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腹腔液体中巨噬细胞转移抑制因子水平升高与子宫内膜异位症浸润深度和分期无相关性

世界核心医学期刊文摘（妇产科学分册） 2005年第1期1卷 28-28页

作者： Mahutte N.g. Matalliotakis I.M. goumenou a.g. A. Arici 闫坤 Div. Repro. Endocrinol. Infertility Dept.of Obstetrics and Gynecology Yale University Sch ool of Medicine New Haven CT United States Dr.

Objective To quantify levels of macrophage migration inhibitory facto r (MIF) i n the peritoneal fluid (PF) of women with endometriosis, and to correlate these levels with the extent of disease. Design Controlled clinical study. Setting Aca demic medical center. Patient(s) Peritoneal fluid samples were collected during laparoscopic surgery in 60 women with endometriosis and 16 controls undergoing t ubal ligation; 52 of the women with endometriosis had received no hormonal treat ment in the 6 months prior to surgery, while 8 were using gonadotropin-releasin g hormone (gnRH) agonists. Main outcome measure(s) Peritoneal fluid migration in hibitory factor (PF MIF) levels. Result(s) Women with endometriosis had signific antly higher PF MIF levels (10.8 ±0.9 ng/mL) than controls (3.0 ±0.7 ng/mL). H owever, no correlation existed between MIF levels and the stage of disease (r = 0.05) or the depth of endometriotic invasion (r = 0.08). Moreover, treatment wit h a.g.RH agonist did not suppress PF MIF levels. Peritoneal fluid MIF levels did not vary significantly between the proliferative and secretory phases of the cy cle, and did not distinguish women with endometriosis-associated infertility fr om women with endometriosis-associated pain. Conclusion(s) Peritoneal fluid mig ration inhibitory factor levels are markedly elevated in women with endometriosi s but are independent of the extent of disease.

关键词：子宫内膜异位症浸润深度巨噬细胞抑制因子腹腔镜检查输卵管结扎术继发不孕分泌期增生期月经周期

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类似晚期卵巢癌的子宫内膜异位症

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世界核心医学期刊文摘（妇产科学分册） 2006年第11期2卷 40-41页

作者： goumenou A. Matalliotakis I. Mahutte N. Koumantakis E. 张旸 Department of Obstetrics and gynecology University of Crete Heraklion Greece Dr.

Objective: To report a case of endometriosis associated with massive ascites, pleural effusion, and extremely elevated Ca- 125. Design: Case report. Setting: University hospital. Patient(s): A 46-year-old, white nulligravida with bilateral adnexal masses, Ca- 125 of 3,504 U/mL, abdominal pain, ascites, and a pleural effusion. Intervention(s): Chemotherapy followed by exploratory laparotomy for suspected ovarian cancer. Main Outcome Measure(s): Surgical findings and histopathology. Result(s): Intraoperative examination and histology ruled out malignancy but found stage IV endometriosis. Conclusion(s): In rare instances advanced endometriosis may be associated with ascites, pleural effusions, and la.g. pelvic masses. For this reason endometriosis should be included in the differential diagnosis of reproductive-age women presenting with apparent ovarian malignancy.

关键词：子宫内膜异位症晚期卵巢癌合并腹水胸膜渗出组织学检查罕见病例未产妇剖腹探查术附件肿物

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