检索结果-南通市图书馆

Improvement in bias current redistribution in superconducting strip ion detectors with parallel configuration

在线全文

学校读者我要写书评

暂无评论

Chinese Physics B 2015年第9期24卷 562-565页

作者： Nobuyuki Zen go fujii Shigetomo Shiki Masahiro Ukibe Masaki Koike Masataka Ohkubo National Institute of Advanced Industrial Science and Technology (AIST)

In time-of-flight mass spectrometry（TOF MS）, superconducting strip ion detectors（SSIDs） in the parallel configuration are promising for ideal ion detection with a nanosecond-scale time response and a practical large sensitive area. In the parallel configuration, the bias current in one strip is diverted into other parallel strips after each detection event. Under high bias current conditions, the diverted bias current induces cascade switching of all parallel strips. Studies show that cascade switching degrades the ion count rate of SSIDs made from niobium and hence is disliked in TOF MS applications. To suppress the bias current redistribution, we connected resistors in a series with the individual parallel strips using aluminum-bonding wires. Their effect was studied by measuring the pulse height distributions.

关键词： superconducting devices time-of-flight mass spectrometry ion-surface impact

Gene expression of CCL8 and CXCL10 in peripheral blood leukocytes during early pregnancy in cows

在线全文

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2018年第4期9卷 813-823页

作者： Ryosuke Sakumoto Kosuke Iga Ken-go Hayashi Shiori fujii Hiroko Kanahara Misa Hosoe Tadashi Furusawa Division of Animal Breeding and Reproduction Research Institute of Livestock and Grassland Science National Agriculture and Food Research Organization (NARO) Division of Livestock and Forage Research Tohoku Agricultural Research CenterNARO Division of Animal Sciences Institute of Agrobiological SciencesNARO

Background: The aim of the present study was to evaluate CCL8 and CXCL10 expression and its regulatory mechanism in peripheral blood leukocytes(PBLs) at the time of maternal recognition in cows. Blood samples were collected on 14, 15, 16, 17 and 18 d after artificial insemination(AI). Based on the day of return of estrus, cows were divided into three groups, pregnant(n = 5), early embryonic mortality(EEM; n = 5) and late embryonic mortality(LEM; n = 5). The gene expression levels in PBLs were assessed with quantitative real-time reverse transcription ***: The expression of CCL8 and CXCL10 mRNA in PBLs gradually increased from 14 to 18 d of pregnant cows and significant differences were observed on 18 d(P < 0.05), whereas no significant changes were observed both in EEM and LEM cows. Interferon-stimulated protein 15 k Da(ISG15), myxovirus-resistance gene(MX) 1 and MX2 mRNA expression in PBLs increased from 14 to 18 d which was significant on 18 d of pregnant cows as well as in LEM cows(P < 0.05), but no changes were observed in EEM cows. To determine whether the expression of CCL8 and CXCL10 in PBLs was regulated by pregnancy-related substances or not, expression level was assessed after exposure to interferon-τ(IFNT) and CCL16. Monocytes, granulocytes and lymphocytes were obtained using density-gradient centrifugation and flow cytometry. The addition of IFNT(100 ng/mL) and CCL16(100 ng/mL) to cultured PBLs increased the expression of CCL8 and CXCL10 mRNA(P < 0.05). The expression of ISG15, MX1 and MX2 mRNA in PBLs was also stimulated by IFNT and CCL16(P < 0.05).Conclusions: The expression of CCL8 and CXCL10 genes increased in PBLs during early pregnancy. Since IFNT stimulated CCL8 and CXCL10 expression in cultured PBLs, the increase of CCL8 and CXCL10 might be pregnancy-dependent *** expression of both CCL8 and CXCL10 in PBLs was stimulated by CCL16 as wel as IFNT, suggesting a chemokine interaction that at least includes CCL8, CXCL10 and CCL16, and m

关键词： CCL8 Cow CXCL10 Leukocytes Pregnancy

Potential sex differences in activation of pain-related brain regions in nonhuman primates with a unilateral spinal nerve ligation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第11期18卷 2466-2473页

