials Science and Engineering Research Institute of Advanced Materials (RIAM) Seoul National University Functional Composite Materials Research Center Jeonbuk Institute of Advanced Composite Materials Korea Institute of Science and Technology (KIST) Department of Organic and Nano System engineering Konkuk University Department of Materials Science and engineering Seoul National University Department of JBNU-KIST Industry Academia Convergence Research Jeonbuk National University

Most organic electrode materials （OeMs） for rechargeable batteries employ n-type redox centers, whose redox potentials are intrinsically limited <3.0 V versus Li+/Li. However, p-type materials possessing high redox ... 详细信息

Most organic electrode materials （OeMs） for rechargeable batteries employ n-type redox centers, whose redox potentials are intrinsically limited ersus Li+/Li. However, p-type materials possessing high redox potentials experience low specific capacities because they are capable of only a single redox reaction within the stable electrochemical window of typical ***, we report 5,11-diethyl-5,11-dihydroindolo[3,2-b]carbazole （DeICZ） as a novel p-type OeM, exhibiting stable plateaus at high discharge potentials of3.44 and 4.09 V versus Li+/Li. Notably, the second redox potential of DeICZ is within the stable electrochemical window. The mechanism of the double redox reaction is investigated using both theoretical calculations and experimental measurements, including density functional theory calculations, ex situ electron spin resonance, and X-ray photoelectron spectroscopy. Finally,hybridization with single-walled carbon nanotubes （SWCNT） improves the cycle stability and rate performance of DeICZ owing to theπ–πinteractions between the SWCNT and co-planar molecular structure of DeICZ, preventing the dissolution of active materials into the electrolyte. The DeICZ/SWCNT composite electrode maintains 70.4%of its initial specific capacity at 1-C rate and also exhibits high-rate capability, even performing well at 100-C rate.

关键词： composite electrodes flexible batteries indolocarbazoles organic rechargeable batteries p-type

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

elucidating regulatory processes of intense physical activity by multi-omics analysis

引用

Military Medical Research 2024年第4期11卷 479-499页

作者： ernesto S.Nakayasu Marina A.Gritsenko Young-Mo kim Jennifer e.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie Munoz Kathleen M.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa M.Bramer Fernando Montes Kathleen A.Clark Grant Tietje Justin Teeguarden Kristin e.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA environmental and Molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA environmental and Molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： Multi-omics analysis Intense exercise Human performance Biofluids Metabolism Immunity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

TMAS:A transaction misbehavior analysis scheme for blockchain

引用

Blockchain(Research and Applications) 2024年第3期5卷 42-52页

作者： Shiyong Huang Xiaohan Hao Yani Sun Chenhuang Wu Huimin Li Wei Ren kim-Kwang Raymond Choo School of Computer Science China University of GeosciencesWuhan430074China Artificial Intelligence Thrust Information HubHong Kong University of Science and TechnologyGuangzhou511400China Yunnan Key Laboratory of Blockchain Application Technology Yunnan Innovation Institute of Beihang UniversityKunming650233China Fujian Key Laboratory of Financial Information Processing Putian UniversityPutian351100China Department of Information Systems and Cyber Security University of Texas at San AntonioSan AntonioTX 78249-0631USA

Blockchain-based cryptocurrencies,such as Bitcoins,are increasingly ***,the decentralized and anonymous nature of these currencies can also be(ab)used for nefarious activities such as money laundering,thus reinforcing the importance of designing tools to effectively detect malicious transaction *** this paper,we propose TMAS,a transaction misbehavior analysis scheme for blockchain-based ***,the proposed system includes ten features in the transaction graph,two heuristic money laundering models,and an analysis method for account linkage,which identifies accounts that are distinct but controlled by an identical *** evaluate the effectiveness of our proposed indicators and models,we analyze 100 million transactions and compute transaction features,and are able to identify a number of suspicious ***,the proposed methods can be applied to other cryptocurrencies,such as token-based cryptocurrencies(e.g.,Bitcoins)and account-based cryptocurrencies(e.g.,ethereum).

关键词： Blockchain Anti-money laundering Bitcoin Cyptocurrency

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Structural and electrochemical stabilization enabling high-energy P3-type Cr-based layered oxide cathode for K-ion batteries

引用

Carbon energy 2024年第5期6卷 81-93页

作者： Wonseok Ko Seokjin Lee Hyunyoung Park Jungmin Kang Jinho Ahn Yongseok Lee Gwangeon Oh Jung-Keun Yoo Jang-Yeon Hwang Jongsoon kim Department of energy Science Sungkyunkwan UniversitySuwonRepublic of Korea SKKU Institute of energy Science and Technology(SIeST) Sungkyunkwan UniversitySuwonRepublic of Korea Department of energy engineering Hanyang UniversitySeoulRepublic of Korea Carbon Composites Department Korea Institute of Materials Science(KIMS)ChangwonRepublic of Korea Department of Battery engineering Hanyang UniversitySeoulRepublic of Korea

