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Dynamic monitoring of carcinoembryonic antigen,CA19-9 and inflammation-based indices in patients with advanced colorectal cancer undergoing chemotherapy

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World Journal of Clinical Cases 2022年第3期10卷 899-918页

作者： Nebojsa Manojlovic goran Savic Bojan Nikolic Nemanja Rancic Clinic for Gastroenterology and Hepatology Military Medical AcademyFaculty of Medicine of the Military Medical AcademyUniversity of DefenceBelgrade 11000Serbia Faculty of Medicine of the Military Medical Academy University of DefenceBelgradeSerbiaMilitary Medical AcademyBelgrade 11000Serbia Institute for Radiology Military Medical AcademyBelgrade 11000Serbia Center for Clinical Pharmacology Institute for RadiologyMilitary Medical AcademyFaculty of Medicine of the Military Medical AcademyUniversity of DefenceBelgrade 11000Serbia

BACKGROUND The roles of carcinoembryonic antigen(CEA)and carbohydrate antigen(CA19-9)in monitoring the patient response to chemotherapy for metastatic colorectal cancer(mCRC)are not clearly defined,and inflammatory indices,including the neutrophil-to-lymphocyte ratio(NLR),lymphocyte-to-monocyte ratio(LMR),platelet-to-lymphocyte ratio(PLR)and systemic immune-inflammation index(SII),have been sparsely investigated for this *** To aim of this study was to evaluate the relationship between the kinetics of CEA,CA19-9,NLR,LMR,PLR and SII in serum and patient response to chemotherapy estimated by computed tomography(CT)in patients with unresectable *** Patients with mCRC treated with a 1st-line and 2nd-line chemotherapy underwent at least 3 whole-body spiral CT scans during response monitoring according to the Response Evaluation Criteria in Solid Tumour 1.1(RECIST 1.1),and simultaneous determination of CEA,CA19-9,neutrophil,lymphocyte,platelet and monocyte levels was *** kinetics of changes in the tumour markers and inflammatory indices were calculated as the percentage change from baseline or nadir,while receiver operating characteristic curves were drawn to select the thresholds to define patients with progressive or responsive disease with the highest sensitivity(Se)and specificity(Sp).The correlation of tumour marker kinetics with inflammatory index changes and RECIST response was determined by univariate and multivariate logistic regression analysis and the clinical utility index(CUI).RESULTS A total of 102 patients with mCRC treated with chemotherapy were *** disease(PD),defined as a CEA increase of 25.52%,resulted in an Se of 80.3%,an Sp of 84%,a good CUI negative[CUI(Ve-)]value of 0.75 and a good fraction correct(FC)value of 81.2;at a CEA cut-off of-60.85%with an Se of 100%and an Sp of 35.7%for PD,CT could be avoided in 25.49%of *** 21.49%CA19-9 cut-off for PD had an Se of 66.5%,an Sp of 87.4%,an acceptable CUI(

关键词： Tumour markers Carcinoembryonic antigen Carbohydrate antigen Inflammatory-based indices Chemotherapy response Metastatic colorectal cancer

Behavior of HSLA A709 Steel under Different Environmental Conditions

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Journal of Wuhan University of Technology(Materials Science) 2010年第6期25卷 897-902页

作者： BRNIC Josip NIU Jitai TURKALJ goran CANADIJA Marko LANC Domagoj Faculty of Engineering University of Rijeka Vukovarska 58 51000 Rijeka Croatia School of Materials Science and Engineering Henan Polytechnic University Jiaozuo 454000 China

According to the requirement of the knowledge of material mechanical properties in structure design procedure,the paper considered experimentally obtained data regarding the high-strength low-alloy A 709 Gr50 *** that way,ultimate tensile strength and 0.2 offset yield strength at both lowered and elevated temperatures were presented and *** effect of temperature exerted on both of the mentioned strengths was *** responses for selected temperatures and selected stress levels were also *** of the tests are related to the uniaxial tensile tests and were performed in the laboratory of the Department for Engineering Mechanics at the Faculty of Engineering Rijeka.

关键词： A 709 steel material mechanical properties lowered temperature elevated temperature creep behavior

Adynamic and dynamic muscle transposition techniques for anal incontinence

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Gastroenterology Report 2014年第2期2卷 98-105页

作者： goran Barišic Zoran Krivokapic Clinic for Digestive Surgery First Surgical ClinicBelgrade School of MedicineUniversity of BelgradeSerbia

Gracilis muscle transposition is well established in general surgery and has been the main muscle transposition technique for anal ***,through a schedule of continuous electrical stimulation,converts the fatigue-prone muscle fibres to a tonic fatigue-resistant morphology with acceptable results in those cases where there is limited sphincter muscle *** differences between gluteoplasty and graciloplasty,as well as the techniques and complications of both procedures,are outlined in this ***,these techniques are rarely carried out in specialized units with experience,as there is a high revision and explantation rate.

