检索结果-南通市图书馆

Potential sex differences in activation of pain-related brain regions in nonhuman primates with a unilateral spinal nerve ligation

引用

Neural Regeneration Research 2023年第11期18卷 2466-2473页

作者： Kanae Murata Kenya Nozawa Mayumi Matsushita Aozora Yamashita Rintaro Fujii Yuji Awaga Aldric Hama Takahiro Natsume go yoshida Yukihiro Matsuyama Hiroyuki Takamatsu Hamamatsu Pharma Research Inc.HamamatsuShizuokaJapan Department of Orthopedic Surgery Hamamatsu University School of MedicineHamamatsuShizuokaJapan

The lack of truly robust analgesics for chronic pain is owed,in part,to the lack of an animal model that reflects the clinical pain state and of a mechanismbased,objective neurological indicator of *** present study examined stimulus-evo ked brain activation with functional magnetic resonance imaging in male and female cynomolgus macaques following unilateral L7 spinal nerve ligation and the effects of clinical analgesics pregabalin,duloxetine,and morphine on brain activation in these macaques.A modified straight leg raise test was used to assess pain severity in awake animals and to evo ke regional brain activation in anesthetized *** potential effects of clinical analgesics on both awake pain behavior and regional brain activation were *** spinal nerve ligation,both male and female macaques showed significantly decreased ipsilateral straight leg raise thresholds,suggesting the presence of radicula rlike *** treatment increased straight leg raise thresholds in both males and females whereas duloxetine and pregabalin did *** male macaques,the ipsilateral straight leg raise activated contralateral insular and somatosensory cortex(Ins/SII),and *** female macaques,the ipsilateral leg raise activated cingulate cortex and contralateral insular and somatosensory *** leg raises of the contralateral,unligated leg did not evoke brain *** reduced activation in all brain regions in both male and female *** males,neither pregabalin nor duloxetine decreased brain activation compared with vehicle *** females,however,pregabalin and duloxetine decreased the activation of cingulate cortex compared with vehicle *** current findings suggest a diffe rential activation of brain areas depending on sex following a peripheral nerve *** rential brain activation observed in this study could underlie qualitative sexual dimorphism in clinical chronic pain perception and responses to

关键词： biomarkers functional magnetic resonance imaging lumbar radicular pain Macaca fascicularis neuroimaging neuropathic pain sciatica straight leg raise

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

In-situ evaluation for activated concrete in accelerator facility with scintillation-type gamma-ray spectrometer

引用

辐射防护 2020年第6期40卷 545-549页

作者： go yoshida Hiroshi Matsumura Koichi Nishikawa Akihiro Toyoda Yoshiharu Miyazaki Kazuyoshi Masumoto Hajime Nakamura Taichi Miura High Energy Accelerator Research Organization(KEK) 1-1 OhoTsukubaIbaraki 305-0801Japan The Medical and Pharmacological Research Center Foundation Wo-32Inoyama-machiHakuiIshikawa 925-0613Japan

The assessment of activated concrete is particularly difficult during the decommissioning of an accelerator *** analysis by core boring is the only method of investigating the activity of concrete *** address this problem,an in-situ and nondestructive analysis method was developed to determineγ-ray-emitting nuclides and their specific activities in the concrete walls and floor by using a portable germanium semiconductor *** this work,we examined a substitute for Ge detector to establish a simpler and more convenient *** candidates,we focused on some scintillation type spectrometers,and the possibility of a substitute for a Ge detector was examined by both simulation and *** detection limits were roughly estimated through Monte Carlo simulation for various scintillation crystals,and it was found that 1.5-inch LaBr3,CeBr3,and SrI2 could distinguish the clearance *** was confirmed that the 1.5-inch LaBr3 could reproduce the calibration curve of the Ge detector in the *** required thickness and length of the radiation shield for suppressing the background radiation during the measurement was also determined for the convenience of an actual decommissioning work.

