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Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease

World Journal of Gastroenterology 2015年第35期21卷 10080-10090页

作者： John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha Dl Hart Kareena l Schnabl gordon M lees Bodil MK larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin Alberta Institute for Human Nutrition University of Alberta Edmonton AB T6G 2R1 Canada Department of laboratory Medicine and Pathology University of Alberta Edmonton AB T6G 2B7 Canada Division of General Surgery University of Alberta Edmonton AB T6G 2B7 Canada Alberta Health Services Edmonton AB T6G 2B7 Canada Alberta Health Services Calgary AB T2N 4N2 Canada Division of Gastroenterology Western University London ON N6A 5A5 Canada Department of Medicine University of Alberta Edmonton AB T6G 2B7 Canada

AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESUlTS: Relative GM3 ganglioside content was 2-fold higher(P lammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P l intestine exhibited 3-fold higher(P lative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P lative content of HEXA in IBD intestine was increased 1.7-fold(P ld

关键词： Ganglioside Phospholipid Fatty acid lipid Inflamma

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Stimulated Brillouin scattering in chiral photonic crystal fiber

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Photonics Research 2022年第3期10卷 711-718页

作者： Xinglin Zeng Wenbin He Michael HFrosz Andreas Geilen Paul Roth gordon K.l.Wong Philip St.J.Russell Birgit Stiller Max-Planck Institute for the Science of light 91058 ErlangenGermany Department of Physics Friedrich-Alexander-Universität91058 ErlangenGermany

Stimulated Brillouin scattering(SBS)has many applications;for example,in sensing,microwave photonics,and signal ***,we report the first experimental study of SBS in chiral photonic crystal fiber(PCF),which displays optical activity and robustly maintains circular polarization states against external *** a result,circularly polarized pump light is cleanly backscattered into a Stokes signal with the orthogonal circular polarization state,as is required by angular momentum *** comparison,untwisted PCF generates a Stokes signal with an unpredictable polarization state,owing to its high sensitivity to external *** use chiral PCF to realize a circularly polarized continuous-wave Brillouin *** results pave the way for a new generation of stable circularly polarized SBS systems with applications in quantum manipulation,optical tweezers,optical gyroscopes,and fiber sensors.

关键词： polarization fiber scattering

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利乐无菌包装纸盒的坏境概况

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中国包装 1996年第5期16卷 29-31页

作者： gordon l.

利乐无菌包装纸盒的坏境概况ＴｈｅＥｎｖｉｒｏｎｍｅｎｔａｌＰｒｏｆｉｌｅｏｆＴｅｔｒａＰａｈＡｓｅｐｔｉｃＣａｒｔｏｎｓ￥ＧＯＲＤＯＮＬ．（新加坡）Ａｂｓｔｒａｃｔ：Ｔｈｅｌｉｆｅｃｙｃｌｅａｎａｌｙｓｉｓｏｆｐａｃ... 详细信息

利乐无菌包装纸盒的坏境概况ＴｈｅＥｎｖｉｒｏｎｍｅｎｔａｌＰｒｏｆｉｌｅｏｆＴｅｔｒａＰａｈＡｓｅｐｔｉｃＣａｒｔｏｎｓ￥ＧＯＲＤＯＮＬ．（新加坡）Ａｂｓｔｒａｃｔ：Ｔｈｅｌｉｆｅｃｙｃｌｅａｎａｌｙｓｉｓｏｆｐａｃｋａｇｉｎｇｗａｓｉｎｉｔｉａｔｅ...

关键词：包装纸盒无菌包装纸盒环境保护寿命周期

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Prevalence and factors associated with vitamin C deficiency in inflammatory bowel disease

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World Journal of Gastroenterology 2022年第33期28卷 4834-4845页

作者： Benjamin langan gordon Jonathan S Galati Stevie Yang Randy S longman Dana lukin Ellen J Scherl Robert Battat Department of Medicine New York Presbyterian/Weill Cornell Medical CenterNew YorkNY 10065United States Department of Gastroenterology and Hepatology New York Presbyterian/Weill Cornell Medical CenterNew YorkNY 10021United States