关键词： anal incontinence muscle transposition gluteoplasty graciloplasty dynamization

Testicular angioleiomyoma presenting wit laematospermia

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Asian Journal of Andrology 2013年第4期15卷 573-574页

作者： goran Stimac Alma Demirovic Bozo Kruslin Davor Tomas Clinical Department of Urology 'Sestre milosrdnice' University Hospital Center Zagreb 10000 Croatia Ljudevit Jurak' Department of Pathology 'Sestre milosrdnice' University Hospital Center Zagreb 10 000 Croatia and School of Medicine University of Zagreb Zagreb 10 000 Croatia

Dear editors, We report an exceedingly rare case of primary testicular angioleio- myoma to increase awareness of this rare entity among urologists and pathologists. To our knowledge, only one case of this rare testicular tumour has been reported in the literature to date, and this is the first report of its presentation with haematospermia.1 A 65-year-old patient was admitted to our clinic for the evaluation of painless haematospermia. The patient＇s past medical history was unremarkable. At presentation and during the scrotal and testis exam- ination, there was no palpable mass. The patient had no voiding symptoms, and there were no signs of infection. The patient also denied experiencing any recent trauma. A digital rectal examination of the prostate was normal. The ultrasonographic findings disclosed a well-circumscribed ovoid hypoechoic nodule within the right testis, near its upper pole, measuring approximately 0.5 cm, and moderate hydrocele （Figure la）. The values of serum prostate-specific antigen, alpha-fetoprotein, beta-human chorionic gonadotropin and lactate dehydrogenase were normal.

关键词： angioleiomyoma presenting haematospermia

Extracellular matrices for gastrointestinal surgery:Ex vivo testing and current applications

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World Journal of Gastroenterology 2010年第32期16卷 4031-4038页

作者： Jens Hoeppner goran Marjanovic Peter Helwig Ulrich Theodor Hopt Tobias Keck Department of General and Visceral Surgery University of FreiburgFreiburg 79106Germany Department of Orthopedics and Traumatology University of FreiburgFreiburg 79106Germany

AIM:To assess the effects of bile and pancreatic juice on structural and mechanical resistance of extracellular matrices(ECMs) in ***:Small-intestinal submucosa(SIS),porcine dermal matrix(PDM),porcine pericardial matrix(PPM) and bovine pericardial matrix(BPM) were incubated in human bile and pancreatic juice in *** were examined by macroscopic observation,scanning electron microscopy(SEM) and testing of mechanical ***:PDM dissolved within 4 d after exposure to bile or pancreatic ***,PPM and PDM retained their integrity for > 60 d when incubated in either digestive *** effect of bile was found to be far more detrimental to mechanical stability than pancreatic juice in all tested *** SIS,the loss of mechanical stability after incubation in either of the digestive secretions was less distinct than in PPM and BPM [mFmax 4.01/14.27 N(SIS) vs 2.08/5.23 N(PPM) vs 1.48/7.89 N(BPM)].In SIS,the extent of structural damage revealed by SEM was more evident in bile than in pancreatic *** PPM and BPM,structural damage was comparable in both ***:PDM is less suitable for support of gastrointestinal *** SIS,PPM and BPM should also be evaluated experimentally for gastrointestinal indications.

关键词： Extracellular matrix Intestinal regeneration Ex-vivo testing Gastrointestinal surgery Gastrointestinal fistula Bioscaffolding

Production of hybrid aspen on agricultural land during one rotation in southern Sweden

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Journal of Forestry Research 2021年第1期32卷 181-189页

作者： Nils Fahlvik Lars Rytter Lars-goran Stener The Forestry Research Institute of Sweden(Skogforsk) Ekebo 225026890 SvalovSweden

High potential productivity together with short rotation periods have made hybrid aspen an interesting option for wood production on former arable land in Nordic *** this study,some of the oldest active experimental plots with hybrid aspen in Sweden were remeasured at 23–30 years of age.A main aim was to assess age and productivity at the time of maximum mean annual volume *** addition,the infl uence of commercial thinning on stand development and diff erences in genetic gain among clones were *** from fi ve experiments in southern Sweden were used,including three genetic trials,one demonstration stand with a clone mixture and one stand regenerated from root *** three genetic trials were treated as single plot experiments,subject to a standard thinning *** the remaining experiments,diff erent thinning strategies were tested in a balanced block *** growth had culminated or was close to maximum at age 25–30 *** annual stem volume increment at culmination was 20–22 m 3 ha^−1 a^−*** height reached 30–35 m at 28–30 years of *** diameter at breast height was 27–29 cm after 29–30 years in the genetic *** ranking based on diameter at age 7–9 years was positively correlated with the ranking at the fi nal measurement in the genetic trials,20 years *** indicates that clones can be selected for superior growth based on results from young *** intense thinning programs increased the mean diameter compared to light *** study indicates that one or two early and relatively heavy thinnings can promote the development of crop trees,without jeopardizing total volume production during a rotation of 25–30 years.

