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Inhibitory Effect of Resveratrol on LPS-induced Glomerular Mesangial Cells Proliferation and TGF-β1 Expression via Sphingosine Kinase 1 Pathway

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Chinese Journal of Integrative Medicine 2023年第6期29卷 500-507页

作者： FENG Fu-zhen gong Wen-yan LI Si-yun DENG Yan-hui Department of Pharmacy the Third Affiliated Hospital of Southern Medical UniversityGuangzhou(510630)China Department of Cardiology the Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou(310000)China

Objective To elucidate the renoprotective effect of resveratrol(RSV)on sphingosine kinase 1(SphK1)signaling pathway and expression of its downstream molecules including activator protein 1(AP-1)and transformation growth factor-β1(TGF-β1)in lipopolysaccharide(LPS)-induced glomerular mesangial cells(GMCs).Methods The rat GMCs line(HBZY-1)were cultured and randomly divided into 5 groups,including control,LPS(100 ng/mL),and 5,10,20µmol/L RSV-treated *** addition,SphK1 inhibitor(SK-II)was used as positive *** were pretreated with RSV for 2 h and treated with LPS for another 24 *** proliferation was determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT)*** proteins expression of SphK1,p-c-Jun and TGF-β1 in GMCs were detected by Western blot,and DNA-binding activity of AP-1 was performed by electrophoretic mobility shift assay(EMSA).The binding activity between RSV and SphK1 protein was detected by AutoDock Vina and visualized by Discovery Studio *** LPS could obviously stimulate GMCs proliferation,elevate SphK1,p-c-Jun and TGF-β1 expression levels and increase the DNA-binding activity of AP-1(P0.05).Moreover,RSV exhibited good binding affinity towards SphK1,with docking scores of−8.1 kcal/moL and formed hydrogen bonds with ASP-178 and LEU-268 in *** RSV inhibited LPS-induced GMCs proliferation and TGF-β1 expression,which may be independent of its hypoglycemic effect on preventing the development of mesangial cell fibrosis and closely related to the direct inhibition of SphK1 pathway.

关键词： resveratrol glomerular mesangial cells proliferation sphingosine kinase 1 pathway transformation growth factor-β1 molecular docking

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Molecular Chaperone-Dependent Polymer Translocation through Nanopores: The Effects of Chaperone Concentration and Chaperone-Polymer Interaction

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Chinese Journal of Polymer Science 2024年第1期42卷 125-132,I0011页

作者： chang-Sheng Zuo Kang Wang Li-zhen Sun Ting-Ting Sun Department of Physics Zhejiang University of Science and TechnologyHangzhou 310023China Department of Applied Physics Zhejiang University of TechnologyHangzhou 310014China

The polymer translocation through a nanopore from a donor space(or named cis side) to a receiver space(trans side) in the chaperone-induced crowded environment has attracted increasing attention in recent years due to its significance in biological systems and technological applications. In this work, we mainly focus on the effects of chaperone concentration and chaperone-polymer interaction on the polymer translocation. By assuming the polymer translocation to be a quasi-equilibrium process, the free energy F of the polymer can be estimated by Rosenbluth-Rosenbluth method and then the translocation time τ can be calculated by Fokker-Plank equation based on the obtained free energy landscape. Our calculation results show that the translocation time can be controlled by independently tuning the chaperone concentration and chaperone-polymer interaction at the cis side or the trans side. There exists a critical chaperone-polymer attraction ε~*=-0.2 at which the volume exclusion and interaction effects of the chaperone can balance each other. Additionally, we also find that at large chaperone-polymer attraction, the translocation time is mainly governed by the diffusion coefficient of the polymer.

关键词： Polymer translocation Rosenbluth-Rosenbluth method Fokker-Plank equation Free energy landscapes

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Composition and construction of high- and low-energy ooid shoals and their relationships with environmental changes: A case study from the Cambrian Zhangxia Formation in the Ordos Basin， North China

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Journal of Earth Science 2020年

作者： zhen Wang Yiming gong State Key Laboratory of Biogeology and Environmental Geology， School of Earth Sciences， China University of Geosciences

On the basis of systematic study of sedimentary facies， microfacies and geochemistry of measured strata sections and wells， the ooid shoals of the Cambrian Miaolingian Zhangxia Formation in the southern Ordos Basin are composed of high- and low-energy ooid shoals. The characteristics of the high-energy shoals are sparry cementation， with moderate to well sorting， large grain size， high ooid content and low micrite， weak micritization， and well-preserved internal textures of the ooids. Macroscopically， the high-energy ooid shoals display a thick-bedded aggradational stacking pattern in upward coarsening and thickening sequences. The low-energy ooid shoals are mainly made up of micritic cementation， with moderate to poor sorting， relatively small grain size， lower ooid content and higher micrite， strong micritization， and poorly-preserved internal textures of the ooids. Macroscopically， the low-energy ooid shoals show a thin-bedded， interbedded stacking pattern in upward fining and thinning sequences. The sedimentological evidence and carbon isotope data show that the differences of internal fabric and sedimentary evolution of high- and low-energy ooid shoals are closely related to the changes of sea levels.