BACKGROUND Patients with inflammatory bowel disease(IBD) are prone to several nutritional deficiencies. However, data are lacking on vitamin C deficiency in Crohn’s disease(CD) and ulcerative colitis(UC) patients, as well as the impact of clinical, biomarker and endoscopic disease severity on the development of vitamin C *** To determine proportions and factors associated with vitamin C deficiency in CD and UC *** In this retrospective study, we obtained clinical, laboratory and endoscopic data from CD and UC patients presenting to the IBD clinic at a single tertiary care center from 2014 to 2019. All patients had an available plasma vitamin C level. Of 353 subjects who met initial search criteria using a cohort discovery tool, 301ultimately met criteria for inclusion in the study. The primary aim described vitamin C deficiency(≤ 11.4 μmol/l) rates in IBD. Secondary analyses compared proportions with deficiency between active and inactive IBD. Multivariate logistic regression analysis evaluated factors associated with *** Of 301 IBD patients, 21.6% had deficiency, including 24.4% of CD patients and 16.0% of UC patients. Patients with elevated C-reactive protein(CRP)(39.1% vs 16.9%, P l calprotectin(50.0% vs 20.0%, P = 0.009) had significantly higher proportions of deficiency compared to those without. Penetrating disease(P = 0.03),obesity(P = 0.02) and current biologic use(P = 0.006) were also associated with deficiency on univariate analysis. On multivariate analysis, the objective inflammatory marker utilized for analysis(elevated CRP) was the only factor associated with deficiency(odds ratio = 3.1, 95%confidence interval: 1.5-6.6, P = 0.003). There was no difference in the presence of clinical symptoms of scurvy in those with vitamin C deficiency and those *** Vitamin C deficiency was common in IBD. Patients with elevated inflammatory markers and penetrating disease had higher rates of vitamin

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis Vitamin C deficiency Scurvy Malnutrition

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Magnetic resonance imaging biomarkers of gastrointestinal motor function and fluid distribution

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World Journal of Gastrointestinal Pathophysiology 2015年第4期6卷 140-149页

作者： Asseel Khalaf Caroline l Hoad Robin C Spiller Penny A Gowland gordon W Moran luca Marciani Nottingham Digestive Diseases Centre and NIHR Nottingham Digestive Diseases Biomedical Research Unit Nottingham University Hospitals NHS Trust University of Nottingham Sir Peter Mansfield Imaging Centre School of Physics and AstronomyUniversity of Nottingham

Magnetic resonance imaging(MRI) is a well established technique that has revolutionized diagnostic radiology. Until recently, the impact that MRI has had in the assessment of gastrointestinal motor function and bowel fluid distribution in health and in disease has been more limited, despite the novel insights that MRI can provide along the entire gastrointestinal tract. MRI biomarkers include intestinal motility indices, small bowel water content and whole gut transit time. The present review discusses new developments and applications of MRI in the upper gastrointestinal tract, the small bowel and the colon reported in the literature in the last 5 years.

关键词： Magnetic resonance imaging Stomach Small bowel Col

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In Vitro-Propagation of Agave tequilana Weber *** in a Temporary Immersion System

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Phyton-International Journal of Experimental Botany 2022年第1期91卷 83-96页

作者： Otilio Vázquez-Martínez Héctor gordon Núñez-Palenius Eugenio M.Pérez-Molphe Balch Mauricio Valencia-Posadas luis Pérez-Moreno Graciela M.l.Ruiz-Aguilar M.Gómez-lim División de Ciencias de la Vida Universidad de GuanajuatoIrapuato36500México Departamento de Química Centro de Ciencias BásicasUniversidad Autónoma de AguascalientesAguascalientes20131México Departamento de Ingeniería Genética CINVESTAV Unidad IrapuatoIrapuato36500México