Layered-type transition metal(TM)oxides are considered as one of the most promising cathodes for K-ion batteries because of the large theoretical gravimetric capacity by low molar ***,they suffer from severe structural change by de/intercalation and diffusion of K^(+)ions with large ionic size,which results in not only much lower reversible capacity than the theoretical capacity but also poor power ***,it is important to enhance the structural stability of the layered-type TM oxides for outstanding electrochemical behaviors under the K-ion battery ***,it is investigated that the substitution of the appropriate Ti^(4+)contents enables a highly enlarged reversible capacity of P3-type KxCrO_(2) using combined studies of first-principles calculation and various *** the pristine P3-type KxCrO_(2) just exhibits the reversible capacity of∼120 mAh g^(−1) in the voltage range of 1.5-4.0 V(vs.K^(+)/K),the∼0.61 mol K^(+)corresponding to∼150 mAh g^(−1) can be reversible de/intercalated at the structure of P3-type K0.71[Cr_(0.75)Ti_(0.25)]O_(2) under the same ***,even at the high current density of 788 mA g^(−1),the specific capacity of P3-type K0.71[Cr_(0.75)Ti_(0.25)]O_(2) is∼120 mAh g^(−1),which is∼81 times larger than that of the pristine P3-type KxCrO_(2).It is believed that this research can provide an effective strategy to improve the electrochemical performances of the cathode materials suffered by severe structural change that occurred during charge/discharge under not only K-ion battery system but also other rechargeable battery systems.

关键词： cathodes first-principles calculations layered-type oxide materials potassium-ion batteries structural stabilization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

计算超导螺线管磁体中电磁应力的解析方法

引用

Acta Mechanica Sinica 2024年第4期40卷 4-20页

作者： Jeonghwan Park Kibum Choi Yufan Yan Jaemin kim Seungyong Hahn Department of electrical and Computer engineering Seoul National UniversitySeoul08826Republic of Korea Applied Superconductivity Center and electric Power Institute Seoul National UniversitySeoul08826Republic of Korea

在高场磁体中,压缩磁径向应力比拉伸应力更受青睐,原因是它能降低磁体绕组内的整体峰值磁应力.这对于无绝缘高温超导(NI HTS)磁体尤为重要,因为压缩径向应力能够产生良好的匝间接触,这对于无绝缘高温超导线圈中的电流共享以及随之而来... 详细信息

在高场磁体中,压缩磁径向应力比拉伸应力更受青睐,原因是它能降低磁体绕组内的整体峰值磁应力.这对于无绝缘高温超导(NI HTS)磁体尤为重要,因为压缩径向应力能够产生良好的匝间接触,这对于无绝缘高温超导线圈中的电流共享以及随之而来的自保护行为至关重要.根据关键磁体设计参数(如目标中心场、背景磁场、内外绕组直径和外部径向堆叠),我们给出了可以从解析上确定高场超导磁体具有压缩径向应力的电磁-力学条件.本文提出的方法可以识别干绕线圈中径向匝间接触行为的3种不同模式:(1)完全分离;(2)完全接触;以及(3)混合模式(即部分分离和接触).文章随后提出一种使用完全压缩径向应力电磁-力学条件来计算干绕线圈中应力分布的解析方法.并通过有限元分析示例验证了解析方法与数值方法的良好一致性.文章结果可以帮助磁体工程师在早期设计阶段更好地概览高场超导磁体的电磁-力学行为.

关键词：高温超导背景磁场径向应力力学条件拉伸应力匝间接触行为混合模式

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Gender-and Age-Group Specific Association of Persistent Organic Pollutants(POPs)exposure with Diabetes Mellitus:Korean National environmental Health Survey(KoNeHS)2015−2017

引用

environment & Health 2024年第5期2卷 322-331页

作者： Inae Lee Min Joo kim Sohyeon Choi Young Joo Park Jeongim Park Gökçe Nur Ayaz Gowoon Lee Yoon Hee Cho Hye Li Jeon Chulwoo Lee Gi Jeong Cheon Min Kyong Moon Kyungho Choi Graduate School of Public Health Seoul National UniversitySeoul 08826Republic of Korea Institute of Health and environment Seoul National UniversitySeoul 08826Republic of Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 03080Republic of Korea Seoul National University Hospital Healthcare System Gangnam Center Seoul 06236Republic of Korea Department of environmental Health Sciences Soonchunhyang UniversityAsan 31538Republic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and TechnologySeoul National UniversitySeoul 08826Republic of Korea Center for environmental Health Sciences Department of Biomedical and Pharmaceutical SciencesUniversity of MontanaMissoulaMontana 59812United States environmental Health Research Division National Institute of Environmental ResearchMinistry of EnvironmentIncheon 22689Republic of Korea Department of Nuclear Medicine Seoul National University College of MedicineSeoul 03080Republic of Korea Division of endocrinology Department of Internal MedicineSeoul National University Boramae Medical CenterSeoul 07061Republic of Korea

exposure to persistent organic pollutants(POPs)has been reported as a potential risk factor for diabetes in ***,effect modifications by sex and age,especially among Asian populations,have seldom been *** the present study,we assessed associations of major POPs exposure including organochlorine pesticides(OCPs),polychlorinated biphenyls(PCBs),and polybrominated diphenyl ethers(PBDes),with diabetes in Korean adults(n=1,295),a subset of the Korean National environmental Health Survey(KoNeHS)Cycle 3(2015−2017).In the adult population,serum levels of dichlorodiphenyltrichloroethanes(DDTs)and PCB167 showed an increased odds ratio(OR)for *** stratified by gender,associations became stronger and more consistent in women:In women,serum levels of OCPs including p,p′-DDT,p,p′-dichlorodiphenyldichloroethylene(p,p′-DDe),andΣOCPs and mono-ortho PCBs,such as PCB118 and PCB157,were significantly associated with *** the male participants,however,no significant positive associations were *** stratified by a cutoff age of 50 years,most studied POPs except PBDes,i.e.,p,p′-DDT,p,p′-DDe,PCB118,PCB157,PCB167,PCB138,and PCB153,showed significant associations with diabetes,in the older *** the younger group,however,no measured POPs showed a significant positive *** of endogenous sex hormones or interaction of POPs on aryl hydrocarbon receptors may partly explain the observed differences by gender and age,although further experimental confirmations should *** findings show that POPs exposure at the current levels is associated with diabetes among general Korean adults,and such associations could be modified by gender and age.

关键词： persistent organic pollutants diabetes age gender toxicity equivalency factor

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Deep learning framework for material design space exploration using active transfer learning and data augmentation

引用

npj Computational Materials 2021年第1期7卷 1261-1267页

作者： Yongtae kim Youngsoo kim Charles Yang Kundo Park grace X.Gu Seunghwa Ryu Department of Mechanical engineering&KI for the NanoCentury Korea Advanced Institute of Science and Technology(KAIST)Yuseong-guDaejeonRepublic of Korea Department of Nature-Inspired System and Application Korea Institute of Machinery and MaterialsDaejeonRepublic of Korea Department of Mechanical engineering University of CaliforniaBerkeleyCAUSA

Neural network-based generative models have been actively investigated as an inverse design method for finding novel materials in a vast design ***,the applicability of conventional generative models is limited because they cannot access data outside the range of training *** generative models that were devised to overcome the limitation also suffer from the weak predictive power on the unseen *** this study,we propose a deep neural network-based forward design approach that enables an efficient search for superior materials far beyond the domain of the initial training *** approach compensates for the weak predictive power of neural networks on an unseen domain through gradual updates of the neural network with active transfer learning and data augmentation *** demonstrate the potential of our framework with a grid composite optimization problem that has an astronomical number of possible design *** show that our proposed framework can provide excellent designs close to the global optima,even with the addition of a very small dataset corresponding to less than 0.5%of the initial training dataset size.

关键词： neural Deep network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The CUL3A–LFH1–UBC15 ubiquitin ligase complex mediates SHORT VeGeTATIVe PHASe degradation to accelerate flowering at high ambient temperature

引用

Plant Communications 2024年第4期5卷 224-238页

作者： Suhyun Jin Geummin Youn Sun Young kim Taewook Kang Hyun-young Shin Ji-Yul Jung Pil Joon Seo Ji Hoon Ahn Department of Life Sciences Korea UniversitySeoul 02841Republic of Korea Department of Chemistry Seoul National UniversitySeoul 08826Republic of Korea These authors contributed equally to this article.

Ambient temperature affects flowering time in plants,and the MADS-box transcription factor SHORT VeGeTATIVe PHASe(SVP)plays a crucial role in the response to changes in ambient *** protein stability is regulated by the 26S proteasome pathway and decreases at high ambient temperature,but the details of SVP degradation are ***,we show that SVP degradation at high ambient temperature is mediated by the CULLIN3–RING e3 ubiquitin ligase(CRL3)complex in Arabidopsis *** identified a previously uncharacterized protein that interacts with SVP at high ambient temperature and contains a BTB/POZ *** named this protein LATe FLOWeRING AT HIGH TeMPeRATURe 1(LFH1).Single mutants of LFH1 or CULLIN3A(CUL3A)showed late flowering specifically at 27***1 protein levels increased at high ambient *** found that LFH1 interacts with CUL3A in the cytoplasm and is important for SVP–CUL3A complex *** in CUL3A and/or LFH1 led to increased SVP protein stability at high ambient temperature,suggesting that the CUL3–LFH1 complex functions in SVP *** e2 ubiquitin-conjugating enzymes(UBCs)using RING-BOX PROTeIN 1(RBX1),a component of the CRL3 complex,as bait identified ***15 mutants also showed late flowering at high ambient *** vitro and in vivo ubiquitination assays using recombinant CUL3A,LFH1,RBX1,and UBC15 showed that SVP is highly ubiquitinated in an ATP-dependent ***,these results indicate that the degradation of SVP at high ambient temperature is mediated by a CRL3 complex comprising CUL3A,LFH1,and UBC15.

关键词： temperature-responsiveflowering SVP CUL3 proteasomal degradation ubiquitination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：