检索结果-南通市图书馆

Epidemiological, Clinical, Biological, Therapeutic Features and Outcome of Congenital Malaria at the Borgou Regional University Teaching Hospital (CHUD-B) in Benin in 2015

引用

Open Journal of Pediatrics 2017年第4期7卷 263-271页

作者： godonou gratien sagbo Alphonse Noudamadjo Joseph Agossou Julien Didier Adedemy Awade Achille Obossou Djewessi Saturnin Lokossou Faculty of Health Sciences University of Abomey-Calavi Cotonou Benin Faculty of Medicine University of Parakou Parakou Benin

Background: The prevalence of congenital malaria is getting more and more significant in Sub-Saharan Africa where is a malaria-endemic area. This study aimed to identify the clinical and therapeutic features as well as the outcome of congenital malaria in CHUD-B in 2015. Method: It was a cohort and descriptive study with analytical purpose, carried out in the Mother and Child Department which includes the Gynecology & Obstetrics and Pediatric Unit of CHUD-B. The study target population consisted of all the infants born in the CHUD-B as well as their mothers. The main variable was the presence of congenital malaria. The independent variables were those related to clinical, therapeutic features and outcome. Results: In the study, among the 300 newborns registered, 57 carried congenital malaria i.e. a prevalence of 19%. 171 (57.0%) of them were males versus 129 (43.0%) females. Among the 281 mothers involved, 48 presented with malaria in pregnancy i.e. a prevalence of 17.0%. At the end of this research work, the factors associated with congenital malaria were fever in the 3rd quarter and malaria in pregnancy in the mother. Conclusion: Nearly one out of five infants born in the CHUD-B was carrier of congenital malaria and approximately one out six mothers presented with malaria detection during pregnancy. A method based on Polymerase Chain Reaction (PCR) should be implemented during the diagnosis in order to confirm malaria cases among both newborns and mothers.

关键词： Congenital Malaria Outcome Benin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frequency of Hypovitaminosis D in 6 - 59 Month Children with Severe Malaria in the Pediatrics Unit of the Teaching Hospital of Parakou (CHUD/BA) in Benin in 2016

引用

Open Journal of Pediatrics 2018年第1期8卷 66-73页

作者： Alphonse Noudamadjo Julien Didier Adédémy Joseph Agossou gratien godonou sagbo Falilatou Agbeille Gérard Kpanidja Jacques Assoklé Simon Akpona Faculty of Medicine University of Parakou CHUD/BA Parakou Benin Faculty of Health Sciences of Cotonou Cotonou Benin

Introduction: Vitamin D’s action outside of bone, especially on immunity, is widely reported in the international scientific literature over the last years. Objective: Calculate the frequency of hypovitaminosis D in children aged 6 to 59 months suffering from severe malaria in the CHUD-P pediatric unit in 2016. Setting and Methods: This research work is a cross-sectional study with descriptive and analytical purposes. Data gathering was prospective. The study involved children aged 6 to 59 months hospitalized for severe malaria in the CHUD-P pediatric unit. The said children were HIV-uninfected, eutrophic and had not received vitamin D supplementation during the last 6 months. Vitamin D dose was measured using the High Performance Liquid Chromatography (HPLC) technique. Results: A total of 80 subjects were involved in the survey. Mean age was 26.08 months, sex ratio was 0.8 and average weight was 10.80 kg. Hypovitaminosis D frequency was 83.8% (67 cases out of 80 children investigated during the survey) with an average plasma concentration of vitamin D estimated at 21.57 ng/ml ± 7.34 with two extremes (11.24 - 42.32) ng/ml. The minimum parasitaemia was 202 P/μl and the maximum was 580,000 P/μl. Conclusion: Hypovitaminosis D is common in children suffering from severe malaria;this result suggests conducting a large-scale community-based study to decide on vitamin D inclusion in national supplementation policies and severe malaria management.