In Mexico,there is a need to produce large quantities of plantlets for the establishment and replanting of blue(***)agave production *** of these plots are within the origin denomination area(DOT,Spanish acronym)of the distilled product of this plant,known as *** objective of this study was to develop an in vitropropagation protocol for Agave tequilana Weber *** using segmented stems in both:solid and liquid media.A disinfection and in vitro technique were developed to obtain shoots,through plantlets collected in commercial plots,which attained 100%surface-disinfection and budding *** the multiplication stage,the effects of 6-Benzylaminopurine(BA)(0.0,4.4 and 13.2μM)and kinetin(0.0,9.4,18.8 and 37.6μM)were evaluated on lateralshoot production of segmented sagittal *** were cultivated on Murashige&Skoog(MS)medium,with the addition of 3.0%sucrose and 8 g l−1 *** was observed that BA and kinetin increased the number of shoots per explant,obtaining up to 18 and 26,***,it was found that just the sagittal segmentation of explants increased axillary *** the other hand,segmented-stem bases were grown in MS liquid medium with 3.0%sucrose,inside a RITAsystem,programmed by a 5 min immersion step with a frequency of every 4 *** effect of Indole−3-Acetic acid(IAA)(0.57,2.9,5.7μM)was evaluated,while maintaining a concentration of BA(13.2μM).It was observed that the greatest concentration of IAA led to the formation of more than 20 buds per *** results offer a new methodology to increase the efficiency of *** Weber ***-in vitro multiplication by sagittal segmentation of stems and the addition of BA and/or IAA.

关键词： Plant tissue culture stem-disk culture tequila in vitro culture

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互联网到底是谁发明的？

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中国证券期货 2012年第9期15卷 78-79页

作者： l. gordon CROVITZ 《华尔街日报》

美国总统奥巴马（Barack Obama）在最近一次拉票演讲中掷地有声地说，“你的生意不是光靠自己做成的，是有人在旁边使了劲。”他以路桥设施为例，力证政府机构相对企业主发挥了更大的作用，并紧接着举例道，“互联网也不是从石头缝里蹦... 详细信息

美国总统奥巴马（Barack Obama）在最近一次拉票演讲中掷地有声地说，“你的生意不是光靠自己做成的，是有人在旁边使了劲。”他以路桥设施为例，力证政府机构相对企业主发挥了更大的作用，并紧接着举例道，“互联网也不是从石头缝里蹦出来的，是政府研究机构发明了互联网，让各路企业从互联网上挣钱。”

关键词：互联网发明政府研究机构美国总统政府机构企业主奥巴马生意

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念珠菌生物膜体外抗真菌药物敏感性研究

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中华皮肤科杂志 2002年第5期35卷 409-410页

作者：孙秋宁 gordon Ramage Jose l.lopez-Ribot 中国医学科学院中国协和医科大学北京协和医院皮肤科北京100730 Department of microbiology Division of Infectious DiseasesUniversity of Texas Health Science Center at San AntonioSan AntonioTexas U.S.A Department of Medicine Division of Infectious DiseasesUniversity of Texas Health Science Center at San AntonioSan AntonioTexas U.S.A

随着医疗技术的不断进步,各种体内装置的应用明显增加,如静脉插管、人工心脏瓣膜、关节置换术等。这些装置均可作为微生物的附着物而形成一种由单层或多层细胞粘附到这些生物材料基质的表面生长的生物膜结构 [1] 。生长在生物膜中的念... 详细信息

随着医疗技术的不断进步,各种体内装置的应用明显增加,如静脉插管、人工心脏瓣膜、关节置换术等。这些装置均可作为微生物的附着物而形成一种由单层或多层细胞粘附到这些生物材料基质的表面生长的生物膜结构 [1] 。生长在生物膜中的念珠菌在其表型上与悬浮的念珠菌有着很大的不同,其中最主要的特点是对许多抗真菌药物的敏感性降低甚至产生耐药 [2] 。

关键词：念珠菌生物膜抗真菌药物药物敏感性悬浮菌粘附菌合理用药

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The Effect of Adrenal Replacement Therapy on Rates of Fungal Colonization and Mortality in Critically Ill Patients Awaiting liver Transplantation

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Journal of Clinical and Translational Hepatology 2013年第1期1卷 2-8页

作者： Stephanie G. Yi Archana R. Sadhu Stephen l. Jones Krista Turner Howard Monsour Kevin Donahue Xuefeng Xia A. Osama Gaber R. Mark Ghobrial Sherilyn gordon Burroughs Department of Surgery The Methodist Hospital Weill Cornell Medical College Houston TX Division of Endocrinology Department of Medicine The Methodist Hospital Houston TX Department of Surgery University of New Mexico at Albuquerque Albuquerque NM Hepatology and Transplant Medicine Department of Medicine The Methodist Hospital Houston TX Department of Pharmacy The Methodist Hospital Houston TX The Methodist Hospital Research Institute The Methodist Hospital Houston TX liver Transplantation and Hepatobiliary Surgery Department of Surgery The Methodist Hospital Weill Cornell Medical College Houston TX

