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New Generalized Transformation Method and its Application in Higher-Dimensional Soliton Equation

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Communications in Theoretical Physics 2006年第3期45卷 447-451页

作者： bai Cheng-Lin GUO Zong-Lin ZHAO Hong Physical Science and information Engineering School Lia~cheng University Liaocheng 252059 China

A new generalized transformation method is differential equation. As an application of the method, we presented to find more exact solutions of nonlinear partial choose the （3＋1）-dimensional breaking soliton equation to illustrate the method. As a result many types of explicit and exact traveling wave solutions, which contain solitary wave solutions, trigonometric function solutions, Jacobian elliptic function solutions, and rational solutions, are obtained. The new method can be extended to other nonlinear partial differential equations in mathematical physics.

关键词： new generalized transformation method, exact solution, (3+1)-dimensional breaking soliton equation, KdV equation mKdV equation cubic nonlinear Klein-gordon equation

Solitary Wave and Doubly Periodic Wave Solutions to Three-Dimensional Nizhnik-Novikov-Veselov Equation

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Communications in Theoretical Physics 2008年第5期49卷 1241-1244页

作者： bai Cheng-Jie HAN Ji-Guang WANG Wei-Tao AN Hong-Yong Communication School Shandong Normal University Jinan 250014 China Physical Science and information Engineering School Liaocheng University Liaocheng 252059 China

The generalized transformation method is utilized to solve three-dimensional Nizhnik-Novikov-Veselov equation and construct a series of new exact solutions including kink-shaped and bell-shaped soliton solutions, trigonometric function solutions, and Jacobi elliptic doubly periodic solutions. Among them, the Jacobi elliptic periodic wave solutions exactly degenerate to the soliton solutions at a certain limit condition. Compared with the existing tanh methods and Jacobi function method, the method we used here gives more general exact solutions without much extra effort.

关键词： generalized transformation method (3+1)-dimensional Nizhnik-Novikov-Veselov equation exactsolution KdV equation mKdV equation cubic nonlinear Klein-gordon equation

The Pi3K/AKT Pathway and Renal Cell Carcinoma

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Journal of Genetics and Genomics 2015年第7期42卷 343-353页

作者： Huifang Guo Peter German Shanshan bai Sean Barnes Wei Guo Xiangjie Qi Hongxiang Lou Jiyong Liang Eric Jonasch gordon B.Mills Zhiyong Ding Department of Systems Biology The University of Texas MD Anderson Cancer Center Department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer Center Department of Radiation Oncology People's Hospital of Linzi District Department of Natural Products Chemistry Key Laboratory of Chemical Biology of Ministry of EducationSchool of Pharmaceutical SciencesShandong University

The phosphatidylinositol 3 kinase （Pi3K）/AKT pathway is genetically targeted in more pathway components and in more tumor types than any other growth factor signaling pathway, and thus is frequently activated as a cancer driver. More importantly, the Pi3K/AKT pathway is composed of multiple bifurcating and converging kinase cascades, providing many potential targets for cancer therapy. Renal cell carcinoma （RCC） is a high-risk and high-mortality cancer that is notoriously resistant to traditional chemotherapies or radiotherapies. The Pi3K/AKT pathway is modestly mutated but highly activated in RCC, representing a promising drug target. indeed, Pi3K pathway inhibitors of the rapalog family are approved for use in RCC. Recent large-scale integrated analyses of a large number of patients have provided a molecular basis for RCC, reiterating the critical role of the Pi3K/AKT pathway in this cancer. in this review, we summarize the genetic alterations of the Pi3K/AKT pathway in RCC as indicated in the latest large-scale genome sequencing data, as well as treatments for RCC that target the aberrant activated Pi3K/AKT pathway.