关键词： Hypovitaminosis D Severe Malaria Children Benin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Benefits of Artesunate versus Quinine in the Treatment of Children with Severe Malaria at the National University Teaching Hospital of Cotonou

引用

Open Journal of Pediatrics 2017年第3期7卷 156-163页

作者： godonou gratien sagbo Laeticia Zohoun Gilles Bognon Joseph Agossou Caroline Padonou Yévèdo Tohodjèdé Florence Alihonou Blaise Ayivi Pediatric Unit Oueme/Plateau Regional University Teaching Hospital (CHUD O/P) Porto Novo Benin Pediatric Unit National University Teaching Hospital (CNHU-HK) Cotonou Bénin Mother and Child Department Faculty of Medicine University of Parakou Parakou Benin

Introduction: Severe malaria is one of the leading causes of death in Sub-Saharan African countries, and artesunate is recommended as a first-line treatment by the Word Heath Organization (WHO.). Objective: Identify the advantages of artesunate compared with quinine in the treatment of severe malaria in children. Methods and patients: This study was a cross-sectional, descriptive and analytical study focused on children hospitalized for severe malaria in the CNHU who were treated with quinine or artesunate. Findings: The hospital-based frequency rate of severe malaria in pediatric patients was estimated to be 28.3% (n = 848). One hundred five children were treated with artesunate, and 743 were treated with quinine. The mean age of the children was 47 months old. The primary signs of severity were anemia (n = 776), neurological manifestations (n = 309) and hemolysis (n = 137). The average duration of treatment was 1.95 days for artesunate versus 2.45 days for quinine, and the difference was statistically significant (p = 0.001). The average length of stay (ALOS) in the hospital was 5 days for the artesunate group versus 5.75 days for the quinine group, and the difference was statistically significant (p < 0.001). Six of the children who received artesunate died, whereas 24 children who treated with quinine died. The total average cost of healthcare was 50,600 FCFA (77 euros) per child treated with artesunate versus 57,100 FCFA (87 euros) per child treated with quinine. Conclusion: The treatment of severe malaria with artesunate is superior to quinine-based treatment.

关键词： Severe Malaria Quinine Artesunate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Determinants of Fatal Outcomes during Severe Malaria in Children at the HKM University Teaching Hospital of Cotonou-Benin

引用

Open Journal of Pediatrics 2017年第4期7卷 245-253页

作者： godonou gratien sagbo Florence Alihonou Marouf Jules Alao Yevedo Tohodjede Lutecia Zohoun Gilles Bognon Joseph Agossou Alphonse Noudamadjo Aida Orou-Guidou Pediatric Unit CNHU-HKMCotonouBenin Lagoon Mother and Child Hospital CotonouBenin Hospital of Porto-Novo Porto-NovoBenin Pediatric Unit CHU-BorgouParakouBenin

Introduction: Malaria particularly affects children in sub-Saharan African countries. This study aimed to investigate the factors associated with death in cases of severe childhood malaria to better understand the determinants of death in these children. Patients and Methods: This cohort, descriptive and analytical study was conducted from April 1 to August 15, 2015, at the CNHU-HKM pediatric clinic in Cotonou. Recruitment was exhaustive for all patients under 15 years of age who were admitted for severe malaria, as confirmed by thick smear microscopy. Results: Among the 1774 admitted patients, 449 had severe malaria caused by Plasmodium falciparum (i.e., a hospital frequency of 25.31%). The age group most affected consisted of children younger than 60 months of age (73%);female predominance was noted. The lethality rate of malaria was 13.1% (n = 59). The factors associated with death were coma (p = 0.032), poor convulsive status epilepticus (p = 0.08) and bacterial co-infection by gram negative bacteria (p = 0.021) with respectively correlations coefficient of 0.003, 3.940 and 2.424. Conclusion: Reduction of the malaria mortality rates in Benin hospitals will depend on appropriate management of poor prognostic factors, such as coma, bacterial co-infection and convulsive illness.

关键词： Children Severe Malaria Lethality Neurological Disorders Bacterial Infection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Contribution of the Urine Dipstick to Urinary Tract Infection Diagnosis among Children in Two Hospitals in Cotonou-Benin

引用

Open Journal of Pediatrics 2017年第4期7卷 272-281页

作者： godonou gratien sagbo Fredias Sogbo Honorat Francis Lalya Joseph Agossou Yevedo Tohodjèdé Florence Alihonou Gilles Bognon Diane Ahinonhossou Afolabi Dissou Blaise Ayivi Pediatric Unit of the Hubert Koutoukou Maga University Teaching Hospital (CNHU-HKM) Cotonou Benin Bacteriology Unit of CNHU-HKM Cotonou Benin Mother & Child Department Faculty of Medicine University of Parakou Parakou Benin Hospital of Porto-Novo Porto-Novo Benin

Introduction: Urinary tract infections are a daily concern in pediatric nephrology with long-term risks for high blood pressure and renal failure. The purpose of this study was to determine the contribution of a urine dipstick (UD) to the diagnosis of urinary infections among children at the CNHU-HKM and the Lagoon Mother and Child University Teaching Hospital (CHU-MEL) of Cotonou. Patients and Methods: This study is a cohort, descriptive and analytical study focused on children with suspected urinary infections in the pediatric units of the CNHU-HKM and CHU-MEL of Cotonou from March 25 to August 25, 2015. Results: Two hundred and four children out of a total of 5125 admitted children (4%) presented with at least one clinical sign of a urinary tract infection. Children under 36 months of age were predominant (41%). The main clinical signs of urinary infections were fever (60.8%) and urinary disorders (38.2%). The urinary dipstick test was positive in 145 children (71.2%). A urinary tract infection was confirmed by urine culture in 38 children (18.6%). In cases with leucocyturia- and nitrituria-positive urine dipstick tests, the sensitivity was estimated to be 13.2%, and the specificity was 95.2%, with a negative predictive value (NPV) of 82.8%. Only when the leucocyturia test was positive, the sensitivity was 76.3%, and the specificity was 31.9%. When the leucocyturia test was negative, the specificity was estimated to be 94%, and the sensitivity was 83% in the nitrituria-positive cases and 15.8% in the nitrituria-negative cases. The main isolated pathogens were Escherichia coli (n = 21) and Klebsiella pneumoniae (n = 14). Conclusion: In our environment, a negative leucocyturia test may help exclude urinary tract infections in most cases.

关键词： Urinary Tract Infection Urinary Dipstick Test Urine Culture

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Factors Associeted with Home Accidents in Childhood at Regional Teaching Hospital of OuéméPlateau

引用

Open Journal of Pediatrics 2022年第2期12卷 358-363页

作者： Caroline Padonou Gilles Bognon Florence Alihonou Lutécia Zohoun Samuel Kisembo Bavi gratien sagbo Pediatrics Department Regional Teaching Hospital of Ouémé-Plateau Porto-Novo Benin Pediatrics Department National Teaching Hospital Hubert Koutoukou Maga Cotonou Benin

Introduction: Home accidents (HA) are often unknown in Benin compared to infectious pathologies. The aim of this work was to determine the prevalence and the factors associated with HA in children admitted to the CHUD-OP. Method: This was a cross-sectional study conducted from August 1st to October 31th 2021. We studied children aged 0 to 18 who presented with HA to the pediatrics and emergency reception and triage departments at CHUD-OP. We defined HA as “any event occurring inside the home or in the immediate vicinity of the home that resulted in an injury which was not done deliberately. Results: The hospital frequency of HA was 8.4% (61/725). The median age was 5 years with a male to female ratio of 1.6. Trauma was the leading cause of HA (59%) followed by poisoning (23%). Falling was the main mechanism of trauma (80.6%). The toxins causing poisoning were dominated by caustics (28.6%). The age of the children (p = 0.02), the level of education of the mothers (p , and the area they occur (kitchen with p = 0.04 and on the stairs with p = 0.03) were statistically associated with the occurrence of trauma. Conclusion: HA are common among children admitted at CHUD-OP and factors associated with HA are identified. Measures to prevent home accidents among children in the community should be considered.

关键词： Caustic Soda Poisoning Home Accidents Unintentional Home Accidents Trauma at Home Associated Factors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Febrile Seizures in Children at the Departmental Teaching Hospital of OuéméPlateau: Etiologies and Risk Factors for Death

引用

Open Journal of Pediatrics 2022年第2期12卷 364-375页

作者： Caroline Padonou Gilles Bognon Lutécia Zohoun Florence Alihonou Mauriella Edjrokinto gratien sagbo Pediatric Department Departmental Teaching Hospital of Ouémé Plateau Porto-Novo Benin Pediatric Department National Teaching Hospital-Hubert Koutoukou Maga Porto-Novo Benin

Background: Febrile seizures are the most frequent neurological disorder in pediatrics. They have multiple etiologies and require urgent management. The aim of this survey was to study febrile seizures in children at the Departmental Teaching Hospital of Ouémé Plateau (DTH/OP). Method: This was a cross-sectional survey, conducted from January 1, 2020, to December 31, 2020, in the pediatric department of the DTH/OP. Children aged 1 month to 18 years, hospitalized for febrile seizures recognized at the anamnesis and/or during the physical examination were included in this study. Results: The frequency of seizures was 17.08% (510/2986). The male to female ratio was equal to 1.4. The mean age was 44.27 ± 40.75 months. The seizure was generalized tonic-clonic in 77.9% of cases and localized in 11.6% of cases. The main etiologies were severe malaria (75.5%), sepsis (21.6%), enteric infections (14.9%) and pneumonia (10.2%). Diazepam was the anticonvulsant treatment used in the first intention (79.7%). Most of the children were hospitalized for 3 to 7 days. The recovery rate was 82.3% and the fatality rate was equal to 17.7%. Eight children presented sequelae. There was a statistically significant link between the children’s clinical outcome and age (p < 0.001);severe malaria (p < 0.001);sepsis (p < 0.001) and enteric infections (p = 0.003). Conclusion: Febrile seizures were frequent in the pediatric emergency department of the DTH/OP. There is a need to intensify sensitization on malaria prevention measures in the community and improve case management at the hospital.

关键词： Febrile Seizures Severe Malaria Sepsis Child

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Interest of Procalcitonin Measurement in Children with Cerebral Malaria in Southern Benin

引用

Open Journal of Pediatrics 2022年第1期12卷 238-244页

作者： Gilles Bognon Elsa Topanou Caroline Padonou Florence Alihonou Nadine Feliho gratien sagbo André Bigot Pediatrics Department Departmental Teaching Hospital of Ouémé-Plateau Porto-Novo Benin Immunology Unit National Teaching Hospital HKM Cotonou Benin Pediatrics Department National Teaching Hospital HKM Cotonou Benin

Introduction: Cerebral malaria is a major complication of the Plasmodium falciparum infection with a high case fatality rate. The objective of this study was to determine the relationship between cerebral malaria and high serum procalcitonin (PCT) level in children. Method: This was a prospective descriptive and analytical cohort study conducted over 12 months, on a series of PCT blood tests in children aged 6 months to 15 years old hospitalized for cerebral malaria in the pediatric wards of four hospitals in southern Benin. The cerebral malaria diagnosis was done based on WHO criteria. Blood samples for PCT measurement were collected on admission, 24 hours and 48 hours after the malaria therapy initiation. Student’s test, Pearson’s chi2 test, Fisher’s test and Kruskal-Wallis test were used where appropriate. For all comparisons the difference was significant when p was less than 5%. Results: Sixty-five children were included in the study with a sex ratio of 1.41. The age group of children under 5 years was the most represented, at 57%. PCT levels were high in 92.3% of children at admission, 90.8% at 24 hours and 84.6% at 48 hours. Forty-nine children had a positive clinical outcome while 16 died (24.6%). PCT levels were generally high over the three days of hospitalization, but higher at admission in case of death (p = 0.000). The association between PCT level and parasitemia at admission was significant (p = 0.04). Conclusion: In the view of the results, blood PCT level measured at admission could be predictive of the disease outcome in children with cerebral malaria.