Background: The effect of adrenal replacement therapy (ART) with hydrocortisone on critical endpoints such as infection and mortality in critically ill patients with cirrhosis remains unclear. We evaluated our indications for ART in patients with cirrhosis with clinical symptoms of adrenal insufficiency (AI), and examined the rate of peri-transplant fungal colonization and mortality associated with ART. Methods: Seventy-eight patients with cirrhosis admitted to our institution's surgical intensive care unit (ICU) over a 4-year period met criteria for AI by vasopressor requirement and baseline cortisol levels. Outcomes included disposition at 90-days, fungal colonization, and fungal infection in the presence or absence of ART. Results: In total, 56 patients received hydrocortisone (HC+) while 22 did not (HC-). The HC+ and HC- groups had comparable median Model for End-stage liver Disease (MElD) scores (26.5 vs. 25, respectively;p=0.93), median ICU lengths of stay (23 vs. 20 days, respectively;p=0.54) and median cortisol levels (18μg/dl for both, p=0.87). Fungal cultures (FC) from blood, urine or bronchoalveolar lavage/sputum were positive for 44% of HC+, and 40.9%of HC-(p=0.77) had mortality rates between HC+and HC-groups that were not significantly different (60.7%vs. 50%, respectively;p=0.39;α=0.05). The 90-day outcomes for HC+ vs. HC- (39.3% vs. 50% discharged, respectively;p=0.39;α=0.05) and those surviving to transplant (17.9%vs. 36.4%, respectively;p=0.08;α=0.05) were not signifi-cantly different between the two ***:In this small single-center series, we found that steroid administration for AI does not affect the rate of fungal colonization/infection or mortality. Further prospective stu-dies are required to determine the utility of ART and factors affecting the rate of FC and mortality in these patients.

关键词： Sepsis Hydrocortisone Antifungal Transplant

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Targeted quantitative profiling of metabolites and gene transcripts associated with 4-aminobutyrate (GABA) in apple fruit stored under multiple abiotic stresses

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Horticulture Research 2018年第1期5卷 66-79页

作者： Carolyne J.Brikis Adel Zarei Greta Z.Chiu Kristen l.Deyman Jingyun liu Christopher P.Trobacher gordon J.Hoover Sanjeena Subedi Jennifer R.DeEll Gale G.Bozzo Barry J.Shelp Department of Plant Agriculture University of GuelphGuelphOntarioN1G 2W1Canada Department of Mathematical Sciences Binghamton UniversityBinghamtonNY13902USA Ontario Ministry of Agriculture Food and Rural AffairsBox 5871283 Blueline Rd.at Highway 3SimcoeOntarioN3Y 4N5Canada

4-Aminobutyrate accumulates in plants under abiotic ***,targeted quantitative profiling of metabolites and transcripts was conducted to monitor glutamate-and polyamine-derived 4-aminobutyrate production and its subsequent catabolism to succinate or 4-hydroxybutyrate in apple(Malus x domestica Borkh.)fruit stored at 0°C with 2.5 kPa O2 and 0.03 or 5 kPa CO2 for 16 ***-temperature-induced protein hydrolysis appeared to be responsible for the enhanced availability of amino acids during early storage,and the resulting higher glutamate level stimulated 4-aminobutyrate levels more than *** CO2 increased the levels of polyamines,as well as succinate and 4-hydroxybutyrate,during early storage,and 4-aminobutyrate and 4-hydroxybutyrate over the longer *** of all of the genes likely involved in 4-aminobutyrate metabolism from glutamate/polyamines to succinate/4-hydroxybutyrate was induced in a co-ordinated ***2-regulated expression of apple GlUTAMATE DECARBOXYlASE 2,AMINE OXIDASE 1,AlDEHYDE DEHYDROGENASE 10A8 and POlYAMINE OXIDASE 2 was evident with longer term *** suggested that respiratory activities were restricted by the elevated CO2/O2 environment,and that decreasing NAD+availability and increasing NADPH and NADPH/NADP+,respectively,played key roles in the regulation of succinate and 4-hydroxybutyate ***,these findings suggest that both transcriptional and biochemical mechanisms are associated with 4-aminobutyrate and 4-hydroxybutyrate metabolism in apple fruit stored under multiple abiotic stresses.

关键词： hydrolysis subsequent restricted

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