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Two Evidence-Based Acupuncture Models

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Chinese Journal of Integrative Medicine 2020年第1期26卷 3-7页

作者： gong chang-zhen LIU Wei American Academy of Acupuncture and Oriental Medicine

Modern clinical trials have produced controversial data interpretation which refutes conventional standard teachings and practices. Acupuncture scholars and practitioners have been stimulated to scrutinize these trials and analyze conventional practices. This paper presents two acupuncture models which address these issues. One rationalizes the clinical trial results with newer understanding of acupuncture points and techniques, while the other reconciles these results with rediscovered techniques of palpating points and performing needling. These two models indicate that acupuncture is in transition from classical model to evidence-based models.

关键词： acupuncture model evidence-based LI Yong-ming’s Balloon model LENG San-hua’s C-Nerve Network Counter-Stimulation model

Acupuncture and the Opioid Epidemic in America

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Chinese Journal of Integrative Medicine 2018年第5期24卷 323-327页

作者： gong chang-zhen LIU Wei American Academy of Acupuncture and Oriental Medicine Roseville MN 55113 USA

The opioid epidemic has become a significant public health crisis in the United States of America. This crisis has elicited a response at high levels of governmental and health care organizations including the American College of Physicians, the Food and Drug Administration, the Joint Commission, the National Academies of Science, Engineering and Medicine, the National Association of Attorneys General, and the White House. In various ways, these organizations have recognized that acupuncture can play an important role in dealing with the opioid epidemic. This paper presents and analyzes the scientific evidence supporting the efficacy of acupuncture in regard to opioid addiction.

关键词： acupuncture opioid addiction public health

Convergence of Medicines: West Meets East in Newly-Discovered Organs and Functions

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Chinese Journal of Integrative Medicine 2019年第5期25卷 323-326页

作者： gong chang-zhen LIU Wei American Academy of Acupuncture and Oriental Medicine MN 55113USA

Although the foundations and evolution of Chinese medicine and Western medicine are very different, an increasing amount of research has revealed that those Eastern medicine principles practiced over thousands of years are con?rmed by new technologies applied to the basic science of the human *** scienti?c discoveries present enticing opportunities to reconcile Chinese medicine theories with Western biomedicine. Is there a trend toward the convergence of Eastern and Western medicine? Four studies which exemplify the potential for convergence are described in this article. The studies present findings in regard to mesentery, interstitium, a gut-lung axis, and lung-centered hematopoiesis, and were published recently in leading journals such as Science, Nature, and Lancet.

关键词： onvergence of medicines mesentery interstitium gut-lung axis

Sequencing of p53 mutation in established human hepatocellular carcinoma cell line of HHC4 and HHC15 in nude mice

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World Journal of Gastroenterology 1998年第6期4卷 51-55页

作者： YANG Shan Min, ZHOU Hong, CHEN Rui Chuan, WANG Yu Fang, CHEN Fu, ZHANG chang gong, zhen Yun, YAN Jiang Hua and SU Jin Hua

AIM To set up cell lines of human hepatocellular carcinoma in nude mice for the research of cell biology and gene therapy. METHODS Xenotransplantation of human hepatoma into nude mice was carried out and the growth rate, histopathology and immunology of the nude mice were studied. The DNA from xenografts were analyzed by HBV gene and PCR amplification of a fragment of p 53 gene exon 7, which were identified by dot blot hybridization, restriction fragments length polymorphism and DNA sequencing. RESULTS hHCC4 and hHCC415 cell lines could be successively transplanted in nude mice and the population doubling time was 7 and 5 days respectively. These strains retained the original characteristics of histopathology, secreting AFP and heteroploid karyotypes in human hepatocellular carcinoma. The fragment of HBV gene was detected in the genomic DNA of both hHCC4 and hHCC15, however only hHCC4 secreted HBsAg. The mutation at 250 code (C→A) and 249 code (G→T) were detected respectively in the genomic DNA of hHCC4 and hHCC15. CONCLUSION The two cell lines are useful material for studying cell biology and gene therapy in human hepatocellular carcinoma and provide molecular biological trace of the relationship between high mortality of hepatoma and AFB1 severe pollution of the daily common foods in this district.