关键词： Procalcitonin Cerebral Malaria Cerebral Malaria Case Fatality Rate

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prise en Charge des Pleuresies Infectieuses de L’Enfant Dans Trois Hopitaux du Sud du Benin Management of Infectious Pleurisies in Three Hospitals in the South of Benin

引用

Open Journal of Pediatrics 2022年第1期12卷 81-88页

作者： Gilles Bognon Caroline Padonou Lutécia Zohoun Nicole Tchiakpe Roméo Dah-Bolinon gratien sagbo Pediatrics Department Departmental Teaching Hospital of Ouémé-Plateau Porto-Novo Benin Pediatrics and Medical Genetics Department National Teaching Hospital HKM Cotonou Benin Pediatrics Department Mother and Child Teaching Hospital Cotonou Benin

Objective: Infectious pleurisy is a frequent hospitalization indication in pediatrics in developing countries. This study aims to describe infectious pleurisies’ features and to identify its death factors in three teaching hospitals in Benin. Design: This was a prospective, descriptive and analytical study including children aged 01 months to 17 years who were hospitalized in pediatrics in the three hospitals for pleurisy from September to December 2019. Results: Among the 3379 children admitted, 25 presented with an infectious pleurisy, making a hospital frequency of 0.74%. The sex ratio was 0.8. The majority (19/25) of the children were less than 5 years old. The mean age was 38 ± 5.88 months. Most of the parents had a low education (42/50) and socio-economic status (18/25). The main symptoms were fever (25 cases), dyspnea (23 cases) and cough (22 cases). The majority of the children (21/25) were up-to-date in regards with the Expanded Immunization Program (EIP) vaccines and none had received non-EIP vaccines. Almost all children (24 cases) had a respiratory distress (24/25). On chest X-ray, there were abundant pleural extravasations in 12 cases. The main pathogens found were Staphylococcus aureus (16 cases), Streptococcus pneumoniae (3 cases) and Streptococcus A (1 case). All children received oxygen and antibiotic therapy;pleural drainage was performed in 22 children. The average length of stay was 14 days ± 6.4. Twenty-one children were healed without sequelae, one child had a post-drainage keloid scar, and two children died. Factors associated with the death of these children were admission delay for more than 7 days (p = 0.035) and presence of respiratory distress (p = 0.049). Conclusion: Pleurisy remains a concern for children admitted in our hospitals and early management is imperative.

关键词： Infectious Pleurisy Respiratory Distress Pleural Drainage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frequency and Sociodemographic Factors Associated with Congenital Malaria at the Borgou Regional University Teaching Hospital (CHUD-B) in Benin in 2015

引用

Open Journal of Pediatrics 2017年第4期7卷 215-221页

作者： Noudamadjo Alphonse sagbo G. gratien Adededmy J. Didier Agossou Joseph Obossou A. Achille Lokossou D. Saturnin Faculty of Medicine University of Parakou Parakou Benin Faculty of Health Sciences of Cotonou University of Abomey-Calavi Cotonou Benin

Background: Every minute a child dies from malaria in Sub-Saharan Africa. Despite this high infant and child mortality associated with malaria, congenital malaria is still not adequately understood as regarding its frequency, severity and management. The objective of this research work was to determine the frequency and identify the socio-demographic factors associated with the onset of congenital malaria at the gynecological and pediatric units of the Borgou Regional Teaching Hospital (CHUD-B) in Benin in 2015. Methods: This study was a cross-sectional survey with analytical purpose, based on exhaustive census performed from April to July 2015 on newborns delivered at CHUD-B and their mothers. The dependent variable was the presence of congenital malaria and the independent variables were socio-demographic characteristics. The data were processed and analyzed using Epi Info software version 7.0 with a significant threshold of 0.05. Findings: The frequency of congenital malaria in newborns was 19%. No sociodemographic factor was associated with congenital malaria. Conclusion: Nearly one in five newborns delivered at CHUD-B had congenital malaria. Due to malaria’s contribution to perinatal morbidity and mortality and subsequent receptivity of child victims to malaria, a longer study covering a whole year and focused on the determinants of congenital malaria should be carried out.

关键词： Congenital Malaria Socio-Demographic Factors Benin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：