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Expedition to the blockchain application potential for higher education institutions

BLOCKCHAIN-RESEARCH AND APPLICATIONS 2024年第3期5卷 53-66页

作者： gottlieb, matthias Deutsch, Christina Hoops, Felix Pongratz, Hans Krcmar, Helmut Bavarian Minist Digital Affairs D-80333 Munich Germany Tech Univ Munich D-85478 Garching Germany TU Dortmund Univ D-44139 Dortmund Germany

In the education sector, blockchain is currently at the end of the peak of inflated expectations in Gartner's Hype Cycle. Thus, it is crucial to understand whether this technology meets the expectations of Higher Education Institutions (HEIs). We go on an expedition to identify blockchain application scenarios and its potential for HEI administration-the universities are digitalized to just 23.3%. Current information systems research addresses classifications of blockchain-based projects (application level) rather than their technical realization (protocol level). Thus, when evaluating blockchain application scenarios in HEI administration, we intensively consider the technical side of blockchain-based projects. We perform a three- step approach: (1) systematic literature review, (2) qualitative exploratory semi-structured interviews to supplement information on market-ready solutions, and (3) an evaluation of the potential of the blockchain-based projects identified, based on HEI administration requirements. We find that the leading blockchain application scenarios are credential verification and record-sharing. At the protocol level, we obtain equivocal results regarding the technical realization of projects, e.g., their underlying blockchain types and storage models. At the application level, when discussing the potential of different projects, we find that most of them address adaptability, complexity decomposition, and cost reduction requirements between HEIs; interest diversity and stakeholder collaboration between HEIs and business actors; privacy and trust between HEIs and students.

关键词： Blockchain Higher education institution (HEI) Administration Protocol level Application level Application

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Experimental arena settings might lead to misinterpretation of movement properties

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Insect Science 2024年第1期31卷 271-284页

作者： Inon Scharf Kimberley Hanna Daphna gottlieb The George S.Wise Faculty of Life Sciences School of ZoologyTel Aviv UniversityTel AvivIsrael Department of Food Science Institute of Post-Harvest and Food ScienceVolcani CenterARORishon LeZionIsrael

Movement is an important animal behavior contributing to reproduction and *** movement is often examined in arenas or enclosures under laboratory *** used the red flour beetle(Tribolium castaneum)to examine here the effect of the arena size,shape,number of barriers,access to the arena's center,and illumination on six movement *** demonstrate great differences among *** example,the beetles moved over longer distances in clear arenas than in obstructed *** along the arena's perimeter was greater in smaller arenas than in larger *** was more directional in round arenas than in rectangular *** general,the beetles stopped moving closer to the perimeter and closer to corners(in the square and rectangular arenas)than expected by *** some cases,the arena properties interacted with the beetle sex to affect several movement *** these suggest that arena properties might also interact with experimental manipulations to affect the outcome of studies and lead to results specific to the arena *** other words,instead of examining animal movement,we in fact examine the animal interaction with the arena *** is therefore advised in interpreting the results of studies on movement in arenas under laboratory conditions and we recommend paying attention also to barriers or obstacles in field *** instance,movement along the arena's perimeter is often interpreted as centrophobism or thigmotaxis but the results here show that such movement is arena dependent.

关键词： activity centrophobism correlated random walk laboratory experiments movement ecology wall-following behavior

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Stability Analysis and Performance Evaluation of Additive Mixed-Precision Runge-Kutta Methods

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Communications on Applied Mathematics and Computation 2024年第1期6卷 705-738页

作者： Ben Burnett Sigal gottlieb Zachary J.Grant Center for Scientific Computing and Data Science Research UMass DartmouthNorth DartmouthMassachusettsUSA CSME Michigan State UniversityEast LansingMichiganUSA

Additive Runge-Kutta methods designed for preserving highly accurate solutions in mixed-precision computation were previously proposed and *** specially designed methods use reduced precision for the implicit computations and full precision for the explicit *** this work,we analyze the stability properties of these methods and their sensitivity to the low-precision rounding errors,and demonstrate their performance in terms of accuracy and *** develop codes in FORTRAN and Julia to solve nonlinear systems of ODEs and PDEs using the mixed-precision additive Runge-Kutta(MP-ARK)*** convergence,accuracy,and runtime of these methods are *** show that for a given level of accuracy,suitably chosen MP-ARK methods may provide significant reductions in runtime.

关键词： Mixed precision Runge-Kutta methods Additive methods Accuracy

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A Review of David gottlieb’s Work on the Resolution of the Gibbs Phenomenon

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Communications in Computational Physics 2011年第3期9卷 497-519页

作者： Sigal gottlieb Jae-Hun Jung Saeja Kim Mathematics Department University of Massachusetts DartmouthNorth DartmouthMA 02747USA Mathematics Department Suny BuffaloBuffaloNew York 14260-2900USA

Given a piecewise smooth function,it is possible to construct a global expansion in some complete orthogonal basis,such as the Fourier ***,the local discontinuities of the function will destroy the convergence of global approximations,even in regions for which the underlying function is *** global expansions are contaminated by the presence of a local discontinuity,and the result is that the partial sums are oscillatory and feature non-uniform *** characteristic behavior is called the Gibbs ***,David gottlieb and Chi-Wang Shu showed that these slowly and non-uniformly convergent global approximations retain within them high order information which can be recovered with suitable *** this paper we review the history of the Gibbs phenomenon and the story of its resolution.

关键词： Gibbs phenomenon post-processing Galerkin approximation collocation approximation spectral methods exponential accuracy

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Galerkin Method for Wave Equations with Uncertain Coefficients

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Communications in Computational Physics 2008年第2期3卷 505-518页

作者： David gottlieb Dongbin Xiu Division of Applied Mathematics Brown UniversityProvidenceRI 02912USA Department of Mathematics Purdue UniversityWest LafayetteIN 47907USA.

Polynomial chaos methods(and generalized polynomial chaos methods)have been extensively applied to analyze PDEs that contain *** this approach is rarely applied to hyperbolic *** this paper we analyze the properties of the resulting deterministic system of equations obtained by stochastic Galerkin *** consider a simple model of a scalar wave equation with random wave *** show that when uncertainty causes the change of characteristic directions,the resulting deterministic system of equations is a symmetric hyperbolic system with both positive and negative eigenvalues.A consistent method of imposing the boundary conditions is proposed and its convergence is *** examples are presented to support the analysis.

关键词： Generalized polynomial chaos stochastic PDE Galerkin method hyperbolic equation uncertainty quantification.

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Targeting the ECM component HA:a new route for mCRC treatment

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Science China(Life Sciences) 2023年第8期66卷 1944-1946页

作者： Wanjing Shang Simone gottlieb Yikun Yao Laboratory of Immune System Biology National Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesda 20892USA

Colorectal cancer(CRC)is a complex and heterogeneous disease that is the second-leading cause of cancer-related deaths *** colorectal cancer(m CRC)accounts for about one-third of all *** significant advances in understanding the molecular mechanisms underlying m CRC,effective treatments for patients with advanced disease remain limited,particularly for the aggressive mesenchymal subtype of CRC(Rawla et al.,2019).

关键词： cancer treatment

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Numerical Issues in the Implementation of High Order Polynomial Multi-Domain Penalty Spectral Galerkin Methods for Hyperbolic Conservation Laws

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Communications in Computational Physics 2009年第2期5卷 600-619页

作者： Sigal gottlieb Jae-Hun Jung Department of Mathematics University of Massachusetts at DartmouthNorth DartmouthMA 02747-2300USA Department of Mathematics SUNY at BuffaloBuffaloNY14260-2900USA

In this paper,we consider high order multi-domain penalty spectral Galerkin methods for the approximation of hyperbolic conservation *** formulation has a penalty parameter which can vary in space and time,allowing for flexibility in the penalty *** flexibility is particularly advantageous for problems with an inhomogeneous *** show that the discontinuous Galerkin method is equivalent to the multi-domain spectral penalty Galerkin method with a particular value of the penalty *** penalty parameter has an effect on both the accuracy and stability of the *** examine the numerical issues which arise in the implementation of high order multi-domain penalty spectral Galerkin *** coefficient truncation method is proposed to prevent the rapid error growth due to round-off errors when high order polynomials are ***,we show that an inconsistent evaluation of the integrals in the penalty method may lead to growth of *** examples for linear and nonlinear problems are presented.