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Numerical study of optical trapping properties of nanoparticle on metallic film with periodic structure

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Chinese Physics B 2019年第2期28卷 223-233页

作者： Cheng-Xian Ge zhen-Sen Wu Jing Bai Lei gong School of Physics and Optoelectronic Engineering Xidian University School of Photoelectric Engineering Xi'an Technological University

Based on the three-dimensional dispersive finite difference time domain method and Maxwell stress tensor equation,the optical trapping properties of nanoparticle placed on the gold film with periodic circular holes are investigated numerically. Surface plasmon polaritons are excited on the metal-dielectric interface, with particular emphasis on the crucial role in tailoring the optical force acting on a nearby nanoparticle. Utilizing a first order corrected electromagnetic field components for a fundamental Gaussian beam, the incident beam is added into the calculation model of the proposed method. To obtain the detailed trapping properties of nanoparticle, the selected calculations on the effects of beam waist radius, sizes of nanoparticle and circular holes, distance between incident Gaussian beam and gold film, material of nanoparticle and polarization angles of incident wave are analyzed in detail to demonstrate that the optical-trapping force can be explained as a virtual spring which has a restoring force to perform positive and negative forces as a nanoparticle moves closer to or away from the centers of circular holes. The results of optical trapping properties of nanoparticle in the vicinity of the gold film could provide guidelines for further research on the optical system design and manipulation of arbitrary composite nanoparticles.

关键词： surface plasmon periodic circular holes optical trapping force Maxwell stress tensor gold film

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Role of calcimicrobes and microbial carbonates in the Late Carboniferous(Moscovian) mounds in southern Guizhou,South China

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Journal of Palaeogeography 2019年第4期8卷 346-359页

作者： Wen-Tao Huang Yong-Li Zhang chang-Qing Guan Zhuo-Wei Miao Xiao-Hong Chen zhen-Yuan Yang Xiao Li En-Pu gong College of Resources and Civil Engineering Northeastern UniversityShenyang 110819Liaoning ProvineeChina College of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao 066004Hebei ProvineeChina

Various microbial fabrics characterize late Moscovian mounds in Houchang Town,southern Guizhou,South *** dominant components of the mounds are microbial boundstones with stromatolitic structures,irregular oncoid-like forms,and wrinkle *** recognized in the mounds include Girvanella,Ortonella,Wetheredella-like,Palaeomicrocodium-like,and some problematic calcimicrobes occurring in deposits between microbial boundstones,in thrombolitic textures,and in some *** carbonates are common in the substrate and interior of the mounds,including thrombolitic textures,microstromatolites,microbial ooids,oncoids,irregular encrusted layers,microbial mat debris,and microbial *** and microbial carbonates played an important role in the construction of the mounds:Girvanella might have contributed as a source of lime mud that formed the mound and stabilized the coral frame;thrombolitic mats could trap and fix sediments and bioclasts,contributing to the stabilization of substrate and mound limestones;and,microbial boundstone,clotted micrite and micritized bioclast could provide a hard substrate for encrusting metazoans(e.g.,bryozoans,Ivanovia).The abundant microbial fabrics in the mounds indicate that microbial activity was widespread in Moscovian reef mounds in southern Guizhou,and this suggests that microbial organisms were the primary mound builders in the study area.

关键词： Microfossils Microbial carbonates Mounds Late Carboniferous Moscovian Guizhou

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Multi-bubble motion behavior of uniform magnetic field based on phase field model

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Chinese Physics B 2020年第3期29卷 303-311页

作者： chang-Sheng Zhu zhen Hu Kai-Ming Wang School of Computer and Communication Lanzhou University of TechnologyLanzhou 730050China State Key Laboratory of Gansu Advanced Processing and Recycling of Non-Ferrous Metal Lanzhou University of TechnologyLanzhou 730050China

Aiming at the interaction and coalescence of bubbles in gas–liquid two-phase flow, a multi-field coupling model was established to simulate deformation and dynamics of multi-bubble in gas–liquid two-phase flow by coupling magnetic field, phase field, continuity equation, and momentum equation. Using the phase field method to capture the interface of two phases, the geometric deformation and dynamics of a pair of coaxial vertical rising bubbles under the applied uniform magnetic field in the vertical direction were investigated. The correctness of results is verified by mass conservation method and the comparison of the existing results. The results show that the applied uniform magnetic field can effectively shorten the distance between the leading bubble and the trailing bubble, the time of bubbles coalescence, and increase the velocity of bubbles coalescence. Within a certain range, as the intensity of the applied uniform magnetic field increases, the velocity of bubbles coalescence is proportional to the intensity of the magnetic field, and the time of bubbles coalescence is inversely proportional to the intensity of the magnetic field.

关键词： bubbles coalescence uniform magnetic field numerical simulation phase field method

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Generalized Square Conservative Multistep Finite Difference Scheme Incorporating Historical Observations

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Atmospheric and Oceanic Science Letters 2013年第4期6卷 223-226页

作者： gong Jing WANG Bin JI Zhong-zhen State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of Sciences Mathematics and Physics Department North China Electric Power University

In this paper,a multistep finite difference scheme has been proposed,whose coefficients are determined taking into consideration compatibility and generalized quadratic conservation,as well as incorporating historical observation *** schemes have three advantages:high-order accuracy in time,generalized square conservation,and smart use of historical *** tests based on the one-dimensional linear advection equations suggest that reasonable consideration of accuracy,square conservation,and inclusion of historical observations is critical for good performance of a finite difference scheme.