关键词： Pi3K AKT mTOR Renal cell carcinoma Targeted therapy

The New infinite Sequence Solutions of Multiple Sine-gordon Equations

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Journal of Applied Mathematics and Physics 2016年第4期4卷 796-805页

作者： Yu Mei bai Taogetusang The College of Mathematical Inner Mongolia University for Nationalities Tongliao China College of Mathematical Science Inner Mongolia Normal University Huhhot China

By the function transformation and the first integral of the ordinary differential equations, the problem of solving the solutions of the double sine-gordon equation and the treble sine-gordon equation is researched, and the new solutions are obtained. First, the problem of solving the solutions of the double sine-gordon equation and the treble sine-gordon equation is changed to the problem of solving the solutions of the nonlinear ordinary differential equation. Second, with the help of the B?cklund transformation and the nonlinear superposition formula of solutions of the first kind of elliptic equation and the Riccati equation, the new infinite sequence soliton-like solutions of two kinds of sine-gordon equations are constructed.

关键词： First integral Multiple Sine-gordon Equation Bäcklund Transformation New infinite Sequence Soliton-Like Solutions

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新型高分子助剂在自动洗碗机清洁剂的应用

日用化学品科学 2017年第7期40卷 24-27,33页

作者：白剑芸曲向华 BRiJMOHAN Smita HSU gordon 路博润特种化工制造(上海)有限公司上海201611 美国路博润先进材料公司克里夫兰441413201

研究了一种新型高分子助剂Noverite^(TM) AD810的钙离子螯合能力、玻璃杯浸泡老化实验及在含氯或含酶自动洗碗凝胶及自动洗碗粉中的应用性能。实验结果表明,Noverite^(TM) AD810有着良好的钙离子螯合能力,并且不会引起有花纹玻璃杯颜色... 详细信息

研究了一种新型高分子助剂Noverite^(TM) AD810的钙离子螯合能力、玻璃杯浸泡老化实验及在含氯或含酶自动洗碗凝胶及自动洗碗粉中的应用性能。实验结果表明,Noverite^(TM) AD810有着良好的钙离子螯合能力,并且不会引起有花纹玻璃杯颜色变化。在所测试的多种自动洗碗机清洁剂产品中,含Noverite^(TM) AD810配方均显示出良好的抗成膜、抗成斑点及阻止碳酸钙沉积在器皿表面性能。

关键词：自动洗碗机清洁剂高分子助剂应用

Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography(PET)

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Acta Pharmaceutica Sinica B 2019年第6期9卷 1204-1215页

作者： Yu Lan Ping bai Zude Chen Ramesh Neelamegam Michael SPlaczek Hao Wang Stephanie AFiedler Jing Yang Gengyang Yuan Xiying Qu Hayden RSchmidt Jinchun Song Marc DNormandin Chongzhao Ran Changning Wang Athinoula A.Martinos Center for Biomedical imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA gordon Center for Medical imaging Department of RadiologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA 02129USA Department of Biological Chemistry and Molecular Pharmacology Harvard Medical SchoolBostonMA 02129USA Department of Pharmacy Renmin Hospital of Wuhan UniversityWuhan 430060China

The sigma-1 receptor(σ1R)is a unique intracellular protein.σ1R plays a major role in various pathological conditions in the central nervous system(CNS),implicated in several neuropsychiatric *** ofσ1R in the brain using positron emission tomography(PET)could serve as a noninvasively tool for enhancing the understanding of the disease’s ***,σ1R PET tracers can be used for target validation and quantification in ***,we describe the radiosynthesis,in vivo PET/CT imaging of novelσ1R11C-labeled radioligands based on 6-hydroxypyridazinone,[11C]HCC0923 and[11C]*** radioligands have high affinities toσ1R,with good *** mice PET/CT imaging,both radioligands showed appropriate kinetics and ***,the specific interactions of two radioligands were reduced by compounds 13 and 15(self-blocking).Ofthe two,[11C]HCC0929 was further investigated in positive ligands blocking studies,using classicσ1R agonist SA 4503 andσ1R antagonist PD ***σ1R ligands could extensively decreased the uptake of[11C]HCC0929 in mice ***,the biodistribution of major brain regions and organs of mice were determined in *** studies demonstrated that two radioligands,especially[11C]HCC0929,possessed ideal imaging properties and might be valuable tools for non-invasive quantification ofσ1R in brain.

关键词： σ1R PET Brain imaging 6-Hydroxypyridazinone 11C-labeled radioligand

An investigation of the Effects of Curcumin on Anxiety and Depression in Obese individuals:A Randomized Controlled Trial

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