关键词： High order polynomial Galerkin methods penalty boundary conditions discontinuous Galerkin methods hyperbolic conservation laws round-off errors truncation methods

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A Weighted Multi-Domain Spectral Penalty Method with Inhomogeneous Grid for Supersonic Injective Cavity Flows

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Communications in Computational Physics 2009年第5期5卷 986-1011页

作者： Wai-Sun Don David gottlieb Jae-Hun Jung Division of Applied Mathematics Brown UniversityProvidenceRI 02912USA Department of Mathematics University of Massachusetts at DartmouthNorth DartmouthMA 02747-2300USA

In[***.192(1),pp.325-354(2003)],we have developed a multidomain spectral method with stable and conservative penalty interface conditions for the numerical simulation of supersonic reactive recessed cavity flows with homogeneous *** this work,the previously developed methodology is generalized to inhomogeneous grid to simulate the two dimensional supersonic injector-cavity ***-physical modes in the solution generated at the domain interfaces due to the spatial grid inhomogeneity are minimized using the new weighted multi-domain spectral penalty *** proposed method yields accurate and stable solutions of the injector-cavity system which agree well with experiments *** the direct numerical simulation of the injector-cavity system using the weighted method,the geometric effect of the cavity wall on pressure fluctuations is *** is shown that the recessed slanted cavity attenuates pressure fluctuations inside cavity enabling the cavity to act potentially as a stable flameholder for scramjet engine.

关键词： Penalty interface conditions weighted multi-domain spectral penalty methods supersonic recessed cavity flame-holder compressible Navier-Stokes equations

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A Strong Stability Preserving Analysis for Explicit Multistage Two-Derivative Time-Stepping Schemes Based on Taylor Series Conditions

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Communications on Applied Mathematics and Computation 2019年第1期1卷 21-59页

作者： Zachary Grant Sigal gottlieb David C.Seal Department of Computational and Applied Mathematics Oak Ridge National LaboratoryOak RidgeUSA Department of Mathematics University of Massachusetts DartmouthDartmouthUSA Department of Mathematics U.S.Naval AcademyAnnapolisUSA

High-order strong stability preserving(SSP)time discretizations are often needed to ensure the nonlinear(and sometimes non-inner-product)strong stability properties of spatial discretizations specially designed for the solution of hyperbolic ***-derivative time-stepping methods have recently been increasingly used for evolving hyperbolic PDEs,and the strong stability properties of these methods are of *** our prior work we explored time discretizations that preserve the strong stability properties of spatial discretizations coupled with forward Euler and a second-derivative ***,many spatial discretizations do not satisfy strong stability properties when coupled with this second-derivative formulation,but rather with a more natural Taylor series *** this work we demonstrate sufficient conditions for an explicit two-derivative multistage method to preserve the strong stability properties of spatial discretizations in a forward Euler and Taylor series *** call these strong stability preserving Taylor series(SSP-TS)*** also prove that the maximal order of SSP-TS methods is p=6,and define an optimization procedure that allows us to find such SSP *** types of these methods are presented and their efficiency ***,these methods are tested on several PDEs to demonstrate the benefit of SSP-TS methods,the need for the SSP property,and the sharpness of the SSP time-step in many cases.

关键词： Strong stability preserving Taylor series.Hyperbolic conservation laws Two derivative Runge Kutta

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Development of drugs for celiac disease:review of endpoints for Phase 2 and 3 trials

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Gastroenterology Report 2015年第2期3卷 91-102页

作者： Klaus gottlieb Jill Dawson Fez Hussain Joseph A.Murray Immunology Internal Medicine-Medical Strategy&ScienceQuintilesDurhamNCUSA Corporate Communications QuintilesDurhamNCUSA Division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA

Celiac disease is a lifelong disorder for which there is currently only one known,effective treatment:a gluten-free *** treatment approaches have recently emerged;several drugs are in Phase 2 trials and results appear promising;however,discussion around regulatory endpoints is in its *** will briefly discuss the drugs that are under development and then shift our attention to potential trial endpoints,such as patient-reported outcomes,histology,serology,gene expression analysis and other *** will outline the differing requirements for proof-of-concept Phase 2 trials and Phase 3 registration trials,with a particular emphasis on current thinking in regulatory *** conclude our paper with recommendations and a glossary of regulatory terms,to enable readers who are less familiar with regulatory language to take maximum advantage of this review.

关键词： celiac disease clinical trials endpoints

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