关键词： activation accelerator concrete scintillation detector PHITS code

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Nondestructive high-sensitivity measurement method for activation estimation in accelerator room concrete

引用

辐射防护 2020年第6期40卷 677-682页

作者： Hiroshi Matsumura go yoshida Akihiro Toyoda Kazuyoshi Masumoto Hajime Nakamura Taichi Miura Koichi Nishikawa Kotaro Bessho Kimikazu Sasa Tetsuaki Moriguchi Fumiyoshi Nobuhara Yoko Nagashima High Energy Accelerator Research Organization(KEK) Oho 1-1Tsukuba Ibaraki 305-0801Japan University of Tsukuba 1-1-1 TennodaiTsukubaIbaraki 305-8577Japan Tokyo Nuclear Services Co. Ltd.1-3-5.TaitoTaito-kuTokyo 110-0016Japan

This study established a method for easily and quickly estimating the specific activity produced in the concrete walls and floors of accelerator rooms during long-term operation of accelerator,for advanced zoning of activated/nonactivated areas in planning the decommissioning of an *** propose a new,highly sensitive method for nondestructively estimating the specific activity in concrete that can be applied to activation *** this method,instead of direct determination of the specific activities of important long-half-life radionuclides for decommissioning,such as 152 Eu and 60 Co,we determine the specific activities of short-half-life radionuclides,24 Na and 56 Mn,in situ to obtain neutron *** obtained neutron flux and accelerator operation history yield the specific activities of 152 Eu and 60 Co for the advance zoning of activated/non-activated *** method is a powerful long-term prediction tool for concrete activation.

关键词： accelerator activation concrete specific activity decommissioning

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Sn addition on the microstructure and mechanical properties of extruded Mg-Bi binary alloy

引用

Journal of Magnesium and Alloys 2022年第3期10卷 920-931页

作者： Sang-Cheol Jin Jong Un Lee Jongbin go Hui Yu Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566South Korea Department of Materials Science and Engineering Kyoto UniversityYoshida-honmachiSakyo-kuKyoto606-8501Japan School of Materials Science and Engineering Hebei University of TechnologyTianjin 300130China

We investigated the effects of Sn addition on the microstructural characteristics and mechanical properties of an extruded Mg-Bi binary alloy by comparing Mg-5 Bi(B5)and Mg-5 Bi-4 Sn(BT54).Both the extruded alloys exhibit a partially recrystallized grain structure with a strong extrusion fiber texture and numerous Mg3Bi2 ***,the addition of Sn significantly decreases the average grain size of the extruded alloy from 123.9 to 75.2μ*** Sn solute atoms inhibit the activity of dislocation slip,which reduces the internal strain energy accumulated in the dynamically recrystallized(DRXed)grains during ***,this reduced strain energy leads to the decrease in the DRXed grain size owing to weakened grain growth during natural *** extruded BT54 alloy exhibits higher tensile strength and ductility than the extruded B5 *** improvement in the strength by the Sn addition is attributed to the combined effects of grain refinement,Sn solute atoms,and increased dislocation *** formation of{10-11}and{10-11}-{10-12}twins during tension is suppressed by the grain refinement,thereby improving the tensile elongation considerably.

关键词： Mg±Bi alloy Extrusion Dynamic recrystallization Microstructure Mechanical properties.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Evaluation of small bowel blood flow in healthy subjects receiving low-dose aspirin

引用

World Journal of Gastroenterology 2011年第2期17卷 226-230页

作者： Urara Nishida Mototsugu Kato Mutsumi Nishida go Kamada Takeshi yoshida Shouko Ono Yuichi Shimizu Masahiro Asaka Department of Gastroenterology Hokkaido University Graduate School of Medicine Division of Endoscopy Hokkaido University Hospital Department of Clinical Laboratory and Transfusion Hokkaido University Hospital