关键词： Populus tremula×Populus tremuloides Rotation length Thinning Biomass

Databases fit for blockchain technology:A complete overview

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Blockchain(Research and Applications) 2023年第1期4卷 116-133页

作者： Jovan Kalajdjieski Mayank Raikwar Nino Arsov goran Velinov Danilo Gligoroski Faculty of Computer Science and Engineering Ss.Cyril and Methodius University1000 SkopjeNorth Macedonia Norwegian University of Science and Technology(NTNU) NO-7491 TrondheimNorway

Efficient data storage and query processing systems play a vital role in many different research *** technology and distributed ledgers attract massive attention and trigger multiple projects in various ***,blockchain still lacks the features of a Database Management System(DBMS or simply databases),such as high throughput,low latency,and high *** that purpose,there have been many proposed approaches for handling data storage and query processing solutions in the *** paper presents a complete overview of many different DBMS types and how these systems can be used to implement,enhance,and further improve blockchain *** concretely,we give an overview of 10 transactional,an extensive overview of 14 analytical,9 hybrids,i.e.,translytical,and 13 blockchain *** explain how database technology has influenced the development of blockchain technology by unlocking different features,such as Atomicity,Consistency,Isolation,and Durability(ACID),transaction consistency,rich queries,real-time analysis,and low *** a relaxation approach analogous to the one used to prove the Consistency,Availability,Partition tolerance(CAP)-theorem,we postulate a“Decentralization,Consistency,and Scalability(DCS)-satisfiability conjecture”and give concrete strategies for achieving the relaxed DCS *** also provide an overview of the different DBMSs,emphasizing their architecture,storage manager,query processing,and implementation.

关键词： Blockchain Databases Transactions ACID Analytics Translytical

Adenosquamous carcinoma arising within a retrorectal tailgut cyst: Report of a case

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World Journal of Gastroenterology 2005年第39期11卷 6225-6227页

作者： Zoran Krivokapic Ivan Dimitrijevic goran Barisic Velimir Markovic Miodrag Krstic Institute for Digestive Diseases Clinical Center of Serbia BelgradeSerbia and Montenegro

Retrorectal, developmental tail gut cysts, include dermoid cysts, rectal duplication cysts and retrorectal cyst-hamartomas. Retrorectal cyst-hamartomas （RCH） are derived from remnants of the tail gut, the most caudal part of the embryonic hincl gut, which normally involutes by the 8^th wk of embryonic development （3-8 mm stage）. They have specific radiological and histopathological features that distinguish them from other similar formations （dermoid cysts, enteric duplication cysts and teratomas）. We report a patient with adenosquamous carcinoma arising within RCH, who underwent complete resection of the cyst through anterior laparotomy, and reached complete （recurrencefree for 14 mo, so far） functional recovery. The cyst was incidentally discovered during hysterectomy 12 years ago. Diagnostic, therapeutic arid histopathological aspects of this rare case are discussed. The mentioned pedod between diagnosis and surgical treatment suggests that RCH, given enough time, can develop malignant degeneration, and should be resected at the time of diagnosis.

关键词： Tailgut cyst Malignant transformation

Evaluation of stability and functionality of BaCe_(1−x)In_(x)O_(3−δ) electrolyte in a wider range of indium concentration

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Journal of Advanced Ceramics 2022年第3期11卷 443-453页

作者： Aleksandar MALESEVIC Aleksandar RADOJKOVIC Milan ZUNIC Aleksandra DAPCEVIC Sanja PERAC Zorica BRANKOVIC goran BRANKOVIC Center of Excellence for Green Technologies Institute for Multidisciplinary ResearchUniversity of BelgradeKneza Viseslava 711030 BelgradeSerbia Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411120 BelgradeSerbia

The properties of BaCe_(1−x)In_(x)O_(3−δ) (x = 0.05, 0.10, 0.15, 0.20, _(0.25), 0.30, 0.35, and 0.40) as proton conducting electrolyte are examined. The dense electrolyte is formed after sintering at 1300 ℃ for 5 h in air. The samples with In content ≥ 25 mol% contain In_(2)O_(3) as a secondary phase. The highest total conductivity is around 5×10^(−3) S/cm for BaCe_(0.75)In_(0.25)O_(3−δ) in the wet hydrogen atmosphere at 700 ℃. After exposure to pure CO_(2) atmosphere at 700 ℃ for 5 h, the concentrations of at least 15 mol% In can completely suppress degradation of the electrolyte. The power density of Ni-BaCe_(0.75)In_(0.25)O_(3−δ)/BaCe_(0.75)In_(0.25)O_(3−δ)/LSCF-BaCe_(0.75)In_(0.25)O_(3−δ) fuel cell tested in wet hydrogen atmosphere reaches 264 mW/cm2 at 700 ℃. This result is an indication of stability and functionality of this electrolyte and its versatility in respect to type of fuel and performing environment.

关键词： ionic conductivity perovskite fuel cell BaCeO_(3)