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Anti-inflammatory natural products modulate interleukins and their related signaling markers in inflammatory bowel disease:A systematic review

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Journal of Pharmaceutical Analysis 2023年第12期13卷 1408-1428页

作者： Gopalsamy Rajiv Gandhi Thiruchenduran Mohana Kumaraswamy Athesh Varghese Edwin Hillary Alan Bruno Silva Vasconcelos Mariana Nobre Farias de Franca Monalisa Martins Montalvão Stanislaus Antony Ceasar gnanasekaran jothi Gurunagarajan Sridharan Ricardo Queiroz Gurgel Baojun Xu Division of Phytochemistry and Drug Design Department of BiosciencesRajagiri College of Social Sciences(Autonomous)KalamaserryKochi683104KeralaIndia Department of Biochemistry Meenakshi Ammal Dental College and Hospital(MAHER)Maduravoyal600095ChennaiTamil NaduIndia Department of Biochemistry Srimad Andavan Arts and Science College(Autonomous)Affiliated to Bharathidasan UniversityTiruchirapalli620005Tamil NaduIndia Division of Plant Molecular Biology and Biotechnology Department of BiosciencesRajagiri College of Social Sciences(Autonomous)KalamaserryKochi683104KeralaIndia Laboratory of Biology and Immunology of Cancer and Leishmania Department of MorphologyFederal University of SergipeSao CristovaoSergipeBrazil Postgraduate Program in Health Sciences(PPGCS) Federal University of Sergipe(UFS)Campus Prof.Joao Cardoso NascimentoAracajuCEP 49060.108SergipeBrazil Programme of Food Science and Technology Department of Life SciencesBNU-HKBU United International CollegeZhuhaiGuangdong519087China

This review aims to identify in vivo studies investigating the potential of plant substances and their natural molecules in managing inflammatory bowel disease(IBD).Specifically,the objective is to examine the impact of these substances on interleukins and other key inflammatory signaling *** articles published up to December 2022 were identified through a search of the PubMed,Scopus,Web of Science,and Embase *** search used keywords including“inflammatory bowel disease”,“medicinal plants”,“natural molecules”,“anti-inflammatory”,and“ulcerative colitis”,and identified 1,878 potentially relevant articles,of which 89 were included in this review after completion of the selection *** study provides preclinical data on natural products(NPs)that can potentially treat IBD,including ulcerative *** main actions of these NPs relate to their effects on nuclear factor kappa B(NF-κβ),the Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling pathway,the regulation of T helper 17/regulatory T cells balance,and oxidative *** ability of these NPs to inhibit intestinal inflammation appears to be dependent on lowering levels of the pro-inflammatory cytokines tumor necrosis factor-alpha(TNF-α),interleukin(IL)-1β,and IL-17,via the Jun N-terminal kinase(JNK)1,NF-κβ-p65,and STAT3 *** addition,NPs were shown to reduce oxidative stress and the severity of ulcerative colitis,as well as increase the activity of antioxidant *** actions suggest that NPs represent a promising treatment for IBD,and potentially have greater efficacy and safety than current treatments.

关键词： Crohn's disease Inflammation Interleukins Oxidative stress Phytochemicals Ulcerative colitis

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Fault Aware Dynamic Resource Manager for Fault Recognition and Avoidance in Cloud

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Computer Systems Science & Engineering 2021年第8期38卷 215-228页

作者： Nandhini Jembu Mohanram gnanasekaran Thangavel N.M.jothi Swaroopan Information and Communication Engineering Department Anna UniversityChennaiTamil NaduIndia Department of Information Technology Sri Sai Ram Institute of TechnologyChennaiTamil NaduIndia RMK Engineering College ChennaiTamil NaduIndia Department of Electrical and Electronics Engineering RMK Engineering CollegeChennaiTamil NaduIndia

Fault tolerance(FT)schemes are intended to work on a minimized and static amount of physical *** a host failure occurs,the conventional FT frequently proceeds with the execution on the accessible working *** methodology saves the execution state and applications to complete without ***,the dynamicity of open cloud assets is not seen when taking scheduling *** optimization techniques are intended in dealing with resource *** method will be utilized for distributing the approaching tasks to the ***,the dynamic scheduling for this procedure doesn’t accomplish the objective of adaptation of internal *** scheme prefers jobs in the activity list with the most elevated execution time on resources that can execute in a shorter timeframe,but it suffers with higher makespan;poor resource usage and unbalance load *** overcome the above mentioned issue,Fault Aware Dynamic Resource Manager(FADRM)is proposed that enhances the mechanism to Multi-stage Resilience Manager at an application-level FT *** FADRM method gives FT a Multi-stage Resilience Manager(MRM)in the client and application layers,and simultaneously decreases the over-head and *** additionally provides safety to the application execution considering the clients,application and framework *** on experimental evaluations,Proposed Fault Aware Dynamic Resource Manager(FADRM)method 157.5 MakeSpan(MS)time,0.38 Fault Rate(FR),0.25 Failure Delay(FD)and improves 5.5 Performance Improvement Ratio(PIR)for 25,50,75 and 100 tasks and 475 MakeSpan(MS)time,0.40 Fault Rate(FR),1.30 Failure Delay(FD)and improves 6.75 improves Performance Improvement Ratio(PER)for 100,200,300 and 500 Tasks compare than existing methodologies.

关键词： Cloud computing fault aware dynamic resource manager fault tolerance makespan fault rate failure delay performance improvement ratio

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