关键词： multistep difference scheme generalized square conservation accuracy historical observations

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Development of CONTHAC-3D and hydrogen distribution analysis of HPR1000

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Nuclear Science and Techniques 2024年第2期35卷 210-221页

作者： Hui Wang Jing-Jing Li Yuan chang gong-Lin Li Ming Ding China Nuclear Power Engineering Co.LTD. Beijing 100084China Fundamental Science on Nuclear Safety and Simulation Technology Laboratory Harbin 100049China

An in-house code,CONTHAC-3D,was developed to calculate and analyze thermal-hydraulic phenomena in containments during severe ***-3D is a three-dimensional computational fluid dynamics code that can be applied to predict gas flow,diffusion,and steam condensation in a containment during a severe hypothetical accident,as well as to obtain an estimate of the local hydrogen concentration in various zones of the ***-3D was developed using multiple models to simulate the features of the proprietary systems and equipment of HPR1000 and ACP100,such as the passive cooling system,passive autocatalytic recombiners and the passive air cooling *** validate CONTHAC-3D,a GX6 test was performed at the Battelle Model Containment *** hydrogen concentration and temperature monitored by the GX6 test are accurately predicted by ***,the hydrogen distribution in the HPR1000 containment during a severe accident was *** results show that the hydrogen removal rates calculated using CONTHAC-3D for different types of PARs agree well with the theoretical values,with an error of less than 1%.As the accident progresses,the hydrogen concentration in the lower compartment becomes higher than that in the large space,which implies that the lower compartment has a higher hydrogen risk than the dome and large space at a later stage of the *** amount of hydrogen removed by the PARs placed on the floor of the compartment is small;therefore,raising the installation height of these recombiners appropriately is ***,we do not recommend installing all autocatalytic recombiners at high *** study findings in regard to the hydrogen distribution in the HPR1000 containment indicate that CONTHAC-3D can be applied to the study of hydrogen risk containment.

关键词： Hydrogen risk mitigation Pressurized water reactor HPR1000 Thermal hydraulic CONTHAC-3D

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Effect of annealing and cooling rate on toughness of G115 heat-resistant steels

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Journal of Iron and Steel Research International 2022年第8期29卷 1245-1256页

作者： zhen Liu Li gong Chi Zhang zheng-dong Liu zheng-zong Chen Yun-he Yu Key Laboratory for Advanced Materials of Ministry of Education School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Institute for Special Steels China Iron and Steel Research InstituteBeijing 100081China

The effects of annealing before normalizing and different cooling ways, i.e., air cooling, quenching, and water mist cooling after normalizing on the toughness of G115 steels were investigated. The impact tests showed that the annealed samples had better toughness compared to the unannealed samples for three cooling ways. Microstructure observations revealed that the annealed samples had a more uniform grain distribution, smaller size and area fraction of M_(23)C_(6) particles along the grain boundaries, and lower dislocation density than those in the unannealed samples, which performed together for good toughness. Among three cooling ways, air cooling gave the best toughness due to the smallest occupancy of M23C6 particles in the grain boundaries. Thus, the combination of annealing conducted before normalizing and air cooling selected after normalizing can improve the toughness a lot of G115 steels.

关键词： G115 steel Annealing M_(23)C_(6)particle Dislocation density Toughness

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Three-Step Difference Scheme for Solving Nonlinear Time-Evolution Partial Differential Equations

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Atmospheric and Oceanic Science Letters 2013年第6期6卷 423-427页

作者： gong Jing WANG Bin JI Zhong-zhen State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics (LASG) Institute of Atmospheric Physics Chinese Academy of Sciences Mathematics and Physics Department North China Electric Power University

In this paper, a special three-step difference scheme is applied to the solution of nonlinear time-evolution equations, whose coefficients are determined according to accuracy constraints, necessary conditions of square conservation, and historical observation information under the linear supposition. As in the linear case, the schemes also have obvious superiority in overall performance in the nonlinear case compared with traditional finite difference schemes, e.g., the leapfrog(LF) scheme and the complete square conservation difference(CSCD) scheme that do not use historical observations in determining their coefficients, and the retrospective time integration(RTI) scheme that does not consider compatibility and square conservation. Ideal numerical experiments using the one-dimensional nonlinear advection equation with an exact solution show that this three-step scheme minimizes its root mean square error(RMSE) during the first 2500 integration steps when no shock waves occur in the exact solution, while the RTI scheme outperforms the LF scheme and CSCD scheme only in the first 1000 steps and then becomes the worst in terms of RMSE up to the 2500th step. It is concluded that reasonable consideration of accuracy, square conservation, and historical observations is also critical for good performance of a finite difference scheme for solving nonlinear equations.

关键词： three-step difference scheme nonlinear square conservation accuracy historical observations

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