AIM:To investigate the relationship between low-dose aspirin-induced small bowel mucosal damage and blood flow,and the effect of rebamipide. METHODS:Ten healthy volunteers were enrolled in this *** subjects were divided into two groups:a placebo group given low-dose aspirin plus placebo and a rebamipide group given low-dose aspirin plus rebamipide for a period of 14 *** endoscopy and contrast-enhanced ultrasonography were performed before and after administration of *** under the curves and peak value of time-intensity curve were calculated. RESULTS:Absolute differences in areas under the curves were-1102.5(95%CI:-1980.3 to-224.7,P=0.0194) in the placebo group and-152.7(95%CI:-1604.2 to 641.6,P=0.8172) in the rebamipide group. Peak values of time intensity curves were-148.0(95% CI:-269.4 to-26.2,P=0.0225) in the placebo group and 28.3(95%CI:-269.0 to 325.6,P=0.8343) in the rebamipide *** endoscopy showed mucosal breaks only in the placebo group. CONCLUSION:Short-term administration of low-dose aspirin is associated with small bowel injuries and blood flow.

关键词：阿司匹林血液流动低剂量小肠健康强度曲线评价药物管理

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Scintillation and optical properties of Ce-doped YAGG transparent ceramics

引用

Journal of Rare Earths 2016年第8期34卷 763-768页

作者： Masaki Mori Jian Xu go Okada Takayuki Yanagida Jumpei Ueda Setsuhisa Tanabe Graduate School of Materials' Science Nara Institute of Science and Technology (NAIST) 8916-5 Takayama-cho Ikoma-shi Nara 630-0192 Japan Graduate School of Human and Environmental Studies Kyoto University Yoshida-nihonmatsu-eho Sakyo-ku Kyoto 606-8501 Japan

We investigated photoluminescence （PL） and scintillation properties of Ce3＋-doped Y3A12Ga3OI2 （Ce：YAGG） trans- parent ceramics synthesized by vacuum sintering with different Ce3＋ concentrations （mol.%） from 0.3% to 1% （0.3%Ce：YAGG, 0.5%Ce：YAGG, 0.8%Ce：YAGG and I%Ce：YAGG）. The samples were synthesized by the vacuum sintering technique. The obtained samples showed a very strong and broad PL emission by the 5dl-4f transition of Ce3＋ in the wavelength range from 470 to 600 nm. The PL decay profiles were approximated by a single exponential decay function with the time constants of around 33-39 ns, Fur- thermore, the scintillation spectra induced by X-rays showed similar features with those observed in PL. The scintillation decay time profiles followed a second-order exponential decay function. The fast component group （ranged 3542 ns） were dominantly contrib- uted by the 5d1-4f transition of Ce3＋. The pulse height spectra utilizing the latter emissions showed a clear photoabsorption peak. Among those samples tested, 0.5%Ce：YAGG sample showed the highest scintillation light yield of 21,400 ph/MeV under 13VCs y-ray irradiation.

关键词： YAGG cerium transparent ceramic scintillation photoluminescence rare earths

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frequent Copy Gain of the <i>MET</i>Gene in Hypopharyngeal and Laryngeal Cancer in the Japanese Population

引用

Journal of Cancer Therapy 2015年第12期6卷 1093-1102页

作者： Ken Akashi Yasuhiro Ebihara go Omura Yuki Saito Masafumi yoshida Mizuo Ando Takahiro Asakage Tatsuya Yamasoba Yoshinori Murakami Division of Molecular Pathology Institute of Medical Science The University of Tokyo Tokyo Japan Department of Otolaryngology-Head and Neck Surgery The University of Tokyo Tokyo Japan Department of Head and Neck Surgery Saitama Medical University International Medical Center Saitama Japan Department of Head and Neck Surgery Tokyo Medical and Dental Graduate School of Medicine Tokyo Japan

Molecular targeting therapy to specific genetic alterations has not been established in head and neck squamous cell carcinoma (HNSCC) except for cetuximab treatment. To characterize alterations of actionable oncogenes in HNSCC, we examined the gain of copy and mutation of the MET gene in 54 Japanese HNSCC. Copy gain of the MET was analyzed by droplet digital PCR (ddPCR) and quantitative real time PCR (qPCR) using 2 distinct fragments of the gene, and mutation was examined in exons 14 - 19 of MET by Sanger sequencing. Both ddPCR and qPCR showed significantly correlated results in copy number at two distinct fragments of the MET gene (R = 0.96 and R = 0.78), although ddPCR gave more significant and sensitive results. Copy gain of the MET was detected in 10 of 54 (19%) HNSCCs and more frequently observed in tumors of the hypopharynx (4 of 12;33%) or larynx (5 of 13;38%) than those of the oral cavity (1 of 21;4%) or oropharynx (0 of 8;0%), suggesting the existence of site-specific features in the oncogenic mechanisms of HNSCCs. Copy gain of the MET was also observed preferentially in older patients, although no correlation in other parameters, including clinical stages and overall or recurrence-free survival, was observed. On the other hand, of the two HNSCCs in which nucleotide substitution was detected, one was R1040Q in exon 15 with unknown function, and the other was a silent mutation in exon16. These results suggest that copy gain of the MET can provide an indicator for treatment with tyrosine kinase inhibitors for MET in a subset of hypopharyngeal or laryngeal cancer.

关键词： Head and Neck Squamous Cell Carcinoma MET Copy Gain Mutation Molecular Targeting Therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Orbit insertion strategy of Hayabusa2’s rover with large release uncertainty around the asteroid Ryugu

引用

Astrodynamics 2020年第4期4卷 309-329页

作者： Yusuke Oki Kent Yoshikawa Hiroshi Takeuchi Shota Kikuchi Hitosi Ikeda Daniel JScheeres Jay WMcMahon Junichiro Kawaguchi Yuto Takei Yuya Mimasu Naoko Ogawa go Ono Fuyuto Terui Manabu Yamada Toru Kouyama Shingo K ameda Kazuya yoshida Kenji Nagaoka Tetsuo Yoshimitsu Takanao Saiki Yuichi Tsuda Japan A erospace Exploration Agency T'sukuba 305-8505Japan Japan Aerospace Exploration Agency Sagamihara 252-5210Japan University of Colorado BoulderCO 80309USA Planetary Exploration Research Center Chiba Institute of TechnologyNarashino 275-0016Japan National Institute of Aduanced Industrial Science and Technology Koto-ku 135-0064Japan Rikkyo University Toshima-ku 171-8501Japan Department of A erospace Engineering Tohoku UniversitySendai 980-8579Japan Kyushu Institute of Technology Kitakyusyu 804-8550Japan

This paper describes the orbit design of the deployable payload Rover 2 of MINERVA-II,installed on the Hayabusa2 *** Rover 2 did not have surface exploration capabilities,the operation team decided to experiment with a new strategy for its deployment to the *** rover was ejected at a high altitude and made a semi-hard landing on the surface of the asteroid Ryugu after several *** on the orbital analysis around Ryugu,the expected collision speed was tolerable for the rover to function *** the rover could not control its position,its motion was entirely governed by the initial ***,the largest challenge was to insert the rover into a stable orbit(despite its large release uncertainty),and avoid its escape from Ryugu due to an environment strongly perturbed by solar radiation pressure and gravitational *** study investigates the solution space of the orbit around Ryugu and evaluates the orbit’s robustness by utilizing Monte Carlo simulations to determine the orbit insertion *** analyzing the flight data of the rover operation,we verified that the rover orbited Ryugu for more than one period and established the possibility of a novel method for estimating the gravity of an asteroid.

关键词： solar radiation pressure augmented elliptic Hill three-body problem gravitational irregularity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Incidence of Null-Type Mutations of the <i>TP</i>53 Gene in Japanese Patients with Head and Neck Squamous Cell Carcinoma

引用

Journal of Cancer Therapy 2014年第7期5卷 664-671页

作者： Yasuhiro Ebihara Miwako Iwai Ken Akashi Takeshi Ito go Omura Yuki Saito Masafumi yoshida Mizuo Ando Takahiro Asakage Tatsuya Yamasoba Yoshinori Murakami Department of Otolaryngology—Head and Neck Surgery The University of Tokyo Tokyo Japan Division of Molecular Pathology Institute of Medical Science The University of Tokyo Tokyo Japan

Objective: Molecular targeting therapy has not been generally established in head and neck squamous cell carcinoma (HNSCC) except for cetuximab treatment for targeting epidermal growth factor receptor (EGFR). We analyzed alterations of the TP53, KRAS2, and EGFR genes in Japanese HNSCC to identify subpopulations of tumors potentially susceptible or not susceptible to specific therapy based on their genetic alterations. Materials and Methods: A total of 56 Japanese subjects were included in this study. Genomic DNA of exons 5 - 9 of the TP53, exons 1 and 2 of the KRAS2, exons 19 - 22 of the EGFR, and their flanking sequences were amplified by polymerase chain reaction (PCR) followed by direct sequencing. Splicing variants of EGFR were examined by reverse transcription (RT)-PCR. Results: Mutations of the TP53 and KRAS genes were detected in 25 (45%) and 2 (4%) of 56 HNSCC cases, respectively, while neither mutation nor splicing variant of EGFR was observed. The TP53 mutation did not correlate with clinical stages or primary sites of the tumors. The patterns of nucleotide substitutions specific to HNSCC were not observed. However, the incidence of null-type mutations of the TP53, which cannot be detected as abnormal by conventional immunohistochemical (IHC) studies, was significantly higher (10/25;40%) than that of HNSCC reported in other countries. Conclusion: Frequent TP53 mutations, especially null-type mutations, but infrequent or no alterations of the KRAS and EGFR suggest that the sequencing analysis of theTP53 mutation rather than IHC analysis of p53 provides a potentially useful marker to predict the response of HNSCC to chemotherapy or radiotherapy.

关键词： Head and Neck Squamous Cell Carcinoma TP53 Mutation KRAS EGFR Molecular Marker

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Identification of altered microRNAs in retinas of mice with oxygen-induced retinopathy

引用

International Journal of Ophthalmology(English edition) 2019年第5期12卷 739-745页

作者： Lu-Si Zhang Ye-Di Zhou Ying-Qian Peng Hui-Lan Zeng Shigeo yoshida Tan-Tai Zhao Department of Ophthalmology the Second Xiangya Hospital of Central South University Hunan Clinical Research Center of Ophthalmic Disease Department of Ophthalmology Kurume University School of Medicine

AIM: To identify disease-related miRNAs in retinas of mice with oxygen-induced retinopathy(OIR), and to explore their potential roles in retinal pathological neovascularization. METHODS: The retinal miRNA expression profile in mice with OIR and room air controls at postnatal day 17(P17) were determined through miRNA microarray analysis. Several miRNAs were significantly up-and down-regulated in retinas of mice with OIR compared to controls by quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR). Two databases including Targetscan7.1 and MirdbV5 were used to predict target genes that associated with those significantly altered mi RNAs in retinas of mice with OIR. Gene Ontology(go) and Kyoto Encyclopedia of Genes and Genomes(KEGG) pathway analyses were also conducted to identify possible biological functions of the target genes. RESULTS: In comparison with room air controls, 3 and 8 miRNAs were significantly up-and down-regulated, respectively, in retinas of mice with OIR. The qRT-PCR data confirmed that mmu-miR-350-3 p and mmu-miR-202-3 p were significantly up-regulated, while mmu-miR-711 and mmu-miR-30 c-1-3 p were significantly down-regulated in mice with OIR compared to controls. go analysis demonstrated that the identified target genes were related to functions such as cellular macromolecule metabolic process. KEGG pathway analysis showed a group of pathways, such as Wnt signaling pathway, transcriptionalmisregulation in cancer, Mucin type O-glycan biosynthesis, and mitogen-activated protein kinase(MAPK) signaling pathway might be involved in pathological process of retinal neovascularization. CONCLUSION: Our findings suggest that the differentially expressed miRNAs in retinas of mice with OIR might provide potential therapeutic targets for treating retinal neovascularization.

关键词： microRNAs retinal neovascularization oxygen-induced retinopathy microarray

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：