作者： Kanae Murata Kenya Nozawa Mayumi Matsushita Aozora Yamashita Rintaro fujii Yuji Awaga Aldric Hama Takahiro Natsume go Yoshida Yukihiro Matsuyama Hiroyuki Takamatsu Hamamatsu Pharma Research Inc.HamamatsuShizuokaJapan Department of Orthopedic Surgery Hamamatsu University School of MedicineHamamatsuShizuokaJapan

The lack of truly robust analgesics for chronic pain is owed,in part,to the lack of an animal model that reflects the clinical pain state and of a mechanismbased,objective neurological indicator of *** present study examined stimulus-evo ked brain activation with functional magnetic resonance imaging in male and female cynomolgus macaques following unilateral L7 spinal nerve ligation and the effects of clinical analgesics pregabalin,duloxetine,and morphine on brain activation in these macaques.A modified straight leg raise test was used to assess pain severity in awake animals and to evo ke regional brain activation in anesthetized *** potential effects of clinical analgesics on both awake pain behavior and regional brain activation were *** spinal nerve ligation,both male and female macaques showed significantly decreased ipsilateral straight leg raise thresholds,suggesting the presence of radicula rlike *** treatment increased straight leg raise thresholds in both males and females whereas duloxetine and pregabalin did *** male macaques,the ipsilateral straight leg raise activated contralateral insular and somatosensory cortex(Ins/SII),and *** female macaques,the ipsilateral leg raise activated cingulate cortex and contralateral insular and somatosensory *** leg raises of the contralateral,unligated leg did not evoke brain *** reduced activation in all brain regions in both male and female *** males,neither pregabalin nor duloxetine decreased brain activation compared with vehicle *** females,however,pregabalin and duloxetine decreased the activation of cingulate cortex compared with vehicle *** current findings suggest a diffe rential activation of brain areas depending on sex following a peripheral nerve *** rential brain activation observed in this study could underlie qualitative sexual dimorphism in clinical chronic pain perception and responses to

关键词： biomarkers functional magnetic resonance imaging lumbar radicular pain Macaca fascicularis neuroimaging neuropathic pain sciatica straight leg raise

Hayabusa2’s superior solar conjunction mission operations: Planning and post-operation results

在线全文

学校读者我要写书评

暂无评论

Astrodynamics 2020年第4期4卷 265-288页

作者： Stefania Soldini Hiroshi Takeuchi Sho Taniguchi Shota Kikuchi Yuto Takei go Ono Masaya Nakano Takafumi Ohnishi Takanao Saiki Yuichi Tsuda Fuyuto Terui Naoko OgawaYuya MimasuTadateru Takahashi Atsushi fujii Satoru NakazawaKent Yoshikawa Yusuke Oki Chikako Hirose Hirotaka Sawada Tomohiro Yamaguchi Makoto Yoshikawa Department of Mechanical Materials and Aerospace EngineeringUniversity of LiverpoolLiverpool L693BXUK Institute of Space and Astronautical Science Japan Aerospace Exploration AgencySagamihara 252-5210Japan Fujitsu Limited Tokyo 105-7123Japan Mitsubishi Electric Corporation Tokyo 100-8310Japan

In late 2018,the asteroid Ryugu was in the Sun's shadow during the superior solar conjunction *** the Sun-Earth-Ryugu angle decreased to below 3°,the Hayabusa2 spacecraft experienced 21 days of planned blackout in the Earth-probe communication *** was the first time a spacecraft had experienced solar conjunction while hovering around a minor *** the safety of the spacecraft,a low energy transfer trajectory named Ayu was designed in the Hill reference frame to increase its altitude from 20 to 110 *** trajectory was planned with the newly developed optNEAR tool and validated with real time *** article shows the results of the conjunction operation,from planning to fight data.

关键词： superior solar conjunction Hayabusa2 Ryugu hovering satellite mission operations