关键词： Liver neoplasms carcinoma, hepatocellular p53 gene mutation HHC4 HHC15 Tumor cell, cultured

中国针灸在美国的本土化——兼论现代针灸学体系的开放性

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中国针灸 2020年第1期40卷 85-88页

作者：陈少宗巩昌镇山东中医药大学针灸研究所济南250355 美国中医学院美国明尼苏达州

中国针灸学的国际化必然伴随着针灸学的本土化进程。针灸学的本土化必然推动针灸学技术与针灸学理论的多元化发展,这种发展充分展现了现代针灸学的开放性。本文从本土化的法律调适、本土化的技术调适、本土化的教育调适、本土化的服务... 详细信息

中国针灸学的国际化必然伴随着针灸学的本土化进程。针灸学的本土化必然推动针灸学技术与针灸学理论的多元化发展,这种发展充分展现了现代针灸学的开放性。本文从本土化的法律调适、本土化的技术调适、本土化的教育调适、本土化的服务调适、本土化的理论调适5个方面考察了中国针灸学在美国本地化的特点。

关键词：针灸学的国际化针灸学的本土化西方针灸学现代针灸学

针灸学理论体系的三种范式与各自的疆界——交叉学科研究推动了针灸学理论体系的变革

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医学与哲学 2021年第22期42卷 70-72页

作者：陈少宗巩昌镇山东中医药大学针灸研究院山东济南250355 美国中医学院美国罗斯威尔55113

随着交叉学科研究的不断拓展,在传统针灸学理论体系之外又发展出了现代针灸学理论体系以及后现代针灸学理论体系(系统针灸学理论体系)两种不同的范式。传统范式是传统文化背景下的理论体系;现代范式则是完全建立在还原论背景下的现代认... 详细信息

随着交叉学科研究的不断拓展,在传统针灸学理论体系之外又发展出了现代针灸学理论体系以及后现代针灸学理论体系(系统针灸学理论体系)两种不同的范式。传统范式是传统文化背景下的理论体系;现代范式则是完全建立在还原论背景下的现代认知体系。后现代范式则是运用整体的、动态的、定量的或定量与定性相结合的系统科学研究方法所建立的体系。这三种范式各有自己独特的探索角度,在核心理论方面既没有内在的逻辑关系,也不存在相互否定的问题,各自具有自己发挥作用的疆界。

关键词：现代针灸学现代范式交叉学科研究

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针灸医学的困惑与交叉思维的引入

中医药导报 2019年第3期25卷 1-7页

作者：巩昌镇美国中医学院全美中医药学会美国明尼苏达州55113

通过描述发生在针灸临床、科研、学派和研究者中对比鲜明的故事,指出针灸医学发展过程中出现的对于针灸认识不同、相互矛盾和甚至冲突的现象。由此提出针灸发展走出困境的针灸临床指导的模型法、针灸研究的剥洋葱法、针灸理论的公理定... 详细信息

通过描述发生在针灸临床、科研、学派和研究者中对比鲜明的故事,指出针灸医学发展过程中出现的对于针灸认识不同、相互矛盾和甚至冲突的现象。由此提出针灸发展走出困境的针灸临床指导的模型法、针灸研究的剥洋葱法、针灸理论的公理定理化、针灸教学的三段论。

关键词：针灸传统医学困惑思考交叉思维

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中西方针刺随机对照试验的比较研究

中国针灸 2022年第1期42卷 3-7,22页

作者：岗卫娟巩昌镇景向红中国中医科学院针灸研究所北京100700 美国中医学院

随着针灸的国际传播及针灸临床研究的迅速发展,中西方针刺随机对照试验(RCT)研究数量持续增长。然而,西方针刺RCT研究得出针刺效应相当于安慰剂的结果,与中国针刺RCT研究几乎全部是阳性结果形成鲜明对比。为什么同一种方法产生如此不同... 详细信息

随着针灸的国际传播及针灸临床研究的迅速发展,中西方针刺随机对照试验(RCT)研究数量持续增长。然而,西方针刺RCT研究得出针刺效应相当于安慰剂的结果,与中国针刺RCT研究几乎全部是阳性结果形成鲜明对比。为什么同一种方法产生如此不同的结果?本文从针刺RCT研究的缘起与国内外针刺RCT研究现状出发,系统比较中西方针刺RCT在需求与起点、研究目的、研究设计、研究者、针刺治疗方案、研究的方法学质量、研究结果、研究结论及研究不足等方面的差异。在此基础上重新思考针刺RCT的价值及针刺临床研究中的方法学困惑,对针刺临床研究范式提出以下建议:根据研究方案成熟度,开展阶梯递进的临床研究;在不同研究阶段设置明确的实施指导和报告规范。

关键词：随机对照试验针刺比较临床研究方法学

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He zhen Wang Yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming